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放射治疗对肺癌患者NKG2D、HMGB1及DC细胞活性的影响 被引量:2
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作者 白璐 张晶晶 +4 位作者 高东奇 刘承一 于晓磊 李文鑫 李青山 《中国现代医学杂志》 CAS 2020年第1期31-35,共5页
目的分析接受放射治疗(以下简称放疗)肺癌患者在放疗不同阶段外周血细胞因子NKG2D、高迁移率蛋白1(HMGB1)的变化及与树突状细胞(DC细胞)活性的相关性。方法选取承德医学院附属医院30例肺癌放疗患者,分别在放疗前及放疗后不同时段通过EL... 目的分析接受放射治疗(以下简称放疗)肺癌患者在放疗不同阶段外周血细胞因子NKG2D、高迁移率蛋白1(HMGB1)的变化及与树突状细胞(DC细胞)活性的相关性。方法选取承德医学院附属医院30例肺癌放疗患者,分别在放疗前及放疗后不同时段通过ELISA检测NKG2D、HMGB1,通过免疫磁珠法检测DC细胞。结果 HMGB1、NKG2D的浓度于放疗2 000、4 000及6 000 cGy时逐渐下降(P<0.05)。DC细胞活性差异无统计学意义(P<0.05)。DC细胞与HMGB1、NKG2D无相关性(r=-0.204和0.105,P=0.281和0.580)。结论放射治疗可降低肺癌患者HMGB1、NKG2D的水平,激活免疫功能,但对肺癌患者外周血中DC细胞的活性无影响,外周血中DC细胞活性与HMGB1、NKG2D无相关。 展开更多
关键词 肺肿瘤 放射治疗 NKG2D HMGB1 DC细胞
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Optimization of pressurization process in low-pressure casting of a 5.4-ton gigantic C95800 copper alloy casting
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作者 Zi-ao Qiu Xin-yi Zhao +9 位作者 Chao-jun Zhang Jun-liu Yang Rui-yun Shi Tang-qi Lü xiao-lei yu Qiu-shi Chen Lin-lin Quan Lun-yong Zhang Fu-yang Cao Jian-fei Sun 《China Foundry》 SCIE EI CAS 2024年第6期717-726,共10页
During the low-pressure casting of extra-large size C95800 copper alloy components,traditional linear pressurization technique leads to a rapid surge of liquid metal inlet velocity at the regions where the mold cavity... During the low-pressure casting of extra-large size C95800 copper alloy components,traditional linear pressurization technique leads to a rapid surge of liquid metal inlet velocity at the regions where the mold cavity cross-section enlarges.This rapid increasement of liquid metal inlet velocity causes serious entrapment of gas and oxide films,and results in various casting defects such as the bifilm defects.These defects detrimentally deteriorate mechanical properties of the castings.To address this issue,an innovative nonlinear pressurization strategy timely matching to the casting structure was proposed.The pressurization rate decreases at sections where the cross-section widens,but it gradually increases as the liquid metal level rises.By this way,the inlet velocity remains below a critical threshold to prevent the entrapment of gas and oxide films.Comparative analyses involving numerical simulations and casting verification illustrate that the nonlinear pressurization technique,compared to the linear pressurization,effectively diminishes both the size and number of bifilm defects.Furthermore,the nonlinear pressurization method enhances the casting yield strength by 10%,tensile strength by 14%,and elongation by 10%.Examination through scanning electron microscopy highlights that the bifilm defects arising from the linear pressurization process result in the reduction of the castings’mechanical properties.These observations underscore the efficacy of nonlinear pressurization in enhancing the quality and reliability of gigantic castings,as exemplified by a 5.4-ton extra-large sized C95800 copper alloy propeller hub with complex structures in the current study. 展开更多
关键词 gigantic copper alloy casting C95800 low-pressure casting nonlinear pressurization process
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