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Expert consensus on pediatric orthodontic therapies of malocclusions in children 被引量:1
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作者 Chenchen Zhou Peipei Duan +22 位作者 Hong He Jinlin Song Min Hu Yuehua liu Yan liu Jie Guo Fang Jin Yang Cao lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang li Rui Zou Yulou Tian li Gao Rui Shu Jianwei Chen Renkai liu Shujuan Zou xiaobing li 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第2期186-196,共11页
Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children... Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in China.Beyond its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these children.Timely intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the growth.Early orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition phase.From an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social importance.This consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early treatment.It elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment. 展开更多
关键词 PERMANENT stated CHILDREN
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Effect of titanium on the sticking of pellets based on hydrogen metallurgy shaft furnace:Behavior analysis and mechanism evolution
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作者 Jinge Feng Jue Tang +4 位作者 Zichuan Zhao Mansheng Chu Aijun Zheng xiaobing li Xiao’ai Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第2期282-291,共10页
Direct reduction based on hydrogen metallurgical gas-based shaft furnace is a promising technology for the efficient and low-carbon smelting of vanadium-titanium magnetite.However,in this process,the sticking of pelle... Direct reduction based on hydrogen metallurgical gas-based shaft furnace is a promising technology for the efficient and low-carbon smelting of vanadium-titanium magnetite.However,in this process,the sticking of pellets occurs due to the aggregation of metal-lic iron between the contact surfaces of adjacent pellets and has a serious negative effect on the continuous operation.This paper presents a detailed experimental study of the effect of TiO2 on the sticking behavior of pellets during direct reduction under different conditions.Results showed that the sticking index(SI)decreased linearly with the increasing TiO2 addition.This phenomenon can be attributed to the increase in unreduced FeTiO3 during reduction,leading to a decrease in the number and strength of metallic iron interconnections at the sticking interface.When the TiO2 addition amount was raised from 0 to 15wt%at 1100°C,the SI also increased from 0.71%to 59.91%.The connection of the slag phase could be attributed to the sticking at a low reduction temperature,corresponding to the low sticking strength.Moreover,the interconnection of metallic iron became the dominant factor,and the SI increased sharply with the increase in re-duction temperature.TiO2 had a greater effect on SI at a high reduction temperature than at a low reduction temperature. 展开更多
关键词 TITANIUM sticking index hydrogen metallurgy direct reduction PELLETS
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Recent advances in artificial intelligence generated content 被引量:1
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作者 Junping ZHANG lingyun SUN +6 位作者 Cong JIN Junbin GAO xiaobing li Jiebo LUO Zhigeng PAN Ying TANG Jingdong WANG 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2024年第1期1-5,共5页
Artificial intelligence generated content(AIGC)has been a research hotspot in the field of artificial intelligence in recent years.It is expected to replace humans in performing some of the work of content generation ... Artificial intelligence generated content(AIGC)has been a research hotspot in the field of artificial intelligence in recent years.It is expected to replace humans in performing some of the work of content generation at a low cost and a high volume,such as music,painting,multimodal content generation,news articles,summary reports,stock commentary summaries,and even content and digital people generated in the meta-universe.AIGC provides a new technical path for the development and implementation of AI in the future. 展开更多
关键词 artificial replace CONTENT
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Influence of mineral species on oil-soil interfacial interaction in petroleum-contaminated soils
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作者 Yang Yang Dandan liu +1 位作者 Xing liang xiaobing li 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第9期147-156,共10页
