The high bandwidth and low latency of 6G network technology enable the successful application of monocular 3D object detection on vehicle platforms.Monocular 3D-object-detection-based Pseudo-LiDAR is a low-cost,lowpow...The high bandwidth and low latency of 6G network technology enable the successful application of monocular 3D object detection on vehicle platforms.Monocular 3D-object-detection-based Pseudo-LiDAR is a low-cost,lowpower solution compared to LiDAR solutions in the field of autonomous driving.However,this technique has some problems,i.e.,(1)the poor quality of generated Pseudo-LiDAR point clouds resulting from the nonlinear error distribution of monocular depth estimation and(2)the weak representation capability of point cloud features due to the neglected global geometric structure features of point clouds existing in LiDAR-based 3D detection networks.Therefore,we proposed a Pseudo-LiDAR confidence sampling strategy and a hierarchical geometric feature extraction module for monocular 3D object detection.We first designed a point cloud confidence sampling strategy based on a 3D Gaussian distribution to assign small confidence to the points with great error in depth estimation and filter them out according to the confidence.Then,we present a hierarchical geometric feature extraction module by aggregating the local neighborhood features and a dual transformer to capture the global geometric features in the point cloud.Finally,our detection framework is based on Point-Voxel-RCNN(PV-RCNN)with high-quality Pseudo-LiDAR and enriched geometric features as input.From the experimental results,our method achieves satisfactory results in monocular 3D object detection.展开更多
By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers t...By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers to link these marks to cis-regulatory elements. With the help of next generation sequencing technologies, we can now correlate one specific chromatin mark with regulatory elements (e.g. enhancers or promoters) and also build tools, such as hidden Markov models, to gain insight into mark combinations. However, hidden Markov models have limitation for their character of generative models and assume that a current observation depends only on a current hidden state in the chain. Here, we employed two graphical probabilistic models, namely the linear conditional random field model and multivariate hidden Markov model, to mark gene regions with different states based on recurrent and spatially coherent character of these eight marks. Both models revealed chromatin states that may correspond to enhancers and promoters, transcribed regions, transcriptional elongation, and low-signal regions. We also found that the linear conditional random field model was more effective than the hidden Markov model in recognizing regulatory elements, such as promoter-, enhancer-, and transcriptional elongation-associated regions, which gives us a better choice.展开更多
Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prognosis has not significantly improved over the last decade. Such improvements could be realized if biomark...Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prognosis has not significantly improved over the last decade. Such improvements could be realized if biomarkers for accurate diagnosis and prognostic stratification were successfully identified. In this study, we propose a method that associates two state-of-the-art array technologies-single nucleotide polymorphism (SNP) array and gene expression array-with gene motifs considered transcription factor -binding sites (TFBS). We are particularly interested in SNP-containing motifs introduced by genetic variation and mutation as TFBS. The potential regulation of SNP-containing motifs affects only when certain mutations occur. These motifs can be identified from a group of co-expressed genes with copy number variation. Then, we used a sliding window to identify motif candidates near SNPs on gene sequences. The candidates were filtered by coarse thresholding and fine statistical testing. Using the regression-based LARS-EN algorithm and a level-wise sequence combination procedure, we identified 28 SNP-containing motifs as candidate TFBS. We confirmed 21 of the 28 motifs with ChIP-chip fragments in the TRANSFAC database. Another six motifs were validated by TRANSFAC via searching binding fragments on coregulated genes. The identified motifs and their location genes can be considered potential biomarkers for myelodysplastic syndromes. Thus, our proposed method, a novel strategy for associating two data categories, is capable of integrating information from different sources to identify reliable candidate regulatory SNP-containing motifs introduced by genetic variation and mutation.展开更多
