Objective: To explore the application effect of CBL combined with rain classroom teaching method in medical statistics courses. Methods: The undergraduate students of medical imaging technology in 2019 and 2020 in a u...Objective: To explore the application effect of CBL combined with rain classroom teaching method in medical statistics courses. Methods: The undergraduate students of medical imaging technology in 2019 and 2020 in a university were selected as the research objects. A cluster sampling method was used to select 79 undergraduate students from 2019 in the control group and 75 undergraduate students from 2020 in the experimental group. Traditional teaching method and CBL combined with rain classroom teaching method was used in the control group and experimental group respectively. The final examination scores of the two groups were compared. In experimental group, the correlation between the average score in the rain classroom and the final examination score was tested, and the teaching effect was evaluated. Results: The average score of final examination in experimental group and control group was 79.13 ± 10.32 points and 71.54 ± 14.752 points, respectively, which had a statistically significant difference (Z = 2.586, P = 0.012);the final examination scores of the students in the experimental group were positively correlated with the average scores of the rain classroom (r = 0.372, P = 0.001), and the proportion of satisfaction in the experimental group was 94.7%. Conclusion: The CBL combined with rain classroom teaching method can improve the teaching effectiveness of medical statistics courses.展开更多
Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this...Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called"NBNC-HCC")and patients positive for the above indices(called"HBV-HCC and HCV-HCC")were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients.展开更多
Longan(Dimocarpus longan Lour.),as an edible fruit and traditional Chinese medicine,has been consumed for thousands of years.Longan pulp has abundant nutritional phytochemicals such as protein,carbohydrate,vitamin C,p...Longan(Dimocarpus longan Lour.),as an edible fruit and traditional Chinese medicine,has been consumed for thousands of years.Longan pulp has abundant nutritional phytochemicals such as protein,carbohydrate,vitamin C,polysaccharides,polyphenols,which shows multiple biological activities including antioxidant,immunomodulatory and antitumor effects.Longan pericarp also demonstrates biological activities because of its rich content of polysaccharides and polyphenols.This review summarizes the bioactive compounds and bioactivities of longan pulp and aims to provide comprehensive information for future development of longan as a functional health food.展开更多
Triboelectric nanogenerators(TENGs) have shown promising potential for large-scale blue energy harvesting. However, the lack of reasonable designs has largely hindered TENG from harvesting energy from both rough and t...Triboelectric nanogenerators(TENGs) have shown promising potential for large-scale blue energy harvesting. However, the lack of reasonable designs has largely hindered TENG from harvesting energy from both rough and tranquil seas. Herein, a fully symmetrical triboelectric nanogenerator based on an elliptical cylindrical structure(EC-TENG) is proposed for all-weather blue energy harvesting. The novel elliptical cylindrical shell provides a unique selfstability, high sensitivity to wave triggering, and most importantly, an anti-overturning capability for the EC-TENG. Moreover, benefiting from its internal symmetrical design, the EC-TENG can produce energy normally, even if it was overturned under a rude oscillation in the rough seas, which distinguishes this work from previous reported TENGs. The working mechanism and output performance are systematically studied. The as-fabricated EC-TENG is capable of lighting 400 light-emitting diodes and driving small electronics. More than that, an automatic monitoring system powered by the EC-TENG can also monitor the water level in real-time and provide an alarm if necessary. This work presents an innovative and reliable approach toward all-weather wave energy harvesting in actual marine environments.展开更多
The processability and ultimate quality of coffee(Coffea arabica)are determined by the composition of the matured fruits.The basis of genetic variation in coffee fruit quality could be explained by studying color form...The processability and ultimate quality of coffee(Coffea arabica)are determined by the composition of the matured fruits.The basis of genetic variation in coffee fruit quality could be explained by studying color formation during fruit maturation.Transcriptome profiling was conducted on matured fruits of four C.arabica varieties(orange colored fruits(ORF);purple colored fruits(PF);red colored fruits(RF)and yellow colored fruits(YF))to identify key color-regulating genes,biosynthesis pathways and transcription factors implicated in fruit color formation.A total of 39,938 genes were identified in the transcriptomes of the four C.arabica varieties.In all,2745,781 and 1224 differentially expressed genes(DEGs)were detected in YF_vs_PF,YF_vs_RF and YF_vs_ORF,respectively,with 1732 DEGs conserved among the three pairwise groups.Functional annotation of the DEGs led to the detection of 28 and 82 key genes involved in the biosynthesis of carotenoids and anthocyanins,respectively.Key transcription factors bHLH,MYB,NAC,MADS,and WRKY implicated in fruit color regulation were detected.The high expression levels of gene-LOC113688784(PSY),gene-LOC113730013(b-CHY),gene-LOC113728842(CCD7),gene-LOC113689681(NCED)and gene-LOC113729473(ABA2)in YF may have accounted for the yellow coloration.The differential expression of several anthocyanin and carotenoid-specific genes in the fruits substantially account for the purple(PF),red(RF),and orange(ORF)colorations.This study provides important insights into fruit color formation and variations in C.arabica and will help to develop coffee varieties with specific color and quality traits.展开更多
