BACKGROUND Cirrhosis results from persistent liver injury that leads to liver fibrosis.Immunological factors play important regulatory roles in the development and progression of cirrhosis.Bibliometrics is one of the ...BACKGROUND Cirrhosis results from persistent liver injury that leads to liver fibrosis.Immunological factors play important regulatory roles in the development and progression of cirrhosis.Bibliometrics is one of the most commonly used methods for systematic evaluation of a field of study.To date,there are no bibliometric studies on the role of immunological factors in cirrhosis.AIM To provide a comprehensive overview of the knowledge structure and research hotspots of immunological factors in cirrhosis.METHODS We retrieved publications related to immunological factors in cirrhosis between 2003 to 2022 from the Web of Science Core Collection database on December 7,2022.The search strategy was TS=((Liver Cirrhosis OR hepatic cirrhosis OR liver fibrosis)AND(Immunologic*Factor*OR Immune Factor*OR Immunomodulator*OR Biological Response Modifier*OR Biomodulator*)).Only original articles and reviews were included.A total of 2873 publications were analyzed using indicators of publication and citation metrics,countries,institutes,authors,journals,references,and keywords by CiteSpace and VOSviewer.RESULTS A total of 5104 authors from 1173 institutions across 51 countries published 2873 papers on cirrhosis and immunological factors in 281 journals.In the past 20 years,the increasing number of related annual publications and citations indicates that research on immunological factors in cirrhosis has become the focus of attention and has entered a period of accelerated development.The United States(781/27.18%),China(538/18.73%),and Germany(300/10.44%)were the leading countries in this field.Most of the top 10 authors were from the United States(4)and Germany(3),with Gershwin ME contributing the most related articles(42).World Journal of Gastroenterology was the most productive journal,whereas Hepatology was the most co-cited journal.Current research hotspots regarding immunological factors in cirrhosis include fibrosis,cirrhosis,inflammation,liver fibrosis,expression,hepatocellular carcinoma,activation,primary biliary cirrhosis,disease,and hepatic stellate cells.Burst keywords(e.g.,epidemiology,gut microbiota,and pathways)represent research frontiers that have attracted the interest of researchers in recent years.CONCLUSION This bibliometric study comprehensively summarizes the research developments and directions of immunological factors in cirrhosis,providing new ideas for promoting scientific research and clinical applications.展开更多
Cu–Al/Al nanostructured metallic multilayers with Al layer thickness hAlvarying from 5 to 100 nm were prepared, and their mechanical properties and deformation behaviors were studied by nanoindentation testing. The r...Cu–Al/Al nanostructured metallic multilayers with Al layer thickness hAlvarying from 5 to 100 nm were prepared, and their mechanical properties and deformation behaviors were studied by nanoindentation testing. The results showed that the hardness increased drastically with decreasing hAldown to about 20 nm, whereafter the hardness reached a plateau that approaches the hardness of the alloyed Cu–Al monolithic thin films. The strain rate sensitivity(SRS, m),however, decreased monotonically with reducing hAl. The layer thickness-dependent strengthening mechanisms were discussed, and it was revealed that the alloyed Cu–Al nanolayers dominated at hAlB 20 nm, while the crystalline Al nanolayers dominated at hAl[ 20 nm. The plastic deformation was mainly related to the ductile Al nanolayers, which was responsible for the monotonic evolution of SRS with hAl. In addition, the hAl-dependent hardness and SRS were quantitatively modeled in light of the strengthening mechanisms at different length scales.展开更多
The taxonomical position of species of the genus Tamarix(Tamaricaceae) has been criticized because of their gross morphological similarities(such as slender, smooth and reddish-brown branches,grey-green foliage and sc...The taxonomical position of species of the genus Tamarix(Tamaricaceae) has been criticized because of their gross morphological similarities(such as slender, smooth and reddish-brown branches,grey-green foliage and scale leaves), and their systematic relationships remain unclear. In this paper, the leaf epidermal features of 17 species from China are studied based on the micro-morphological characters of the epidermal cells, stomata, salt glands, papillae and epidermal hairs. According to the studies, the leaf epidermal features, together with the