This paper considers a secure multigroup multicast multiple-input single-output(MISO)communication system aided by an intelligent reflecting surface(IRS).Specifically,we aim to minimize the transmit power at Alice via...This paper considers a secure multigroup multicast multiple-input single-output(MISO)communication system aided by an intelligent reflecting surface(IRS).Specifically,we aim to minimize the transmit power at Alice via jointly optimizing the transmit beamformer,artificial noise(AN)vector and phase shifts at the IRS subject to the secrecy rate constraints as well as the unit modulus constraints of IRS phase shifts.To tackle the optimization problem,we first transform it into a semidefinite relaxation(SDR)problem,and then alternately update the transmit beamformer and AN matrix as well as the phase shifts at the IRS.In order to reduce the high computational complexity,we further propose a low-complexity algorithm based on second-order cone programming(SOCP).We decouple the optimization problem into two sub-problems and optimize the transmit beamformer,AN vector and the phase shifts alternately by solving two corresponding SOCP subproblem.Simulation results show that the proposed SDR and SOCP schemes require half or less transmit power than the scheme without IRS,which demonstrates the advantages of introducing IRS and the effectiveness of the proposed methods.展开更多
Organic solar cell(OSC)has attracted great interests due to its potential applications[1-9].To date,18%power conversion efficiency(PCE)has been achieved in single-junction OSC[10−13],indicating the feasibility of comm...Organic solar cell(OSC)has attracted great interests due to its potential applications[1-9].To date,18%power conversion efficiency(PCE)has been achieved in single-junction OSC[10−13],indicating the feasibility of commercialization.This photovoltaic technology currently faces the performance gap between laboratory cells and large-area modules.展开更多
In this editorial preface, I briefly r eview cancer bioinformatics and introduce the four articles in this special issue highlighting important applications of the field: detection of chromatin states; detection of SN...In this editorial preface, I briefly r eview cancer bioinformatics and introduce the four articles in this special issue highlighting important applications of the field: detection of chromatin states; detection of SNP- containing motifs and association with transcription factor-binding sites; improvements in functional enrichment modules; and gene association studies on aging and cancer. We expect this issue to provide bioinformatics scientists, cancer biologists, and clinical doctors with a better understanding of how cancer bioinformatics can be used to identify candidate biomarkers and targets and to conduct functional analysis.展开更多
Background Takotsubo syndrome （TS） is an important cardiac disease that affects predominantly postmenopausal women. This study was conducted to determine the impact of age on the short- and long-term outcome of TS p...Background Takotsubo syndrome （TS） is an important cardiac disease that affects predominantly postmenopausal women. This study was conducted to determine the impact of age on the short- and long-term outcome of TS patients. Methods ＆ Results The data from a collective of 114 TS patients with a mean follow-up of 1591 ：E 1079 days was retrospectively analysed. The study population was divided into two groups （≤ 65 and 〉 65 years） so as to evaluate the impact of age on the short- and long-term mortality of TS patients. In-hospital eventslike life-threatening arrhythmias （14.58% vs. 9.09%; P = 0.036）, need for mechanical respiratory support （41.66% vs. 28.78%; P = 0.15） as well as inotropic agent use （22.91% vs. 15.15%; P = 0.29）, although not reaching the statistical cut-of, tended to occur more often in the younger group. Heart failure was more common in the elderly age group （P = 0.03）. The use of multivariate analysis ruled out age as a significant marker of long term mortality （HR： 1.0; 95% CI： 0.9-1.0; P = 0.60）. Conclusions Age does not influence the clinical course of TS in terms of the short- as well as long-term outcome. The study revealed a higher incidence of life threatening arrhythmias in the younger patient age-group and a higher incidence of heart failure among the older group of patients.展开更多
Seasonal distribution of mono-modal, monsoonal rainfall across the semi-arid ecotone of sub-Saharan of West Africa is highly variable and unpredictable. The ever-present risk of drought and crop failure in this enviro...Seasonal distribution of mono-modal, monsoonal rainfall across the semi-arid ecotone of sub-Saharan of West Africa is highly variable and unpredictable. The ever-present risk of drought and crop failure in this environment often results in food shortages that are met by emergency food aid. Humanitarian assistance planners would be better prepared for such interventions in a timely manner if they have reliable indicators that forewarn the impending failure of the rains. A good indicator would be a characteristic of the seasonal rainfall distribution that can be shown to be reasonably invariant over time and space. The objective of this study is to investigate