Eye health has become a global health concern and attracted broad attention.Over the years,researchers have proposed many state-of-the-art convolutional neural networks(CNNs)to assist ophthalmologists in diagnosing oc...Eye health has become a global health concern and attracted broad attention.Over the years,researchers have proposed many state-of-the-art convolutional neural networks(CNNs)to assist ophthalmologists in diagnosing ocular diseases efficiently and precisely.However,most existing methods were dedicated to constructing sophisticated CNNs,inevitably ignoring the trade-off between performance and model complexity.To alleviate this paradox,this paper proposes a lightweight yet efficient network architecture,mixeddecomposed convolutional network(MDNet),to recognise ocular diseases.In MDNet,we introduce a novel mixed-decomposed depthwise convolution method,which takes advantage of depthwise convolution and depthwise dilated convolution operations to capture low-resolution and high-resolution patterns by using fewer computations and fewer parameters.We conduct extensive experiments on the clinical anterior segment optical coherence tomography(AS-OCT),LAG,University of California San Diego,and CIFAR-100 datasets.The results show our MDNet achieves a better trade-off between the performance and model complexity than efficient CNNs including MobileNets and MixNets.Specifically,our MDNet outperforms MobileNets by 2.5%of accuracy by using 22%fewer parameters and 30%fewer computations on the AS-OCT dataset.展开更多
A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and locat...A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.展开更多
Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participant...Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood cells.Methods:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific emotions.Relative expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also determined.Results:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative emotions.Relative gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia groups.Regarding the emotional score of disgust on video stage,the main effect was significant(F=335.58,P<.001),which showed that watching the three videos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency groups.The symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional status.Our findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological problems and negative emotions,particularly disgust.We also demonstrate that emotional regulation is related to mir191-Riok3-Mxi1 pathway activity,identifying these pathway components are potential targets for genetic therapies in combination with psychological therapy.展开更多
Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectivenes...Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be elucidated.This study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric cancer.Methods:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere collected.Clinical andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment groups.Efficacy was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement scale.Results:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs group.There were no significant differences in baseline characteristics between the 2 groups.Compared with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy group.The enhanced efficacy of immune combination with SOX is evident,as demonstrated by the significantly prolonged surgical duration in operated patients(206.6±26.6 min vs 197.8±19.8 min,P=0.35)and intraoperative blood loss(158.9±21.2 mL vs 148.9±25.1 mL,P=0.59).No significant differences were observed in postoperative complications.Conclusions:Compared with the SOX conversion therapy regimen,SOX combined with ICIs demonstrated higher conversion rates,R0 resection rates,pathological response rates,and disease-free survival without increasing surgical difficulty or complications.Nonoperable patients also experienced longer progression-free survival and objective response rates.展开更多
Undergraduate graduation design is an important link in the process of undergraduate training,and university platforms have invested a lot of manpower and material resources for this purpose.However,while carrying out...Undergraduate graduation design is an important link in the process of undergraduate training,and university platforms have invested a lot of manpower and material resources for this purpose.However,while carrying out student training,it has gradually become the consensus of most university platforms to achieve a win-win situation for teachers and training platforms in order to achieve optimization of resource allocation and motivation of student training.After discussion and practice,this paper proposes a set of undergraduate graduation design training concepts and training modes with a win-win situation for students,teachers,and training platforms.展开更多
Prostate cancer is a common male malignant tumor,and bone metastasis is one of the common complications in the late stage of prostate cancer.The mechanism of prostate cancer bone metastasis is a complex process involv...Prostate cancer is a common male malignant tumor,and bone metastasis is one of the common complications in the late stage of prostate cancer.The mechanism of prostate cancer bone metastasis is a complex process involving multiple factors and steps.In recent years,with in-depth research on the mechanism of prostate cancer bone metastasis and the development of new drugs,important progress has been made in the treatment of prostate cancer bone metastasis.Based on this,this article introduces the mechanism of prostate cancer bone metastasis and the research progress of several bone-targeted drugs to provide reference and inspiration for future research.展开更多
