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A salt-induced tackifying polymer for enhancing oil recovery in highsalinity reservoirs:Synthesis,evaluation,and mechanism
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作者 Yining Wu Peihan li +5 位作者 Bin Yan xiaohan li Yongping Huang Juncong Yuan Xiang Feng Caili Dai 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第11期1747-1758,共12页
Polymerflooding is an effective method widely applied for enhancing oil recovery(EOR)by reducing the mobility ratio between theinjected water and crude oil.However,traditional polymers encounter challenges in high sali... Polymerflooding is an effective method widely applied for enhancing oil recovery(EOR)by reducing the mobility ratio between theinjected water and crude oil.However,traditional polymers encounter challenges in high salinity reservoirs due to their salt sensitivity.Toovercome this challenge,we synthesized a zwitterion polymer(PAMNS)with salt-induced tackifying property through copolymerization ofacrylamide and a zwitterion monomer,methylacrylamide propyl-N,N-dimethylbutylsulfonate(NS).NS monomer is obtained from thereaction between 1,4-butanesultone and dimethylamino propyl methylacrylamide.In this study,the rheological properties,salt responsiveness,and EOR efficiency of PAMNS were evaluated.Results demonstrate that PAMNS exhibits desirable salt-induced tackifyingcharacteristics,with viscosity increasing up to 2.4 times as the NaCl concentration reaches a salinity of 30×10^(4)mg L^(-1).Furthermore,highvalence ions possess a much stronger effect on enhancing viscosity,manifested as Mg^(2+)>Ca^(2+)>Na^(+).Molecular dynamics simulations(MD)andfluid dynamics experiment results demonstrate that PAMNS molecules exhibit a more stretched state and enhanced intermolecularassociations in high-salinity environments.It is because of the salt-induced tackifying,PAMNS demonstrates superior performance inpolymerflooding experiments under salinity ranges from 5×10^(4)mg L^(-1)to 20×10^(4)mg L^(-1),leading to 10.38–19.83%higher EOR thantraditional polymers. 展开更多
关键词 High salinity reservoirs Salt-induced tackifying polymer Anti-polyelectrolyte behavior Enhanced oil recovery
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Coupling Au with BO_(x) matrix induced by Closo-boron cluster for electrochemical synthesis of ammonia
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作者 Wenjing liu Nan Yang +10 位作者 Yuao Wei Yingjie Yu Jie Chen Mo Wei Yuting Huang xiaohan li linghai Zhang Faisal Saleem Weina Zhang Haibo Zhang Fengwei Huo 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期471-477,I0012,共8页
Au is considered as one of the most promising catalysts for nitrogen reduction reaction(NRR),however maximizing the activity utilization rate of Au and understanding the synergistic effects between Au and carriers pos... Au is considered as one of the most promising catalysts for nitrogen reduction reaction(NRR),however maximizing the activity utilization rate of Au and understanding the synergistic effects between Au and carriers pose ongoing challenges.Herein,we systematically explore the synergistic catalytic effect of incorporating Au with boron clusters for accelerating NRR kinetics.An in-situ abinitio strategy is employed to construct B-doped Au nanoparticles(2-6 nm in diameter)loaded on BO_(x) substrates(AuBO_(x)),in which B not only modulates the surface electronic structure of Au but also forms strong coupling interactions to stabilize the nanoparticles.The electrochemical results show that Au-BO_(x) possesses excellent NRR activity(NH_(3) yield of 48.52μg h^(-1)mg_(cat)^(-1),Faraday efficiency of 56.18%),and exhibits high stability and reproducibility throughout the electrocatalytic NRR process.Theoretical calculations reveal that the introduction of B induces the formation of both Au dangling bond and Au-B coupling bond.which considerably facilitates the hydrogenation of~*N_(2)^(-)~*NH_(3).The present work provides a new avenue for the preparation of metal-boron materials achieved by one-step reduction and doping process,utilizing boron clusters as reducing and stabilizing agents. 展开更多
关键词 Boron clusters Nitrogen reduction reaction Au–B coupling
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Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation 被引量:2
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作者 Jingjing liang Meina Zhang +6 位作者 xiaohan li Yuan Yue Xiaowei Wang Mengzhen Han Tianli Yue Zhouli Wang Zhenpeng Gao 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期421-433,共13页
Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were... Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were extracted from fermented and non-fermented L.edodes and purified via DEAE-52 and Sephadex G-100.The components designated F-LEP-2a and NF-LEP-2a were analyzed by FT-IR,HPGPC,HPAEC,SEM,GC-MS and NMR.The results revealed that probiotic fermentation increased the molecular weight from 1.16×10^(4) Da to 1.87×10^(4) Da and altered the proportions of glucose,galactose and mannose,in which glucose increased from 45.94%to 48.16%.Methylation analysis and NMR spectra indicated that F-LEP-2a and NF-LEP-2a had similar linkage patterns.Furthermore,their immunomodulatory activities were evaluated with immunosuppressive mice.NF-LEP and F-LEP improved immune organ indices,immunoglobulin(Ig G and Ig M)and cytokines concentrations;restored the antioxidation capacity of liver;and maintained the balance of gut microbiota.F-LEP displayed better moderating effects on the spleen index,immunoglobulin,cytokines and the diversity of gut microbiota than NF-LEP(200,400 mg/kg).Our study provides an efficient and environment-friendly way for the structural modification of polysaccharides,which helps to enhance their biological activity and promote their wide application in food,medicine and other fields. 展开更多
关键词 Lentinus edodes polysaccharide Lactobacillus fermentum fermentation Structural analysis Immunoregulatory activity Nuclear magnetic resonance
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Improved Diurnal Cycle of Precipitation on Land in a Global Non-Hydrostatic Model Using a Revised NSAS Deep Convective Scheme
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作者 Yifan ZHAO Xindong PENG +1 位作者 xiaohan li Siyuan CHEN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1217-1234,共18页
In relatively coarse-resolution atmospheric models,cumulus parameterization helps account for the effect of subgridscale convection,which produces supplemental rainfall to the grid-scale precipitation and impacts the ... In relatively coarse-resolution atmospheric models,cumulus parameterization helps account for the effect of subgridscale convection,which produces supplemental rainfall to the grid-scale precipitation and impacts the diurnal cycle of precipitation.In this study,the diurnal cycle of precipitation was studied using the new simplified Arakawa-Schubert scheme in a global non-hydrostatic atmospheric model,i.e.,the Yin-Yang-grid Unified Model for the Atmosphere.Two new diagnostic closures and a convective trigger function were suggested to emphasize the job of the cloud work function corresponding to the free tropospheric large-scale forcing.Numerical results of the 0.25-degree model in 3-month batched real-case simulations revealed an improvement in the diurnal precipitation variation by using a revised trigger function with an enhanced dynamical constraint on the convective initiation and a suitable threshold of the trigger.By reducing the occurrence of convection during peak solar radiation hours,the revised scheme was shown to be effective in delaying the appearance of early-afternoon rainfall peaks over most land areas and accentuating the nocturnal peaks that were wrongly concealed by the more substantial afternoon peak.In addition,the revised scheme enhanced the simulation capability of the precipitation probability density function,such as increasing the extremely low-and high-intensity precipitation events and decreasing small and moderate rainfall events,which contributed to the reduction of precipitation bias over mid-latitude and tropical land areas. 展开更多
关键词 cumulus parameterization diurnal cycle of precipitation large-scale dynamic forcing global non-hydrostatic atmospheric model performance verification
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Influence of blasting load directions on tunnel stability in fractured rock mass 被引量:6
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作者 xiaohan li Zheming Zhu +3 位作者 Meng Wang Yun Shu Shuai Deng Dingjun Xiao 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第2期346-365,共20页