whether such invariance existed for the seasonal median date (meaning the date when 50% of the seasonal total occurs). Such invariance is expected since the sun’s cyclic declination forces the advance and retreat of the Inter-tropical Front over West Africa. We examined the statistical properties of the seasonal median date for 1349 station-years of rainfall records for 30 rainfall stations in Burkina Faso and Niger with coordinates ranging from 9.88° to 18.5° north latitude and -4.77° to 13.2° longitude. The results showed that the median date was quite narrowly distributed over years with rather weak dependence on geographical coordinates. It can therefore be used as a reasonable ex-ante indicator of the success or failure of the rains as the rainy season progress.展开更多
In this paper, we propose a novel seismic blind deconvolution approach based on the Spearman’s rho in the case of band-limited seismic data with a low dominant frequency and short data records. The Spearman’s rho is...In this paper, we propose a novel seismic blind deconvolution approach based on the Spearman’s rho in the case of band-limited seismic data with a low dominant frequency and short data records. The Spearman’s rho is a measure of the dependence between two continuous random variables without the influence of the marginal distributions, by which a new criterion for blind deconvolution is constructed. The optimization program for new criterion of blind deconvolution is performed by applying Neidell’s wavelet model to the inverse filter. The noise-free and noisy synthetic data, onshore seismic trace in the Ordos Basin, and offshore stacked section in the Bohai Bay Basin examples show good results of the method.展开更多
Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90%of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse cancers.However,the comprehensive map for functional A...Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90%of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse cancers.However,the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient.To fill this gap,we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas.For individual candidate among1,500,000 quantified RNA editing events,we performed diverse types of downstream functional annotations.Finally,we identified 24,236 potentially functional A-to-I RNA editing events,including the cases in APOL1,IGFBP3,GRIA2,BLCAP,and miR-589-3p.These events might play crucial roles in the scenarios of tumorigenesis,due to their tumor-related editing frequencies or probable effects on altered expression profiles,protein functions,splicing patterns,and microRNA regulations of tumor genes.Our functional A-to-I RNA editing events(https://ccsm.uth.edu/CAeditome/)will help better understand the cancer pathology from the A-to-I RNA editing aspect.展开更多
Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital diso...Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital disorders,infection,irradiation,or cancer.However,in those patients,abnormal cells obtained by biopsy fromthe compromised tissue could potentially contaminate the engineered tissues.Thus,an alternative cell source for construction of the neo-organ or functional recovery of the injured or diseased tissues would be useful.Recently,we have found stem cells existing in the urine.These cells are highly expandable,and have self-renewal capacity,paracrine properties,and multi-differentiation potential.As a novel cell source,urine-derived stem cells(USCs)provide advantages for cell therapy and tissue engineering applications in regeneration of various tissues,particularly in the genitourinary tract,because they originate from the urinary tract system.Importantly,USCs can be obtained via a non-invasive,simple,and low-cost approach and induced with high efficiency to differentiate into three dermal cell lineages.展开更多
Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbat...Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.展开更多
To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least squar...To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least square fitting of a polynomial, we define and give the operators of left prediction and right prediction, left smoothing and right smoothing, central smoothing and cross-validation smoothing. In simulated experiments, it is shown that the present method is an effective one.展开更多
基金supported by the National Key Research and Development Program of China(2020YFB1807500)the National Natural Science Foundation of China(62072360,62001357,62172438,61901367)+4 种基金the key research and development plan of Shaanxi province(2021ZDLGY02-09,2023-GHZD-44,2023-ZDLGY-54)the Natural Science Foundation of Guangdong Province of China(2022A1515010988)Key Project on Artificial Intelligence of Xi'an Science and Technology Plan(2022JH-RGZN-0003,2022JH-RGZN-0103,2022JH-CLCJ-0053)Xi'an Science and Technology Plan(20RGZN0005)the Proof-ofconcept fund from Hangzhou Research Institute of Xidian University(GNYZ2023QC0201).