character of the flower, are taxonomically clearly distinct. The establishment of Tamarix albiflonum is consolidated. Tamarix korolkowi and Tamarix ramosissima have minimal differences in epidermal characters, and the former is suggested to be a junior synonym. Tamarix ramosissima, Tamarix tarimensis, Tamarix arceuthoides and Tamarix hohenackeri are most similar with respect to their leaf epidermis; considering the common morphological features, habit, distribution and especially the hybridization, it is suggested that these four species are closely genetically related and that the variations among them are probably intraspecific. The new taxonomical evidence indicates the occurrence of13 species and four variants in China. Presently, Tamarix is a typical plant of arid and semi-arid regions, but its Eocene ancestors lived in warm and humid climates in the coastal areas of the ancient Mediterranean Sea.Thus, the papillae or epidermal hairs, which are outgrowths of the outer epidermal cells facilitating the leaf to respond to water stress and commonly seen in the plants growing in arid or semi-arid areas rather than the plants in warm and humid climates, are of relatively recent origin in Tamarix. The primitive species lack papillae or epidermal hairs, while in evolved species these structures are abundant. Based on the ecological adaptations of the epidermal features, the palaeogeographic implications of Tamarix in the Late Cenozoic of Northwest China are also discussed.展开更多
This paper describes the fossil fruits of Scirpus weichangensis X.Q.Liang,sp.nov.from the early Miocene of Guangyongfa Village,Weichang County,Hebei Province,North China.The fossil fruits are obovate in shape and thei...This paper describes the fossil fruits of Scirpus weichangensis X.Q.Liang,sp.nov.from the early Miocene of Guangyongfa Village,Weichang County,Hebei Province,North China.The fossil fruits are obovate in shape and their lateral sections are plumply trigonous.The cell walls of the surface are straight.The persistent stout bristles have downward-directed barbellae in distal 1/2.The occurrence of the fossil Scirpus indicates that Guangfayong was a wetland in the early Miocene.Based on the fossil data,the genus likely originated in Western Siberia in the Oligocene,spread during the Miocene,and was finally distributed worldwide in the Holocene.展开更多
基金the National Multi-Center Clinical Research Project of Peking University First Hospital,No.2022CR57.
文摘BACKGROUND Cirrhosis results from persistent liver injury that leads to liver fibrosis.Immunological factors play important regulatory roles in the development and progression of cirrhosis.Bibliometrics is one of the most commonly used methods for systematic evaluation of a field of study.To date,there are no bibliometric studies on the role of immunological factors in cirrhosis.AIM To provide a comprehensive overview of the knowledge structure and research hotspots of immunological factors in cirrhosis.METHODS We retrieved publications related to immunological factors in cirrhosis between 2003 to 2022 from the Web of Science Core Collection database on December 7,2022.The search strategy was TS=((Liver Cirrhosis OR hepatic cirrhosis OR liver fibrosis)AND(Immunologic*Factor*OR Immune Factor*OR Immunomodulator*OR Biological Response Modifier*OR Biomodulator*)).Only original articles and reviews were included.A total of 2873 publications were analyzed using indicators of publication and citation metrics,countries,institutes,authors,journals,references,and keywords by CiteSpace and VOSviewer.RESULTS A total of 5104 authors from 1173 institutions across 51 countries published 2873 papers on cirrhosis and immunological factors in 281 journals.In the past 20 years,the increasing number of related annual publications and citations indicates that research on immunological factors in cirrhosis has become the focus of attention and has entered a period of accelerated development.The United States(781/27.18%),China(538/18.73%),and Germany(300/10.44%)were the leading countries in this field.Most of the top 10 authors were from the United States(4)and Germany(3),with Gershwin ME contributing the most related articles(42).World Journal of Gastroenterology was the most productive journal,whereas Hepatology was the most co-cited journal.Current research hotspots regarding immunological factors in cirrhosis include fibrosis,cirrhosis,inflammation,liver fibrosis,expression,hepatocellular carcinoma,activation,primary biliary cirrhosis,disease,and hepatic stellate cells.Burst keywords(e.g.,epidemiology,gut microbiota,and pathways)represent research frontiers that have attracted the interest of researchers in