Tunnels in fractured rock masses are typically damaged by dynamic disturbances from various directions.To investigate the influence of blasting load directions on the stability of a tunnel with a precrack nearby,blast... Tunnels in fractured rock masses are typically damaged by dynamic disturbances from various directions.To investigate the influence of blasting load directions on the stability of a tunnel with a precrack nearby,blasting tests were conducted on the physical models of an external crack around a tunnel(ECT)in this study.Failure modes of the tunnels were analysed based on stress wave theory.The Riedel-Hiermaier-Thoma(RHT)material model was employed to perform the numerical simulations on ECT models.Stress distribution around the tunnels and final failure patterns of the tunnels were characterised.The results show that,under blasting loads,the pre-crack propagates and then new cracks initiates on the incident side of the tunnel.These cracks extend towards each other and eventually coalesce.Blasting load directions significantly influence the ultimate failure mode of the tunnel in the fractured rock masses.The new cracks on the shadow side of the tunnel appear at different positions when the blasting stress waves come from various directions.The results are meaningful to the analysis of tunnel stability and optimisation of the tunnel support scheme. 展开更多
关键词 BLASTING Tunnel stability Crack propagation Failure mode Numerical simulation
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Focuses and trends of the studies on pediatric palliative care:A bibliometric analysis from 2004 to 2018
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作者 Miao Zhang xiaohan li 《International Journal of Nursing Sciences》 CSCD 2021年第1期5-14,I0001,共11页
Objectives:To investigate the focuses and trends of the studies on pediatric palliative care(PPC)and provide directions for future research.Methods:Relevant papers about PPC published from 2004 to 2018 were analyzed u... Objectives:To investigate the focuses and trends of the studies on pediatric palliative care(PPC)and provide directions for future research.Methods:Relevant papers about PPC published from 2004 to 2018 were analyzed using bibliometric analysis methods,including co-word analysis,biclustering analysis,and strategic diagram analysis.The included papers were divided into three groups based on the publication time,including 2004-2008,2009-2013,and 2014-2018.Results:A total of 1132 papers were published between 2004 and 2018,and there were 293 papers published between 2004 and 2008,396 between 2009 and 2013,and 443 between 2014 and 2018.There were 42 high-frequency MeSH terms/MeSH subheadings in papers published between 2004 and 2018,including 12 between 2004 and 2008,13 between 2009 and 2013,and 17 between 2014 and 2018.Conclusion:Studies on PPC were making progress,with the increasing number,expanding scope,and uneven global distribution.Integration palliative care into pediatrics,cancer treatments in pediatric oncology,education methods on PPC,and establishment of professional teams were the major themes during 2004e2008,then the themes changed into establishing interventions to enhance the quality of life of the patients and parents,building professional-family relationship,and investigating attitude of health personnel in PPC during 2009-2013 and subsequently turned into communication skills,end-oflife decision making,and guidelines making on PPC during 2014-2018.Underdeveloped and protential themes including effective approaches to deal with the ethical dilemmas,training programs on communication skills,family support and guideline making are worth studying in the future. 展开更多
关键词 BIBLIOMETRICS Communication Decision making Hospice and palliative care nursing NEOPLASMS PARENTS PEDIATRICS Professional-family relations
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Impact of Revised Trigger and Closure of the Double-Plume Convective Parameterization on Precipitation Simulations over East Asia 被引量:2
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作者 xiaohan li Yi ZHANG +4 位作者 Yanluan liN Xindong PENG Baiquan ZHOU Panmao ZHAI Jian li 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第7期1225-1243,共19页
A double-plume convective parameterization scheme is revised to improve the precipitation simulation of a global model(Global-to-Regional Integrated Forecast System;GRIST).The improvement is achieved by considering th... A double-plume convective parameterization scheme is revised to improve the precipitation simulation of a global model(Global-to-Regional Integrated Forecast System;GRIST).The improvement is achieved by considering the effects of large-scale dynamic processes on the trigger of deep convection.The closure,based on dynamic CAPE,is improved accordingly to allow other processes to consume CAPE under the more restricted convective trigger condition.The revised convective parameterization is evaluated with a variable-resolution model setup(110–35 km,refined over East Asia).The Atmospheric Model Intercomparison Project(AMIP)simulations demonstrate that the revised convective parameterization substantially delays the daytime precipitation peaks over most land areas,leading to an improved simulated diurnal cycle,evidenced by delayed and less frequent afternoon precipitation.Meanwhile,changes to the threshold of the trigger function yield a small impact on the diurnal amplitude of precipitation because of the consistent setting of dCAPE-based trigger and closure.The simulated mean precipitation remains reasonable,with some improvements evident along the southern slopes of the Tibetan Plateau.The revised scheme increases convective precipitation at the lower levels of the windward slope and reduces the large-scale precipitation over the upper slope,ultimately shifting the rainfall peak southward,which is in better agreement with the observations. 展开更多