Taking Haotang Village in Xinyang City of Henan Province as an example,this paper analyzed experience of this village in development of new socialist countryside construction. The new socialist countryside planning an...Taking Haotang Village in Xinyang City of Henan Province as an example,this paper analyzed experience of this village in development of new socialist countryside construction. The new socialist countryside planning and construction should attach importance to research on original spatial pattern of villages,really respect and bring into play subject function of farmers,and deeply explore rural financial services. It is expected to provide reference for future new socialist countryside planning and construction.展开更多
Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a ...Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels,heart,kidney,retina,nervous system,etc.In recent years,DM has attracted more and more attention due to its high morbidity and mortality.In addition to achieve effective glycemic control,prevention of complications has also been considered a priority for type 2 diabetes mellitus(T2DM)management.Herein,we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs.展开更多
We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtyp...We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtype 1 multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.The morphology of bone marrow cells,immunofixation electrophoresis,serum free light chain(sFLC)and other detection indexes of a patient with IgD-λtype MM treated in Handan Central Hospital in December 2020 were analyzed.The patient bone marrow smears showed 62%of abnormal cells-which were distributed in clusters and resembled lymphoma and metastatic cancer cells.The Flowcytometry indicates that the cell is a plasma cell tumor.Immunoglobulin IgG,IgA and IgM were all lower than the normal range.There is a monoclonal light chainλcomponent in immunofixation electrophoresis.The serum free light chainλwas 2700.00 mg/L,light chain k/λis 0.0023,the high of serum calcium,LDH,β2 microglobulin.IgD-λtype MM is a rare type of MM.The age of onset is young,the invasiveness is strong,the prognosis is poor,the clinical manifestation is complex,and it is easy to be misdiagnosed or missed.The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in the diagnosis,treatment and prognosis of the disease.展开更多
Chief editors are the souls of journals,and can guarantee a journal's success by enhancing the efficiency of the manuscript submission and publication process through promptness and speedy response rates to author...Chief editors are the souls of journals,and can guarantee a journal's success by enhancing the efficiency of the manuscript submission and publication process through promptness and speedy response rates to authors.In this study,a total of 867 international journals—indexed by Science Citation Index,Social Sciences Citation Index,and Arts&Humanities Citation Index,and 567 Chinese journals—indexed by Chinese Science Citation Database and Chinese Social Science Citation Information database,were randomly selected to explore whether significant differences in the response rate and speed exist between chief editors.639 chief editors'email addresses were obtained for the international journals,whereas 357 email addresses were gathered for the Chinese journals.However,due to mail servers,only 274 international and 330 Chinese editors were successfully contacted.All messages contained a questionnaire geared to determine the total length of time required for the manuscript submission and publication process.After two months,a 100% response rate was achieved for international chief editors,while Chinese chief editors had a significantly lower rate(P<0.01)of 30.6%.Nevertheless,for both international and Chinese chief editors,66% and 58% provided a response within 12 hours,respectively.Although several reasons exist for the Chinese journals'lagging behind international journals,this study demonstrates that the response rate of chief editors to authors may also be a contributing factor.Thus,chief editors of Chinese journals should enhance their response rate to improve the current situation and further contribute to Chinese journals'success.展开更多
This study aimed to investigate the sleep quality of medical staff in China who are combatting novel coronavirus pneumonia(COVID-19).To perform this,a survey of 127 medical staff from three separate wards(the general ...This study aimed to investigate the sleep quality of medical staff in China who are combatting novel coronavirus pneumonia(COVID-19).To perform this,a survey of 127 medical staff from three separate wards(the general ward,isolation ward,and fever clinic)of a Grade A tertiary hospital in China was conducted.The survey questionnaire measured general characteristics and included the Pittsburgh Sleep Quality Index(PSQI).We consequently found that global PSQI scores differed significantly between the different wards(χ2=44.561,P<0.001).Whilst the medical staff in the general ward did not report any sleep disturbances,those in the isolation ward and the fever clinic both