BACKGROUND：Animal experiments showed that recruitment maneuver （RM） and protective ventilation strategy of the lung could improve oxygenation and reduce extravascular lung water. This study was to investigate the e...BACKGROUND：Animal experiments showed that recruitment maneuver （RM） and protective ventilation strategy of the lung could improve oxygenation and reduce extravascular lung water. This study was to investigate the effects of RM on respiratory mechanics and extravascular lung water index （EVLWI） in patients with acute respiratory distress syndrome （ARDS）. METHODS：Thirty patients with ARDS were randomized into a RM group and a non-RM group. In the RM group, after basic mechanical ventilation stabilized for 30 minutes, RM was performed and repeated once every 12 hours for 3 days. In the non-RM group, lung protective strategy was conducted without RM. Oxygenation index （PaO2/FiO2）, peak inspiratory pressure （PIP）, Plateau pressure （Pplat）, static pulmonary compliance （Cst） and EVLWI of patients before treatment and at 12, 24, 48, 72 hours after the treatment were measured and compared between the groups. Hemodynamic changes were observed before and after RM. One-way ANOVA, Student＇s t test and Fisher＇s exact test were used to process the data. RESULTS：The levels of PaO2/FiO2 and Cst increased after treatment in the two groups, but they were higher in the RM group than in the non-RM group （P〈0.05）. The PIP and Pplat decreased after treatment in the two groups, but they were lower in the RM group than in the non-RM group （P〈0.05）. The EVLWI in the two groups showed downward trend after treatment （P〈0.05）, and the differences were signifcant at all time points （P〈0.01）; the EVLWI in the RM group was lower than that in the non-RM group at 12, 24, 48 and 72 hours （P〈0.05 or P〈0.01）. Compared with pre-RM, hemodynamics changes during RM were significantly different （P〈0.01）; compared with pre-RM, the changes were not significantly different at 120 seconds after the end of RM （P〉0.05）. CONCLUSIONS： RM could reduce EVLWI, increase oxygenation and lung compliance. The effect of RM on hemodynamics was transient.展开更多
BACKGROUND Severe eyelid edema and blood accumulation in the submandibular space after preauricular fistula surgery is rarely reported.CASE SUMMARY We report a 4-year-old girl with eyelid edema and swelling of the sub...BACKGROUND Severe eyelid edema and blood accumulation in the submandibular space after preauricular fistula surgery is rarely reported.CASE SUMMARY We report a 4-year-old girl with eyelid edema and swelling of the submandibular region after preauricular fistula resection under general anesthesia.When drug treatment failed,neck computed tomography examination was performed,which confirmed severe bleeding in the submandibular space.Later,exploration and ligation of the superficial temporal artery were performed under general anesthesia to stop the bleeding.The child was successfully treated,and there were no abnormalities over 1 year of follow-up.CONCLUSION When severe bleeding occurs after preauricular fistula surgery,superficial temporal artery rupture should be considered as a cause.展开更多
The efficient extraction of uranium,as the primary component of nuclear energy,holds significant implications.Drawing inspiration from the charge interaction observed in biological ion channels,we encapsulated negativ...The efficient extraction of uranium,as the primary component of nuclear energy,holds significant implications.Drawing inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of COF-AO.The synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium recovery.The negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with uranium.Due to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO alone.Their adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption processes.This work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.展开更多
Extracting uranium from seawater offers opportunities for sustainable nuclear fuel supply,but the task is quite challenging due to the low uranium concentration(~3 ppb)in seawater.Here,based on the Knoevenagel condens...Extracting uranium from seawater offers opportunities for sustainable nuclear fuel supply,but the task is quite challenging due to the low uranium concentration(~3 ppb)in seawater.Here,based on the Knoevenagel condensation reaction of aldehyde and acetonitrile groups,a novel stable sp^(2)carbon-linked three-dimensional covalent organic framework(3D COF),TFPM-PDANAO was prepared as a porous platform for uranium extraction from seawater.The TFPM-PDAN-AO designed with regular 3D pore channel of 7.12 