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Attenuated niacin-induced skin flush response in individuals with clinical high risk for psychosis 被引量:2
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作者 Ranpiao Gan Yanyan Wei +9 位作者 Guisen Wu Jiahui Zeng Yegang Hu Lihua Xu xiaochen tang Xiaohua Liu Haichun Liu Tao Chen Jijun Wang Tianhong Zhang 《General Psychiatry》 CAS CSCD 2022年第2期92-100,共9页
Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia Howewer.prior studies have usaly focused on postonset psychusis,and ll is knowm about... Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia Howewer.prior studies have usaly focused on postonset psychusis,and ll is knowm about the dinical high-risk(CHR)phase of niacin senstity in psychosis Aims To proftle and compare the miacin flush responsge among CHR individuals(converters and non-coverters)patients with frstepso schinophrenia(FES)and healty controls(HCs).Methods Sensivily 1o ftour concentralions (0.1-0001M)of aqueous methylnicotinate was tested in 105 CHR individuals,57 patients with FES and 52 HCs.CHR individuals were further grouped as converters and non converters according to the 2-year follow-up outcomes.Skin flush response scores were rated on a 4-point scale.Results Of the 105 CHR individuals,21 individuals were lost during the study,leaving 84 CHR individuals;16(19.0%)converted to full psychosis at 2 years of fllow-up.Flush response scores identifed in the CHR samples were characterised as modest degree levels,intermediate between those of HC individuals and patients with FES.The flush responses in the CHR group mimicked the responses observed in the FES group at higher concentrations(0.01 M,0.1 M)and longer time points(15 min,20min);however,these became comparable vith the responses in the HC group at the shorter time points and at lower concentr ations.The converters exhibited lower mean flush response scores than the non-converters.Conclusions Attenuated niacin-induced flushing emerged during the early phase of psychosis.New devices should be developed and verified for objective quantification of skin responses in the CHR population. 展开更多
关键词 SKIN HIGH shorter
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Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants 被引量:1
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作者 Wenjun Su Zhixing Li +7 位作者 Lihua Xu Jiahui Zeng Yingying tang xiaochen tang Yanyan Wei Qian Guo Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期109-118,共10页
Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for psychosis.Several lines of evidence suggest that fatty acids,especially unsaturated fatty acids(U... Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for psychosis.Several lines of evidence suggest that fatty acids,especially unsaturated fatty acids(UFAs),might play a crucial role in the WM pathology of early onset psychosis.However,evidence linking UFA and WM microstructure in CHR is quite sparse.Aims We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls(HC).Methods Plasma fatty acids were assessed and diffusion tensor imaging(DTI)data were performed with tract-based spatial statistics(TBSS)analysis for 66 individuals at CHR for psychosis and 70 HC.Results Both the global and regional diffusion measures showed significant between-group differences,with decreased fractional anisotropy(FA)but increased mean diffusivity(MD)and radial diffusivity(RD)found in the CHR group compared with the HC group.On top of that,we found that in the HC group,plasma arachidic acid showed obvious trend-level associations with higher global FA,lower global MD and lower global RD,which regionally spread over the corpus callosum,right anterior and superior corona radiata,bilateral anterior and posterior limb of the internal capsule,and bilateral superior longitudinal fasciculus.However,there were no associations between global WM measures and any UFA in the CHR group.Conversely,we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR group.Conclusions Compared with the HC group,CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA,with a neuroprotective effect found in the HC group but not in the CHR group.Such discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group,highlighting the role of balanced plasma-membrane fatty acids homeostasis in WM development. 展开更多
关键词 UNSATURATED diffusion LINKING
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Abnormal neural oscillations in clinical high risk for psychosis:a magnetoencephalography method study 被引量:1
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作者 Yegang Hu Jun Wu +10 位作者 Yujiao Cao xiaochen tang Guisen Wu Qian Guo Lihua Xu Zhenying Qian Yanyan Wei Yingying tang Chunbo Li Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期148-153,共6页