The lithium-sulfur(Li-S)battery with an ultrahigh theoretical energy density has emerged as a promising rechargeable battery system.However,the practical applications of Li-S batteries are severely plagued by the slug...The lithium-sulfur(Li-S)battery with an ultrahigh theoretical energy density has emerged as a promising rechargeable battery system.However,the practical applications of Li-S batteries are severely plagued by the sluggish reaction kinetics of sulfur species and notorious shuttling of soluble lithium polysulfides(LiPSs)intermediates that result in low sulfur utilization.The introduction of functional layers on separators has been considered as an effective strategy to improve the sulfur utilization in Li-S batteries by achieving effective regulation of LiPSs.Herein,a promising self-assembly strategy is proposed to achieve the low-cost fabrication of hollow and hierarchically porous Fe_(3)O_(4)nanospheres(p-Fe_(3)O_(4)-NSs)assembled by numerous extremely-small primary nanocrystals as building blocks.The rationally-designed p-Fe_(3)O_(4)-NSs are utilized as a multifunctional layer on the separator with highly efficient trapping and conversion features toward LiPSs.Results demonstrate that the nanostructured p-Fe_(3)O_(4)-NSs provide chemical adsorption toward LiPSs and kinetically promote the mutual transformation between LiPSs and Li_(2)S_(2)/Li_(2)S during cycling,thus inhibiting the LiPSs shuttling and boosting the redox reaction kinetics via a chemisorption-catalytic conversion mechanism.The enhanced wettability of the p-Fe_(3)O_(4)-NSs-based separator with the electrolyte enables fast transportation of lithium ions.Benefitting from these alluring properties,the functionalized separator with p-Fe_(3)O_(4)-NSs endows the battery with an admirable rate performance of 877 mAh g^(−1)at 2 C,an ultra-durable cycling performance of up to 2176 cycles at 1 C,and a promising areal capacity of 4.55 mAh cm^(−2)under high-sulfur-loading and lean-electrolyte conditions(4.29 mg cm^(−2),electrolyte/ratio:8μl mg^(−1)).This study will offer fresh insights on the rational design and low-cost fabrication of multifunctional separator to strengthen electrochemical reaction kinetics by regulating LiPSs conversion for developing efficient and long-life Li-S batteries.展开更多
Various types of plasma events emerge in specific parameter ranges and exhibit similar characteristics in diagnostic signals,which can be applied to identify these events.A semisupervised machine learning algorithm,th...Various types of plasma events emerge in specific parameter ranges and exhibit similar characteristics in diagnostic signals,which can be applied to identify these events.A semisupervised machine learning algorithm,the k-means clustering algorithm,is utilized to investigate and identify plasma events in the J-TEXT plasma.This method can cluster diverse plasma events with homogeneous features,and then these events can be identified if given few manually labeled examples based on physical understanding.A survey of clustered events reveals that the k-means algorithm can make plasma events(rotating tearing mode,sawtooth oscillations,and locked mode)gathering in Euclidean space composed of multi-dimensional diagnostic data,like soft x-ray emission intensity,edge toroidal rotation velocity,the Mirnov signal amplitude and so on.Based on the cluster analysis results,an approximate analytical model is proposed to rapidly identify plasma events in the J-TEXT plasma.The cluster analysis method is conducive to data markers of massive diagnostic data.展开更多
This paper is concerned with finite-time H_(∞) filtering for Markov jump systems with uniform quantization. The objective is to design quantized mode-dependent filters to ensure that the filtering error system is not...This paper is concerned with finite-time H_(∞) filtering for Markov jump systems with uniform quantization. The objective is to design quantized mode-dependent filters to ensure that the filtering error system is not only mean-square finite-time bounded but also has a prescribed finite-time H_(∞) performance. First, the case where the switching modes of the filter align with those of the MJS is considered. A numerically tractable filter design approach is proposed utilizing a mode-dependent Lyapunov function, Schur’s complement, and Dynkin’s formula. Then, the study is extended to a scenario where the switching modes of the filter can differ from those of the MJS. To address this situation, a mode-mismatched filter design approach is developed by leveraging a hidden Markov model to describe the asynchronous mode switching and the double expectation formula. Finally, a spring system model subject to a Markov chain is employed to validate the effectiveness of the quantized filter design approaches.展开更多
The detailed density perturbations provided by the advanced polarimeter-interferometer system(Polaris) during sawtooth collapse on the Joint Texas Experimental Tokamak(J-TEXT) are reported in this article.During a saw...The detailed density perturbations provided by the advanced polarimeter-interferometer system(Polaris) during sawtooth collapse on the Joint Texas Experimental Tokamak(J-TEXT) are reported in this article.During a sawtooth collapse and the crash of plasma pressure at the center,it is found that the increase in density in the region between the inversion radius and mixing radius is poloidally asymmetrical,while the increase in temperature is poloidally symmetrical.The poloidal location where the density increases is dependent on the phase of the precursory m/n=1/1 kink mode.It is always out of phase with the hot core of the m/n=1/1 mode.The behaviors of density perturbations during sawtooth collapse observed in J-TEXT are beyond the expectations of the standard model,and this can shed new light on the understanding of sawtooth collapse.展开更多
Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied ...Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied to bionic robotic actuators, artificial muscles, as well as dynamic sensors. However, IPMC has the major drawback of low generative blocking force. In this paper, in order to enhance the blocking force, the Nation membranes with thickness of 0.22 mm, 0.32 mm, 0.42 mm, 0.64 mm and 0.8 mm were prepared by casting from liquid solution. By employing these Nation membranes, IPMCs with varying thickness were fabricated by electroless plating. The elastic modulus of the casted Nation membranes were obtained by a nano-indenter, and the current, the displacement and the blocking force were respectively measured by the apparatus for actuation test. Finally, the effects of the thickness on the performance of IPMC were analyzed with an electromechanical model. Experimental study and theory analysis indicate that as the thickness increases, the elastic modulus of Nation membrane and the blocking force of IPMC increase, however, the current and the displacement decrease.展开更多
