Professor An Yin,a world-class geologist,was well known for his significant contribution to the understanding of tectonic evolution of the Earth,especially the Himalayas and Tibetan plateau(Yin A and Harrison,2000;Yin...Professor An Yin,a world-class geologist,was well known for his significant contribution to the understanding of tectonic evolution of the Earth,especially the Himalayas and Tibetan plateau(Yin A and Harrison,2000;Yin A,2006),and other planets and their satellites,such as Enceladus and Europa(Yin A et al.,2016;Leonard et al.,2018).He applied mechanical analysis to structural geology in order to understand the deformation process,not only on terrestrial planets(Yin A,2012),but also on icy Charon,the largest moon of Pluto(Chen HZ and Yin A,2022).He passed away unexpectedly in the afternoon of July 12,2023 while teaching a summer field camp at White Mountain,California,USA.展开更多
Objective：Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid cancer.The purpose of this study was to identify the common and characteristic...Objective：Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid cancer.The purpose of this study was to identify the common and characteristic preoperative ultrasonography features that are associated with the pathologic extranodal extension of metastatic papillary thyroid carcinoma.Methods：We retrospectively assessed and compared clinicopathologic and ultrasound features between 60 papillary thyroid cancer patients with extranodal extension and 120 control patients with papillary thyroid cancer without extranodal extension.Results：With respect to the pathological N stage and clinicopathologic features,N1b stage papillary thyroid carcinomas were more frequently found in patients who were extranodal extension-positive,in comparison with those who were extranodal extension-negative（78.3%vs.63.3%,P=0.043）.Extranodal extension was detected most frequently in level VI cervical lymph nodes（48.7%）.In our univariate analysis of patients with papillary thyroid carcinoma,cervical lymph nodes with extranodal extension showed higher incidences of node matting,microcalcification,cystic area,aspect ratio＆lt;2,and larger diameter than those without extranodal extension（all P〈0.05）.Our multivariate analysis demonstrated that node matting and cystic area were independent risk factors for the presence of extranodal extension[odds ratio（OR）：4.751,95%confidence interval（CI）：1.212~18.626,P=0.025;OR：2.707,95%CI：1.127~6.502,P=0.026].Conclusions：Common ultrasound features may indicate the presence of extranodal extension in patients with metastatic cervical lymph nodes of papillary thyroid carcinoma.展开更多
Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coro...Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated mortality.With the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome sequencing.However,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of SARS-CoV-2.We recruited 4 human leukocyte antigen A2(HLA-A2)infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2 HLA-A2 and HLA-A24 epitope-specific CD8^(+)T cells.From individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than 1.The enzyme-linked immunospot(ELISpot)results further validate this result.This study forms a“method for understanding the infection history of SARS-CoV-2 subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2+and HLA-A24+donors,providing a novel method for SARS-CoV-2 infected case tracing.展开更多
Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory...Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron infections and related symptoms.What is added by this report?The self-reported infection rate,as determined from an online survey,reached its peak(15.5%)between December 19 and 21,2022,with an estimated 82.4%of individuals in China being infected as of February 7,2023.During the epidemic,the effectiveness of booster vaccinations against SARS-CoV-2 Omicron infection was found to be 49.0%within three months of vaccination and 37.9%between 3 and 6 months following vaccination.Furthermore,the vaccine effectiveness of the booster vaccination in relation to symptom prevention varied from 48.7%to 83.2%within three months and from 25.9%to 69.0%between 3 and 6 months post-booster vaccination.展开更多
The Tibetan Plateau has been known for its highest elevation and thickest crust on earth,and become a key region for comprehending the rheology and tectonic evolution of continental plates and associated dynamic proce...The Tibetan Plateau has been known for its highest elevation and thickest crust on earth,and become a key region for comprehending the rheology and tectonic evolution of continental plates and associated dynamic processes.Over the past years,numerous geophysical studies have been conducted to explore the deep structure of the Tibetan Plateau,resulting in significant advancements in understanding the formation and growth of the Plateau.This paper aims to provide a comprehensive summary and discussion of the geophysical observations and underlying mechanisms of the plateau uplift.First,major relevant tectonic models are reviewed,and the corresponding features of crustal structures and related deformation are presented.Then,recent observations,including the identification of a high-velocity layer in the lower crust of the Lhasa block,the spatial distribution of crustal channel flow,and the decoupling of shallow and deep crustal deformation,are synthesized to gain insights into the crustal structures,and multidisciplinary data are integrated to discuss the potential mechanisms of the plateau uplift.Lastly,some pertinent suggestions are put forward for future research on the Tibetan Plateau.展开更多
Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these ...Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics.展开更多
With the acceleration of the investigation and development of marine resources,the detection and location of submarine pipelines have become a necessary part of modern marine engineering.Submarine pipelines are a typi...With the acceleration of the investigation and development of marine resources,the detection and location of submarine pipelines have become a necessary part of modern marine engineering.Submarine pipelines are a typical weak magnetic anomaly target,and their magnetic anomaly detection can only be realized within a certain distance.At present,a towfish or an autonomous underwater vehicle(AUV)is mainly used as the platform to equip magnetometers close to the submarine pipelines for magnetic anomaly detection.However,the mother ship directly affects the towfish,thus causing control interference.The AUV cannot detect in real time,which affects the magnetic anomaly detection and creates problems regarding detection efficiency.Meanwhile,a two-part towed platform has convenient control,thus reducing the interference of the towed mother ship and real-time detection.If the platform can maintain constant altitude sailing through the controller,the data accuracy in the actual magnetic anomaly detection can be guaranteed.On the basis of a two-part towed platform,a magnetic detection system with constant altitude sailing ability for submarine pipelines was constructed in this study.In addition,experimental verification was conducted.The experimental verification research shows that the constant altitude sailing experiment of the two-part towed platform verifies that the platform has good constant altitude sailing ability in both a hydrostatic environment and the actual marine environment.Meanwhile,the offshore magnetic anomaly detection experiment of submarine pipelines verifies the stable measurement function of the magnetic field and the function of the system to detect magnetic anomaly of submarine pipelines.展开更多
Summary What is already known about this topic?As one of the populations at high risk of hepatitis B virus(HBV)infection,patients with chronic kidney disease(CKD)require rapid and effective development of hepatitis B ...Summary What is already known about this topic?As one of the populations at high risk of hepatitis B virus(HBV)infection,patients with chronic kidney disease(CKD)require rapid and effective development of hepatitis B surface antibodies(anti-HBs).What is added by this report?The short-course,high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen,achieving a seroconversion rate of 88.5%,a high-response rate of 64.1%,and anti-HBs geometric mean concentrations of 824.1 mIU/mL.What are the implications for public health practice?The short-course,high-dose regimen represents an effective rapid immunization strategy for CKD patients,particularly when administered prior to immunosuppressive therapy.This study provides compelling evidence for optimizing immunization protocols in the CKD population.展开更多
Numerous continents have rifted and drifted away from Gondwana to repeatedly open ocean basins over the past-500 millionyears.These Gondwana-derived continents drifted towards and collided with components of the Euras...Numerous continents have rifted and drifted away from Gondwana to repeatedly open ocean basins over the past-500 millionyears.These Gondwana-derived continents drifted towards and collided with components of the Eurasian continent to successively close the preexisting oceans between the two.Plate tectonics satisfactorily describes the continental drift from Gondwana to Eurasia but does not define the geodynamic mechanism of continuously rifting to collisions of continents in the Tethy an Realm.After reappraisal of geological records of the rift,collision and subduction initiation from the surface and various geophysical observations from depth,we propose that Eurasia-directed subducting oceanic slabs would have driven Tethyan system in the Phanerozoic.The Eurasia-directed subduction would have dragged the passive Gondwana margin to rift and drift northwards,giving birth to new oceans since the Paleozoic.The closure of preexisting oceans between the Gondwana-derived continents and Eurasia led to continental collisions,which would have induced the initiation of oceanic subduction in the Tethyan Realm.Multiple episodic switches between collision-subduction-rift repeatedly led to the separation of continental fragments from Gondwana and dragged them to drift towards Eurasia.The final disappearance of Neo-Tethy s would have induced collision of the Gondwana-derived continents with the Eurasian continent,giving rise to the Cenozoic Alpine-Zagros-Himalayan collisional system.Therefore,the Eurasia-directed oceanic subduction would have acted as a’one-way train’that successively transferred the ruptured Gondwana continental fragments in the south,into the terminal in the north.In this regard,the engine of this"Tethyan one-way train"is the negative buoyancy of subducting oceanic slabs.展开更多
Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half ...Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half a century ago,considerable debates have remained regarding the driving forces for plate motion.The early"Bottom up"view,i.e.,the convecting mantledriven mechanism,states that mantle plumes originating from the core-mantle boundary act at the base of plates,accelerating continental breakup and driving plate motion.Toward the present,however,the"Top down"idea is more widely accepted,according to which the negative buoyancy of oceanic plates is the dominant driving force for plate motion,and the subducting slabs control surface tectonics and mantle convection.In this regard,plate tectonics is also known as subduction tectonics."Top down"tectonics has received wide supports from numerous geological and geophysical observations.On the other hand,recent studies indicate that the acceleration/deceleration of individual plates over the million-year timescale may reflect the effects of mantle plumes.It is also suggested that surface uplift and subsidence within stable cratonic areas are correlated with plumerelated magmatic activities over the hundred-million-year timescale.On the global scale,the cyclical supercontinent assembly and breakup seem to be coupled with superplume activities during the past two billion years.These correlations over various spatial and temporal scales indicate the close relationship and intensive interactions between plate tectonics and plume tectonics throughout the history of the Earth and the considerable influence of plumes on plate motion.Indeed,we can acquire a comprehensive understanding of the driving forces for plate motion and operation mechanism of the Earth's dynamic system only through joint analyses and integrated studies on plate tectonics and plume tectonics.展开更多
Summary What is already known about this topic?Hong Kong Special Administrative Region(SAR),China and Singapore are both facing considerable Omicron variant epidemic.However,the overwhelmed medical system and high cas...Summary What is already known about this topic?Hong Kong Special Administrative Region(SAR),China and Singapore are both facing considerable Omicron variant epidemic.However,the overwhelmed medical system and high case fatality ratio(CFR)just occurred in Hong Kong SAR,China but not in Singapore.What is added by this report?The low vaccination coverage in Hong Kong SAR,China,especially among the older adults,is shown to be a primary reason of its recent high CFR.What are the implications for public health practice?Facing the potential epidemic risk,non-vaccinated,non-fully-vaccinated,and non-booster-vaccinated people in China,especially the elderly,should get any type of accessible vaccine,which could save lives when the infection unfortunately befalls.展开更多
The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,...The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.展开更多
Based on the major findings of our studies,we found that in the past two or three decades,China’s noncommunicable diseases(NCDs)prevention and control policies experienced rapid development.The service mode of NCDs m...Based on the major findings of our studies,we found that in the past two or three decades,China’s noncommunicable diseases(NCDs)prevention and control policies experienced rapid development.The service mode of NCDs management was transformed,the service capabilities at primary medical facilities were comprehensively improved,and the health literacy and action capability of residents were improved.Remarkable achievements have been made in the prevention and control of NCDs,and a lot of experience has been accumulated.However,unhealthy lifestyles among Chinese residents are still common,and the control of NCDs and related behavioral risk factors faces great challenges.Therefore,in order to implement the Healthy China strategy,early prevention and strengthening of the health management of NCDs in high-risk groups are essential.展开更多
Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China ...Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic.展开更多
文摘Professor An Yin,a world-class geologist,was well known for his significant contribution to the understanding of tectonic evolution of the Earth,especially the Himalayas and Tibetan plateau(Yin A and Harrison,2000;Yin A,2006),and other planets and their satellites,such as Enceladus and Europa(Yin A et al.,2016;Leonard et al.,2018).He applied mechanical analysis to structural geology in order to understand the deformation process,not only on terrestrial planets(Yin A,2012),but also on icy Charon,the largest moon of Pluto(Chen HZ and Yin A,2022).He passed away unexpectedly in the afternoon of July 12,2023 while teaching a summer field camp at White Mountain,California,USA.