文摘The high bandwidth and low latency of 6G network technology enable the successful application of monocular 3D object detection on vehicle platforms.Monocular 3D-object-detection-based Pseudo-LiDAR is a low-cost,lowpower solution compared to LiDAR solutions in the field of autonomous driving.However,this technique has some problems,i.e.,(1)the poor quality of generated Pseudo-LiDAR point clouds resulting from the nonlinear error distribution of monocular depth estimation and(2)the weak representation capability of point cloud features due to the neglected global geometric structure features of point clouds existing in LiDAR-based 3D detection networks.Therefore,we proposed a Pseudo-LiDAR confidence sampling strategy and a hierarchical geometric feature extraction module for monocular 3D object detection.We first designed a point cloud confidence sampling strategy based on a 3D Gaussian distribution to assign small confidence to the points with great error in depth estimation and filter them out according to the confidence.Then,we present a hierarchical geometric feature extraction module by aggregating the local neighborhood features and a dual transformer to capture the global geometric features in the point cloud.Finally,our detection framework is based on Point-Voxel-RCNN(PV-RCNN)with high-quality Pseudo-LiDAR and enriched geometric features as input.From the experimental results,our method achieves satisfactory results in monocular 3D object detection.
基金funded by grants from the NIH R01LM010185-03(Zhou),NIH U01HL111560-01(Zhou),NIH 1R01DE022676-01(Zhou),and DoD TATRC (Zhou)
文摘By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers to link these marks to cis-regulatory elements. With the help of next generation sequencing technologies, we can now correlate one specific chromatin mark with regulatory elements (e.g. enhancers or promoters) and also build tools, such as hidden Markov models, to gain insight into mark combinations. However, hidden Markov models have limitation for their character of generative models and assume that a current observation depends only on a current hidden state in the chain. Here, we employed two graphical probabilistic models, namely the linear conditional random field model and multivariate hidden Markov model, to mark gene regions with different states based on recurrent and spatially coherent character of these eight marks. Both models revealed chromatin states that may correspond to enhancers and promoters, transcribed regions, transcriptional elongation, and low-signal regions. We also found that the linear conditional random field model was more effective than the hidden Markov model in recognizing regulatory elements, such as promoter-, enhancer-, and transcriptional elongation-associated regions, which gives us a better choice.
基金supported by grants from NIH(No.1R01LM010185,1U01CA166886,and 1U01HL111560)
文摘Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prognosis has not significantly improved over the last decade. Such improvements could be realized if biomarkers for accurate diagnosis and prognostic stratification were successfully identified. In this study, we propose a method that associates two state-of-the-art array technologies-single nucleotide polymorphism (SNP) array and gene expression array-with gene motifs considered transcription factor -binding sites (TFBS). We are particularly interested in SNP-containing motifs introduced by genetic variation and mutation as TFBS. The potential regulation of SNP-containing motifs affects only when certain mutations occur. These motifs can be identified from a group of co-expressed genes with copy number variation. Then, we used a sliding window to identify motif candidates near SNPs on gene sequences. The candidates were filtered by coarse thresholding and fine statistical testing. Using the regression-based LARS-EN algorithm and a level-wise sequence combination procedure, we identified 28 SNP-containing motifs as candidate TFBS. We confirmed 21 of the 28 motifs with ChIP-chip fragments in the TRANSFAC database. Another six motifs were validated by TRANSFAC via searching binding fragments on coregulated genes. The identified motifs and their location genes can be considered potential biomarkers for myelodysplastic syndromes. Thus, our proposed method, a novel strategy for associating two data categories, is capable of integrating information from different sources to identify reliable candidate regulatory SNP-containing motifs introduced by genetic variation and mutation.
基金supported in part by the National Natural Science Foundation of China under Grants 62071234,61901121 and 61771244in part by the Natural Science Research Project of Education Department of Anhui Province of China under Grant KJ2019A1002.