Ni-Co bimetallic catalysts with different Ni/Co content were derived from cold plasma jet decomposition and reduction of hydrotalcite-like compounds containing Ni,Co,Mg and Al,and their catalytic performance was inves...Ni-Co bimetallic catalysts with different Ni/Co content were derived from cold plasma jet decomposition and reduction of hydrotalcite-like compounds containing Ni,Co,Mg and Al,and their catalytic performance was investigated with dry reforming of methane.Experimental results showed that the hydrotalcite-like precursors could be completely decomposed and partly reduced by cold plasma jet,and the Nicontained catalysts exhibited much higher activity than the catalyst without Ni.Especially,the catalyst with Ni/Co ratio of 8/2 achieved not only the highest conversions of 80.3%and 69.3%for CH4 and CO2,respectively,but also the best stability in 100 h testing.The catalysts were characterized by XRD,XPS,TEM and N2 adsorption techniques,and the results showed that the better performance of the 8Ni2Co bimetallic catalyst was attributed to its higher metal dispersion,smaller metal particle size,as well as the interaction effect between Ni and Co,which were brought by the special catalyst preparation method.展开更多
The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is th...The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma.展开更多
The J-TEXT tokamak has been operated for ten years since its first plasma obtained at the end of 2007. The diagnostics development and main modulation systems, i.e. resonant magnetic perturbation （RMP） systems and m...The J-TEXT tokamak has been operated for ten years since its first plasma obtained at the end of 2007. The diagnostics development and main modulation systems, i.e. resonant magnetic perturbation （RMP） systems and massive gas injection （MGI） systems, will be introduced in this paper. Supported by these efforts, J-TEXT has contributed to research on several topics, especially on RMP physics and disruption mitigation. Both experimental and theoretical research show that RMP could lock, suppress or excite the tearing modes, depending on the RMP amplitude, frequency difference between RMP and rational surface rotation, and initial stabilities. The plasma rotation, particle transport and operation region are influenced by the RMP. Utilizing the MGI valves, disruptions have been mitigated with pure He, pure Ne, and a mixture of He and Ar （9：1）. A significant runaway current plateau could be generated with moderate amounts of Ar injection. The RMP has been shown to suppress the generation of runaway current during disruptions.展开更多
Heart arrhythmia is a group of irregular heartbeat conditions and is usually detected by electrocardiograms(ECG)signals.Over the past years,deep learning methods have been developed to classify different types of hear...Heart arrhythmia is a group of irregular heartbeat conditions and is usually detected by electrocardiograms(ECG)signals.Over the past years,deep learning methods have been developed to classify different types of heart arrhythmias through ECG based on computer-aided diagnosis systems(CADs),but these deep learning methods usually cannot trade-off between classification performance and parameters of deep learning methods.To tackle this problem,this work proposes a convolutional neural network(CNN)model named PDNet to recognize different types of heart arrhythmias efficiently.In the PDNet,a convolutional block named PDblock is devised,which is comprised of a pointwise convolutional layer and a depthwise convolutional layer.Furthermore,an improved loss function is utilized to improve the results of heart arrhythmias classification.To verify the proposed CNN model,extensive experiments are conducted on publicMIT-BIH ECG databases.The experimental results demonstrate that the proposed PDNet achieves an accuracy of 98.2%accuracy and outperforms state-of-the-art methods about 2%.展开更多
An active thermo-acoustic network model of regenerator which is a key component to accomplish the con-version between thermal-and acoustic power in thermo-acoustic system has been established in this paper. The experi...An active thermo-acoustic network model of regenerator which is a key component to accomplish the con-version between thermal-and acoustic power in thermo-acoustic system has been established in this paper. The experiment was carried out to quantify the network. A method called least square is employed in order to identify the H matrix describing the system. The results obtained here show that the active thermo-acoustic network can reliably depict the characteristics of a thermo-acoustic system.展开更多
To extend the operation region of the Joint-Texas Experimental tokamak(J-TEXT) to the divertor configuration and even the H-mode,the divertor configuration discharge has been realized for the first time in the J-TEXT ...To extend the operation region of the Joint-Texas Experimental tokamak(J-TEXT) to the divertor configuration and even the H-mode,the divertor configuration discharge has been realized for the first time in the J-TEXT tokamak.Along with the establishment of a power supply for the divertor configuration,the construction of relevant diagnostics,and the installation of the divertor target on the high-field side,divertor discharge has been tested.Through the equilibrium calculation and position stability analysis,the control strategy has evolved to be more stable.High-density experiments and auxiliary heating experiments have been carried out on the divertor configuration.The special midplane single-null(MSN) divertor configuration is shown to be more stable than the limiter configuration in the density limit condition and can reach a higher density in the experiment.In the ECRH experiment,the power injection enhances the electron temperature and density,while more heat outflux is loaded on the divertor target tiles and causes more intensive recycling and impurity release.The future plan for the divertor configuration operation in the J-TEXT tokamak is also included.展开更多