文摘目的:探讨代谢综合征(metabolic syndrome,MetS)与胃癌发病风险及其临床病理特征的相关性。方法:回顾性分析2011年2月至2013年6月天津医科大学肿瘤医院经病理确诊的808例胃癌患者的病例情况、术前检查及临床病理资料,同时选取1 146例随机对照者,分析其Mets与临床病理特征相关性。结果:与对照组相比,所有胃癌患者甘油三酯(triglyceride,TG)水平较高,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平较低,高血压发病率较高。胃癌患者MetS阳性率显著高于对照组(19.1%vs. 9.6%)。MetS的发生与胃癌发病风险相关[总体:OR=2.535(1.805~3.562),女性:OR=1.514(1.197~2.390),男性:OR=2.683(1.798~4.004)]。MetS包含的各个代谢因素异常均能提高胃癌患者的发病风险,包括高身体质量指数(body mass index,BMI)及TG、低HDL-C、高血压和糖尿病。在男性胃癌患者中,高BMI、高血压和糖尿病是胃癌发病风险升高的重要因素;在女性胃癌患者中,低HDL-C、高血压和糖尿病与胃癌发病风险增加密切相关。MetS与低分化腺癌,较晚的T、N分期及TNM分期相关。结论:本研究胃癌患者MetS及其包含的各项代谢相关因素异常率均高于对照组,并且在低、未分化和进展期胃癌患者中MetS相关的代谢异常更为多见,提示代谢紊乱可能在胃癌发生发展中发挥一定作用。
文摘Objective：Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid cancer.The purpose of this study was to identify the common and characteristic preoperative ultrasonography features that are associated with the pathologic extranodal extension of metastatic papillary thyroid carcinoma.Methods：We retrospectively assessed and compared clinicopathologic and ultrasound features between 60 papillary thyroid cancer patients with extranodal extension and 120 control patients with papillary thyroid cancer without extranodal extension.Results：With respect to the pathological N stage and clinicopathologic features,N1b stage papillary thyroid carcinomas were more frequently found in patients who were extranodal extension-positive,in comparison with those who were extranodal extension-negative（78.3%vs.63.3%,P=0.043）.Extranodal extension was detected most frequently in level VI cervical lymph nodes（48.7%）.In our univariate analysis of patients with papillary thyroid carcinoma,cervical lymph nodes with extranodal extension showed higher incidences of node matting,microcalcification,cystic area,aspect ratio＆lt;2,and larger diameter than those without extranodal extension（all P〈0.05）.Our multivariate analysis demonstrated that node matting and cystic area were independent risk factors for the presence of extranodal extension[odds ratio（OR）：4.751,95%confidence interval（CI）：1.212~18.626,P=0.025;OR：2.707,95%CI：1.127~6.502,P=0.026].Conclusions：Common ultrasound features may indicate the presence of extranodal extension in patients with metastatic cervical lymph nodes of papillary thyroid carcinoma.
基金the Key Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324115411030)Natural Science Foundation of China(92169102)+10 种基金R&D Program of Guangzhou Laboratory(SRPG22-006)Sanming Project of Medicine in Shenzhen(SZSM202211023)GuangDong Basic and Applied Basic Research Foundation(2022B1515120043)the Open Project Fund of Guangdong Provincial People’s Hospital(YKY-KF202208)National Natural Science Foundation of China(81902097)Funding by Science and Technology Projects in Guangzhou(SL2023A04J01160)the Guangdong Basic andApplied Basic Research Foundation(2023A1515140117)the fellowship of China Postdoctoral Science Foundation(2023TQ0136,2023M741379)supported by grants from the National Key Research and Development Plan(2023YFE0118700,2021YFC2301604)the Fundamental Research Funds for the Central Q4 Universities(21623406).