A provides a specific channel for uranyl diffusion,which exhibits high selectivity and fast kinetics for uranium adsorption.Meanwhile,the superior stability and optoelectronic properties enable it an excellent porous platform for uranium electroextraction.By applying alternating voltages between-5 and 0 V,uranyl ions can rapidly migrate and enrich into the porous structure of TFPM-PDAN-AO,then inducing the electrodeposition of uranium compounds to form the charge neutral species(Na_(2)O(UO_(3)H_(2)O)x)with an unprecedentedly high adsorption capacity of 4,685 mg g^(-1).This work not only expands the application prospects of functionalized 3D COFs,but also provides a technical support for the electrodeposition adsorption of uranium from seawater.展开更多
Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes(T1D)children and their associations as environmental triggers through gut microbiota shifts remained unkno...Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes(T1D)children and their associations as environmental triggers through gut microbiota shifts remained unknown.We thus investigated the antibiotics and neonicotinoids’exposure levels and their associations with gut microbiota in pediatric T1D.Methods Fifty-one newly onset T1D children along with 67 age-matched healthy controls were recruited.Urine concentrations of 28 antibiotics and 12 neonicotinoids were measured by mass spectrometry.Children were grouped according to the kinds of antibiotics’and neonicotinoids’exposures,respectively.The 16S rRNA of fecal gut microbiota was sequenced,and the correlation with urine antibiotics and neonicotinoids’concentrations was analyzed.Results The overall detection rates of antibiotics were 72.5%and 61.2%among T1D and healthy children,whereas the neonicotinoids detection rates were 70.6%and 52.2%(P=0.044).Children exposed to one kind of antibiotic or two or more kinds of neonicotinoids had higher risk of T1D,with the odd ratios of 2.579 and 3.911.Furthermore,co-exposure to antibiotics and neonicotinoids was associated with T1D,with the odd ratio of 4.924.Antibiotics or neonicotinoids exposure did not affect overall richness and diversity of gut microbiota.However,children who were exposed to neither antibiotics nor neonicotinoids had higher abundance of Lachnospiraceae than children who were exposed to antibiotics and neonicotinoids alone or together.Conclusion High antibiotics and neonicotinoids exposures were found in T1D children,and they were associated with changes in gut microbiota featured with lower abundance of butyrate-producing genera,which might increase the risk of T1D.展开更多
文摘BACKGROUND：Animal experiments showed that recruitment maneuver （RM） and protective ventilation strategy of the lung could improve oxygenation and reduce extravascular lung water. This study was to investigate the effects of RM on respiratory mechanics and extravascular lung water index （EVLWI） in patients with acute respiratory distress syndrome （ARDS）. METHODS：Thirty patients with ARDS were randomized into a RM group and a non-RM group. In the RM group, after basic mechanical ventilation stabilized for 30 minutes, RM was performed and repeated once every 12 hours for 3 days. In the non-RM group, lung protective strategy was conducted without RM. Oxygenation index （PaO2/FiO2）, peak inspiratory pressure （PIP）, Plateau pressure （Pplat）, static pulmonary compliance （Cst） and EVLWI of patients before treatment and at 12, 24, 48, 72 hours after the treatment were measured and compared between the groups. Hemodynamic changes were observed before and after RM. One-way ANOVA, Student＇s t test and Fisher＇s exact test were used to process the data. RESULTS：The levels of PaO2/FiO2 and Cst increased after treatment in the two groups, but they were higher in the RM group than in the non-RM group （P〈0.05）. The PIP and Pplat decreased after treatment in the two groups, but they were lower in the RM group than in the non-RM group （P〈0.05）. The EVLWI in the two groups showed downward trend after treatment （P〈0.05）, and the differences were signifcant at all time points （P〈0.01）; the EVLWI in the RM group was lower than that in the non-RM group at 12, 24, 48 and 72 hours （P〈0.05 or P〈0.01）. Compared with pre-RM, hemodynamics changes during RM were significantly different （P〈0.01）; compared with pre-RM, the changes were not significantly different at 120 seconds after the end of RM （P〉0.05）. CONCLUSIONS： RM could reduce EVLWI, increase oxygenation and lung compliance. The effect of RM on hemodynamics was transient.
基金the Natural Science Research Project of Wanbei Health Vocational College,No.WZK201909.