The reliability of diagnostic systems in tokamak plasma is of great significance for physics researches or fusion reactor.When some diagnostics fail to detect information about the plasma status,such as electron tempe...The reliability of diagnostic systems in tokamak plasma is of great significance for physics researches or fusion reactor.When some diagnostics fail to detect information about the plasma status,such as electron temperature,they can also be obtained by another method:fitted by other diagnostic signals through machine learning.The paper herein is based on a machine learning method to predict electron temperature,in case the diagnostic systems fail to detect plasma temperature.The fully-connected neural network,utilizing back propagation with two hidden layers,is utilized to estimate plasma electron temperature approximately on the J-TEXT.The input parameters consist of soft x-ray emission intensity,electron density,plasma current,loop voltage,and toroidal magnetic field,while the targets are signals of electron temperature from electron cyclotron emission and x-ray imaging crystal spectrometer.Therefore,the temperature profile is reconstructed by other diagnostic signals,and the average errors are within 5%.In addition,generalized regression neural network can also achieve this function to estimate the temperature profile with similar accuracy.Predicting electron temperature by neural network reveals that machine learning can be used as backup means for plasma information so as to enhance the reliability of diagnostics.展开更多
Relay-assisted transmission could effectively enhance the performance of Device-to-Device(D2D)communications when D2D user equipments(UEs)are too far away from each other or the quality of D2D channel is not good enou...Relay-assisted transmission could effectively enhance the performance of Device-to-Device(D2D)communications when D2D user equipments(UEs)are too far away from each other or the quality of D2D channel is not good enough for direct communications.Meanwhile,security is one of the major concerns for proximity services.The secure relay selection problem for D2D communications underlaying cellular network is studied in this paper.Firstly,we define a relay selection area and derive the closed-form of outage probability in D2D links using a Poisson Point Process(PPP)method.Next,in the defined relay selection area,we propose a secure relay selection scheme for the relay-assisted D2D communication system by exploiting the social relation as a security factor.Simulation results show that the scheme based on social relation can greatly improve the security performance of relay-assisted D2D communications.展开更多
The North China Craton(NCC)is a key region to study the destruction of the ancient craton.Two groups of phases(denoted as"Pw1"and"Pw2"),which are parallel to the PmP phase reflected from the Moho d...The North China Craton(NCC)is a key region to study the destruction of the ancient craton.Two groups of phases(denoted as"Pw1"and"Pw2"),which are parallel to the PmP phase reflected from the Moho discontinuity and the PLP phase reflected from the Lithosphere and Asthenosphere Boundary(LAB)respectively,are found on the record section of the Rongcheng-XinzhouAlxa long-range deep seismic sounding profile.The nature of the two phases is still unclear,although they are clearly observable and reverberant.In this paper,we use travel time inversion and amplitude forward modelling to fit the reflected and refracted phases in the lithosphere.The results show:(1)the Pw1 is a multiple reflected phase which is successively reflected by the crystalline basement,the surface,the Moho and then finally received on the surface;(2)the Pw2 phase is also a multiple reflected phase successively reflected by the crystalline basement,the surface,the LAB interface and then received on the surface.We conclude that the significant velocity difference between the thick sedimentary cover and the crystalline basement in the North China rifted basin may be the main reason for generating the multiple reflections.Furthermore,the two multiple reflections provide potent constraints on the lithospheric velocity model,and constitute seismological evidence for the lithospheric thinning in the eastern NCC.展开更多
基金Stable Support Plan Program,Grant/Award Number:20200925174052004Shenzhen Natural Science Fund,Grant/Award Number:JCYJ20200109140820699+2 种基金National Natural Science Foundation of China,Grant/Award Number:82272086Guangdong Provincial Department of Education,Grant/Award Numbers:2020ZDZX3043,SJZLGC202202Guangdong Provincial Key Laboratory,Grant/Award Number:2020B121201001。
文摘Eye health has become a global health concern and attracted broad attention.Over the years,researchers have proposed many state-of-the-art convolutional neural networks(CNNs)to assist ophthalmologists in diagnosing ocular diseases efficiently and precisely.However,most existing methods were dedicated to constructing sophisticated CNNs,inevitably ignoring the trade-off between performance and model complexity.To alleviate this paradox,this paper proposes a lightweight yet efficient network architecture,mixeddecomposed convolutional network(MDNet),to recognise ocular diseases.In MDNet,we introduce a novel mixed-decomposed depthwise convolution method,which takes advantage of depthwise convolution and depthwise dilated convolution operations to capture low-resolution and high-resolution patterns by using fewer computations and fewer parameters.We conduct extensive experiments on the clinical anterior segment optical coherence tomography(AS-OCT),LAG,University of California San Diego,and CIFAR-100 datasets.The results show our MDNet achieves a better trade-off between the performance and model complexity than efficient CNNs including MobileNets and MixNets.Specifically,our MDNet outperforms MobileNets by 2.5%of accuracy by using 22%fewer parameters and 30%fewer computations on the AS-OCT dataset.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China(Nos.2018YFE0309100 and 2019YFE03010004)National Natural Science Foundation of China(No.51821005)。
文摘A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.