文摘Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a key step for interrupting chains of transmission of SARS-CoV-2 and reducing COVID-19-associated mortality.With the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome sequencing.However,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of SARS-CoV-2.We recruited 4 human leukocyte antigen A2(HLA-A2)infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2 HLA-A2 and HLA-A24 epitope-specific CD8^(+)T cells.From individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than 1.The enzyme-linked immunospot(ELISpot)results further validate this result.This study forms a“method for understanding the infection history of SARS-CoV-2 subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2+and HLA-A24+donors,providing a novel method for SARS-CoV-2 infected case tracing.
基金This study was supported by the National Key Research and Development Program of China(2021YFC2301604)the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)+1 种基金Emergency Grants for Prevention and Control of SARS-CoV-2 in Guangdong Province(2022A1111090004)the Science and Technology Program of Guangzhou(202102021285).
文摘Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron infections and related symptoms.What is added by this report?The self-reported infection rate,as determined from an online survey,reached its peak(15.5%)between December 19 and 21,2022,with an estimated 82.4%of individuals in China being infected as of February 7,2023.During the epidemic,the effectiveness of booster vaccinations against SARS-CoV-2 Omicron infection was found to be 49.0%within three months of vaccination and 37.9%between 3 and 6 months following vaccination.Furthermore,the vaccine effectiveness of the booster vaccination in relation to symptom prevention varied from 48.7%to 83.2%within three months and from 25.9%to 69.0%between 3 and 6 months post-booster vaccination.
基金supported by the Supercomputing Laboratory at the Institute of Geology and Geophysics,Chinese Academy of Sciencessupported by the National Natural Science Foundation of China (Grant No.42074067)the Key Research Program of the Institute of Geology and Geophysics,CAS (Grant No.IGGCAS-202204)。
文摘The Tibetan Plateau has been known for its highest elevation and thickest crust on earth,and become a key region for comprehending the rheology and tectonic evolution of continental plates and associated dynamic processes.Over the past years,numerous geophysical studies have been conducted to explore the deep structure of the Tibetan Plateau,resulting in significant advancements in understanding the formation and growth of the Plateau.This paper aims to provide a comprehensive summary and discussion of the geophysical observations and underlying mechanisms of the plateau uplift.First,major relevant tectonic models are reviewed,and the corresponding features of crustal structures and related deformation are presented.Then,recent observations,including the identification of a high-velocity layer in the lower crust of the Lhasa block,the spatial distribution of crustal channel flow,and the decoupling of shallow and deep crustal deformation,are synthesized to gain insights into the crustal structures,and multidisciplinary data are integrated to discuss the potential mechanisms of the plateau uplift.Lastly,some pertinent suggestions are put forward for future research on the Tibetan Plateau.
基金supported by the National Natural Science Foundation of China(91855207,42074067,and 42030308)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(XDB18000000)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017093)。
基金Supported by the Beijing Natural Science Foundation[No.7232195]National Natural Science Foundation of China[No.81870406,and No.81602939]+2 种基金Capital’s Funds for Health Improvement and Research[No.2020-4-4087]Peking University Medicine Sailing Program for Young Scholars’Scientific&Technological Innovation[No.BMU2023YFJHPY025]Chinese foundation for hepatitis prevention and control-TianQing liver disease research fund subject[No.TQGB20210139]。
文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics.
基金the support of the Fund of State Key Laboratory of Ocean Engineering(GKZD010068,GKZD010074,GKZD010075).
