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Leukocyte immunoglobulin-like receptor B2:A promising biomarker for colorectal cancer 被引量:1
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作者 Wen-Zhuo Zhao Hong-Gang Wang xiao-zhong yang 《World Journal of Gastroenterology》 SCIE CAS 2024年第4期421-423,共3页
According to the latest global cancer statistics,colorectal cancer(CRC)has emerged as the third most prevalent malignant tumor across the globe.In recent decades,the medical field has implemented several levels of CRC... According to the latest global cancer statistics,colorectal cancer(CRC)has emerged as the third most prevalent malignant tumor across the globe.In recent decades,the medical field has implemented several levels of CRC screening tests,encompassing fecal tests,endoscopic examinations,radiological examinations and blood tests.Previous studies have shown that leukocyte immunoglobulin-like receptor B2(LILRB2)is involved in inhibiting immune cell function,immune evasion,and promoting tumor progression in acute myeloid leukemia and nonsmall cell lung cancer.However,its interaction with CRC has not been reported yet.Recently,a study published in the World Journal of Gastroenterology revealed that LILRB2 and its ligand,angiopoietin-like protein 2,are markedly overexpressed in CRC.This overexpression is closely linked to tumor progression and is indicative of a poor prognosis.The study highlights the potential of utilizing the concentration of LILRB2 in serum as a promising biomarker for tumors.However,there is still room for discussion regarding the data processing and analysis in this research. 展开更多
关键词 Colorectal cancer Leukocyte immunoglobulin-like receptor B2 Angiopoietinlike protein 2 Therapeutic target Noninvasive screening biomarker
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Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway
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作者 Xin Wen Rui Xie +4 位作者 Hong-Gang Wang Min-Na Zhang Le He Meng-Hui Zhang xiao-zhong yang 《World Journal of Gastroenterology》 SCIE CAS 2023年第30期4657-4670,共14页
BACKGROUND Fecal microbiota transplantation(FMT)has shown promising therapeutic effects on mice with experimental colitis and patients with ulcerative colitis(UC).FMT modulates the Toll-like receptor 4(TLR4)signaling ... BACKGROUND Fecal microbiota transplantation(FMT)has shown promising therapeutic effects on mice with experimental colitis and patients with ulcerative colitis(UC).FMT modulates the Toll-like receptor 4(TLR4)signaling pathway to treat some other diseases.However,it remains unknown whether this modulation is also involved in the treatment of UC.AIM To clarify the necessity of TLR4 signaling pathway in FMT on dextran sodium sulphate(DSS)-induced mice and explain the mechanism of FMT on UC,through association analysis of gut microbiota with colon transcriptome in mice.METHODS A mouse colitis model was constructed with wild-type(WT)and TLR4-knockout(KO)mice.Fecal microbiota was transplanted by gavage.Colon inflammation severity was measured by disease activity index(DAI)scoring and hematoxylin and eosin staining.Gut microbiota structure was analyzed through 16S ribosomal RNA sequencing.Gene expression in the mouse colon was obtained by transcriptome sequencing.RESULTS The KO(DSS+Water)and KO(DSS+FMT)groups displayed indistinguishable body weight loss,colon length,DAI score,and histology score,which showed that FMT could not inhibit the disease in KO mice.In mice treated with FMT,the relative abundance of Akkermansia decreased,and Lactobacillus became dominant.In particular,compared with those in WT mice,the scores of DAI and colon histology were clearly decreased in the KO-DSS group.Microbiota structure showed a significant difference between KO and WT mice.Akkermansia were the dominant genus in healthy KO mice.The ineffectiveness of FMT in KO mice was related to the decreased abundance of Akkermansia.Gene Ontology enrichment analysis showed that differentially expressed genes between each group were mainly involved in cytoplasmic translation and cellular response to DNA damage stimulus.The top nine genes correlating with Akkermansia included Aqp4,Clca4a,Dpm3,Fau,Mcrip1,Meis3,Nupr1 L,Pank3,and Rps13(|R|>0.9,P<0.01).CONCLUSION FMT may ameliorate DSS-induced colitis by regulating the TLR4 signaling pathway.TLR4 modulates the composition of gut microbiota and the expression of related genes to ameliorate colitis and maintain the stability of the intestinal environment.Akkermansia bear great therapeutic potential for colitis. 展开更多
关键词 Toll-like receptor 4 Fecal microbiota transplantation COLITIS Akkermansia LACTOBACILLUS Aquaporin 4 Transcriptome sequencing
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冷圈套切除术治疗≤1.0cm结直肠息肉的有效性和安全性 被引量:19
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作者 曹婷婷 陶国全 +3 位作者 杨晓钟 张娟 孙素华 戴伟杰 《中国内镜杂志》 2021年第5期1-6,共6页