exhibited various degrees of sleep disturbance(global PSQI score>7).Medical staff in the isolation ward had the worst sleep quality(mean rank=91.74),followed by those in the fever clinic(mean rank=70.52)and the general ward(mean rank=39.10),respectively.The primary sleep disturbances reported by the medical staff from the isolation ward included difficulty falling asleep(24 cases,71.42%),waking early or at night(28 cases,80%),and nightmares(18 cases,51.42%).In addition,31.42%(11 cases)of the medical staff from the isolation ward had less than six hours of sleep a night,and 65.71%(23 cases)felt that their sleep quality was poor;meanwhile,for the staff from the fever clinic these ratios were 16.67%(seven cases)and 33.33%(14 cases),respectively.In contrast,among medical staff in the general ward,98%(49 cases)reported sleeping for more than six hours a night,and 96%felt that their sleep quality was good.In conclusion,of the medical staff providing treatment for COVID-19,those in isolation wards and fever clinics are more likely to experience sleep disturbances.展开更多
Objective:To investigate the effectiveness of using quality control circle(QCC)techniques to reduce the cost of non-priced consumables in medical oncology.Methods:Analytic statistics were compiled on the performance a...Objective:To investigate the effectiveness of using quality control circle(QCC)techniques to reduce the cost of non-priced consumables in medical oncology.Methods:Analytic statistics were compiled on the performance appraisal form.Aiming at the key points of improvement with respect to the excess cost of non-valuable consumables,the reasons were analyzed,and corresponding measures were formulated to compare the cost before and after the improvement.Results:After the QCC activity,the cost of non-priced consumables decreased from RMB 6.57/bed day to RMB 3.96/bed day.Conclusion:QCC has effectively reduced the cost of non-priced consumables in the oncology department,and it is worthy of promotion.展开更多
Covalent organic frameworks(COFs),which are constructed by linking organic building blocks via dynamic covalent bonds,are newly emerged and burgeoning crystalline porous copolymers with features including programmable...Covalent organic frameworks(COFs),which are constructed by linking organic building blocks via dynamic covalent bonds,are newly emerged and burgeoning crystalline porous copolymers with features including programmable topological architecture,pre-designable periodic skeleton,well-defined micro-/meso-pore,large specific surface area,and customizable electroactive functionality.Those benefits make COFs as promising candidates for advanced electrochemical energy storage.Especially,for now,structure engineering of COFs from multiscale aspects has been conducted to enable optimal overall electrochemical performance in terms of structure durability,electrical conductivity,redox activity,and charge storage.In this review,we give a fundamental and insightful study on the correlations between multi-scale structure engineering and eventual electrochemical properties of COFs,started with introducing their basic chemistries and charge storage principles.The careful discussion on the significant achievements in structure engineering of COFs from linkages,redox sites,polygon skeleton,crystal nanostructures,and composite microstructures,and further their effects on the electrochemical behavior of COFs are presented.Finally,the timely cutting-edge perspectives and in-depth insights into COFbased electrodematerials to rationally screen their electrochemical behaviors for addressing future challenges and implementing electrochemical energy storage applications are proposed.展开更多
Inflammatory bowel disease(IBD)is prevalent,and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood.In this study,we discovered that increased expr...Inflammatory bowel disease(IBD)is prevalent,and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood.In this study,we discovered that increased expression of methyltransferase-like 3(METTL3)in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate(DSS)-induced colitis.Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase(PGP),which resulted in glucose metabolism reprogramming and the suppression of CD4+T helper 1(Th1)cell differentiation.Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to ameliorate colitis symptoms.In addition,we developed two potent small molecule METTL3 inhibitors,namely,F039-0002 and 7460-0250,that strongly ameliorated DSS-induced colitis.Overall,our study suggests that METTL3 plays crucial roles in the progression of colitis and highlights the potential of targeting METTL3 to attenuate intestinal inflammation for the treatment of colitis.展开更多
At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean...At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean energy applications. In this work, a reticulated porous ceria ceramic material with interconnected porous structure was prepared by the impregnation technique using organic polyurethane sponges as template. The influences of pretreated sponge, dipping time length, pore size and sintering temperature on the porosity and strength of the porous ceria ceramics were system atically studied. With the increasing sintering temperature, the glass phase occurred and led to an increase in strength, but an decrease in porosity. Eventually, we analyzed the relationships betw een porosity and strength of these porous materials, aiming to provide theoretical and practical references for its application in clean-energy field.展开更多
