Double-bonded spray membrane waterproofing materials have excellent waterproofing performance and can improve the load-bearing capacity of tunnel linings,leading to an increasing global application.However,due to the ...Double-bonded spray membrane waterproofing materials have excellent waterproofing performance and can improve the load-bearing capacity of tunnel linings,leading to an increasing global application.However,due to the double-bonded capability of spray membrane materials,traditional interlayer drainage methods cannot be applied.This limitation makes it difficult to use them in drainage-type tunnels,significantly restricting their range of applications.In this regard,a novel tunnel waterproof-drainage system based on double-bonded spray membrane materials was proposed in this paper.The proposed drainage system primarily comprises upper drainage sheets and bottom drainage blind pipes,both located in the tunnel circumferential direction,as well as longitudinal drainage pipes within the tunnel.Subsequently,numerical calculation methods are employed to analyze the seepage characteristics of this system,revealing the water pressure distribution around the tunnel.The results indicate that in the novel waterproof-drainage system,the water pressure in the secondary lining exhibits a“mushroom-shaped”distribution in the circumferential direction,while the water pressure in the longitudinal direction exhibits a“wave-like”distribution.Furthermore,comparative results with other waterproof-drainage systems indicate that under typical working conditions with a water head of 160 m and a rock permeability coefficient of 10^(−6)m/s,the maximum water pressure in the secondary lining of the novel waterproof-drainage system is 0.6 MPa.This represents a significant reduction compared to fully encapsulated waterproofing and traditional drainage systems,which respectively reduce the water pressure by 65%and 30%.The applicability analysis of the double-bonded waterproofing and drainage system reveals that it can reduce at least 40%of the static water pressure in any groundwater environments.The novel drainage system provides a valuable reference for the application of double-bonded spray membrane waterproofing materials in drainage-type tunnels.展开更多
The outcome of controlled ovarian hyperstimulation(COH)is various and unpredictable.According to previous studies,2 single nucleotide polymorphisms,Asn680Ser and-29A/G,have a pharmacogenetic association with ovarian r...The outcome of controlled ovarian hyperstimulation(COH)is various and unpredictable.According to previous studies,2 single nucleotide polymorphisms,Asn680Ser and-29A/G,have a pharmacogenetic association with ovarian response to COH.However,studies on the Asn680Ser polymorphism have yielded inconsistent conclusions and only a few studies with small sample sizes have been performed on-29A/G.The association of these 2 polymorphisms with ovarian response remains unclear.The present study evaluated the association of Asn680Ser and-29A/G genotypes with COH.A total of 414 Chinese women undergoing in vitro fertilization-embryo transfer were included.Genotypes for these single nucleotide polymorphisms were identified by high-resolution melting-curve analysis.The value of exogenous follicle-stimulating hormone dosage per oocyte divided by the body surface area(Dosage/OocyteSurface)was calculated for each patient as an indicator of ovarian response.The results of statistical analyses showed no association between Asn680Ser genotype and ovarian response.As for-29A/G,heterozygote individuals had more oocytes retrieved(P=0.034).Combinatorial analysis of these 2 single nucleotide polymorphisms showed that genotype A/G-Asn/Asn had lower basal-follicle-stimulating hormone and more oocytes retrieved.Analysis of genotype association with ovarian response also revealed this genotype had a significantly higher risk of developing hyper response(OR=7.86;95%CI:1.31-9.43).To some extent,there were associations between the studied polymorphisms and ovarian response;however,the power of this link is weak and has limited value for clinical prediction.展开更多
基金supported by the Fundamental Research Funds for the Central Universities of Central South University(No.2023ZZTS0183)the Fundamental Research Funds for the Central Universities(No.502802002).
文摘Double-bonded spray membrane waterproofing materials have excellent waterproofing performance and can improve the load-bearing capacity of tunnel linings,leading to an increasing global application.However,due to the double-bonded capability of spray membrane materials,traditional interlayer drainage methods cannot be applied.This limitation makes it difficult to use them in drainage-type tunnels,significantly restricting their range of applications.In this regard,a novel tunnel waterproof-drainage system based on double-bonded spray membrane materials was proposed in this paper.The proposed drainage system primarily comprises upper drainage sheets and bottom drainage blind pipes,both located in the tunnel circumferential direction,as well as longitudinal drainage pipes within the tunnel.Subsequently,numerical calculation methods are employed to analyze the seepage characteristics of this system,revealing the water pressure distribution around the tunnel.The results indicate that in the novel waterproof-drainage system,the water pressure in the secondary lining exhibits a“mushroom-shaped”distribution in the circumferential direction,while the water pressure in the longitudinal direction exhibits a“wave-like”distribution.Furthermore,comparative results with other waterproof-drainage systems indicate that under typical working conditions with a water head of 160 m and a rock permeability coefficient of 10^(−6)m/s,the maximum water pressure in the secondary lining of the novel waterproof-drainage system is 0.6 MPa.This represents a significant reduction compared to fully encapsulated waterproofing and traditional drainage systems,which respectively reduce the water pressure by 65%and 30%.The applicability analysis of the double-bonded waterproofing and drainage system reveals that it can reduce at least 40%of the static water pressure in any groundwater environments.The novel drainage system provides a valuable reference for the application of double-bonded spray membrane waterproofing materials in drainage-type tunnels.
基金supported by the National Key Research and Development Program of China(No.2016YFC1000202)by the National Natural Science Foundation of China(No.81671522).
文摘The outcome of controlled ovarian hyperstimulation(COH)is various and unpredictable.According to previous studies,2 single nucleotide polymorphisms,Asn680Ser and-29A/G,have a pharmacogenetic association with ovarian response to COH.However,studies on the Asn680Ser polymorphism have yielded inconsistent conclusions and only a few studies with small sample sizes have been performed on-29A/G.The association of these 2 polymorphisms with ovarian response remains unclear.The present study evaluated the association of Asn680Ser and-29A/G genotypes with COH.A total of 414 Chinese women undergoing in vitro fertilization-embryo transfer were included.Genotypes for these single nucleotide polymorphisms were identified by high-resolution melting-curve analysis.The value of exogenous follicle-stimulating hormone dosage per oocyte divided by the body surface area(Dosage/OocyteSurface)was calculated for each patient as an indicator of ovarian response.The results of statistical analyses showed no association between Asn680Ser genotype and ovarian response.As for-29A/G,heterozygote individuals had more oocytes retrieved(P=0.034).Combinatorial analysis of these 2 single nucleotide polymorphisms showed that genotype A/G-Asn/Asn had lower basal-follicle-stimulating hormone and more oocytes retrieved.Analysis of genotype association with ovarian response also revealed this genotype had a significantly higher risk of developing hyper response(OR=7.86;95%CI:1.31-9.43).To some extent,there were associations between the studied polymorphisms and ovarian response;however,the power of this link is weak and has limited value for clinical prediction.