目的探讨冷圈套切除术(CSP)与热圈套切除术(HSP)治疗直径≤1.0 cm结直肠息肉的有效性和安全性。方法选取2018年6月-2020年3月南京医科大学附属淮安第一医院因结直肠息肉(直径≤1.0 cm)行内镜下切除治疗的1403例患者作为研究对象,分为CSP... 目的探讨冷圈套切除术(CSP)与热圈套切除术(HSP)治疗直径≤1.0 cm结直肠息肉的有效性和安全性。方法选取2018年6月-2020年3月南京医科大学附属淮安第一医院因结直肠息肉(直径≤1.0 cm)行内镜下切除治疗的1403例患者作为研究对象,分为CSP组(n=213)和HSP组(n=1190),比较两组钛夹使用、出血穿孔发生率、术后内镜下止血率和组织学完整切除率等。结果HSP组术后迟发性出血发生率明显高于CSP组(4.9%和0.9%,P=0.003)。HSP组有5例发生术后迟发性穿孔,而CSP组无1例。CSP组息肉组织完整切除率为95.8%(204/213),与HSP组的97.6%(1162/1190)比较,差异无统计学意义。结论CSP治疗直径≤1.0 cm的结直肠息肉术后出血风险低,钛夹使用数少,术后内镜下止血率低,而组织学完整切除率与HSP接近,是一种安全、有效的治疗方式。 展开更多
关键词 结直肠息肉 冷圈套切除术 热圈套切除术 出血 完整切除
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Interleukin-8 associates with adhesion,migration,invasion and chemosensitivity of human gastric cancer cells 被引量:21
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作者 Wen-Xia Kuai Qiong wang +3 位作者 xiao-zhong yang Yao Zhao Ren Yu Xiao-Jun Tang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第9期979-985,共7页
AIM: To investigate the relationship between Interleu- kin-8 (IL-8) and proliferation, adhesion, migration, inva- sion and chemosensitivity of gastric cancer (GC) cells.
关键词 INTERLEUKIN-8 Gastric cancer ADHESION Mi-gration INVASION
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Effective immune-inflammation index for ulcerative colitis and activity assessments 被引量:13
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作者 Meng-Hui Zhang Han Wang +2 位作者 Hong-Gang Wang Xin Wen xiao-zhong yang 《World Journal of Clinical Cases》 SCIE 2021年第2期334-343,共10页
BACKGROUND The inverse association between systemic immune-inammation index(SII)and overall survival in tumors has been studied.AIM To evaluate the hematological indexes for assessing the activity of ulcerative colit... BACKGROUND The inverse association between systemic immune-inammation index(SII)and overall survival in tumors has been studied.AIM To evaluate the hematological indexes for assessing the activity of ulcerative colitis(UC).METHODS In this case-control study,172 UC patients and healthy participants were included.Comparisons were made among groups of white blood cells,hemoglobin,platelets,neutrophils,lymphocytes,monocytes,SII,neutrophil-tolymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR).The relationship with hematological inflammation was verified by Spearman correlation analyses.The efficiency of SII,NLR,and PLR for distinguishing between UC and severe disease status was assessed by the receiver operator curve and logistic regression analyses.RESULTS The values of SII,NLR,and PLR were higher in UC patients than in controls(P<0.001)and were positively correlated with the Mayo endoscopic score,extent,Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score,and Ulcerative Colitis Endoscopic Index of Severity(UCEIS).The cut-off NLR value of 562.22 predicted UC with a sensitivity of 79.65%and a specificity of 76.16%.Logistic regression analysis revealed that patients with SII and NLR levels above the median had a significantly higher risk of UC(P<0.05).Risk factors independently associated with DUBLIN≥3 included SII≥1776.80[odds ratio(OR)=11.53,P=0.027]and NLR value of 2.67-4.23(OR=2.96,P=0.047)on multivariate analysis.Compared with the first quartile,SII≥1776.80 was an independent predictor of UCEIS≥5(OR=18.46,P=0.012).CONCLUSION SII has a certain value in confirming UC and identifying its activity. 展开更多
关键词 Ulcerative colitis Systemic immune-inflammation index Endoscopic score Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Disease activity
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Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation 被引量:10
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作者 Xin Wen Hong-Gang Wang +3 位作者 Min-Na Zhang Meng-Hui Zhang Han Wang xiao-zhong yang 《World Journal of Gastroenterology》 SCIE CAS 2021年第21期2834-2849,共16页
BACKGROUND Emerging evidence has demonstrated that fecal microbiota transplantation(FMT)has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis(UC),although the mechan... BACKGROUND Emerging evidence has demonstrated that fecal microbiota transplantation(FMT)has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis(UC),although the mechanism of FMT is unclear.AIM To evaluate the protective effect of FMT on UC and clarify its potential dependence on the gut microbiota,through association analysis of gut microbiota with colon transcriptome in mice.METHODS Dextran sodium sulfate(DSS)-induced experimental colitis was established and fecal microbiota was transplanted by gavage.Severity of colon inflammation was measured by body weight,disease activity index,colon length and histological score.Gut microbiota alteration was analyzed through 16S ribosomal ribonucleic acid sequencing.The differentially expressed genes(DEGs)in the colon were obtained by transcriptome sequencing.The activation status of colonic T lymphocytes in the lamina propria was evaluated by flow cytometry.RESULTS Compared with the DSS group,the weight loss,colon length shortening and inflammation were significantly alleviated in the FMT group.The scores of disease activity index and colon histology decreased obviously after FMT.FMT restored the balance of gut microbiota,especially by upregulating the relative abundance of Lactobacillus and downregulating the relative abundance of Clostridium_sensu_stricto_1 and Turicibacter.In the transcriptomic analysis,128 DEGs intersected after DSS treatment and FMT.Functional annotation analysis suggested that these DEGs were mainly involved in T-lymphocyte activation.In the DSS group,there was an increase in colonic T helper CD4^(+)and T cytotoxic CD8^(+)cells by flow cytometry.FMT selectively downregulated the ratio of colonic CD4^(+)and CD8^(+)T cells to maintain intestinal homeostasis.Furthermore,Clostri dium_sensu_stricto_1 was significantly related to inflammation-related genes including REG3G,CCL8 and IDO1.CONCLUSION FMT ameliorated DSS-induced colitis in mice via regulating the gut microbiota and T-cell modulation. 展开更多