基金supported by the National Natural Science Foundation of China(81674100).
文摘Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood cells.Methods:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific emotions.Relative expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also determined.Results:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative emotions.Relative gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia groups.Regarding the emotional score of disgust on video stage,the main effect was significant(F=335.58,P<.001),which showed that watching the three videos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency groups.The symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional status.Our findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological problems and negative emotions,particularly disgust.We also demonstrate that emotional regulation is related to mir191-Riok3-Mxi1 pathway activity,identifying these pathway components are potential targets for genetic therapies in combination with psychological therapy.
基金funded by the Science and Technology Plan of Inner Mongolia Autonomous Region(no.2022YFSH0097)the Medical Research Advancement Fund Project(no.TB212014).
文摘Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be elucidated.This study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric cancer.Methods:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere collected.Clinical andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment groups.Efficacy was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement scale.Results:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs group.There were no significant differences in baseline characteristics between the 2 groups.Compared with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy group.The enhanced efficacy of immune combination with SOX is evident,as demonstrated by the significantly prolonged surgical duration in operated patients(206.6±26.6 min vs 197.8±19.8 min,P=0.35)and intraoperative blood loss(158.9±21.2 mL vs 148.9±25.1 mL,P=0.59).No significant differences were observed in postoperative complications.Conclusions:Compared with the SOX conversion therapy regimen,SOX combined with ICIs demonstrated higher conversion rates,R0 resection rates,pathological response rates,and disease-free survival without increasing surgical difficulty or complications.Nonoperable patients also experienced longer progression-free survival and objective response rates.
基金Hebei Provincial Department of Science and Technology Youth Science Fund Project(Project number:C2022407007)。
文摘Undergraduate graduation design is an important link in the process of undergraduate training,and university platforms have invested a lot of manpower and material resources for this purpose.However,while carrying out student training,it has gradually become the consensus of most university platforms to achieve a win-win situation for teachers and training platforms in order to achieve optimization of resource allocation and motivation of student training.After discussion and practice,this paper proposes a set of undergraduate graduation design training concepts and training modes with a win-win situation for students,teachers,and training platforms.
基金Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Research Project of Tianjin Municipal Administration of Traditional Chinese Medicine(2021106)Beijing-Tianjin-Hebei Traditional Chinese Medicine Collaborative Development Specialty Alliance Construction Project(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Qingxian County Traditional Chinese Medicine Hospital).
文摘Prostate cancer is a common male malignant tumor,and bone metastasis is one of the common complications in the late stage of prostate cancer.The mechanism of prostate cancer bone metastasis is a complex process involving multiple factors and steps.In recent years,with in-depth research on the mechanism of prostate cancer bone metastasis and the development of new drugs,important progress has been made in the treatment of prostate cancer bone metastasis.Based on this,this article introduces the mechanism of prostate cancer bone metastasis and the research progress of several bone-targeted drugs to provide reference and inspiration for future research.