Background Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks.Abnormal neural oscillations have been discovered in patients with s... Background Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks.Abnormal neural oscillations have been discovered in patients with schizophrenia.However,there is limited evidence available on abnormal spontaneous neural oscillations in clinical high risk for psychosis(CHR-P).The brain signals recorded by the magnetoencephalography(MEG)technique are not to be disrupted by the skull and scalp.Methods In this study,we applied the MEG technique to record the resting-state neural activities in CHR-P.This was followed by a detailed MEG analysis method including three steps:(1)preprocessing,which was band-pass filtering based on the 0.5-60Hz frequency range,removal of 50Hz power frequency interference,and removal of electrocardiography(ECG)and electrooculography(EOG)artefacts by independent component analysis;(2)time-frequency analysis,a multitaper time-frequency transformation based on the Hanning window,and(3)source localisation.an exact low-resolution brain electromagnetic tomography.The method was verified by comparing aparticipant with CHR-P with a healthy control during the MEG recordings with an eyes-closed resting state.Results Experimental results show that the neural oscillations in CHR-P were significantly abnormal in the theta frequency band(4-7Hz)and the delta frequency band(1-3Hz).Also,relevant brain regions were located in the left occipital lobe and left temporo-occipital junction for the theta band and in the right dorsolateral prefrontal lobe and near orbitofrontal gyrus for the delta band.Conclusions Abnormal neural oscillations based on specific frequency bands and corresponding brain sources may become biomarkers for high-risk groups.Further work will validate these characteristics in CHR-P cohorts. 展开更多
关键词 STEPS BANDS EXACT
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Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study 被引量:1
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作者 Yanyan Wei xiaochen tang +6 位作者 Tingyu Zhang Wenjun Su Lihua Xu Huiru Cui Zhenying Qian Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期101-108,共8页
Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cogn... Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cognitive deficits;however,the underlying neurobiological mechanisms remain unclear.This study aimed to investigate whether brain activation measured by the levels of oxygenated hemoglobin(oxy-Hb)in CHR subjects could be correlated with cognitive deficits.Methods Fifty-eight CHR individuals who fulfilled the criteria for attenuated positive syndrome as specified in the Structured Interview for Prodromal Syndrome(SIPS)and the Scale of Prodromal Syndrome(SOPS)and 58 age-and sex-matched healthy participants were included in the study.All subjects completed the Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS)Consensus Cognitive Battery(MCCB)that includes tests measuring attention,verbal memory,verbal fluency,executive function,and general intelligence.Functional near-infrared spectroscopy(fNIRS)was used to measure the level of oxy-Hb in the dorsolateral prefrontal and frontotemporal cortices.Results We observed significantly decreased oxy-Hb levels in channel 32(located in the right superior temporal gyrus,rSTG)within the CHR individuals compared with that in the healthy controls(HCs)(t=−3.44,Bonferroni-corrected p=0.002),indicating lower brain activity.A significant positive correlation was observed between task-relatedβvalues and working memory in the CHR group(r=0.35,p=0.008).Conclusions The brain activation of rSTG is abnormal among subjects at clinicial high risk for psychosis.This abnormality is probably associated with the neural mechanisms of deficits in the working memory during the early stage of psychosis. 展开更多
关键词 DISTRESS ACTIVATION VERBAL
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Relationships between selfreflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis
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作者 Lihua Xu Huiru Cui +9 位作者 Yanyan Wei Zhenying Qian xiaochen tang Yegang Hu Yingchan Wang Hao Hu Qian Guo Yingying tang Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第3期163-172,共10页
Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophre... Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness.Aims This study aimed to explore the relationship patterns between self-reflectiveness and clinical symptoms in individuals during the pre-morbid and early clinical stages of psychosis.Methods A total of 181 subjects,including individuals with attenuated positive symptoms(APS,n=122)and patients with first-episode psychosis(FEP,n=59),completed the Beck Cognitive Insight Scale and were evaluated using the Schedule of Assessment of Insight and Positive and Negative Syndrome Scale.All subjects were classified into three groups according to their level of selfreflectiveness:low level(LSR,n=59),medium level(MSR,n=67)and high level(HSR,n=55).Both linear and nonlinear relationships between self-reflectiveness and clinical symptoms were explored.Results More individuals with APS were classified into the MSR group,while more patients with FEP were classified into the LSR group.The LSR group demonstrated less awareness of illness than the MSR and HSR groups,more stereotyped thinking and poorer impulse control but less anxiety than the MSR group,and lower levels of blunted affect and guilt feelings than the HSR group.The MSR group demonstrated lower stereotyped thinking than the HSR group.Compared to the LSR group,the MSR group had increased selfreflectiveness,improved awareness of illness,decreased stereotyped thinking,and better impulse control,but increased feelings of guilt.The HSR group showed increased stereotyped thinking when compared to the MSR group,but the other variables did not change significantly between these two groups.Overall,self-reflectiveness demonstrated an approximately inverse S-shaped relationship with the awareness of illness,a U-shaped relationship with stereotyped thinking and poor impulse control,and an almost linear relationship with anxiety and guilt feelings.Conclusions Self-reflectiveness demonstrates complex relationships with clinical symptoms and fails to exert significant positive effects when reaching a certain high level. 展开更多
关键词 CLINICAL SYMPTOMS MORBID
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精神病临床高危综合征认知功能损伤的功能磁共振成像研究进展
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作者 吴观福 崔慧茹 +4 位作者 唐晓晨 徐丽华 张天宏 王继军 唐莺莹 《中华精神科杂志》 CAS CSCD 北大核心 2023年第1期47-51,共5页
精神病临床高危综合征以弱化的精神病性症状和认知功能损伤为特征, 随访时转化为精神分裂症的患者往往表现出更严重的认知功能损伤。近年来, 任务态功能磁共振成像研究为揭示不同认知功能损伤的神经生物学基础提供了客观特征, 为预测精... 精神病临床高危综合征以弱化的精神病性症状和认知功能损伤为特征, 随访时转化为精神分裂症的患者往往表现出更严重的认知功能损伤。近年来, 任务态功能磁共振成像研究为揭示不同认知功能损伤的神经生物学基础提供了客观特征, 为预测精神病高转化风险的人群提供了生物学标志, 并为发展早期干预提供了潜在靶点。本文对精神病临床高危综合征认知功能损伤的功能磁共振成像研究进展进行综述, 包括认知功能相关的脑区活动异常特征、与临床症状的关联等, 并对利用功能磁共振成像特征预测转化风险进行展望。 展开更多
关键词 磁共振成像 精神病临床高危综合征 认知
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Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma after chimeric antigen receptor T cell therapy
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作者 Lili Zhou Ping Li +4 位作者 Shiguang Ye xiaochen tang Junbang Wang Jie Liu Aibin Liang 《Frontiers of Medicine》 SCIE CAS CSCD 2020年第6期786-791,共6页
Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T(CAR-T)cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma(r/r NHL)have not been well characterized.In ... Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T(CAR-T)cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma(r/r NHL)have not been well characterized.In this study,we found that the different sites of extranodal involvement may affect response,overall survival(OS),and progression-free survival(PFS)in patients with r/r NHL treated with anti-CD19 CAR-T cells.In a cohort of 32 treated patients,12(37.5%)and 8(25%)patients exhibited soft tissue lymphoma and bone marrow(BM)infiltrations,respectively,and 13(41%)patients exhibited infiltration at other sites.The factors that may affect prognosis were identified through multivariable analysis.As an independent risk factor,soft tissue infiltration was the only factor significantly correlated with adverse prognosis(P<0.05),whereas other factors did not reach statistical significance.Furthermore,the site of extranodal tumor infiltration significantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cell therapy.PFS and OS in patients with BM involvement were not significantly different from those of patients with lymph node involvement alone.Thus,anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration. 展开更多
关键词 anti-CD19 chimeric antigen receptor T cell soft tissue bone marrow relapsed or refractory non-Hodgkin lymphoma
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Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle cell lymphoma
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作者 Ping Li Ningxin Dong +8 位作者 Yu Zeng Jie Liu xiaochen tang Junbang Wang Wenjun Zhang Shiguang Ye Lili Zhou Alex Hongsheng Chang Aibin Liang 《Frontiers of Medicine》 SCIE CAS CSCD 2020年第6期811-815,共5页
Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s t... Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory(r/r)MCL but often have short-term responses.Chimeric antigen receptor(CAR)T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma.However,long-term safety and tolerability associated with CAR T-cell therapy are not defined well,especially in MCL.In this report,we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy.CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient.This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL,who are generally elderly and have comorbid conditions. 展开更多
关键词 anti-CD19 chimeric antigen receptor T cells mantle cell lymphoma relapsed or refractory long-term follow-up
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