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磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用
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作者 孙孝斌 苗志伟 《大学化学》 CAS 2020年第12期35-43,共9页
抗病毒药物是人类战胜病毒的有力武器,2019年底爆发的新型冠状病毒肺炎(COVID-19)疫情给人类带来巨大危害,同时也使人们意识到研发抗病毒药物的重要性。本文综述了磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用,介绍了核苷-... 抗病毒药物是人类战胜病毒的有力武器,2019年底爆发的新型冠状病毒肺炎(COVID-19)疫情给人类带来巨大危害,同时也使人们意识到研发抗病毒药物的重要性。本文综述了磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用,介绍了核苷-磷酰胺酯前药的合成策略,概述了核苷-磷酰胺酯在不同抗病毒药物中的应用,为新型抗病毒药物研发提供借鉴和参考。 展开更多
关键词 抗病毒药物研发 核苷-磷酰胺酯前药 ProTide技术
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Analysis of the Quasi-Static Buffeting Responses of Transmission Lines to Moving Downburst
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作者 Qigang sun Jian Wu +3 位作者 Dahai Wang Yue Xiang Haitao Liu xiaobin sun 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第7期287-302,共16页
Downburst event is identified as a major cause to failure of transmission lines in non-coastal regions.In this paper,a novel nonlinear analytical frame for quasi-static buffeting responses of hinged and multi-span ins... Downburst event is identified as a major cause to failure of transmission lines in non-coastal regions.In this paper,a novel nonlinear analytical frame for quasi-static buffeting responses of hinged and multi-span insulator-line systems are derived based on the theory of cable structure.The closed-form solutions are presented and applied to predict nonlinear response including displacements and other reactions of the system subjected to a moving downburst wind in a case study.Accuracy and efficiency of the derived analytical frame are validated via comparisons with results from finite element method. 展开更多
关键词 DOWNBURST WIND transmission line buffeting responses cable QUASISTATIC
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High-speed colour-converting photodetector with all-inorganic CsPbBr_(3) perovskite nanocrystals for ultraviolet light communication 被引量:17
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作者 Chun Hong Kang Ibrahim Dursun +10 位作者 Guangyu Liu Lutfan Sinatra xiaobin sun Meiwei Kong Jun Pan Partha Maity Ee-Ning Ooi Tien Khee Ng Omar F.Mohammed Osman M.Bakr Boon S.Ooi 《Light(Science & Applications)》 SCIE EI CAS CSCD 2019年第1期306-317,共12页
Optical wireless communication(OWC)using the ultra-broad spectrum of the visible-to-ultraviolet(UV)wavelength region remains a vital field of research for mitigating the saturated bandwidth of radio-frequency(RF)commu... Optical wireless communication(OWC)using the ultra-broad spectrum of the visible-to-ultraviolet(UV)wavelength region remains a vital field of research for mitigating the saturated bandwidth of radio-frequency(RF)communication.However,the lack of an efficient UV photodetection methodology hinders the development of UV-based communication.The key technological impediment is related to the low UV-photon absorption in existing silicon photodetectors,which offer low-cost and mature platforms.To address this technology gap,we report a hybrid Sibased photodetection scheme by incorporating CsPbBr_(3) perovskite nanocrystals(NCs)with a high photoluminescence quantum yield(PLQY)and a fast photoluminescence(PL)decay time as a UV-to-visible colourconverting layer for high-speed solar-blind UV communication.The facile formation of drop-cast CsPbBr_(3) perovskite NCs leads to a high PLQY of up to ~73% and strong absorption in the UV region.With the addition of the NC layer,a nearly threefold improvement in the responsivity and an increase of ~25% in the external quantum efficiency(EQE)of the solar-blind region compared to a commercial silicon-based photodetector were observed.Moreover,timeresolved photoluminescence measurements demonstrated a decay time of 4.5 ns under a 372-nm UV excitation source,thus elucidating the potential of this layer as a fast colour-converting layer.A high data rate of up to 34 Mbps in solar-blind communication was achieved using the hybrid CsPbBr_(3)-silicon photodetection scheme in conjunction with a 278-nm UVC light-emitting diode(LED).These findings demonstrate the feasibility of an integrated high-speed photoreceiver design of a composition-tuneable perovskite-based phosphor and a low-cost silicon-based photodetector for UV communication. 展开更多
关键词 PEROVSKITE ULTRAVIOLET INORGANIC
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10 Gbps wavelength division multiplexing using UV-A, UV-B, and UV-C micro-LEDs 被引量:4
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作者 Daniel M.Maclure Jonathan J.D.McKendry +10 位作者 Mohamed Sufyan Islim Enyuan Xie Cheng Chen xiaobin sun Xudong Liang Xiaohui Huang Hanaa Abumarshoud Johannes Herrnsdorf Erdan Gu Harald Haas Martin D.Dawson 《Photonics Research》 SCIE EI CAS CSCD 2022年第2期516-523,共8页
Deep ultraviolet(DUV) optical wireless communications have seen increased interest in recent years due to the unique properties of light in this spectral region. However, the reported DUV data rates remain significant... Deep ultraviolet(DUV) optical wireless communications have seen increased interest in recent years due to the unique properties of light in this spectral region. However, the reported DUV data rates remain significantly lower than comparable demonstrations at visible wavelengths due to lower modulation bandwidths and/or output power of the sources. Here, we present a wavelength division multiplexing demonstration using three UV microlight-emitting diodes emitting at nominal peak wavelengths of 285, 317, and 375 nm, respectively, each with an emitting area of approximately 1369 μm^(2)(equivalent to circular device pixels of diameter;0 μm). Using orthogonal frequency division multiplexing, data rates of 4.17, 3.02, and 3.13 Gbps were achieved from the 285, 317, and 375 nm devices, respectively, for a combined data rate of 10.32 Gbps transmitted over a distance of 0.5 m. 展开更多