基金financially supported by National Natural Science Foundation of China (Nos. U22A20193 and 51975218)Fundamental Research Funds for the Central Universities(No. 2022ZYGXZR101)+3 种基金Natural Science Foundation of Guangdong Province (No. 2021A1515010642)GuangdongHong Kong Joint Innovation Project of Guangdong Province(No. 2021A0505110002)Guangdong-Foshan Joint Foundation (No. 2021B1515120031)Innovation Group Project of Foshan (No. 2120001010816)
文摘The lithium-sulfur(Li-S)battery with an ultrahigh theoretical energy density has emerged as a promising rechargeable battery system.However,the practical applications of Li-S batteries are severely plagued by the sluggish reaction kinetics of sulfur species and notorious shuttling of soluble lithium polysulfides(LiPSs)intermediates that result in low sulfur utilization.The introduction of functional layers on separators has been considered as an effective strategy to improve the sulfur utilization in Li-S batteries by achieving effective regulation of LiPSs.Herein,a promising self-assembly strategy is proposed to achieve the low-cost fabrication of hollow and hierarchically porous Fe_(3)O_(4)nanospheres(p-Fe_(3)O_(4)-NSs)assembled by numerous extremely-small primary nanocrystals as building blocks.The rationally-designed p-Fe_(3)O_(4)-NSs are utilized as a multifunctional layer on the separator with highly efficient trapping and conversion features toward LiPSs.Results demonstrate that the nanostructured p-Fe_(3)O_(4)-NSs provide chemical adsorption toward LiPSs and kinetically promote the mutual transformation between LiPSs and Li_(2)S_(2)/Li_(2)S during cycling,thus inhibiting the LiPSs shuttling and boosting the redox reaction kinetics via a chemisorption-catalytic conversion mechanism.The enhanced wettability of the p-Fe_(3)O_(4)-NSs-based separator with the electrolyte enables fast transportation of lithium ions.Benefitting from these alluring properties,the functionalized separator with p-Fe_(3)O_(4)-NSs endows the battery with an admirable rate performance of 877 mAh g^(−1)at 2 C,an ultra-durable cycling performance of up to 2176 cycles at 1 C,and a promising areal capacity of 4.55 mAh cm^(−2)under high-sulfur-loading and lean-electrolyte conditions(4.29 mg cm^(−2),electrolyte/ratio:8μl mg^(−1)).This study will offer fresh insights on the rational design and low-cost fabrication of multifunctional separator to strengthen electrochemical reaction kinetics by regulating LiPSs conversion for developing efficient and long-life Li-S batteries.
基金supported by the National Magnetic Confinement Fusion Science Program of China(Nos.2018YFE0301104 and 2018YFE0301100)National Natural Science Foundation of China(Nos.12075096 and 51821005)。
文摘Various types of plasma events emerge in specific parameter ranges and exhibit similar characteristics in diagnostic signals,which can be applied to identify these events.A semisupervised machine learning algorithm,the k-means clustering algorithm,is utilized to investigate and identify plasma events in the J-TEXT plasma.This method can cluster diverse plasma events with homogeneous features,and then these events can be identified if given few manually labeled examples based on physical understanding.A survey of clustered events reveals that the k-means algorithm can make plasma events(rotating tearing mode,sawtooth oscillations,and locked mode)gathering in Euclidean space composed of multi-dimensional diagnostic data,like soft x-ray emission intensity,edge toroidal rotation velocity,the Mirnov signal amplitude and so on.Based on the cluster analysis results,an approximate analytical model is proposed to rapidly identify plasma events in the J-TEXT plasma.The cluster analysis method is conducive to data markers of massive diagnostic data.
基金Project supported by the Natural Science Foundation of the Anhui Higher Education Institutions (Grant Nos. KJ2020A0248 and 2022AH050310)。
文摘This paper is concerned with finite-time H_(∞) filtering for Markov jump systems with uniform quantization. The objective is to design quantized mode-dependent filters to ensure that the filtering error system is not only mean-square finite-time bounded but also has a prescribed finite-time H_(∞) performance. First, the case where the switching modes of the filter align with those of the MJS is considered. A numerically tractable filter design approach is proposed utilizing a mode-dependent Lyapunov function, Schur’s complement, and Dynkin’s formula. Then, the study is extended to a scenario where the switching modes of the filter can differ from those of the MJS. To address this situation, a mode-mismatched filter design approach is developed by leveraging a hidden Markov model to describe the asynchronous mode switching and the double expectation formula. Finally, a spring system model subject to a Markov chain is employed to validate the effectiveness of the quantized filter design approaches.
基金supported by the National MCF Energy R&D Program of China (No.2018YFE0310300)National Natural Science Foundation of China (No.51821005)。
文摘The detailed density perturbations provided by the advanced polarimeter-interferometer system(Polaris) during sawtooth collapse on the Joint Texas Experimental Tokamak(J-TEXT) are reported in this article.During a sawtooth collapse and the crash of plasma pressure at the center,it is found that the increase in density in the region between the inversion radius and mixing radius is poloidally asymmetrical,while the increase in temperature is poloidally symmetrical.The poloidal location where the density increases is dependent on the phase of the precursory m/n=1/1 kink mode.It is always out of phase with the hot core of the m/n=1/1 mode.The behaviors of density perturbations during sawtooth collapse observed in J-TEXT are beyond the expectations of the standard model,and this can shed new light on the understanding of sawtooth collapse.