recent years.CONCLUSION This bibliometric study comprehensively summarizes the research developments and directions of immunological factors in cirrhosis,providing new ideas for promoting scientific research and clinical applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.5132100351322104and 51201123)+5 种基金the National Basic Research Program of China(Grant No.2010CB631003)the 111 Project of China(Grant No.B06025)the support from the Fundamental Research Funds for the Central Universitiesthe Tengfei Scholar projectthe Natural Science Basic Research Plan in Shaanxi Province of China(Program No.2015JM5158)the Shaanxi Province Postdoctoral Scientific Research Project for partial financial support
文摘Cu–Al/Al nanostructured metallic multilayers with Al layer thickness hAlvarying from 5 to 100 nm were prepared, and their mechanical properties and deformation behaviors were studied by nanoindentation testing. The results showed that the hardness increased drastically with decreasing hAldown to about 20 nm, whereafter the hardness reached a plateau that approaches the hardness of the alloyed Cu–Al monolithic thin films. The strain rate sensitivity(SRS, m),however, decreased monotonically with reducing hAl. The layer thickness-dependent strengthening mechanisms were discussed, and it was revealed that the alloyed Cu–Al nanolayers dominated at hAlB 20 nm, while the crystalline Al nanolayers dominated at hAl[ 20 nm. The plastic deformation was mainly related to the ductile Al nanolayers, which was responsible for the monotonic evolution of SRS with hAl. In addition, the hAl-dependent hardness and SRS were quantitatively modeled in light of the strengthening mechanisms at different length scales.
基金supported by the National Natural Science Foundation of China, Grant 41271070the West Light Foundation of the Chinese Academy of Sciences, Grant 2015-XBQN-B-25
文摘The taxonomical position of species of the genus Tamarix(Tamaricaceae) has been criticized because of their gross morphological similarities(such as slender, smooth and reddish-brown branches,grey-green foliage and scale leaves), and their systematic relationships remain unclear. In this paper, the leaf epidermal features of 17 species from China are studied based on the micro-morphological characters of the epidermal cells, stomata, salt glands, papillae and epidermal hairs. According to the studies, the leaf epidermal features, together with the character of the flower, are taxonomically clearly distinct. The establishment of Tamarix albiflonum is consolidated. Tamarix korolkowi and Tamarix ramosissima have minimal differences in epidermal characters, and the former is suggested to be a junior synonym. Tamarix ramosissima, Tamarix tarimensis, Tamarix arceuthoides and Tamarix hohenackeri are most similar with respect to their leaf epidermis; considering the common morphological features, habit, distribution and especially the hybridization, it is suggested that these four species are closely genetically related and that the variations among them are probably intraspecific. The new taxonomical evidence indicates the occurrence of13 species and four variants in China. Presently, Tamarix is a typical plant of arid and semi-arid regions, but its Eocene ancestors lived in warm and humid climates in the coastal areas of the ancient Mediterranean Sea.Thus, the papillae or epidermal hairs, which are outgrowths of the outer epidermal cells facilitating the leaf to respond to water stress and commonly seen in the plants growing in arid or semi-arid areas rather than the plants in warm and humid climates, are of relatively recent origin in Tamarix. The primitive species lack papillae or epidermal hairs, while in evolved species these structures are abundant. Based on the ecological adaptations of the epidermal features, the palaeogeographic implications of Tamarix in the Late Cenozoic of Northwest China are also discussed.
基金supported by grants from the National Natural Science Foundation of China(Nos.31760057,31860049,41502017,41072022)
文摘This paper describes the fossil fruits of Scirpus weichangensis X.Q.Liang,sp.nov.from the early Miocene of Guangyongfa Village,Weichang County,Hebei Province,North China.The fossil fruits are obovate in shape and their lateral sections are plumply trigonous.The cell walls of the surface are straight.The persistent stout bristles have downward-directed barbellae in distal 1/2.The occurrence of the fossil Scirpus indicates that Guangfayong was a wetland in the early Miocene.Based on the fossil data,the genus likely originated in Western Siberia in the Oligocene,spread during the Miocene,and was finally distributed worldwide in the Holocene.
