Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-i...Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet known.In the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of action.In vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial polarization.Lipopolysaccharide,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were administered.RNA-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of dexamethasone.The Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our hypothesis.High-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain injury.Thus dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in vivo.Glucocorticoid receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain injury.Additionally,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is the GR/JAK1/STAT3 pathway.Overactivation of glucocorticoid receptor by high-dose dexamethasone reduced the expression of M2 microglia,which plays an antiinflammatory role.In contrast,inhibiting the activation of glucocorticoid receptor reduced the number of apoptotic glia and neurons and decreased the loss of dendritic spines after traumatic brain injury.Dexamethasone may exe rt its neurotoxic effects by inhibiting M2 microglia through the GR/JAK1/STAT3 signaling pathway.展开更多
The problem of combined radar imagery from multiple sparse frequency subbands initially incoherent to each other is of practical importance for radar target discrimination.A new coherent processing technique based on ...The problem of combined radar imagery from multiple sparse frequency subbands initially incoherent to each other is of practical importance for radar target discrimination.A new coherent processing technique based on probability density analysis of the subband data is proposed,which is applicable for radar imaging from measurements of two or more initially incoherent radar subbands.The coherence parameters for both amplitude and phase are obtained by combining modern spectral analysis with probability density estimation.The major advantage of the proposed technique lies in that it enables much more robust cohering for the sparse subband data of real-world complex targets.展开更多
The exact radar cross-section （RCS） measurement is difficult when the scattering of targets is low. Ful polarimetric cali-bration is one technique that offers the potential for improving the accuracy of RCS measurem...The exact radar cross-section （RCS） measurement is difficult when the scattering of targets is low. Ful polarimetric cali-bration is one technique that offers the potential for improving the accuracy of RCS measurements. There are numerous polarimetric calibration algorithms. Some complex expressions in these algo-rithms cannot be easily used in an engineering practice. A radar polarimetric coefficients matrix （RPCM） with a simpler expression is presented for the monostatic radar polarization scattering matrix （PSM） measurement. Using a rhombic dihedral corner reflector and a metal ic sphere, the RPCM can be obtained by solving a set of equations, which can be used to find the true PSM for any target. An example for the PSM of a metal ic dish shows that the proposed method obviously improves the accuracy of cross-polarized RCS measurements.展开更多
The inconsistences of the higher-order shear resultant expressed in terms of displacement(s) and the complete boundary value problems of structures modeled by the nonlocal strain gradient theory have not been well add...The inconsistences of the higher-order shear resultant expressed in terms of displacement(s) and the complete boundary value problems of structures modeled by the nonlocal strain gradient theory have not been well addressed. This paper develops a size-dependent Timoshenko beam model that considers both the nonlocal effect and strain gradient effect. The variationally consistent boundary conditions corresponding to the equations of motion of Timoshenko beams are reformulated with the aid of the weighted residual method. The complete boundary value problems of nonlocal strain gradient Timoshenko beams undergoing buckling are solved in closed forms. All the possible higher-order boundary conditions induced by the strain gradient are selectively suggested based on the fact that the buckling loads increase with the increasing aspect ratios of beams from the conventional mechanics point of view. Then, motivated by the expression for beams with simply-supported (SS) boundary conditions, some semiempirical formulae are obtained by curve fitting procedures.展开更多
Angular glint is a significant electromagnetic （EM） scattering signature of extended radar targets. Based on the adaptive cross approximation （ACA） algorithm accelerated method of moments （MoM） and the plane inc...Angular glint is a significant electromagnetic （EM） scattering signature of extended radar targets. Based on the adaptive cross approximation （ACA） algorithm accelerated method of moments （MoM） and the plane incident wave assumption, the narrowband, wideband and newly developed high-resolution range profile （HRRP） based angular glint calculation formulations are derived and applied to arbitrarily shaped three-dimensional （3D） perfectly electrical y conducting （PEC） objects. In addition, the near-field angular glint is emphasized, which is of great importance for radarseeker applications. Furthermore, with the HRRP based angular glint, an approach to rigorously determine range resolution cel s which own relatively smal er angular glint is provided. Numerical results are presented with new findings to demonstrate the usefulness of the developed formulations.展开更多
