The accurate fault-cause identification for overhead transmission lines supports the operation and maintenance personnel in formulating targeted maintenance strategies and shortening the time of inspecting faulty line...The accurate fault-cause identification for overhead transmission lines supports the operation and maintenance personnel in formulating targeted maintenance strategies and shortening the time of inspecting faulty lines.With the goal of achieving“carbon peak and carbon neutrality”,the schemes for clean energy generation have rapidly developed.Moreover,new energy-consuming equipment has been widely connected to the power grid,and the operating characteristics of the power system have significantly changed.Consequently,these have impacted traditional fault identification methods.Based on the time-frequency characteristics of the fault waveform,new energy-related parameters,and deep learning model,this study proposes a fault identification method suitable for scenarios where a high proportion of new energy is connected to the power grid.Ten parameters related to the causes of transmission line fault and new energy connection scenarios are selected as model characteristic parameters.Further,a fault identification model based on adaptive deep belief networks was constructed,and its effect was verified by field data.展开更多
Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal ep...Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal epithelial lineages and maintaining intestinal epithelial replenishment. The technique of three‐dimensional culture based upon intestinal stem cell biology has been recently developed to study gastrointestinal development and disease pathogenesis. Here, we summarize the techniques used to isolate Lgr5‐ positive IESCs to form the enteroids from intestine or colonoids from colon, and present the means to examine these organoid functions. This study will provide a simple and practical way for producing intestinal tissues in the laboratory.展开更多
CDC42 controls intestinal epithelial(IEC)stem cell(IESC)division.How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear.We utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,a...CDC42 controls intestinal epithelial(IEC)stem cell(IESC)division.How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear.We utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and neoplasia.Intestinal specimens were collected to determine the levels of CDC42 in IBD or colorectal cancer.Cdc42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient mice.Irradiation,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC repair.Our studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD colon.Colonic Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt dysplasia.Colonic Cdc42 depletion markedly enhanced irra-diation-or chemical-induced colitis.Depletion or inhibition of Cdc42 reduced colonic Lgr5+IESC regeneration.In conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal inflammation.Constitutive monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.展开更多
This paper describes the research on a largescale dispatchable grid-connected photovoltaic(PV)system for supplying power to the grid for dispatch instead of supplying the electricity to a local load.In order to maximi...This paper describes the research on a largescale dispatchable grid-connected photovoltaic(PV)system for supplying power to the grid for dispatch instead of supplying the electricity to a local load.In order to maximise the value of the solar energy,a hybrid electricity storage consisting of batteries and supercapacitors is used with the PV system.This paper proposes a control strategy focusing on theDCpower at theDClink rather than at the grid-connected inverter.Two typical sets of real data,collected from existing sites,are used to demonstrate the practicality of the system.Finally,the simulation results are used to demonstrate the good performance and feasibility of the proposed system together with the proposed control strategy.展开更多
The polymer waveguide optical biosensor based on the Mach-Zehnder interferometer （MZI） by using spectral splitting effect is investigated. The MZI based biosensor has two unequal width sensing arms. With the differe...The polymer waveguide optical biosensor based on the Mach-Zehnder interferometer （MZI） by using spectral splitting effect is investigated. The MZI based biosensor has two unequal width sensing arms. With the different mode dispersion responses of the two-arm waveguides to the cladding refractive index change, the spectral splitting effect of the output interference spectrum is obtained, inducing a very high sensitivity. The influence of the different mode dispersions between the two-arm waveguides on the spectral splitting characteristic is analyzed. By choosing different lengths of the two unequal width sensing arms, the initial dip wavelength of the interference spectrum and the spectral splitting range can be controlled flexibly. The polymer waveguide optical biosensor is designed, and its sensing property is analyzed. The results show that the sensitivity of the polymer waveguide optical biosensor by using spectral splitting effect is as high as 10^4nm/RIU, with an improvement of 2-3 orders of magnitude compared with the slot waveguide based microring biosensor.展开更多
A 2 × 2 optical waveguide coupler at 850 nm based on the multimode interference （MMI） structure with the polysilsesquioxanes liquid series （PSQ-Ls） polymer material and the imprint technique is presented. The...A 2 × 2 optical waveguide coupler at 850 nm based on the multimode interference （MMI） structure with the polysilsesquioxanes liquid series （PSQ-Ls） polymer material and the imprint technique is presented. The influence of the structural parameters, such as the single mode condition, the waveguide spacing of input/output ports, and the width and length of the multimode waveguide, on the optical splitting performance including the excess loss and the uniformity is simulated by the beam propagation method. By inserting a taper section of isosceles trapezoid between the single mode and multimode waveguides, the optimized structural parameters for low excess loss and high uniformity are obtained with the excess loss of -0.040 dB and the uniformity of-0.007 dB. The effect of the structure deviations induced during the imprint process on the optical splitting performance at different residual layer thicknesses is also investigated. The analysis results provide useful instructions for the waveguide device fabrication.展开更多
基金This work was supported by State Grid Science and Technology Project(B3440821K003).