文摘This paper considers a secure multigroup multicast multiple-input single-output(MISO)communication system aided by an intelligent reflecting surface(IRS).Specifically,we aim to minimize the transmit power at Alice via jointly optimizing the transmit beamformer,artificial noise(AN)vector and phase shifts at the IRS subject to the secrecy rate constraints as well as the unit modulus constraints of IRS phase shifts.To tackle the optimization problem,we first transform it into a semidefinite relaxation(SDR)problem,and then alternately update the transmit beamformer and AN matrix as well as the phase shifts at the IRS.In order to reduce the high computational complexity,we further propose a low-complexity algorithm based on second-order cone programming(SOCP).We decouple the optimization problem into two sub-problems and optimize the transmit beamformer,AN vector and the phase shifts alternately by solving two corresponding SOCP subproblem.Simulation results show that the proposed SDR and SOCP schemes require half or less transmit power than the scheme without IRS,which demonstrates the advantages of introducing IRS and the effectiveness of the proposed methods.
基金The authors thank National Natural Science Foundation of China(61774077,61804065,51673070,51521002,21704082,21875182,21534003,61705090 and 51320105014)National Key Research and Development Program of China(2016YFA0200700)+6 种基金China Postdoctoral Science Foundation(2017M623162),111 Project 2.0(BP2018008)the Basic and Applied Basic Research Fund of Guangdong Province(2019B1515120073)the Research and Development Program in Key Areas of Guangdong Province(2019B090921002 and 2019B010132004)the Fundamental Research Funds for the Central Universities(21618308)the State Key Laboratory of Luminescent Materials and Devices(2019-skllmd-05)the Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials Open Fund(KFVE20200006)for financial support.L.Ding thanks the National Key Research and Development Program of China(2017YFA0206600)the National Natural Science Foundation of China(51773045,21772030,51922032,and 21961160720)for financial support.
文摘Organic solar cell(OSC)has attracted great interests due to its potential applications[1-9].To date,18%power conversion efficiency(PCE)has been achieved in single-junction OSC[10−13],indicating the feasibility of commercialization.This photovoltaic technology currently faces the performance gap between laboratory cells and large-area modules.
文摘In this editorial preface, I briefly r eview cancer bioinformatics and introduce the four articles in this special issue highlighting important applications of the field: detection of chromatin states; detection of SNP- containing motifs and association with transcription factor-binding sites; improvements in functional enrichment modules; and gene association studies on aging and cancer. We expect this issue to provide bioinformatics scientists, cancer biologists, and clinical doctors with a better understanding of how cancer bioinformatics can be used to identify candidate biomarkers and targets and to conduct functional analysis.
文摘Background Takotsubo syndrome （TS） is an important cardiac disease that affects predominantly postmenopausal women. This study was conducted to determine the impact of age on the short- and long-term outcome of TS patients. Methods ＆ Results The data from a collective of 114 TS patients with a mean follow-up of 1591 ：E 1079 days was retrospectively analysed. The study population was divided into two groups （≤ 65 and 〉 65 years） so as to evaluate the impact of age on the short- and long-term mortality of TS patients. In-hospital eventslike life-threatening arrhythmias （14.58% vs. 9.09%; P = 0.036）, need for mechanical respiratory support （41.66% vs. 28.78%; P = 0.15） as well as inotropic agent use （22.91% vs. 15.15%; P = 0.29）, although not reaching the statistical cut-of, tended to occur more often in the younger group. Heart failure was more common in the elderly age group （P = 0.03）. The use of multivariate analysis ruled out age as a significant marker of long term mortality （HR： 1.0; 95% CI： 0.9-1.0; P = 0.60）. Conclusions Age does not influence the clinical course of TS in terms of the short- as well as long-term outcome. The study revealed a higher incidence of life threatening arrhythmias in the younger patient age-group and a higher incidence of heart failure among the older group of patients.