Partially observable Markov decision processes （POMDPs） provide a rich mathematical framework for planning tasks in partially observable stochastic environments. The notion of the covering number, a metric of captur...Partially observable Markov decision processes （POMDPs） provide a rich mathematical framework for planning tasks in partially observable stochastic environments. The notion of the covering number, a metric of capturing the search space size of a POMDP planning problem, has been proposed as a complexity measure of approximate POMDP planning. Existing theoretical results are based on POMDPs with finite and discrete state spaces and measured in the l1- metric space. When considering heuristics, they are assumed to be always admissible. This paper extends the theoretical results on the covering numbers of different search spaces, including the newly defined space reachable under inadmissible heuristics, to the ln-metric spaces. We provide a simple but scalable algorithm for estimating covering numbers. Experimentally, we provide estimated covering numbers of the search spaces reachable by following different policies on several benchmark problems, and analyze their abilities to predict the runtime of POMDP planning algorithms.展开更多
To improve the acoustic radiation performance of the spherical transducer,a prestressed layer is formed in the transducer through fiber winding.The influence of the prestressed layer on the transducer is studied from ...To improve the acoustic radiation performance of the spherical transducer,a prestressed layer is formed in the transducer through fiber winding.The influence of the prestressed layer on the transducer is studied from the effects of the radial prestress(Tr)and acoustic impedance,respectively.First,a theoretical estimation of Tr is established with a thin shell approximation of the prestressed layer.Then,the acoustic impedance is measured to evaluate the efficiency of sound energy transmission within the prestressed layer.Further,the ideal effects of Tr on the sound radiation performances of the transducer are analyzed through finite element analysis(FEA).Finally,four spherical transducers are fabricated and tested to investigate their dependence of actual properties on the prestressed layer.The results show that with the growth of Tr,the acoustic impedance of the prestressed layer grows,mitigating the enormous impedance mismatch between the piezoelectric ceramic and water,while increasing attenuation of the acoustic energy,resulting in a peak value of the maximum transmitting voltage response(TVRmax)at 1.18 MPa.The maximum drive voltage increases with Tr,leading to a steady growth of the maximum transmitting sound level(SLmax),with a noticeable ascend of 3.9 dB at a 3.44 MPa Tr.This is a strong credibility that the prestressed layer could improve the sound radiation performance of the spherical transducer.展开更多
Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-bin...Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules.It was reported as a major responsive factor of paclitaxel resistance for clinical chemotherapy of tumor patients.But the function of abnormally high level of STMN1 and its regulation mechanism in cancer cells remain unclear.In this study,we used public database and tissue microarrays to analyze the expression pattern of FoxM1 and STMN1 and found a strong positive correlation between FoxM1 and STMN1 in multiple types of cancer.Lentivirus-mediated FoxM1/STMN1-knockdown cell lines were established to study the function of FoxM1/STMN1 by performing cell viability assay,plate clone formation assay,soft agar assay in vitro and xenograft mouse model in vivo.Our results showed that FoxMl promotes cell proliferation by upregulating STMN1.Further ChIP assay showed that FoxM1 upregulates STMN1 in a transcriptional level.Prognostic analysis showed that a high level of FoxM1 and STMN1 is related to poor prognosis in solid tumors.Moreover,a high co-expression of FoxM1 and STMN1 has a more significant correlation with poor prognosis.Our findings suggest that a general FoxMl-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma,gastric cancer and colorectal cancer.The combination of FoxM1 and STMN1 can be a more precise biomarker for prognostic prediction.展开更多
文摘Objective: To explore the application effect of CBL combined with rain classroom teaching method in medical statistics courses. Methods: The undergraduate students of medical imaging technology in 2019 and 2020 in a university were selected as the research objects. A cluster sampling method was used to select 79 undergraduate students from 2019 in the control group and 75 undergraduate students from 2020 in the experimental group. Traditional teaching method and CBL combined with rain classroom teaching method was used in the control group and experimental group respectively. The final examination scores of the two groups were compared. In experimental group, the correlation between the average score in the rain classroom and the final examination score was tested, and the teaching effect was evaluated. Results: The average score of final examination in experimental group and control group was 79.13 ± 10.32 points and 71.54 ± 14.752 points, respectively, which had a statistically significant difference (Z = 2.586, P = 0.012);the final examination scores of the students in the experimental group were positively correlated with the average scores of the rain classroom (r = 0.372, P = 0.001), and the proportion of satisfaction in the experimental group was 94.7%. Conclusion: The CBL combined with rain classroom teaching method can improve the teaching effectiveness of medical statistics courses.