关键词 convective parameterization diurnal cycle of precipitation East Asia variable-resolution modeling
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Multi-branched AgAuPt nanoparticles for efficient electrocatalytic hydrogen evolution:Synergism of tip-enhanced electric field effect and local electric field effect 被引量:1
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作者 Wenliang liu xiaohan li +4 位作者 Yuqi Wang Debo Yang Zongzhen Guo Mengfei liu Jiqian Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第6期339-348,I0008,共11页
High-curvature multi-noble metallic heterostructures can effectively enhance the electrocatalytic hydrogen evolution performance by utilizing the synergism of tip-enhanced electric field effect and local electric fiel... High-curvature multi-noble metallic heterostructures can effectively enhance the electrocatalytic hydrogen evolution performance by utilizing the synergism of tip-enhanced electric field effect and local electric field effect.Herein,we report a two-step synthesis strategy to obtain multi-branched high-curvature Ag Au Pt heterostructure,firstly amino acids-induced growth of Au branches on Ag nanocubes,and secondly L-AA reduction of H_(2)PtCl_(6) to incorporate tiny Pt nanoparticles on Au branches.The D-CAgAuPt results in a low overpotential of 38 m V to deliver a cathodic current density of 10 m A cm^(-2),which is superior to commercial 20%Pt/C(46 m V).The strong electronic interactions between multi-noble metals intrinsically enhance the durability and stability of the catalysts.The intrinsic mechanism of promoting HER performance is investigated and revealed in-depth via the FDTD simulations and DFT calculations.In addition,D-CAg Au Pt can also achieve efficient and stable hydrogen evolution in a proton exchange membrane electrolyzer,which has the potential for commercial practical application.This work designs a novel multi-branched high-curvature multi-noble metallic heterostructure,and fully provides insights into the generical and efficient enhancement of electrocatalytic HER performance of multi-noble metallic heterostructures. 展开更多
关键词 High-curvature AgAuPt heterostructures Hydrogen evolution FDTD simulations DFT calculations
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Impact of a Three-Dimensional Reference State in a Global Semi-Implicit Semi-Lagrangian Non-Hydrostatic Atmospheric Model on Yin–Yang Grids
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作者 Yifan ZHAO Xindong PENG +3 位作者 Dehui CHEN Yerong FENG xiaohan li Juan GU 《Journal of Meteorological Research》 SCIE CSCD 2024年第5期901-922,共22页
The definition of a reference state close to the realistic atmosphere in an atmospheric model is essential for deriving prognostic deviations and improving numerical accuracy.In this study,a new dynamical framework al... The definition of a reference state close to the realistic atmosphere in an atmospheric model is essential for deriving prognostic deviations and improving numerical accuracy.In this study,a new dynamical framework allowing easy switching between a one-dimensional(1D)and a three-dimensional(3D)time-independent reference state is developed for the semi-implicit semi-Lagrangian solver in a global non-hydrostatic atmospheric model on Yin–Yang grids.The 3D reference state is introduced with consideration of additional horizontal gradient terms of referencestate terms,which is different from the 1D reference state.It is characterized by reduced magnitude of deviations,more accurate pressure gradient force,as well as alleviated numerical noise.Four idealized benchmark tests and multiple full-physics real-case forecasts are carried out to assess the impact of the 3D and 1D reference states.The 3D reference state shows significant advantages in the simulation of atmospheric transport and wave propagation in the idealized experiments.In the real-case forecasts,batched forecasts from June to August 2021 show a comprehensive improvement in medium-range prediction by using the 3D reference state.The new scheme achieves an enhanced prediction skill for large-scale circulation and extends the effective forecast period by 0.8 days in the Northern Hemisphere. 展开更多