文摘With the acceleration of the investigation and development of marine resources,the detection and location of submarine pipelines have become a necessary part of modern marine engineering.Submarine pipelines are a typical weak magnetic anomaly target,and their magnetic anomaly detection can only be realized within a certain distance.At present,a towfish or an autonomous underwater vehicle(AUV)is mainly used as the platform to equip magnetometers close to the submarine pipelines for magnetic anomaly detection.However,the mother ship directly affects the towfish,thus causing control interference.The AUV cannot detect in real time,which affects the magnetic anomaly detection and creates problems regarding detection efficiency.Meanwhile,a two-part towed platform has convenient control,thus reducing the interference of the towed mother ship and real-time detection.If the platform can maintain constant altitude sailing through the controller,the data accuracy in the actual magnetic anomaly detection can be guaranteed.On the basis of a two-part towed platform,a magnetic detection system with constant altitude sailing ability for submarine pipelines was constructed in this study.In addition,experimental verification was conducted.The experimental verification research shows that the constant altitude sailing experiment of the two-part towed platform verifies that the platform has good constant altitude sailing ability in both a hydrostatic environment and the actual marine environment.Meanwhile,the offshore magnetic anomaly detection experiment of submarine pipelines verifies the stable measurement function of the magnetic field and the function of the system to detect magnetic anomaly of submarine pipelines.
基金Supported by the National Science and Technology Major Project of the Ministry of Science and Technology of the People’s Republic of China under Grant[2018ZX10721202]the Key Research and Development Program of Lvliang under Grant[2020SHFZ52]the Key Research and Development Program of Science and Technology of Linfen under Grant[2136].
文摘Summary What is already known about this topic?As one of the populations at high risk of hepatitis B virus(HBV)infection,patients with chronic kidney disease(CKD)require rapid and effective development of hepatitis B surface antibodies(anti-HBs).What is added by this report?The short-course,high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen,achieving a seroconversion rate of 88.5%,a high-response rate of 64.1%,and anti-HBs geometric mean concentrations of 824.1 mIU/mL.What are the implications for public health practice?The short-course,high-dose regimen represents an effective rapid immunization strategy for CKD patients,particularly when administered prior to immunosuppressive therapy.This study provides compelling evidence for optimizing immunization protocols in the CKD population.
基金supported by the National Natural Science Foundation of China (Grant Nos. 91855207, 41888101)the Programs of the Chinese Academy of Sciences (Grant Nos. 2013047, GJHZ1776)
文摘Numerous continents have rifted and drifted away from Gondwana to repeatedly open ocean basins over the past-500 millionyears.These Gondwana-derived continents drifted towards and collided with components of the Eurasian continent to successively close the preexisting oceans between the two.Plate tectonics satisfactorily describes the continental drift from Gondwana to Eurasia but does not define the geodynamic mechanism of continuously rifting to collisions of continents in the Tethy an Realm.After reappraisal of geological records of the rift,collision and subduction initiation from the surface and various geophysical observations from depth,we propose that Eurasia-directed subducting oceanic slabs would have driven Tethyan system in the Phanerozoic.The Eurasia-directed subduction would have dragged the passive Gondwana margin to rift and drift northwards,giving birth to new oceans since the Paleozoic.The closure of preexisting oceans between the Gondwana-derived continents and Eurasia led to continental collisions,which would have induced the initiation of oceanic subduction in the Tethyan Realm.Multiple episodic switches between collision-subduction-rift repeatedly led to the separation of continental fragments from Gondwana and dragged them to drift towards Eurasia.The final disappearance of Neo-Tethy s would have induced collision of the Gondwana-derived continents with the Eurasian continent,giving rise to the Cenozoic Alpine-Zagros-Himalayan collisional system.Therefore,the Eurasia-directed oceanic subduction would have acted as a’one-way train’that successively transferred the ruptured Gondwana continental fragments in the south,into the terminal in the north.In this regard,the engine of this"Tethyan one-way train"is the negative buoyancy of subducting oceanic slabs.