基金Acknowledgement The authors thank the financial support from the National Natural Science Foundation of China （Grant No. 50705043, 60535020 and 60910007）.
文摘Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied to bionic robotic actuators, artificial muscles, as well as dynamic sensors. However, IPMC has the major drawback of low generative blocking force. In this paper, in order to enhance the blocking force, the Nation membranes with thickness of 0.22 mm, 0.32 mm, 0.42 mm, 0.64 mm and 0.8 mm were prepared by casting from liquid solution. By employing these Nation membranes, IPMCs with varying thickness were fabricated by electroless plating. The elastic modulus of the casted Nation membranes were obtained by a nano-indenter, and the current, the displacement and the blocking force were respectively measured by the apparatus for actuation test. Finally, the effects of the thickness on the performance of IPMC were analyzed with an electromechanical model. Experimental study and theory analysis indicate that as the thickness increases, the elastic modulus of Nation membrane and the blocking force of IPMC increase, however, the current and the displacement decrease.
基金supported by the National Natural Science Foundation of China(11075113)
文摘Ni-Co bimetallic catalysts with different Ni/Co content were derived from cold plasma jet decomposition and reduction of hydrotalcite-like compounds containing Ni,Co,Mg and Al,and their catalytic performance was investigated with dry reforming of methane.Experimental results showed that the hydrotalcite-like precursors could be completely decomposed and partly reduced by cold plasma jet,and the Nicontained catalysts exhibited much higher activity than the catalyst without Ni.Especially,the catalyst with Ni/Co ratio of 8/2 achieved not only the highest conversions of 80.3%and 69.3%for CH4 and CO2,respectively,but also the best stability in 100 h testing.The catalysts were characterized by XRD,XPS,TEM and N2 adsorption techniques,and the results showed that the better performance of the 8Ni2Co bimetallic catalyst was attributed to its higher metal dispersion,smaller metal particle size,as well as the interaction effect between Ni and Co,which were brought by the special catalyst preparation method.
基金funded by NSFC (No. 40872137)Hebei Natural Foundation (No. D2015403013)+1 种基金Science and Technology Research Project of Colleges and Universities in Hebei Province (No. ZC2016060)Doctor Foundation of Hebei GEO University (No. BQ201320)
文摘The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma.
基金supported by the National Magnetic Confinement Fusion Science Program of China(Nos.2014GB118000,2014GB106001,2015GB111001,2015GB111002 and 2015GB120003)National Natural Science Foundation of China(Nos.11505069,11275079 and 11405068)
文摘The J-TEXT tokamak has been operated for ten years since its first plasma obtained at the end of 2007. The diagnostics development and main modulation systems, i.e. resonant magnetic perturbation （RMP） systems and massive gas injection （MGI） systems, will be introduced in this paper. Supported by these efforts, J-TEXT has contributed to research on several topics, especially on RMP physics and disruption mitigation. Both experimental and theoretical research show that RMP could lock, suppress or excite the tearing modes, depending on the RMP amplitude, frequency difference between RMP and rational surface rotation, and initial stabilities. The plasma rotation, particle transport and operation region are influenced by the RMP. Utilizing the MGI valves, disruptions have been mitigated with pure He, pure Ne, and a mixture of He and Ar （9：1）. A significant runaway current plateau could be generated with moderate amounts of Ar injection. The RMP has been shown to suppress the generation of runaway current during disruptions.
文摘Heart arrhythmia is a group of irregular heartbeat conditions and is usually detected by electrocardiograms(ECG)signals.Over the past years,deep learning methods have been developed to classify different types of heart arrhythmias through ECG based on computer-aided diagnosis systems(CADs),but these deep learning methods usually cannot trade-off between classification performance and parameters of deep learning methods.To tackle this problem,this work proposes a convolutional neural network(CNN)model named PDNet to recognize different types of heart arrhythmias efficiently.In the PDNet,a convolutional block named PDblock is devised,which is comprised of a pointwise convolutional layer and a depthwise convolutional layer.Furthermore,an improved loss function is utilized to improve the results of heart arrhythmias classification.To verify the proposed CNN model,extensive experiments are conducted on publicMIT-BIH ECG databases.The experimental results demonstrate that the proposed PDNet achieves an accuracy of 98.2%accuracy and outperforms state-of-the-art methods about 2%.
文摘An active thermo-acoustic network model of regenerator which is a key component to accomplish the con-version between thermal-and acoustic power in thermo-acoustic system has been established in this paper. The experiment was carried out to quantify the network. A method called least square is employed in order to identify the H matrix describing the system. The results obtained here show that the active thermo-acoustic network can reliably depict the characteristics of a thermo-acoustic system.