关键词 semi-implicit semi-Lagrange three-dimensional reference state global non-hydrostatic atmospheric model linearized equation medium-range weather prediction
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DRP1 deficiency induces mitochondrial dysfunction and oxidative stress-mediated apoptosis during porcine oocyte maturation 被引量:1
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作者 Haolin Zhang Zhennan Pan +4 位作者 Jiaqian Ju Chunhua Xing xiaohan li Mengmeng Shan Shaochen Sun 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2021年第1期262-271,共10页
Background: Environmental pollution induces oxidative stress and apoptosis in mammalian oocytes, which can cause defects in reproduction;however, the molecular regulation of oxidative stress in oocytes is still largel... Background: Environmental pollution induces oxidative stress and apoptosis in mammalian oocytes, which can cause defects in reproduction;however, the molecular regulation of oxidative stress in oocytes is still largely unknown. In the present study, we identified that dynamin-related protein 1(DRP1) is an important molecule regulating oocyte mitochondrial function and preventing oxidative stress/apoptosis. DRP1 is a member of the dynamin GTPase superfamily localized at the mitochondrial-endoplasmic reticulum interaction site, where it regulates the fission of mitochondria and other related cellular processes.Results: Our results show that DRP1 was stably expressed during different stages of porcine oocyte meiosis, and might have a potential relationship with mitochondria as it exhibited similar localization. Loss of DRP1 activity caused failed porcine oocyte maturation and cumulus cell expansion, as well as defects in polar body extrusion.Further analysis indicated that a DRP1 deficiency caused mitochondrial dysfunction and induced oxidative stress,which was confirmed by increased reactive oxygen species levels. Moreover, the incidence of early apoptosis increased as detected by positive Annexin-V signaling.Conclusions: Taken together, our results indicate that DRP1 is essential for porcine oocyte maturation and that a DRP1 deficiency could induce mitochondrial dysfunction, oxidative stress, and apoptosis. 展开更多
关键词 Apoptosis MEIOSIS MITOCHONDRIA OOCYTE Oxidative stress
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Boosting self-trapped exciton emission from Cs_(3)Cu_(2)I_(5)nanocrystals by doping-enhanced exciton-phonon coupling 被引量:1
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作者 xiaohan li Aijun liu +5 位作者 Zhaoyu Wang Youchao Wei Qun lin Yameng Chen Yongsheng liu Maochun Hong 《Nano Research》 SCIE EI CSCD 2023年第7期10476-10482,共7页
Self-trapped excitons(STEs)emission from halide perovskites with strong exciton-phonon coupling has attracted considerable attention due to the widespread application in optoelectronic devices.Nevertheless,the in-dept... Self-trapped excitons(STEs)emission from halide perovskites with strong exciton-phonon coupling has attracted considerable attention due to the widespread application in optoelectronic devices.Nevertheless,the in-depth understanding of the relationship between exciton-phonon coupling and luminescence intensity remains incomplete.Herein,a doping-enhanced exciton-phonon coupling effect is observed in Cs_(3)Cu_(2)I_(5)nanocrystals(NCs),which leads to a remarkable increasement of their STEs emission efficiency.Mechanism study shows that the hetero-valent substitution of Cu+with alkaline-earth metal ions(AE^(2+))causes a greater degree of Jahn-Teller distortion between the ground state and excited state structures of[Cu_(2)I_(5)]_(3)-clusters as evidenced by our spectral analysis and first-principles calculations.As a consequence,an X-ray detector based on these Cs_(3)Cu_(2)I_(5):AE NCs delivers an X-ray imaging resolution of up to 10 lp·mm^(-1) and a low detection limit of 0.37μGyair·s^(-1),disclosing the potential of doping-enhanced exciton-phonon coupling effect in improving STEs-emission and practical application for X-ray imaging. 展开更多
关键词 Cs_(3)Cu_(2)I_(5) NANOCRYSTALS self-trapped exciton exciton-phonon coupling X-ray image
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lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis 被引量:1
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作者 Yuhua Fan Yue Zhang +13 位作者 Hongrui Zhao Wenfeng liu Wanqing Xu lintong Jiang Ranchen Xu Yue Zheng Xueqing Tang xiaohan li limin Zhao Xin liu Yang Hong Yuan lin Hui Chen Yong Zhang 《Frontiers of Medicine》 SCIE CSCD 2023年第2期317-329,共13页
Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expressi... Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen content.Moreover,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells.By contrast,lncR-GAS5 knockdown promoted autophagy.Moreover,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and autophagosomes.Mechanistically,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of SRSF10.Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,SRSF10.Notably,miR-193-5p overexpression decreased plaque size and increased collagen content.Altogether,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy.In conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway.Thus,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis. 展开更多
关键词 lncR-GAS5 miR-193-5p splicing factor SRSF10 AUTOPHAGY ATHEROGENESIS
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Correction:Interfaces in Sulfide Solid Electrolyte‑Based All‑Solid‑State Lithium Batteries:Characterization,Mechanism and Strategy 被引量:1
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作者 Zhan Wu xiaohan li +8 位作者 Chao Zheng Zheng Fan Wenkui Zhang Hui Huang Yongping Gan Yang Xia Xinping He Xinyong Tao Jun Zhang 《Electrochemical Energy Reviews》 SCIE EI CSCD 2023年第1期186-186,共1页
Correction to:Electrochemical Energy Reviews(2023)6:10 https://doi.org/10.1007/s41918-022-00176-0 The publication of this article unfortunately contained mistakes.The conflict of interest of one of the authors was mis... Correction to:Electrochemical Energy Reviews(2023)6:10 https://doi.org/10.1007/s41918-022-00176-0 The publication of this article unfortunately contained mistakes.The conflict of interest of one of the authors was missing. 展开更多
关键词 SOLID CORRECTION ELECTROCHEMICAL
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Macrophage-derived exosomal miR-342-3p promotes the progression of renal cell carcinoma through the NEDD4L/CEP55 axis
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作者 JIAFU FENG BEI XU +6 位作者 CHUNMEI DAI YAODONG WANG GANG XIE WENYU YANG BIN ZHANG xiaohan li JUN WANG 《Oncology Research》 SCIE 2021年第5期331-349,共19页
Due to its difficulty in early diagnosis and lack of sensitivity to chemotherapy and radiotherapy,renal cell carcinoma(RCC)remains to be a frequent cause of cancer-related death.Here,we probed into new targets for its ... Due to its difficulty in early diagnosis and lack of sensitivity to chemotherapy and radiotherapy,renal cell carcinoma(RCC)remains to be a frequent cause of cancer-related death.Here,we probed into new targets for its early diagnosis and treatment for RCC.microRNA(miRNA)data of M2-EVs and RCC were searched on the Gene Expression Omnibus database,followed by the prediction of the potential downstream target.Expression of target genes was measured via RT-qPCR and Western blot,respectively.M2 macrophage was obtained viaflow cytometry with M2-EVs extracted.The binding ability of miR-342-3p to NEDD4L and to CEP55 ubiquitination was studied with their roles in the physical abilities of RCC cells assayed.Subcutaneous tumor-bearing mouse models and lung metastasis models were prepared to observe in vivo role of target genes.M2-EVs induced RCC growth and metastasis.miR-342-3p showed high expression in both M2-EVs and RCC cells.M2-EVs carrying miR-342-3p promoted RCC cell abilities to proliferate,invade and migrate.In RCC cells,M2-EV-derived miR-342-3p could specifically bind to NEDD4L and consequently elevate CEP55 protein expression via suppressing NEDD4L,thereby exerting tumor-promoting effects.CEP55 could be degraded by ubiquitination under the function of NEDD4L,and miR-342-3p delivered by M2-EVs facilitated the RCC occurrence and development by activating the PI3K/AKT/mTOR signaling pathway.In conclusion,M2-EVs promote RCC growth and metastasis by delivering miR-342-3p to suppress NEDD4L and subsequently inhibit CEP55 ubiquitination and degradation via activation of the PI3K/AKT/mTOR signaling pathway,strongly driving the proliferative,migratory and invasive of RCC cells. 展开更多
关键词 Renal cell carcinoma M2 macrophage miR-342-3p NEDD4L CEP55 PI3K/AKT/mTOR signaling pathway
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Interfaces in Sulfide Solid Electrolyte‑Based All‑Solid‑State Lithium Batteries:Characterization,Mechanism and Strategy
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作者 Zhan Wu xiaohan li +8 位作者 Chao Zheng Zheng Fan Wenkui Zhang Hui Huang Yongping Gan Yang Xia Xinping He Xinyong Tao Jun Zhang 《Electrochemical Energy Reviews》 SCIE EI CSCD 2023年第1期573-613,共41页