基金supported by the National Natural Science Foundation of China (Grant Nos. 91855207 and 41688103)the Strategic Priority Research Program (A) of the Chinese Academy of Sciences (Grant No. XDA20070302)the independent project of the State Key Laboratory of the Lithospheric Evolution, IGGCAS (Grant No. SKLZ201704-11712180)
文摘Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half a century ago,considerable debates have remained regarding the driving forces for plate motion.The early"Bottom up"view,i.e.,the convecting mantledriven mechanism,states that mantle plumes originating from the core-mantle boundary act at the base of plates,accelerating continental breakup and driving plate motion.Toward the present,however,the"Top down"idea is more widely accepted,according to which the negative buoyancy of oceanic plates is the dominant driving force for plate motion,and the subducting slabs control surface tectonics and mantle convection.In this regard,plate tectonics is also known as subduction tectonics."Top down"tectonics has received wide supports from numerous geological and geophysical observations.On the other hand,recent studies indicate that the acceleration/deceleration of individual plates over the million-year timescale may reflect the effects of mantle plumes.It is also suggested that surface uplift and subsidence within stable cratonic areas are correlated with plumerelated magmatic activities over the hundred-million-year timescale.On the global scale,the cyclical supercontinent assembly and breakup seem to be coupled with superplume activities during the past two billion years.These correlations over various spatial and temporal scales indicate the close relationship and intensive interactions between plate tectonics and plume tectonics throughout the history of the Earth and the considerable influence of plumes on plate motion.Indeed,we can acquire a comprehensive understanding of the driving forces for plate motion and operation mechanism of the Earth's dynamic system only through joint analyses and integrated studies on plate tectonics and plume tectonics.
基金National Key Research and Development Program of China(2021YFC2301604)Chinese Postdoctoral Science Foundation(2020T130020ZX)+1 种基金the Science and Technology Program of Guangzhou(202102021285)the Emergency Grants for Prevention and Control of SARS-CoV-2 of Guangdong Province(2022A1111090004).
文摘Summary What is already known about this topic?Hong Kong Special Administrative Region(SAR),China and Singapore are both facing considerable Omicron variant epidemic.However,the overwhelmed medical system and high case fatality ratio(CFR)just occurred in Hong Kong SAR,China but not in Singapore.What is added by this report?The low vaccination coverage in Hong Kong SAR,China,especially among the older adults,is shown to be a primary reason of its recent high CFR.What are the implications for public health practice?Facing the potential epidemic risk,non-vaccinated,non-fully-vaccinated,and non-booster-vaccinated people in China,especially the elderly,should get any type of accessible vaccine,which could save lives when the infection unfortunately befalls.
基金supported by the Megaproject for Infectious Disease Research of China(2016ZX10004222-003)the research of Ebola pathogen from the National Natural Science Foundation of China(NSFC,81590763)+4 种基金National Key Research and Development Program of China(2016YFC1200200 to Y.Shu)the Distinguished Young Scientist Program of the NSFC(81525017 to Y.Shu)the Excellent Young Scientist Program of the NSFC(81822040 to W.J.Liu)the Taishan Scholar Project of Shandong Province(ts201511056 to W.Shi)G.F.Gao is a primary principal investigator of the NSFC Innovative Research Group(81621091).
文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.
文摘Based on the major findings of our studies,we found that in the past two or three decades,China’s noncommunicable diseases(NCDs)prevention and control policies experienced rapid development.The service mode of NCDs management was transformed,the service capabilities at primary medical facilities were comprehensively improved,and the health literacy and action capability of residents were improved.Remarkable achievements have been made in the prevention and control of NCDs,and a lot of experience has been accumulated.However,unhealthy lifestyles among Chinese residents are still common,and the control of NCDs and related behavioral risk factors faces great challenges.Therefore,in order to implement the Healthy China strategy,early prevention and strengthening of the health management of NCDs in high-risk groups are essential.
基金Supported by National Key Research and Development Program of China(2021YFC2301604)Chinese Postdoctoral Science Foundation(2020T130020ZX)+1 种基金the Science and Technology Program of Guangzhou(202102021285)Innovation and Development Project of China Meteorological Administration(CXFZ2021J045).
文摘Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic.