基金supported by the National Natural Science Foundation of China(Grant Nos.81972656 and 31671421)the Key Project of Tianjin Natural Science Foundation(Grant No.18JCZDJC35200)+1 种基金the State Key Project on Infectious Diseases of China(Grant No.2018ZX10723204)the National 135 Major Project of China(2018ZX10302205)。
文摘Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called"NBNC-HCC")and patients positive for the above indices(called"HBV-HCC and HCV-HCC")were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients.
基金This project was supported by the National Natural Science Foundation of China(No.31570348).
文摘Longan(Dimocarpus longan Lour.),as an edible fruit and traditional Chinese medicine,has been consumed for thousands of years.Longan pulp has abundant nutritional phytochemicals such as protein,carbohydrate,vitamin C,polysaccharides,polyphenols,which shows multiple biological activities including antioxidant,immunomodulatory and antitumor effects.Longan pericarp also demonstrates biological activities because of its rich content of polysaccharides and polyphenols.This review summarizes the bioactive compounds and bioactivities of longan pulp and aims to provide comprehensive information for future development of longan as a functional health food.
基金the financial support from the National Key Research and Development Project(Grant No.2021YFA1201602)National Natural Science Foundation of China(Grant No.52076024)+3 种基金Guangxi Natural Science Foundation Project(Grant No.2021GXNSFAA075009)Guangxi Science and Technology Project(Grant No.GUIKEAD22035178)Natural Science Foundation of Chongqing(Grant No.cstc2021jcyjmsxmX0625)the Fundamental Research Funds for the Central Universities(Grant No.2020CDCGJ005)。
文摘Triboelectric nanogenerators(TENGs) have shown promising potential for large-scale blue energy harvesting. However, the lack of reasonable designs has largely hindered TENG from harvesting energy from both rough and tranquil seas. Herein, a fully symmetrical triboelectric nanogenerator based on an elliptical cylindrical structure(EC-TENG) is proposed for all-weather blue energy harvesting. The novel elliptical cylindrical shell provides a unique selfstability, high sensitivity to wave triggering, and most importantly, an anti-overturning capability for the EC-TENG. Moreover, benefiting from its internal symmetrical design, the EC-TENG can produce energy normally, even if it was overturned under a rude oscillation in the rough seas, which distinguishes this work from previous reported TENGs. The working mechanism and output performance are systematically studied. The as-fabricated EC-TENG is capable of lighting 400 light-emitting diodes and driving small electronics. More than that, an automatic monitoring system powered by the EC-TENG can also monitor the water level in real-time and provide an alarm if necessary. This work presents an innovative and reliable approach toward all-weather wave energy harvesting in actual marine environments.
基金financially supported by the Yunnan Science and Technology Introducing project(International Science and Technology Cooperation):Construction Project of Coffee Scientific and Technological Demonstration Districts in Mountainous Areas of Northern Laos(2019IB013)High-end Foreign Experts Program of Yunnan Thousand Talents Program(2019013)Yunnan provincial key programs(2019ZG00901,202002AA10007).
文摘The processability and ultimate quality of coffee(Coffea arabica)are determined by the composition of the matured fruits.The basis of genetic variation in coffee fruit quality could be explained by studying color formation during fruit maturation.Transcriptome profiling was conducted on matured fruits of four C.arabica varieties(orange colored fruits(ORF);purple colored fruits(PF);red colored fruits(RF)and yellow colored fruits(YF))to identify key color-regulating genes,biosynthesis pathways and transcription factors implicated in fruit color formation.A total of 39,938 genes were identified in the transcriptomes of the four C.arabica varieties.In all,2745,781 and 1224 differentially expressed genes(DEGs)were detected in YF_vs_PF,YF_vs_RF and YF_vs_ORF,respectively,with 1732 DEGs conserved among the three pairwise groups.Functional annotation of the DEGs led to the detection of 28 and 82 key genes involved in the biosynthesis of carotenoids and anthocyanins,respectively.Key transcription factors bHLH,MYB,NAC,MADS,and WRKY implicated in fruit color regulation were detected.The high expression levels of gene-LOC113688784(PSY),gene-LOC113730013(b-CHY),gene-LOC113728842(CCD7),gene-LOC113689681(NCED)and gene-LOC113729473(ABA2)in YF may have accounted for the yellow coloration.The differential expression of several anthocyanin and carotenoid-specific genes in the fruits substantially account for the purple(PF),red(RF),and orange(ORF)colorations.This study provides important insights into fruit color formation and variations in C.arabica and will help to develop coffee varieties with specific color and quality traits.