The mineral species in soils vary in a wide variety of places,thus resulting in the petroleumcontaminated soil(PCS)with complex characters.Thus,the research on the effect of mineral species on oil-soil interactions in... The mineral species in soils vary in a wide variety of places,thus resulting in the petroleumcontaminated soil(PCS)with complex characters.Thus,the research on the effect of mineral species on oil-soil interactions in PCS takes on a critical significance.In this study,the desorption and adsorption behaviors of aromatic hydrocarbons(Ar)on two minerals surfaces were examined.Meanwhile,the interfacial forces between minerals and Ar were studied and the sources of these forces were analyzed.Moreover,molecular dynamics(MD)simulations were conducted to gain insight into the interfacial interaction mechanisms.As revealed by the results of this study,in comparison with Qs-Ar(quartz sand,Qs),Mnt-Ar(montmorillonite,Mnt)contaminants required higher temperature and activation energies for thermal desorption(201.95 kJ·mol^(-1)vs.127.82 kJ·mol^(-1))The above difference was generated since the adhesive forces between Ar and Mnt surfaces were greater than those between Ar and Qs.As indicated by the analysis of the adhesion force sources,the van der Waals forces were responsible for facilitating oil adhesion to mineral surfaces,even though the electrostatic force prevented oil-mineral adhesion.Furthermore,the hydrophobic forces facilitated adhesion in 3 nm.The MD results demonstrated that compared with the Qs system,there existed larger binding energies between Ar and Mnt,a lower diffusion coefficient for Ar on the Mnt surface,as well as more significant adsorption of Ar on Mnt.In general,the different mineral species affect the strength of the interaction at the oil-soil interface,which is a guideline for proposing targeted oil-soil separation measures. 展开更多
关键词 Oil-soil interface Thermal desorption Isothermal adsorption Extended-DLVO(EDLVO) Molecular dynamics
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DNA N^6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs 被引量:7
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作者 Chenchen Zhou Yuting liu +2 位作者 xiaobing li Jing Zou Shujuan Zou 《Bone Research》 SCIE CAS CSCD 2016年第3期174-182,共9页
ALKBH1 was recently discovered as a demethylase for DNA N6-methyladenine (N6-mA), a new epigenetic modification, and interacts with the core transcriptional pluripotency network of embryonic stem cells. However, the... ALKBH1 was recently discovered as a demethylase for DNA N6-methyladenine (N6-mA), a new epigenetic modification, and interacts with the core transcriptional pluripotency network of embryonic stem cells. However, the role of ALKBH1 and DNA N6-mA in regulating osteogenic differentiation is largely unknown. In this study, we demonstrated that the expression of ALKBH1 in human mesenchymal stem cells (MSCs) was upregulated during osteogenic induction. Knockdown of ALKBH1 increased the genomic DNA N6-mA levels and significantly reduced the expression of osteogenic-related genes, alkaline phosphatase activity, and mineralization. ALKBHl-depleted MSCs also exhibited a restricted capacity for bone formation in vivo. By contrast, the ectopic overexpression of ALKBH1 enhanced osteoblastic differentiation. Mechanically, we found that the depletion of ALKBH1 resulted in the accumulation of N6-mA on the promoter region of ATF4, which subsequently silenced ATF4 transcription. In addition, restoring the expression of ATP by adenovirus-mediated transduction successfully rescued osteogenic differentiation. Taken together, our results demonstrate that ALKBH1 is indispensable for the osteogenic differentiation of MSCs and indicate that DNA N6-mA modifications area new mechanism for the epigenetic regulation of stem cell differentiation. 展开更多
关键词 ATF Figure MSCS DNA N~6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
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Runxl protects against the pathological progression of osteoarthritis 被引量:5
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作者 Chenchen Zhou Yujia Cui +6 位作者 Yueyi Yang Daimo Guo Demao Zhang Yi Fan xiaobing li Jing Zou Jing Xie 《Bone Research》 SCIE CAS CSCD 2021年第4期618-629,共12页
Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runx... Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runxl in joint diseases is not well known.In the current study,we aimed to explore the role of Runxl in osteoarthritis induced by anterior cruciate ligament transaction(ACLT)surgery.We showed that chondrocyte-specific Runxl knockout(Runx1f/fCol2a1-Cre)aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis.Moreover,we observed thinning and ossification of the growth plate,a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis.We overexpressed Runxl by adeno-associated virus(AAV)in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis.ChIP-seq analysis identified new targets that interacted with Runxl in cartilage pathology,and we confirmed the direct interactions of these factors with Runxl by ChIP-qPCR.This study helps us to understand the function of Runxl in osteoarthritis and provides new clues for targeted osteoarthritis therapy. 展开更多
关键词 OSTEOARTHRITIS protective DISEASES
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MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population 被引量:2
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作者 Pu Fang Wenyuan Xu +3 位作者 Chengsi Wu Min Zhu xiaobing li Daojun Hong 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第33期3116-3123,共8页
A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau (MAPT) gene was significantly associated with sp... A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau (MAPT) gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis. Here, we tested this association in 107 sporadic amyotrophic lateral sclerosis patients and 100 healthy controls from the Chinese Han population. We screened the mutation-susceptible regions of MAPT- the 3' and 5' untranslated regions as well as introns 9, 10, 11, and 12 - by direct sequencing, and identified 33 genetic variations. Two of these, 105788 A 〉 G in intron 9 and 123972 T 〉 A in intron 11, were not present in the control group. The age of onset in patients with the 105788 A 〉 G and/or the 123972 T 〉 A variant was younger than that in patients without either genetic variation. Moreover, the pa- tients with a genetic variation were more prone to bulbar palsy and breathing difficulties than those with the wild-type genotype. This led to a shorter survival period in patients with a MAPT genetic variant. Our study suggests that the MAPT gene is a potential risk gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population. 展开更多
关键词 neural regeneration sporadic amyotrophic lateral sclerosis microtubule-associated protein Tau gene MAPT Chinese Han population GENOTYPE NEUROREGENERATION
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A transformer generative adversarial network for multi-track music generation 被引量:4
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作者 Cong Jin Tao Wang +7 位作者 xiaobing li Chu Jie Jiessie Tie Yun Tie Shan liu Ming Yan Yongzhi li Junxian Wang Shenze Huang 《CAAI Transactions on Intelligence Technology》 SCIE EI 2022年第3期369-380,共12页
This study proposes a new generation network based on transformers and guided by the music theory to produce high-quality music work.In this study,the decoding block of the transformer is used to learn the internal in... This study proposes a new generation network based on transformers and guided by the music theory to produce high-quality music work.In this study,the decoding block of the transformer is used to learn the internal information of single-track music,and cross-track transformers are used to learn the information amongst the tracks of different musical instruments.A reward network based on the music theory is proposed,which optimizes the global and local loss objective functions while training and discriminating the network so that the reward network can provide a reliable adjustment method for the generation of the network.The method of combining the reward network and cross entropy loss is used to guide the training of the generator and produce high-quality music work.Compared with other multi-track music generation models,the experimental results verify the validity of the model. 展开更多
关键词 artificial intelligence deep learning MULTIMEDIA
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Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai 被引量:2
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作者 Yuhan liU Hongli WANG +12 位作者 Shengao JING Ming ZHOU Shenrong LOU Kun QU Wanyi QIU Qian WANG Shule li Yaqin GAO Yusi liU xiaobing li Zhong-Ren PENG Junhui CHEN Keding LU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第7期1177-1187,共11页