文摘BACKGROUND Severe eyelid edema and blood accumulation in the submandibular space after preauricular fistula surgery is rarely reported.CASE SUMMARY We report a 4-year-old girl with eyelid edema and swelling of the submandibular region after preauricular fistula resection under general anesthesia.When drug treatment failed,neck computed tomography examination was performed,which confirmed severe bleeding in the submandibular space.Later,exploration and ligation of the superficial temporal artery were performed under general anesthesia to stop the bleeding.The child was successfully treated,and there were no abnormalities over 1 year of follow-up.CONCLUSION When severe bleeding occurs after preauricular fistula surgery,superficial temporal artery rupture should be considered as a cause.
基金supported by the National Natural Science Foundation of China(22036003,22176082 and 22376023)Natural Science Foundation of Jiangxi Province(20232BBE50031)。
文摘The efficient extraction of uranium,as the primary component of nuclear energy,holds significant implications.Drawing inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of COF-AO.The synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium recovery.The negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with uranium.Due to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO alone.Their adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption processes.This work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.
基金supported by the National Natural Science Foundation of China(22036003,21976077)the Natural Science Foundation of Jiangxi Province(20212ACB203009,20212ACB-203011)。
文摘Extracting uranium from seawater offers opportunities for sustainable nuclear fuel supply,but the task is quite challenging due to the low uranium concentration(~3 ppb)in seawater.Here,based on the Knoevenagel condensation reaction of aldehyde and acetonitrile groups,a novel stable sp^(2)carbon-linked three-dimensional covalent organic framework(3D COF),TFPM-PDANAO was prepared as a porous platform for uranium extraction from seawater.The TFPM-PDAN-AO designed with regular 3D pore channel of 7.12 A provides a specific channel for uranyl diffusion,which exhibits high selectivity and fast kinetics for uranium adsorption.Meanwhile,the superior stability and optoelectronic properties enable it an excellent porous platform for uranium electroextraction.By applying alternating voltages between-5 and 0 V,uranyl ions can rapidly migrate and enrich into the porous structure of TFPM-PDAN-AO,then inducing the electrodeposition of uranium compounds to form the charge neutral species(Na_(2)O(UO_(3)H_(2)O)x)with an unprecedentedly high adsorption capacity of 4,685 mg g^(-1).This work not only expands the application prospects of functionalized 3D COFs,but also provides a technical support for the electrodeposition adsorption of uranium from seawater.
基金supported by the National Key Research and Development Program of China(2016YFC1305302)the Clinical special project of integrated traditional Chinese and Western medicine in 2019,Shanghai Municipal Health Commission,Shanghai Municipal Administrator of Traditional Chinese Medicine.
文摘Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes(T1D)children and their associations as environmental triggers through gut microbiota shifts remained unknown.We thus investigated the antibiotics and neonicotinoids’exposure levels and their associations with gut microbiota in pediatric T1D.Methods Fifty-one newly onset T1D children along with 67 age-matched healthy controls were recruited.Urine concentrations of 28 antibiotics and 12 neonicotinoids were measured by mass spectrometry.Children were grouped according to the kinds of antibiotics’and neonicotinoids’exposures,respectively.The 16S rRNA of fecal gut microbiota was sequenced,and the correlation with urine antibiotics and neonicotinoids’concentrations was analyzed.Results The overall detection rates of antibiotics were 72.5%and 61.2%among T1D and healthy children,whereas the neonicotinoids detection rates were 70.6%and 52.2%(P=0.044).Children exposed to one kind of antibiotic or two or more kinds of neonicotinoids had higher risk of T1D,with the odd ratios of 2.579 and 3.911.Furthermore,co-exposure to antibiotics and neonicotinoids was associated with T1D,with the odd ratio of 4.924.Antibiotics or neonicotinoids exposure did not affect overall richness and diversity of gut microbiota.However,children who were exposed to neither antibiotics nor neonicotinoids had higher abundance of Lachnospiraceae than children who were exposed to antibiotics and neonicotinoids alone or together.Conclusion High antibiotics and neonicotinoids exposures were found in T1D children,and they were associated with changes in gut microbiota featured with lower abundance of butyrate-producing genera,which might increase the risk of T1D.