文摘Taking Haotang Village in Xinyang City of Henan Province as an example,this paper analyzed experience of this village in development of new socialist countryside construction. The new socialist countryside planning and construction should attach importance to research on original spatial pattern of villages,really respect and bring into play subject function of farmers,and deeply explore rural financial services. It is expected to provide reference for future new socialist countryside planning and construction.
基金supported by the National Natural Science Foundation of China(NSFC)(No.81770809).
文摘Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels,heart,kidney,retina,nervous system,etc.In recent years,DM has attracted more and more attention due to its high morbidity and mortality.In addition to achieve effective glycemic control,prevention of complications has also been considered a priority for type 2 diabetes mellitus(T2DM)management.Herein,we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs.
文摘We aimed to explore the changes of laboratory indexes of IgD-λtype multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.To explore the changes of laboratory indexes of IgD-λtype 1 multiple myeloma with special cell morphology,and to improve the cognition of IgD-λtype MM.The morphology of bone marrow cells,immunofixation electrophoresis,serum free light chain(sFLC)and other detection indexes of a patient with IgD-λtype MM treated in Handan Central Hospital in December 2020 were analyzed.The patient bone marrow smears showed 62%of abnormal cells-which were distributed in clusters and resembled lymphoma and metastatic cancer cells.The Flowcytometry indicates that the cell is a plasma cell tumor.Immunoglobulin IgG,IgA and IgM were all lower than the normal range.There is a monoclonal light chainλcomponent in immunofixation electrophoresis.The serum free light chainλwas 2700.00 mg/L,light chain k/λis 0.0023,the high of serum calcium,LDH,β2 microglobulin.IgD-λtype MM is a rare type of MM.The age of onset is young,the invasiveness is strong,the prognosis is poor,the clinical manifestation is complex,and it is easy to be misdiagnosed or missed.The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in the diagnosis,treatment and prognosis of the disease.
基金This research was funded by the National Natural Science Foundation of China(41461109)the Major Program of the Natural Science Foundation of Gansu province,China(18JR4RA002)+1 种基金Opening Fund of Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions,CAS(LPCC2018008)the Key Laboratory of Ecohydrology of Inland River Basin,Chinese Academy of Science(KLERB-ZS-16-01).
文摘Chief editors are the souls of journals,and can guarantee a journal's success by enhancing the efficiency of the manuscript submission and publication process through promptness and speedy response rates to authors.In this study,a total of 867 international journals—indexed by Science Citation Index,Social Sciences Citation Index,and Arts&Humanities Citation Index,and 567 Chinese journals—indexed by Chinese Science Citation Database and Chinese Social Science Citation Information database,were randomly selected to explore whether significant differences in the response rate and speed exist between chief editors.639 chief editors'email addresses were obtained for the international journals,whereas 357 email addresses were gathered for the Chinese journals.However,due to mail servers,only 274 international and 330 Chinese editors were successfully contacted.All messages contained a questionnaire geared to determine the total length of time required for the manuscript submission and publication process.After two months,a 100% response rate was achieved for international chief editors,while Chinese chief editors had a significantly lower rate(P<0.01)of 30.6%.Nevertheless,for both international and Chinese chief editors,66% and 58% provided a response within 12 hours,respectively.Although several reasons exist for the Chinese journals'lagging behind international journals,this study demonstrates that the response rate of chief editors to authors may also be a contributing factor.Thus,chief editors of Chinese journals should enhance their response rate to improve the current situation and further contribute to Chinese journals'success.