关键词 GBPS multiplexing DIODES
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The effect of turbulence on NLOS underwater wireless optical communication channels [Invited] 被引量:2
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作者 Mohammed Sait xiaobin sun +4 位作者 Omar Alkhazragi Nasir Alfaraj Meiwei Kong Tien Khee Ng Boon S.Ooi 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第10期80-87,共8页
Conventional line-of-sight underwater wireless optical communication(UWOC)links suffer from huge signal fading in the presence of oceanic turbulence due to misalignment,which is caused by variations in the refractive ... Conventional line-of-sight underwater wireless optical communication(UWOC)links suffer from huge signal fading in the presence of oceanic turbulence due to misalignment,which is caused by variations in the refractive index in the water.Non-line-of-sight(NLOS)communication,a novel underwater communication configuration,which has eased the requirements on the alignment,is supposed to enhance the robustness of the UWOC links in the presence of such turbulence.This Letter experimentally and statistically studies the impact of turbulence that arises from temperature gradient variations and the presence of different air bubble populations on NLOS optical channels.The results suggest that temperature gradient-induced turbulence causes negligible signal fading to the NLOS link.Furthermore,the presence of air bubbles with different populations and sizes can enhance the received signal power by seizing the scattering phenomena from an ultraviolet 377 nm laser diode. 展开更多
关键词 COMMUNICATION SCATTERING TURBULENCE
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The Basal Level Ethylene Response is Important to the Wall and Endomembrane Structure in the Hypocotyl Cells of Etiolated Arabidopsis Seedlings
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作者 Chan Xu Xiaoyan Gao +1 位作者 xiaobin sun Chi-Kuang Wen 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2012年第7期434-455,共22页
The sub-cellular events that occur during the ethylene-modulated cell elongation were characterized by examining the ultra-structure of etiolated Arabidopsis seedling hypocotyl cells. Preventing the basal level ethyle... The sub-cellular events that occur during the ethylene-modulated cell elongation were characterized by examining the ultra-structure of etiolated Arabidopsis seedling hypocotyl cells. Preventing the basal level ethylene response facilitated cell elongation, and the cells exhibited wall loosening and separation phenotype. Nearby the wall separation sites were frequently associated with an increase in the cortical rough endoplasmic reticulum (rER) membranes, the presence of paramural bodies, and the circular Golgi formation. The cortical rER proliferation and circular Golgi phenotype were reverted by the protein biosynthesis inhibitor cycloheximide. The cortical rER membranes were longer when the ethylene response was prevented and shortened with elevated ethylene responses. Proteomic changes between wild type and the ethylene-insensitive mutant ethylene insensitive2 (ein2) seedling hypocotyls indicated that distinct subsets of proteins involving endomembrane trafficking, remodeling, and wall modifications were differentially expressed. FM4-64 staining supported the proteomic changes, which indicated reduced endocytosis activity with alleviation of the ethylene response. The basal level ethylene response has an important role in endomembrane trafficking, biological materials transport and maintenance of the endomembrane organization. It is possible that endomembrane alterations may partly associate with the wall modifications, though the biological significance of the alterations should be addressed in future studies. 展开更多
关键词 ER proliferation cell walls circular Golgi endomembrane trafficking ethylene.
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A tutorial on laser-based lighting and visible light communications:device and technology [Invited]
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作者 Yujian Guo Omar Alkhazragi +5 位作者 Chun Hong Kang Chao Shen Yuan Mao xiaobin sun Tien Khee Ng Boon S.Ooi 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第4期19-33,共15页
This tutorial focuses on devices and technologies that are part of laser-based visible light communication(VLC)systems. Laser-based VLC systems have advantages over their light-emitting-diode-based counterparts, inclu... This tutorial focuses on devices and technologies that are part of laser-based visible light communication(VLC)systems. Laser-based VLC systems have advantages over their light-emitting-diode-based counterparts, including having high transmission speed and long transmission distance. We summarize terminologies related to laser-based solid-state lighting and VLC, and further review the advances in device design and performance.The high-speed modulation characteristics of laser diodes and superluminescent diodes and the on-chip integration of optoelectronic components in the visible color regime, such as the high-speed integrated photodetector,are introduced. The modulation technology for laser-based white light communication systems and the challenges for future development are then discussed. 展开更多
关键词 TUTORIAL focuses TECHNOLOGIES COMMUNICATION systems
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Smooth densities for SDEs driven by subordinated Brownian motion with Markovian switching
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作者 xiaobin sun Yingchao XIE 《Frontiers of Mathematics in China》 SCIE CSCD 2018年第6期1447-1467,共21页
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