Wave propagation in two-dimensional hierarchical honeycomb structures with two- order hierarchy is investigated by using the symplectic algorithm. By applying the variational prin- ciple to the dual variables, the wav...Wave propagation in two-dimensional hierarchical honeycomb structures with two- order hierarchy is investigated by using the symplectic algorithm. By applying the variational prin- ciple to the dual variables, the wave propagation problem is transformed into a two-dimensional symplectie eigenvalue problem. The band gaps and spatial filtering phenomena are examined to find the stop bands and directional stop bands. Special attention is directed to the effects of the relative density and the length ratio on the band gaps and phase constant surfaces. This work provides new opportunities for designing hierarchical honeycomb structures in sound insulation applications.展开更多
The use of condition monitoring and fault diagnosis(CMFD)in marine power systems significantly influences ship safety.This study divides the development of CMFD for marine power systems into three periods and reviews ...The use of condition monitoring and fault diagnosis(CMFD)in marine power systems significantly influences ship safety.This study divides the development of CMFD for marine power systems into three periods and reviews the content,state and limitations of CMFD research for each period.According to the research achievements and engineering experience of the authors’team,typical application cases are introduced for CMFD in ships,including CMFD platforms on engineering ships,salvage ships,container ships and ro-ro ships powered by solar photovoltaic systems.Finally,prospective research directions are proposed for CMFD in marine power systems,considering the research status of CMFD and the trend toward intelligent and eco-friendly ships.展开更多
Based on Mindlin plate models and Kirchhoff plate models,this study was concerned with the wave propagation characteristics in thick conventional and auxetic cellular structures,with the objective to clarify the effec...Based on Mindlin plate models and Kirchhoff plate models,this study was concerned with the wave propagation characteristics in thick conventional and auxetic cellular structures,with the objective to clarify the effects of negative Poisson＇s ratio,shear factor and orthotropic mechanical properties on the dynamic behaviors of thick plates.Numerical results revealed that the predictions using variable shear factor in Mindlin plate models resulted in high wave frequencies,which were more significant for plates with negative values of Poisson＇s ratio.The present study can be useful for the design of critical applications by varying the values of Poisson＇s ratio.展开更多
Shipping is perhaps themost international of all the world’s great industries and one of the most dangerous.It is essential to study maritime safety and take reasonable measurements to ensure the security of life and...Shipping is perhaps themost international of all the world’s great industries and one of the most dangerous.It is essential to study maritime safety and take reasonable measurements to ensure the security of life and property.With the rapid development of Artificial Intelligence,industrial upgrading is undergoing a change in the maritime industry,where many techniques have been developed to enhance maritime safety and improve the automation and intelligence of ships,equipment,and infrastructure.展开更多
基金supported by research grants from the Ningbo Science and Technology Plan Project,No.2022Z143hezuo(to BL)the National Natural Science Foundation of China,No.82201520(to XD)。
文摘Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet known.In the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of action.In vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial polarization.Lipopolysaccharide,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were administered.RNA-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of dexamethasone.The Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our hypothesis.High-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain injury.Thus dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in vivo.Glucocorticoid receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain injury.Additionally,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is the GR/JAK1/STAT3 pathway.Overactivation of glucocorticoid receptor by high-dose dexamethasone reduced the expression of M2 microglia,which plays an antiinflammatory role.In contrast,inhibiting the activation of glucocorticoid receptor reduced the number of apoptotic glia and neurons and decreased the loss of dendritic spines after traumatic brain injury.Dexamethasone may exe rt its neurotoxic effects by inhibiting M2 microglia through the GR/JAK1/STAT3 signaling pathway.
文摘The problem of combined radar imagery from multiple sparse frequency subbands initially incoherent to each other is of practical importance for radar target discrimination.A new coherent processing technique based on probability density analysis of the subband data is proposed,which is applicable for radar imaging from measurements of two or more initially incoherent radar subbands.The coherence parameters for both amplitude and phase are obtained by combining modern spectral analysis with probability density estimation.The major advantage of the proposed technique lies in that it enables much more robust cohering for the sparse subband data of real-world complex targets.
基金supported by the National Basic Research Program of China(973 Program)(2010CB731905)
文摘The exact radar cross-section （RCS） measurement is difficult when the scattering of targets is low. Ful polarimetric cali-bration is one technique that offers the potential for improving the accuracy of RCS measurements. There are numerous polarimetric calibration algorithms. Some complex expressions in these algo-rithms cannot be easily used in an engineering practice. A radar polarimetric coefficients matrix （RPCM） with a simpler expression is presented for the monostatic radar polarization scattering matrix （PSM） measurement. Using a rhombic dihedral corner reflector and a metal ic sphere, the RPCM can be obtained by solving a set of equations, which can be used to find the true PSM for any target. An example for the PSM of a metal ic dish shows that the proposed method obviously improves the accuracy of cross-polarized RCS measurements.