As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of V... As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of VOCs in Shanghai’s Jinshan district on 8 September and 9 September in 2016 to investigate their distribution and impact on local atmospheric oxidation in the near surface layer.Vertical samples were collected from heights between 50 m and 400 m by summa canisters using an unmanned aerial vehicle(UAV).Concentrations of VOCs(VOCs refers to the 52 species measured in this study)varied minimally below 200 m,and decreased by 21.2%from 100 m to 400 m.The concentrations of VOCs above 200 m decreased significantly in comparison to those below 200 m.The proportions of alkanes and aromatics increased from 55.2%and 30.5%to 57.3%and 33.0%,respectively.Additionally,the proportion of alkenes decreased from 13.2%to 8.4%.Toluene and m/p-xylene were the key species in the formation of SOA and ozone.Principal component analysis(PCA)revealed that the VOCs measured in this study mainly originated from industrial emissions. 展开更多
关键词 VOCS vertical profiles secondary organic aerosol PCA OZONE
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Machine learning phase transitions of the three-dimensional Ising universality class 被引量:1
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作者 李笑冰 郭冉冉 +5 位作者 周宇 刘康宁 赵佳 龙芬 吴元芳 李治明 《Chinese Physics C》 SCIE CAS CSCD 2023年第3期138-145,共8页
Exploration of the QCD phase diagram and critical point is one of the main goals in current relativistic heavy-ion collisions.The QCD critical point is expected to belong to a three-dimensional(3D)Ising universality c... Exploration of the QCD phase diagram and critical point is one of the main goals in current relativistic heavy-ion collisions.The QCD critical point is expected to belong to a three-dimensional(3D)Ising universality class.Machine learning techniques are found to be powerful in distinguishing different phases of matter and provide a new way to study the phase diagram.We investigate phase transitions in the 3D cubic Ising model using supervised learning methods.It is found that a 3D convolutional neural network can be trained to effectively predict physical quantities in different spin configurations.With a uniform neural network architecture,it can encode phases of matter and identify both second-and first-order phase transitions.The important features that discriminate different phases in the classification processes are investigated.These findings can help study and understand QCD phase transitions in relativistic heavy-ion collisions. 展开更多
关键词 machine learning phase transition QCD critical point three-dimensional Ising universality class
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The role of externally-modulated electrostatic interactions in amplifying charge transport across lysine-doped peptide junctions
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作者 xiaobing li Pierre-Andre Cazade +2 位作者 Pan Qi Damien Thompson Cunlan Guo 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第3期254-258,共5页
Many evolved biomolecular functions such as ion pumping or redox catalysis rely on controlled charge transport through the polypeptide matrix, which can be regulated by shifts in molecular protonation states and depen... Many evolved biomolecular functions such as ion pumping or redox catalysis rely on controlled charge transport through the polypeptide matrix, which can be regulated by shifts in molecular protonation states and dependent supramolecular packing modes in response to environmental cues. However, the exact roles of such dynamic, non-covalent interactions in peptide charge transport have remained elusive. To tackle this challenge, here we report the modulation of charge transport in a series of lysine(Lys)-substituted hepta-glycine(Gly) peptide self-assembled monolayers(SAMs) on template-striped gold(Au^(TS)) bottom electrodes with eutectic gallium-indium(EGaIn) liquid metal top electrodes. We demonstrate systematic modulation of hydrogen bonding and more general electrostatic interactions by shifting the position of the charged Lys-residue and creating different protonation patterns by changing the environmental pH in the Au^(TS)/peptide//Ga Ox/EGa In junctions. The effective modulation is evidenced by current density-voltage(J-V) measurements combined with SAM characterization using ultraviolet photoelectron spectroscopy(UPS) and angle-resolved X-ray photoelectron spectroscopy(ARXPS), polarization modulation-infrared reflection-absorption spectroscopy(PM-IRRAS), and molecular dynamics(MD) simulations. Decreasing the hydrogen bonding inside the peptide SAMs and increasing the electrostatic interactions by environmental counterions amplifies the charge transport differently with Lys-position, which means that the sensitive electrical response of peptide SAMs can be tuned by the peptide sequence. Our results provide insights into the relationship between molecular design and in situ modulation of charge transport properties for the development of bionanoelectronics. 展开更多