关键词 Fecal microbiota transplantation COLITIS Gut microbiota Transcriptome sequencing T lymphocyte
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Cholecystectomy does not significantly increase the risk of fatty liver disease 被引量:3
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作者 Hong-Gang Wang Li-Zhen Wang +6 位作者 Hang-Jiang Fu Peng Shen Xiao-Dan Huang Fa-Ming Zhang Rui Xie xiao-zhong yang Guo-Zhong Ji 《World Journal of Gastroenterology》 SCIE CAS 2015年第12期3614-3618,共5页
AIM: To investigate the relationship between cholecystectomy and fatty liver disease(FLD) in a Chinese population.METHODS: A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second A... AIM: To investigate the relationship between cholecystectomy and fatty liver disease(FLD) in a Chinese population.METHODS: A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were included in this study. Basic data collection, physical examination, laboratory examination, and abdominal ultrasound examination were performed.RESULTS: Subjects undergoing cholecystectomy were associated with greater age, female sex, higher body mass index, and higher levels of systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, and triglycerides. However, no significant differences were found in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, gammaglutamyl transpeptidase, albumin, and serum uric acid. The overall prevalence of FLD diagnosed by ultrasonography was high at 38.4%. The prevalence of FLD was significantly higher for subjects who had undergone cholecystectomy(46.9%) than those who had not undergone cholecystectomy(38.1%; χ2 test, P < 0.001). Cholecystectomy was positively associated with FLD(OR = 1.433, 95%CI: 1.259-1.631). However, after adjusting for possible factors associated withFLD, multivariate regression analysis showed that the association between cholecystectomy and FLD was not statistically significant(OR = 1.096; 95%CI: 0.939-1.279). CONCLUSION: According to our study results, cholecystectomy may not be a significant risk factor for FLD. 展开更多
关键词 CHOLECYSTECTOMY FATTY LIVER DISEASE Relationship C
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Bregman Iterative Model Using theG-norm
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作者 Yu-ying SHI xiao-zhong yang Yong-gui ZHU 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2014年第1期179-186,共8页
In this paper, we analyze the Bregman iterative model using the G-norm. Firstly, we show the convergence of the iterative model. Secondly, using the source condition and the symmetric Bregman distance, we consider the... In this paper, we analyze the Bregman iterative model using the G-norm. Firstly, we show the convergence of the iterative model. Secondly, using the source condition and the symmetric Bregman distance, we consider the error estimations between the iterates and the exact image both in the case of clean and noisy data. The results show that the Bregman iterative model using the G-norm has the similar good properties as the Bregman iterative model using the L2-norm. 展开更多
关键词 Bregman distance image restoration total variation error estimation iterative regularization
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A Difference Scheme with Intrinsic Parallelism for Fractional Diffusion-wave Equation with Damping
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作者 Li-Fei WU xiao-zhong yang Min LI 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2021年第3期602-616,共15页
Anomalous diffusion is a widespread physical phenomenon,and numerical methods of fractional diffusion models are of important scientific significance and engineering application value.For time fractional diffusion-wav... Anomalous diffusion is a widespread physical phenomenon,and numerical methods of fractional diffusion models are of important scientific significance and engineering application value.For time fractional diffusion-wave equation with damping,a difference(ASC-N,alternating segment Crank-Nicolson)scheme with intrinsic parallelism is proposed.Based on alternating technology,the ASC-N scheme is constructed with four kinds of Saul’yev asymmetric schemes and Crank-Nicolson(C-N)scheme.The unconditional stability and convergence are rigorously analyzed.The theoretical analysis and numerical experiments show that the ASC-N scheme is effective for solving time fractional diffusion-wave equation. 展开更多
关键词 time fractional diffusion-wave equation with damping intrinsic parallelism ASC-N scheme stability parallel computing
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