Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a ...Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis.The relationship between heme oxygenase-1and ferroptosis remains controve rsial.In this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord injury.In addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury.Furthe r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme oxygenase-1.Thus,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd injury.These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.展开更多
A new knowledge measure with parameter of intuitionistic fuzzy sets (IFSs) is presented based on the membership degree and the non-membership degree of IFSs, which complies with the extended form of Szmidt-Kacprzyk ax...A new knowledge measure with parameter of intuitionistic fuzzy sets (IFSs) is presented based on the membership degree and the non-membership degree of IFSs, which complies with the extended form of Szmidt-Kacprzyk axioms for intuitionistic fuzzy entropy. And a sufficient and necessary condition of order property in the Szmidt-Kacprzyk axioms is discussed. Additionally, some numerical examples are given to illustrate the applications of the proposed knowledge measure and some conventional entropies and knowledge measures of IFSs. The experimental results show that the results of the parametric model proposed in this paper are more accurate than those of most of the classic models.展开更多
In this study,we review the Rheotanytarsus acerbus species group based on adult males from China.Two new species,R.cangshanensis Lin&Yao,sp.nov.and R.yamamotoi Lin&Yao,sp.nov.,are described.R.adjectus(Johannse...In this study,we review the Rheotanytarsus acerbus species group based on adult males from China.Two new species,R.cangshanensis Lin&Yao,sp.nov.and R.yamamotoi Lin&Yao,sp.nov.,are described.R.adjectus(Johannsen,1932)is re-described for its new record from China.A world key to adult males of acerbus species group is provided for the first time.展开更多
基金supported by grants from Jiangsu Commission of Health,No.Z2021086(to XL)Science and Technology Program of Suzhou,Nos.SYSD2020008(to XL),SKYD2022012(to XL)+1 种基金Suzhou Municipal Health Commission,No.KJXW2020058(to XL)Science and Technology Program of Zhangjiagang,No.ZKS2018(to XL)。
文摘Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis.The relationship between heme oxygenase-1and ferroptosis remains controve rsial.In this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord injury.In addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury.Furthe r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme oxygenase-1.Thus,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd injury.These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.
文摘A new knowledge measure with parameter of intuitionistic fuzzy sets (IFSs) is presented based on the membership degree and the non-membership degree of IFSs, which complies with the extended form of Szmidt-Kacprzyk axioms for intuitionistic fuzzy entropy. And a sufficient and necessary condition of order property in the Szmidt-Kacprzyk axioms is discussed. Additionally, some numerical examples are given to illustrate the applications of the proposed knowledge measure and some conventional entropies and knowledge measures of IFSs. The experimental results show that the results of the parametric model proposed in this paper are more accurate than those of most of the classic models.
基金The work is financially supported from the research start-up fund project for young teachers of Shanghai Ocean University(A2-2006-23-200303)National Natural Science Foundation of China(31900344)the China Postdoctoral Science Foundation Grant(2018M640227).
文摘In this study,we review the Rheotanytarsus acerbus species group based on adult males from China.Two new species,R.cangshanensis Lin&Yao,sp.nov.and R.yamamotoi Lin&Yao,sp.nov.,are described.R.adjectus(Johannsen,1932)is re-described for its new record from China.A world key to adult males of acerbus species group is provided for the first time.