关键词 Bioelectronics and biosensors Charge transport Linear peptide PROTONATION Self-assembled monolayer
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柔性无损检测超声线阵换能器的仿真研究
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作者 李尧 夏子颐 +4 位作者 李晓兵 孙瑞雨 陈兴飞 孙丰龙 杨钊萍 《建模与仿真》 2024年第3期2223-2232,共10页
为了突破传统刚性超声探头无法完全贴合零部件曲面的限制,论文设计了一种由压电材料PZT-5H和聚二甲基硅氧烷(PDMS)组成的柔性超声线阵换能器。针对设计的柔性换能器采用有限元分析方法对其电阻抗性能、脉冲回波特性进行了仿真分析,获得... 为了突破传统刚性超声探头无法完全贴合零部件曲面的限制,论文设计了一种由压电材料PZT-5H和聚二甲基硅氧烷(PDMS)组成的柔性超声线阵换能器。针对设计的柔性换能器采用有限元分析方法对其电阻抗性能、脉冲回波特性进行了仿真分析,获得了换能器的中心频率,−6 dB带宽以及发射电压响应。此外分别仿真了此柔性换能器应用于凹面和凸面金属管时对其内部裂纹的检测情况。仿真结果显示换能器的中心频率为21.5 MHz,−6 dB带宽为51.2%。换能器为凹形和凸形时其声压级均满足检测需求,可以用于对钢管中裂隙进行检测。 展开更多
关键词 线阵换能器 柔性超声 超声成像 有限元仿真
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Insights into the role of W/B alloying on high-temperature oxidation behavior of Ti42Al5Mn alloy
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作者 Pengxiang Zhao Hui Ma +3 位作者 xiaobing li Ming Gao Yingche Ma Kui liu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第11期188-200,共13页
In this study,the oxidation behavior of Ti42Al5Mn,Ti42Al5Mn0.5 W,Ti42Al5Mn0.5W0.1B,and Ti42Al5Mn0.8 W was investigated at 800℃.Due to the inability to form a dense protective Al2O_(3) layer,Ti42Al5Mn suffered severe ... In this study,the oxidation behavior of Ti42Al5Mn,Ti42Al5Mn0.5 W,Ti42Al5Mn0.5W0.1B,and Ti42Al5Mn0.8 W was investigated at 800℃.Due to the inability to form a dense protective Al2O_(3) layer,Ti42Al5Mn suffered severe spallation during oxidation at 800℃and the mass gain was significant.The intermediate layer between the scale and the substrate was first composed of Laves/Z phase but changed toα2/Z phase with prolonged oxidation.The intermediate layer with high Ti/Al ratio favors the forma-tion of a thick Al2O_(3)+TiO_(2) mixed layer in the oxide scale which is prone to initiate cracks and cause the spalling of oxides.The doping of W in TiO_(2) effectively inhibited its generation and promoted the for-mation of a dense Al2O_(3) layer,resulting in a significant improvement in the oxidation resistance of the alloy.Compared to Ti42Al5Mn alloy,Ti42Al5Mn0.8 W showed no spallation after 300 h cyclic oxidation and the kinetic curve changed from liner law to parabolic law.The intermediate layer of Ti42Al5Mn0.8 W alloy was composed of a single Laves phase and remained unchanged even after 1000 h oxidation at 800℃,offering a favorable basis for the generation of a stable protective oxide layer in the alloy.The addi-tion of 0.1 at.%B to Ti42Al5Mn0.5 W alloy refined its microstructure and further improved its spallation resistance to a level close to that of Ti42Al5Mn0.8 W alloy. 展开更多
关键词 β-γ-TiAl High-temperature oxidation TUNGSTEN Intermediate layer Z phase
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Advances in the prerequisite and consequence of STING downstream signalosomes
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作者 Xinliang Lu xiaobing li +2 位作者 lili li Chuanhui Han Sirui li 《Medical Review》 2024年第5期435-451,共17页
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)pathway is an evolving DNA-sensing mechanism involved in innate immunity and pathogen defense that has been optimized while remaining conserved.As... The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)pathway is an evolving DNA-sensing mechanism involved in innate immunity and pathogen defense that has been optimized while remaining conserved.Aside from recognizing pathogens through conserved motifs,these receptors also detect aberrant or misplaced self-molecules as possible signs of perturbed homeostasis.Upon binding external or self-derived DNA,a mobile sec-ondary messenger 2′3′-cyclic GMP-AMP(cGAMP)is produced by cGAS and in turn activates its adapter STING in the endo-plasmic reticulum(ER).Resting-state or activated STING protein isfinely restricted by multiple degradation machin-eries.The post-translational changes of the STING protein,along with the regulatory machinery ofthe secret routes,limit the onset,strength and sustention of STING signal.STING experiences a conformational shift and relocates with TBK1 from the ER to perinuclear vesicles containing transcription factors,provoking the transcription activity of IRF3/IFN-I and NF-κB pathways,as well as to initiate a number of cellular processes that have been shown to alter the immune landscape in cancer,such as autophagy,NLRP3 inflamma-some,ER stress,and cell death.STING signal thus serves as a potent activator for immune mobilization yet also triggers immune-mediated pathology in tissues.Recent advances have established the vital role of STING in immune surveil-lance as well as tumorigenic process.This review provides an overview of the disparate outcomes of cancer attributed to the actions of pleiotropic and coordinated STING downstream signalosomes,along with the underlying mechanisms of STING function in pathologies,providing therapeutic impli-cations for new approaches in hunt for the next generation of cancer immunotherapy base on STING. 展开更多