Owing to the advantages of high energy density and environmental friendliness,lithium-ion batteries(LIBs)have been widely used as power sources in electric vehicles,energy storage systems and other devices.Conventiona... Owing to the advantages of high energy density and environmental friendliness,lithium-ion batteries(LIBs)have been widely used as power sources in electric vehicles,energy storage systems and other devices.Conventional LIBs composed of liquid electrolytes(LEs)have potential safety hazards;thermal runaway easily leads to battery explosion and spontaneous combustion.To realize a large-scale energy storage system with higher safety and higher energy density,replacing LEs with solid-state electrolytes(SSEs)has been pursued.Among the many SSEs,sulfide SSEs are attractive because of their high ionic conductivities,easy processabilities and high thermostabilities.However,interfacial issues(interfacial reactions,chemo-mechanical failure,lithium dendrite formation,etc.)between sulfide SSEs and electrodes are factors limiting widespread application.In addition,the intrinsic interfacial issues of sulfide SSEs(electrochemical windows,diffusion mechanisms of Li^(+),etc.)should not be ignored.In this review,the behaviors,properties and mechanisms of interfaces in all-solid-state lithium batteries with a variety of sulfide SSEs are comprehensively summarized.Additionally,recent research progress on advanced characterization methods and designs used to stabilize interfaces is discussed.Finally,outlooks,challenges and possible interface engineering strategies are analyzed and proposed. 展开更多
关键词 All-solid-state lithium batteries Sulfide solid electrolytes Interface
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光致变色吡啶三嗪鎓盐配体的合成和晶体结构
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作者 李筱涵 李小菊 蔡丽璇 《有机化学研究》 2018年第4期95-101,共7页
本文通过1,3,5-三(4-吡啶)-2,4,6-三嗪(TPT)三齿三角配体与对溴甲基苯甲酸的亲核取代设计合成了一例三取代吡啶鎓盐分子,并对其进行核磁、红外光谱和单晶X-射线衍射分析等结构表征。采用溶液挥发法得到的单晶结构分析表明,该配体属于正... 本文通过1,3,5-三(4-吡啶)-2,4,6-三嗪(TPT)三齿三角配体与对溴甲基苯甲酸的亲核取代设计合成了一例三取代吡啶鎓盐分子,并对其进行核磁、红外光谱和单晶X-射线衍射分析等结构表征。采用溶液挥发法得到的单晶结构分析表明,该配体属于正交晶系,空间群为Fdd2。该化合物具有良好的光致变色性能,通过光照前后的电子自旋共振光谱测试,发现光照后的样品出现强的吡啶鎓盐特征自由基顺磁信号(g = 2.0039)。 展开更多
关键词 吡啶鎓盐 晶体结构 光致变色
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青藏高原盆栽一年生和多年生豆科牧草对土壤线虫群落的影响
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作者 孙怡欣 侯春雨 +5 位作者 周磊 魏雪 马金豪 薛娟 李小涵 吴鹏飞 《生物多样性》 CAS CSCD 北大核心 2024年第7期65-79,共15页
查明一年生及多年生豆科牧草对土壤线虫群落的影响,可为青藏高原地区科学种植豆科牧草提供技术支撑。作者于2020–2022年在川西北红原县盆栽种植一年生光叶紫花苕(Viciavillosa,VV)和多年生紫花苜蓿(Medicagosativa,MS),以天然草地的植... 查明一年生及多年生豆科牧草对土壤线虫群落的影响,可为青藏高原地区科学种植豆科牧草提供技术支撑。作者于2020–2022年在川西北红原县盆栽种植一年生光叶紫花苕(Viciavillosa,VV)和多年生紫花苜蓿(Medicagosativa,MS),以天然草地的植物作对照(control,CK)。每年9月下旬对土壤线虫组成、密度、多样性和营养类群,植物的高度、盖度、生物量及土壤理化性质进行调查。结果表明:(1)3种处理间的线虫群落组成结构存在差异,并随年际变化而增大;(2)光叶紫花苕的土壤线虫群落密度显著高于紫花苜蓿和对照,紫花苜蓿的线虫类群数和Shannon-Wiener指数显著高于光叶紫花苕和对照;随着年际变化,光叶紫花苕的线虫类群数及Shannon-Wiener指数、紫花苜蓿的线虫密度及Shannon-Wiener指数均显著下降;(3)光叶紫花苕的食真菌和植物寄生线虫密度显著高于紫花苜蓿和对照,捕食杂食线虫相对密度显著低于紫花苜蓿和对照;紫花苜蓿的植物寄生线虫相对密度显著低于光叶紫花苕和对照;随年际变化,光叶紫花苕的食细菌和植物寄生线虫相对密度分别显著下降和上升,紫花苜蓿和对照的食细菌线虫和食真菌线虫密度及食细菌线虫相对密度显著下降,捕食杂食线虫相对密度显著上升;(4)光叶紫花苕线虫群落的基础指数、结构指数和通道指数显著高于紫花苜蓿;(5)影响土壤线虫群落的主要环境因子主要为土壤pH、有效钾和植物群落高度、盖度和地上生物量。研究结果表明,一年生和多年生豆科牧草分别有利于维持较高的线虫群落密度和多样性,二者间作可能有利于提高线虫群落密度、多样性及生态功能。 展开更多
关键词 土壤动物 豆科牧草 盆栽试验 多样性 高寒草甸
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Simulation of nonlinear vibration responses of cab system subject to suspension damper complete failure for trucks 被引量:3
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作者 Leilei Zhao Jian Guo +2 位作者 Yuewei Yu xiaohan li Changcheng Zhou 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2020年第2期133-145,共13页
The strong vibration responses of the cab system can be restrained by the damper force and the friction of the suspensions for trucks.After the failures of dampers,especially in the case of the complete failure,the an... The strong vibration responses of the cab system can be restrained by the damper force and the friction of the suspensions for trucks.After the failures of dampers,especially in the case of the complete failure,the anti vibration effect of the friction is prominent.However,the nonlinear vibration response characteristics of the cab subject to the damper complete failure have not been revealed.In order to reveal the nonlinear vibration response characteristics,a dynamic model of the cab system was established and its vibration equations were given.The friction forces existing in the suspensions were determined by the bench test.The influences of the friction forces on the cab vibration under different amplitude harmonic inputs were investigated when the dampers completely fail.The cab vertical displacement changes with the excitation amplitude and the vibration represents various motion states,including the periodic motion,the quasi-periodic motion,and the chaotic motion.The simulation results show that when the dampers fail,the proper friction forces help to suppress the quasi-periodic motion and the chaotic motion of the cab and to reduce the amplitude of the periodic motion.The proper friction forces can make the cab movement far away from the chaos area.They also help to avoid the fatigue damage of the cab floor and suspension parts to improve the service life of the suspension parts and to reduce the maintenance cost of the cab suspensions. 展开更多