文摘The accurate fault-cause identification for overhead transmission lines supports the operation and maintenance personnel in formulating targeted maintenance strategies and shortening the time of inspecting faulty lines.With the goal of achieving“carbon peak and carbon neutrality”,the schemes for clean energy generation have rapidly developed.Moreover,new energy-consuming equipment has been widely connected to the power grid,and the operating characteristics of the power system have significantly changed.Consequently,these have impacted traditional fault identification methods.Based on the time-frequency characteristics of the fault waveform,new energy-related parameters,and deep learning model,this study proposes a fault identification method suitable for scenarios where a high proportion of new energy is connected to the power grid.Ten parameters related to the causes of transmission line fault and new energy connection scenarios are selected as model characteristic parameters.Further,a fault identification model based on adaptive deep belief networks was constructed,and its effect was verified by field data.
基金The Non-profit Central Institute Fund of Chinese Academy of Medical Sciences,Grant/Award Number:2016RC310011The National Key Research and Development Program of China,Grant/Award Number:2017YFA0105200Peking Medical College(PUMC)Scholar-Endowed Professorship
文摘Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal epithelial lineages and maintaining intestinal epithelial replenishment. The technique of three‐dimensional culture based upon intestinal stem cell biology has been recently developed to study gastrointestinal development and disease pathogenesis. Here, we summarize the techniques used to isolate Lgr5‐ positive IESCs to form the enteroids from intestine or colonoids from colon, and present the means to examine these organoid functions. This study will provide a simple and practical way for producing intestinal tissues in the laboratory.
基金supported by NIDDK RO1,USA(No.R01DK123299)(X.H.)MHMC/CWRU start-up(X.H.).R.M.was supported by a private cancer metabolism grant donation from Liechtenstein and the Austrian Science Fund(FWF)(No.SFB F4707 and SFB-F06105).
文摘CDC42 controls intestinal epithelial(IEC)stem cell(IESC)division.How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear.We utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and neoplasia.Intestinal specimens were collected to determine the levels of CDC42 in IBD or colorectal cancer.Cdc42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient mice.Irradiation,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC repair.Our studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD colon.Colonic Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt dysplasia.Colonic Cdc42 depletion markedly enhanced irra-diation-or chemical-induced colitis.Depletion or inhibition of Cdc42 reduced colonic Lgr5+IESC regeneration.In conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal inflammation.Constitutive monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.
基金This work was supported by National High Technology Research and Development Program,“863 key technologies and development on large-scale grid-connected PV plants”(No.2011AA05A301).
文摘This paper describes the research on a largescale dispatchable grid-connected photovoltaic(PV)system for supplying power to the grid for dispatch instead of supplying the electricity to a local load.In order to maximise the value of the solar energy,a hybrid electricity storage consisting of batteries and supercapacitors is used with the PV system.This paper proposes a control strategy focusing on theDCpower at theDClink rather than at the grid-connected inverter.Two typical sets of real data,collected from existing sites,are used to demonstrate the practicality of the system.Finally,the simulation results are used to demonstrate the good performance and feasibility of the proposed system together with the proposed control strategy.
基金This work was supported in part by the International Science ＆ Technology Cooperation Program of China （No. 2014DFG32590）, National Natural Science Foundation of China （No. 61307040）, National R＆D Program （No. 2012AA040406）, National Research Foundation of China （No. 6140450010305）, Natural Science Foundation of Liaoning Province （No. 2014020002）, and Fundamental Research Funds for the Central Universities （DUT 15ZD231 and DUT2015TD47）.
文摘The polymer waveguide optical biosensor based on the Mach-Zehnder interferometer （MZI） by using spectral splitting effect is investigated. The MZI based biosensor has two unequal width sensing arms. With the different mode dispersion responses of the two-arm waveguides to the cladding refractive index change, the spectral splitting effect of the output interference spectrum is obtained, inducing a very high sensitivity. The influence of the different mode dispersions between the two-arm waveguides on the spectral splitting characteristic is analyzed. By choosing different lengths of the two unequal width sensing arms, the initial dip wavelength of the interference spectrum and the spectral splitting range can be controlled flexibly. The polymer waveguide optical biosensor is designed, and its sensing property is analyzed. The results show that the sensitivity of the polymer waveguide optical biosensor by using spectral splitting effect is as high as 10^4nm/RIU, with an improvement of 2-3 orders of magnitude compared with the slot waveguide based microring biosensor.
基金This work was supported in part by the International Science ＆ Technology Cooperation Program of China （No. 2014DFG32590）, National Natural Science Foundation of China （No.61077015, 61307040）, National R＆D Program （No.2012AA040406）, Natural Science Foundation of Liaoning Province （No. 2014020002）, Opening Project of Shanghai Key Laboratory of All Solid-state Laser and Applied Techniques （No. 2013ADL04）, and Fundamental Research Funds for the Central Universities （DUT 13JB01, DUT 15ZD231, and DUT2015TD47）.
文摘A 2 × 2 optical waveguide coupler at 850 nm based on the multimode interference （MMI） structure with the polysilsesquioxanes liquid series （PSQ-Ls） polymer material and the imprint technique is presented. The influence of the structural parameters, such as the single mode condition, the waveguide spacing of input/output ports, and the width and length of the multimode waveguide, on the optical splitting performance including the excess loss and the uniformity is simulated by the beam propagation method. By inserting a taper section of isosceles trapezoid between the single mode and multimode waveguides, the optimized structural parameters for low excess loss and high uniformity are obtained with the excess loss of -0.040 dB and the uniformity of-0.007 dB. The effect of the structure deviations induced during the imprint process on the optical splitting performance at different residual layer thicknesses is also investigated. The analysis results provide useful instructions for the waveguide device fabrication.