基金supported by the National MCF Energy R&D Program of China(Nos.2018YFE0301104 and 2018YFE0310300)National Natural Science Foundation of China(No.51821005)
文摘To extend the operation region of the Joint-Texas Experimental tokamak(J-TEXT) to the divertor configuration and even the H-mode,the divertor configuration discharge has been realized for the first time in the J-TEXT tokamak.Along with the establishment of a power supply for the divertor configuration,the construction of relevant diagnostics,and the installation of the divertor target on the high-field side,divertor discharge has been tested.Through the equilibrium calculation and position stability analysis,the control strategy has evolved to be more stable.High-density experiments and auxiliary heating experiments have been carried out on the divertor configuration.The special midplane single-null(MSN) divertor configuration is shown to be more stable than the limiter configuration in the density limit condition and can reach a higher density in the experiment.In the ECRH experiment,the power injection enhances the electron temperature and density,while more heat outflux is loaded on the divertor target tiles and causes more intensive recycling and impurity release.The future plan for the divertor configuration operation in the J-TEXT tokamak is also included.
基金supported by the National Magnetic Confinement Fusion Science Program(Nos.2018YFE0301104,2018YFE0301100)State Key Laboratory of Advanced Electromagnetic Engineering and Technology(No.AEET2020KF001)National Natural Science Foundation of China(Nos.12075096,51821005)。
文摘The reliability of diagnostic systems in tokamak plasma is of great significance for physics researches or fusion reactor.When some diagnostics fail to detect information about the plasma status,such as electron temperature,they can also be obtained by another method:fitted by other diagnostic signals through machine learning.The paper herein is based on a machine learning method to predict electron temperature,in case the diagnostic systems fail to detect plasma temperature.The fully-connected neural network,utilizing back propagation with two hidden layers,is utilized to estimate plasma electron temperature approximately on the J-TEXT.The input parameters consist of soft x-ray emission intensity,electron density,plasma current,loop voltage,and toroidal magnetic field,while the targets are signals of electron temperature from electron cyclotron emission and x-ray imaging crystal spectrometer.Therefore,the temperature profile is reconstructed by other diagnostic signals,and the average errors are within 5%.In addition,generalized regression neural network can also achieve this function to estimate the temperature profile with similar accuracy.Predicting electron temperature by neural network reveals that machine learning can be used as backup means for plasma information so as to enhance the reliability of diagnostics.
基金This work is supported by the National Natural Science Foundation of China under Grant No.61371188and the National Key R&D Plan under Grant No.2017YFC0803403.
文摘Relay-assisted transmission could effectively enhance the performance of Device-to-Device(D2D)communications when D2D user equipments(UEs)are too far away from each other or the quality of D2D channel is not good enough for direct communications.Meanwhile,security is one of the major concerns for proximity services.The secure relay selection problem for D2D communications underlaying cellular network is studied in this paper.Firstly,we define a relay selection area and derive the closed-form of outage probability in D2D links using a Poisson Point Process(PPP)method.Next,in the defined relay selection area,we propose a secure relay selection scheme for the relay-assisted D2D communication system by exploiting the social relation as a security factor.Simulation results show that the scheme based on social relation can greatly improve the security performance of relay-assisted D2D communications.
基金This research is financially supported by the National Key Research and Development Program of China(No.2016YFC0600101)National Natural Science Foundation of China(Nos.90814012,41874065 and 41774097)the Doctor fund of Binzhou University(No.2018Y15)。
文摘The North China Craton(NCC)is a key region to study the destruction of the ancient craton.Two groups of phases(denoted as"Pw1"and"Pw2"),which are parallel to the PmP phase reflected from the Moho discontinuity and the PLP phase reflected from the Lithosphere and Asthenosphere Boundary(LAB)respectively,are found on the record section of the Rongcheng-XinzhouAlxa long-range deep seismic sounding profile.The nature of the two phases is still unclear,although they are clearly observable and reverberant.In this paper,we use travel time inversion and amplitude forward modelling to fit the reflected and refracted phases in the lithosphere.The results show:(1)the Pw1 is a multiple reflected phase which is successively reflected by the crystalline basement,the surface,the Moho and then finally received on the surface;(2)the Pw2 phase is also a multiple reflected phase successively reflected by the crystalline basement,the surface,the LAB interface and then received on the surface.We conclude that the significant velocity difference between the thick sedimentary cover and the crystalline basement in the North China rifted basin may be the main reason for generating the multiple reflections.Furthermore,the two multiple reflections provide potent constraints on the lithospheric velocity model,and constitute seismological evidence for the lithospheric thinning in the eastern NCC.