基金Project supported by the National Natural Science Foundation of China(No.11602032)the China Postdoctoral Science Foundation(No.2016M602733)+1 种基金the Shaanxi Postdoctoral Science Foundation(No.2017BSHEDZZ123)the Fundamental Research Funds for the Central Universities of Ministry of Education of China(Nos.310821163502 and 300102219315)
文摘The inconsistences of the higher-order shear resultant expressed in terms of displacement(s) and the complete boundary value problems of structures modeled by the nonlocal strain gradient theory have not been well addressed. This paper develops a size-dependent Timoshenko beam model that considers both the nonlocal effect and strain gradient effect. The variationally consistent boundary conditions corresponding to the equations of motion of Timoshenko beams are reformulated with the aid of the weighted residual method. The complete boundary value problems of nonlocal strain gradient Timoshenko beams undergoing buckling are solved in closed forms. All the possible higher-order boundary conditions induced by the strain gradient are selectively suggested based on the fact that the buckling loads increase with the increasing aspect ratios of beams from the conventional mechanics point of view. Then, motivated by the expression for beams with simply-supported (SS) boundary conditions, some semiempirical formulae are obtained by curve fitting procedures.
文摘Angular glint is a significant electromagnetic （EM） scattering signature of extended radar targets. Based on the adaptive cross approximation （ACA） algorithm accelerated method of moments （MoM） and the plane incident wave assumption, the narrowband, wideband and newly developed high-resolution range profile （HRRP） based angular glint calculation formulations are derived and applied to arbitrarily shaped three-dimensional （3D） perfectly electrical y conducting （PEC） objects. In addition, the near-field angular glint is emphasized, which is of great importance for radarseeker applications. Furthermore, with the HRRP based angular glint, an approach to rigorously determine range resolution cel s which own relatively smal er angular glint is provided. Numerical results are presented with new findings to demonstrate the usefulness of the developed formulations.
基金Project supported by the National Basic Research Program of China(No.2011CB610300)the National Natural Science Foundation of China(Nos.11172239 and 11372252)+3 种基金the Doctoral Program Foundation of Education Ministry of China(No.20126102110023)the Fundamental Research Funds for the Central Universities(Nos.310201401JCQ01001 and 3102015ZY036)China Postdoctoral Science Foundation(No.2013M540724)Shaanxi postdoctoral research projects
文摘Wave propagation in two-dimensional hierarchical honeycomb structures with two- order hierarchy is investigated by using the symplectic algorithm. By applying the variational prin- ciple to the dual variables, the wave propagation problem is transformed into a two-dimensional symplectie eigenvalue problem. The band gaps and spatial filtering phenomena are examined to find the stop bands and directional stop bands. Special attention is directed to the effects of the relative density and the length ratio on the band gaps and phase constant surfaces. This work provides new opportunities for designing hierarchical honeycomb structures in sound insulation applications.
基金support from the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(grant no.U1709215)the NSFC(grant nos 52071241,61903108)the Natural Science Foundation of Zhejiang Province(grant no.LY21F030011).
文摘The use of condition monitoring and fault diagnosis(CMFD)in marine power systems significantly influences ship safety.This study divides the development of CMFD for marine power systems into three periods and reviews the content,state and limitations of CMFD research for each period.According to the research achievements and engineering experience of the authors’team,typical application cases are introduced for CMFD in ships,including CMFD platforms on engineering ships,salvage ships,container ships and ro-ro ships powered by solar photovoltaic systems.Finally,prospective research directions are proposed for CMFD in marine power systems,considering the research status of CMFD and the trend toward intelligent and eco-friendly ships.
基金Project supported by the National Natural Science Foundation of China(No.11172239)the 111 project(No.B07050)the Doctoral Program Foundation of Education Ministry of China(20126102110023)
文摘Based on Mindlin plate models and Kirchhoff plate models,this study was concerned with the wave propagation characteristics in thick conventional and auxetic cellular structures,with the objective to clarify the effects of negative Poisson＇s ratio,shear factor and orthotropic mechanical properties on the dynamic behaviors of thick plates.Numerical results revealed that the predictions using variable shear factor in Mindlin plate models resulted in high wave frequencies,which were more significant for plates with negative values of Poisson＇s ratio.The present study can be useful for the design of critical applications by varying the values of Poisson＇s ratio.
文摘Shipping is perhaps themost international of all the world’s great industries and one of the most dangerous.It is essential to study maritime safety and take reasonable measurements to ensure the security of life and property.With the rapid development of Artificial Intelligence,industrial upgrading is undergoing a change in the maritime industry,where many techniques have been developed to enhance maritime safety and improve the automation and intelligence of ships,equipment,and infrastructure.