文摘This study aimed to investigate the sleep quality of medical staff in China who are combatting novel coronavirus pneumonia(COVID-19).To perform this,a survey of 127 medical staff from three separate wards(the general ward,isolation ward,and fever clinic)of a Grade A tertiary hospital in China was conducted.The survey questionnaire measured general characteristics and included the Pittsburgh Sleep Quality Index(PSQI).We consequently found that global PSQI scores differed significantly between the different wards(χ2=44.561,P<0.001).Whilst the medical staff in the general ward did not report any sleep disturbances,those in the isolation ward and the fever clinic both exhibited various degrees of sleep disturbance(global PSQI score>7).Medical staff in the isolation ward had the worst sleep quality(mean rank=91.74),followed by those in the fever clinic(mean rank=70.52)and the general ward(mean rank=39.10),respectively.The primary sleep disturbances reported by the medical staff from the isolation ward included difficulty falling asleep(24 cases,71.42%),waking early or at night(28 cases,80%),and nightmares(18 cases,51.42%).In addition,31.42%(11 cases)of the medical staff from the isolation ward had less than six hours of sleep a night,and 65.71%(23 cases)felt that their sleep quality was poor;meanwhile,for the staff from the fever clinic these ratios were 16.67%(seven cases)and 33.33%(14 cases),respectively.In contrast,among medical staff in the general ward,98%(49 cases)reported sleeping for more than six hours a night,and 96%felt that their sleep quality was good.In conclusion,of the medical staff providing treatment for COVID-19,those in isolation wards and fever clinics are more likely to experience sleep disturbances.
文摘Objective:To investigate the effectiveness of using quality control circle(QCC)techniques to reduce the cost of non-priced consumables in medical oncology.Methods:Analytic statistics were compiled on the performance appraisal form.Aiming at the key points of improvement with respect to the excess cost of non-valuable consumables,the reasons were analyzed,and corresponding measures were formulated to compare the cost before and after the improvement.Results:After the QCC activity,the cost of non-priced consumables decreased from RMB 6.57/bed day to RMB 3.96/bed day.Conclusion:QCC has effectively reduced the cost of non-priced consumables in the oncology department,and it is worthy of promotion.
基金Hubei Provincial Natural Science Foundation of China,Grant/Award Number:2022CFB555Open Project of State Key Laboratory of New Textile Materials and Advanced Processing Technologies,Grant/Award Number:FZ2021003。
文摘Covalent organic frameworks(COFs),which are constructed by linking organic building blocks via dynamic covalent bonds,are newly emerged and burgeoning crystalline porous copolymers with features including programmable topological architecture,pre-designable periodic skeleton,well-defined micro-/meso-pore,large specific surface area,and customizable electroactive functionality.Those benefits make COFs as promising candidates for advanced electrochemical energy storage.Especially,for now,structure engineering of COFs from multiscale aspects has been conducted to enable optimal overall electrochemical performance in terms of structure durability,electrical conductivity,redox activity,and charge storage.In this review,we give a fundamental and insightful study on the correlations between multi-scale structure engineering and eventual electrochemical properties of COFs,started with introducing their basic chemistries and charge storage principles.The careful discussion on the significant achievements in structure engineering of COFs from linkages,redox sites,polygon skeleton,crystal nanostructures,and composite microstructures,and further their effects on the electrochemical behavior of COFs are presented.Finally,the timely cutting-edge perspectives and in-depth insights into COFbased electrodematerials to rationally screen their electrochemical behaviors for addressing future challenges and implementing electrochemical energy storage applications are proposed.
基金National Natural Science Foundation of China(grants 81630069 and 31771439 to YAG,82173046 to ZR,and 31801128 to YHL,and 82173162 to ZX)Program for Ph.D.Starting Research Funding from Xinxiang Medical University(grant 505249 to YHL)+1 种基金Fund of State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers(grant CBSKL2022KF03 to YHL)National Key Research and Development Program(grant 2016YFC1303200 to ZR).
文摘Inflammatory bowel disease(IBD)is prevalent,and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood.In this study,we discovered that increased expression of methyltransferase-like 3(METTL3)in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate(DSS)-induced colitis.Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase(PGP),which resulted in glucose metabolism reprogramming and the suppression of CD4+T helper 1(Th1)cell differentiation.Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to ameliorate colitis symptoms.In addition,we developed two potent small molecule METTL3 inhibitors,namely,F039-0002 and 7460-0250,that strongly ameliorated DSS-induced colitis.Overall,our study suggests that METTL3 plays crucial roles in the progression of colitis and highlights the potential of targeting METTL3 to attenuate intestinal inflammation for the treatment of colitis.