关键词 Vibration behaviors complete failure friction chaos quasi-periodic motion
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Modeling and analytic optimization of dynamic comfort for wheelchair robots undergoing random roads 被引量:1
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作者 Leilei Zhao Yuewei Yu +2 位作者 Changcheng Zhou xiaohan li Fuxing Yang 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2018年第5期162-173,共12页
To make a rapid comfort assessment and a reasonable dynamic parameters choice of wheelchair robots,this paper proposes a dynamic comfort coefficientκand analytically optimizes the cushion damping.Firstly,a traveling ... To make a rapid comfort assessment and a reasonable dynamic parameters choice of wheelchair robots,this paper proposes a dynamic comfort coefficientκand analytically optimizes the cushion damping.Firstly,a traveling vibration model of the occupantwheelchair system for wheelchair robots running on random roads was created.Secondly,the analytic formula of the occupant RMS(root mean square)acceleration was deduced.Moreover,the dynamic coefficientκwas proposed and its influence laws were revealed.Finally,the cushion system optimal damping ratio was calculated based onκ.The results show that theκvalue is only determined by the parameters of the occupant-wheelchair system.The smaller theκvalue is,the better the dynamic comfort is for wheelchair robots running on random roads.By minimizingκ,the occupant-wheelchair system can achieve a statistically optimal dynamic comfort effect. 展开更多
关键词 Wheelchair robots simulation evaluation comfort coefficient optimization.
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Effects of feature selection on lane-change maneuver recognition:an analysis of naturalistic driving data 被引量:1
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作者 xiaohan li Wenshuo Wang +1 位作者 Zhang Zhang Matthias Rötting 《Journal of Intelligent and Connected Vehicles》 2018年第3期85-98,共14页
Purpose–Feature selection is crucial for machine learning to recognize lane-change(LC)maneuver as there exist a large number of feature candidates.Blindly using feature could take up large storage and excessive compu... Purpose–Feature selection is crucial for machine learning to recognize lane-change(LC)maneuver as there exist a large number of feature candidates.Blindly using feature could take up large storage and excessive computation time,while insufficient feature selection would cause poor performance.Selecting high contributive features to classify LC and lane-keep behavior is effective for maneuver recognition.This paper aims to propose a feature selection method from a statistical view based on an analysis from naturalistic driving data.Design/methodology/approach–In total,1,375 LC cases are analyzed.To comprehensively select features,the authors extract the feature candidates from both time and frequency domains with various LC scenarios segmented by an occupancy schedule grid.Then the effect size(Cohen’s d)and p-value of every feature are computed to assess their contribution for each scenario.Findings–It has been found that the common lateral features,e.g.yaw rate,lateral acceleration and time-to-lane crossing,are not strong features for recognition of LC maneuver as empirical knowledge.Finally,cross-validation tests are conducted to evaluate model performance using metrics of receiver operating characteristic.Experimental results show that the selected features can achieve better recognition performance than using all the features without purification.Originality/value–In this paper,the authors investigate the contributions of each feature from the perspective of statistics based on big naturalistic driving data.The aim is to comprehensively figure out different types of features in LC maneuvers and select the most contributive features over various LC scenarios. 展开更多
关键词 Feature selection Machine learning Effect size Lane-change maneuvers Naturalistic driving data
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