文摘Seasonal distribution of mono-modal, monsoonal rainfall across the semi-arid ecotone of sub-Saharan of West Africa is highly variable and unpredictable. The ever-present risk of drought and crop failure in this environment often results in food shortages that are met by emergency food aid. Humanitarian assistance planners would be better prepared for such interventions in a timely manner if they have reliable indicators that forewarn the impending failure of the rains. A good indicator would be a characteristic of the seasonal rainfall distribution that can be shown to be reasonably invariant over time and space. The objective of this study is to investigate whether such invariance existed for the seasonal median date (meaning the date when 50% of the seasonal total occurs). Such invariance is expected since the sun’s cyclic declination forces the advance and retreat of the Inter-tropical Front over West Africa. We examined the statistical properties of the seasonal median date for 1349 station-years of rainfall records for 30 rainfall stations in Burkina Faso and Niger with coordinates ranging from 9.88° to 18.5° north latitude and -4.77° to 13.2° longitude. The results showed that the median date was quite narrowly distributed over years with rather weak dependence on geographical coordinates. It can therefore be used as a reasonable ex-ante indicator of the success or failure of the rains as the rainy season progress.
文摘In this paper, we propose a novel seismic blind deconvolution approach based on the Spearman’s rho in the case of band-limited seismic data with a low dominant frequency and short data records. The Spearman’s rho is a measure of the dependence between two continuous random variables without the influence of the marginal distributions, by which a new criterion for blind deconvolution is constructed. The optimization program for new criterion of blind deconvolution is performed by applying Neidell’s wavelet model to the inverse filter. The noise-free and noisy synthetic data, onshore seismic trace in the Ordos Basin, and offshore stacked section in the Bohai Bay Basin examples show good results of the method.
基金supported by the National Natural Science Foundation of China(Grant No.62002270)the Fundamental Research Funds for the Central Universities,the Natural Science Foundation of Shaanxi Province of China(Grant No.2020JQ-332)+3 种基金the China Postdoctoral Science Foundation(Grant No.2018M643583)the National Natural Science Foundation of China(Grant No.82227802)the National Key R&D Program of China(Grant No.2017YFA0205202)partially funded by the National Natural Science Foundation of China(Grant No.61672422).
文摘Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90%of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse cancers.However,the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient.To fill this gap,we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas.For individual candidate among1,500,000 quantified RNA editing events,we performed diverse types of downstream functional annotations.Finally,we identified 24,236 potentially functional A-to-I RNA editing events,including the cases in APOL1,IGFBP3,GRIA2,BLCAP,and miR-589-3p.These events might play crucial roles in the scenarios of tumorigenesis,due to their tumor-related editing frequencies or probable effects on altered expression profiles,protein functions,splicing patterns,and microRNA regulations of tumor genes.Our functional A-to-I RNA editing events(https://ccsm.uth.edu/CAeditome/)will help better understand the cancer pathology from the A-to-I RNA editing aspect.
基金The authors acknowledge funding support from NIH grant U01CA166886(X.Zhou)National Natural Science Foundation of China(No.81100415)and(No.81371704)+1 种基金Chongqing Natural Science Foundation of Committee of Science and Technology(No.CSTC,2010BB5377)Doctoral Program of the Ministry of Education(No.20115503120009).
文摘Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital disorders,infection,irradiation,or cancer.However,in those patients,abnormal cells obtained by biopsy fromthe compromised tissue could potentially contaminate the engineered tissues.Thus,an alternative cell source for construction of the neo-organ or functional recovery of the injured or diseased tissues would be useful.Recently,we have found stem cells existing in the urine.These cells are highly expandable,and have self-renewal capacity,paracrine properties,and multi-differentiation potential.As a novel cell source,urine-derived stem cells(USCs)provide advantages for cell therapy and tissue engineering applications in regeneration of various tissues,particularly in the genitourinary tract,because they originate from the urinary tract system.Importantly,USCs can be obtained via a non-invasive,simple,and low-cost approach and induced with high efficiency to differentiate into three dermal cell lineages.
基金supported by grants from the National Natural Science Foundation of China(81821002,81790251,81430071,81672381,81972665 and 81772487)Guangdong Basic and Applied Basic Research Foundation(2019B030302012)+1 种基金the National 973 Basic Research Program of China(2013CB911300)the Science and Technology Department of Sichuan Province(No.2017SZ0057,2019YJ0050).
文摘Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.
文摘To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least square fitting of a polynomial, we define and give the operators of left prediction and right prediction, left smoothing and right smoothing, central smoothing and cross-validation smoothing. In simulated experiments, it is shown that the present method is an effective one.