关键词 stimulator of interferon genes signalosomes cellular heterogeneity cancer therapeutics
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Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment 被引量:27
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作者 Xu Wu Wei Hu +11 位作者 Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao lin Zhang Hanyu Zhang xiaobing li Wanping li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing li 《Acta Pharmaceutica Sinica B》 SCIE CSCD 2019年第2期203-219,共17页
Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiolog... Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. 展开更多
关键词 Vitamin D 25-Dihydroxyvitamin D3 TUMOR microenvironment CANCER stem CELL Tumor-infiltrating LYMPHOCYTE Tumor-derived endothelial CELL Cancer-associated FIBROBLAST
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The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice 被引量:14
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作者 Shuying Zhang Gang li +10 位作者 Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue liu Xianfeng Zhao xiaobing li Chengcai Chu Qi Xie Xiangning Jiang lihuang Zhu 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2010年第7期626-638,共13页
Previous studies have shown that DWARFIO (D10) is a rice ortholog of MAX41RMS1/DAD1, encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives (SL) biosynthesis. Here w... Previous studies have shown that DWARFIO (D10) is a rice ortholog of MAX41RMS1/DAD1, encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives (SL) biosynthesis. Here we use DIO. RNA interference (RNAi) transgenic plants similar to dlO mutant in phenotypes to investigate the interactions among DIO, auxin and cytokinin in regulating rice shoot branching. Auxin levels in node 1 of both decapitated DIO.RNAi and wild type plants decreased significantly, showing that decapitation does reduce endogenous auxin concentration, but decapitation has no clear effects on auxin levels in node 2 of the same plants. This implies that node 1 may be the location where a possible interaction between auxin and DIO gene would be detected. DIO expression in node 1 is inhibited by decapitation, and this inhibition can be restored by exogenous auxin application, indicating that DIO may play an important role in auxin regulation of SL. The decreased expression of most OsPINs in shoot nodes of DIO-RNAi plants may cause a reduced auxin transport capacity. Furthermore, effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that DIO promotes cytokinin biosynthesis by reducing auxin levels. Besides, in DIO-RNAi plants, decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents, resulting in more tillering phenotypes. 展开更多
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Effects of simulated microgravity on the alkaline phosphatase activity and intracellular calcium concentration of cultured chondrocytes
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作者 xiaobing li Shuzhang Yang +2 位作者 Shengguang li Peidong Jiang Zhihuan lin 《Chinese Science Bulletin》 SCIE EI CAS 1999年第3期218-221,共4页
The effects of simulated microgravity on matrix mineralization of chondrocytes were examined using cultured chicken embryonic chondrocytes as the model. In four days, there was a time course decrease in alkaline phosp... The effects of simulated microgravity on matrix mineralization of chondrocytes were examined using cultured chicken embryonic chondrocytes as the model. In four days, there was a time course decrease in alkaline phosphatase activity of chondrocytes, a marker of matrix mineralization.Meanwhile, in two days, there was a significant drop in intracellular calcium concentration in contrast to the control. These results indicate that simulated microgravity can suppress matrix calcification of cultured chondrocytes, and intracellular calcium may be involved in the regulation of matrix calcification as the second messenger. 展开更多
关键词 CHONDROCYTE CALCIFICATION simulated MICROGRAVITY alkaline PHOSPHATASE activity INTRACELLULAR calcium concentration.