基金financial supports from the fund of the State Key Laboratory of Solidification Processing in NWPU (SKLSP201704)
文摘At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean energy applications. In this work, a reticulated porous ceria ceramic material with interconnected porous structure was prepared by the impregnation technique using organic polyurethane sponges as template. The influences of pretreated sponge, dipping time length, pore size and sintering temperature on the porosity and strength of the porous ceria ceramics were system atically studied. With the increasing sintering temperature, the glass phase occurred and led to an increase in strength, but an decrease in porosity. Eventually, we analyzed the relationships betw een porosity and strength of these porous materials, aiming to provide theoretical and practical references for its application in clean-energy field.
文摘Partially observable Markov decision processes （POMDPs） provide a rich mathematical framework for planning tasks in partially observable stochastic environments. The notion of the covering number, a metric of capturing the search space size of a POMDP planning problem, has been proposed as a complexity measure of approximate POMDP planning. Existing theoretical results are based on POMDPs with finite and discrete state spaces and measured in the l1- metric space. When considering heuristics, they are assumed to be always admissible. This paper extends the theoretical results on the covering numbers of different search spaces, including the newly defined space reachable under inadmissible heuristics, to the ln-metric spaces. We provide a simple but scalable algorithm for estimating covering numbers. Experimentally, we provide estimated covering numbers of the search spaces reachable by following different policies on several benchmark problems, and analyze their abilities to predict the runtime of POMDP planning algorithms.
基金supported by the National Natural Science Foundation of China(Nos.U1806221 and U2006218)Shandong Provincial Natural Science Foundation(Grant No.ZR2020KA003)Taishan Scholars Program and case-by-case project for Top Outstanding Talents of Jinan,the Project of“20 Items of University”of Jinan(Grant Nos.T202009 and T201907).
文摘To improve the acoustic radiation performance of the spherical transducer,a prestressed layer is formed in the transducer through fiber winding.The influence of the prestressed layer on the transducer is studied from the effects of the radial prestress(Tr)and acoustic impedance,respectively.First,a theoretical estimation of Tr is established with a thin shell approximation of the prestressed layer.Then,the acoustic impedance is measured to evaluate the efficiency of sound energy transmission within the prestressed layer.Further,the ideal effects of Tr on the sound radiation performances of the transducer are analyzed through finite element analysis(FEA).Finally,four spherical transducers are fabricated and tested to investigate their dependence of actual properties on the prestressed layer.The results show that with the growth of Tr,the acoustic impedance of the prestressed layer grows,mitigating the enormous impedance mismatch between the piezoelectric ceramic and water,while increasing attenuation of the acoustic energy,resulting in a peak value of the maximum transmitting voltage response(TVRmax)at 1.18 MPa.The maximum drive voltage increases with Tr,leading to a steady growth of the maximum transmitting sound level(SLmax),with a noticeable ascend of 3.9 dB at a 3.44 MPa Tr.This is a strong credibility that the prestressed layer could improve the sound radiation performance of the spherical transducer.
基金supported by the National Natural Science Foundation of China(grantnumbers 81630069,81421003,31771439,81773262,81572763,81672751)the National Key Research and Development Program(grant number 2016YFC1303200)+1 种基金the Key Research and Development Program of Shaanxi(2019SF-010)Opening Projects of the State Key Laboratory of Cancer Biology(CBSKL201703,CBSKL201704,CBSKL201726)。
文摘Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules.It was reported as a major responsive factor of paclitaxel resistance for clinical chemotherapy of tumor patients.But the function of abnormally high level of STMN1 and its regulation mechanism in cancer cells remain unclear.In this study,we used public database and tissue microarrays to analyze the expression pattern of FoxM1 and STMN1 and found a strong positive correlation between FoxM1 and STMN1 in multiple types of cancer.Lentivirus-mediated FoxM1/STMN1-knockdown cell lines were established to study the function of FoxM1/STMN1 by performing cell viability assay,plate clone formation assay,soft agar assay in vitro and xenograft mouse model in vivo.Our results showed that FoxMl promotes cell proliferation by upregulating STMN1.Further ChIP assay showed that FoxM1 upregulates STMN1 in a transcriptional level.Prognostic analysis showed that a high level of FoxM1 and STMN1 is related to poor prognosis in solid tumors.Moreover,a high co-expression of FoxM1 and STMN1 has a more significant correlation with poor prognosis.Our findings suggest that a general FoxMl-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma,gastric cancer and colorectal cancer.The combination of FoxM1 and STMN1 can be a more precise biomarker for prognostic prediction.