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Genomic footprints of Kam Sweet Rice domestication indicate possible migration routes of theDongpeople inChina andprovide resources for future rice breeding 被引量:6
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作者 Chunhui liu Tianyi Wang +10 位作者 Huicha Chen Xiaoding Ma Chengzhi Jiao Di Cui Bing Han xiaobing li Aixia Jiao Renchao Ruan Dayuan Xue Yanjie Wang Longzhi Han 《Molecular Plant》 SCIE CAS CSCD 2023年第2期415-431,共17页
The Dong people are one of China’s 55 recognized ethnic minorities,but there has been a long-standing debate about their origins.In this study,we performed whole-genome resequencing of Kam Sweet Rice(KSR),a valuable,... The Dong people are one of China’s 55 recognized ethnic minorities,but there has been a long-standing debate about their origins.In this study,we performed whole-genome resequencing of Kam Sweet Rice(KSR),a valuable,rare,and ancient rice landrace unique to the Dong people.Through comparative genomic analyses of KSR and other rice landraces from south of the Yangtze River Basin in China,we provide evidence that the ancestors of the Dong people likely originated from the southeast coast of China at least 1000 years ago.Alien introgression and admixture in KSR demonstrated multiple migration events in the history of the Dong people.Genomic footprints of domestication demonstrated characteristics of KSR that arose from artificial selection and geographical adaptation by the Dong people.The key genes GS3,Hd1,and DPS1(related to agronomic traits)and LTG1 and MYBS3(related to cold tolerance)were identified as domestication targets,reflecting crop improvement and changes in the geographical environment of the Dong people during migration.A genome-wide association study revealed a candidate yield-associated gene,Os01g0923300,a specific haplotype in KSR that is important for regulating grain number per panicle.RNA-sequencing and quantitative reverse transcription-PCR results showed that this gene was more highly expressed in KSR than in ancestral populations,indicating that it may have great value in increasing yield potential in other rice accessions.In summary,our work develops a novel approach for studying human civilization and migration patterns and provides valuable genomic datasets and resources for future breeding of high-yield and climate-resilient rice varieties. 展开更多
关键词 Dong ethnic group Kam Sweet Rice genomic evolution population genetics
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大气边界层内挥发性有机物的垂直观测方法及应用进展 被引量:2
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作者 刘智杰 李小兵 +6 位作者 袁斌 莫梓伟 谭鑫 周俊 王思行 何贤俊 邵敏 《科学通报》 EI CAS CSCD 北大核心 2021年第32期4098-4111,共14页
总结分析了大气边界层内挥发性有机物(VOCs)的主要垂直观测方法与应用进展,着重对高层建筑物、系留气球、载人飞机、无人机和激光雷达等不同平台的VOCs垂直观测技术进行介绍,并对不同VOCs垂直观测平台的优缺点和主要应用场景进行归纳总... 总结分析了大气边界层内挥发性有机物(VOCs)的主要垂直观测方法与应用进展,着重对高层建筑物、系留气球、载人飞机、无人机和激光雷达等不同平台的VOCs垂直观测技术进行介绍,并对不同VOCs垂直观测平台的优缺点和主要应用场景进行归纳总结.同时,较为系统地总结了大气边界层内VOCs垂直观测的主要应用进展,着重对VOCs垂直分布特征的关键影响因素、排放通量计算、排放清单验证、光化学臭氧生成机制的垂直分布特征,以及夜间边界层内VOCs氧化降解的垂直分布特征等方面进行归纳总结.目前对于环境大气中VOCs化学过程的研究主要以地面观测数据为主,而获取大气边界层内关键VOCs组分浓度的垂直分布数据是深入解析区域大气二次污染成因机制的重要前提. 展开更多
关键词 大气边界层 挥发性有机物 垂直观测 二次污染
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Effects of simulated microgravity on the cell growth and extracellular matrix of cultured chondrocytes
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作者 Shuzhang Yang xiaobing li +2 位作者 Shengguang li Peidong Jiang Zhihuan lin 《Chinese Science Bulletin》 SCIE EI CAS 1999年第15期1372-1375,共4页
The effects of simulated microgravity on cell growth and extracellular matrix of chondrocytes have been examined by a light microscope and a scanning electron microscope using cultured chicken embryonic chondrocytes a... The effects of simulated microgravity on cell growth and extracellular matrix of chondrocytes have been examined by a light microscope and a scanning electron microscope using cultured chicken embryonic chondrocytes as the model. No notable difference of the cell density between the rotation group and the control group has been found. But during the same period,the growth spots of the rotation group were sparser than those of the control group. These results indicated that the lower level of cell development and differentiation happened in the rotation group. Observation by the scanning electron microscope showed that the extracellualr matrix decreased after rotating, and the fibres in the extracellular matrix were slighter and blurrier than those of the control group. It is concluded that the simulated microgravity can affect the secreting and assembly of the extracellular matrix. The possible mechanism for them is discussed. 展开更多
关键词 CHONDROCYTE simulated MICROGRAVITY EXTRACELLULAR matrix.
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