Background:We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and the risk for idiopathic generalized epilepsies(IGEs).Methods:Medline,Embase,Cochrane Library and Chines...Background:We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and the risk for idiopathic generalized epilepsies(IGEs).Methods:Medline,Embase,Cochrane Library and Chinese National Knowledge Infrastructure(CNKI)databases were searched for eligible studies(until May 5,2020)on the association between GABRG2 rs211037 polymorphism and IGE.The odds ratios were calculated using a fixed or random model in STATA 15.0 software.Subgroup analyses for ethnicity,age,source of controls,type of seizure syndrome and therapeutic responses were conducted.Results:We found no significant associations between GABRG2 rs211037 polymorphism and the susceptibility to IGEs.In addition,no significant association was detected between GABRG2 rs211037 polymorphism and drug resistance in IGE patients.The results did not change after stratification by Asian population,healthy controls,children,juvenile myoclonic epilepsy,and childhood absence epilepsy.Conclusion:The current studies indicated that the GABRG2 rs211037 polymorphism was not related to susceptibility or drug resistance of IGE.Further well-designed studies are needed to verify the results.展开更多
Picornaviridae are a family of small positive-strand RNA viruses,and transmitted via the respiratory or fecal-oral route.The neurotropic picornaviruses can induce acute or late recurrent seizures following central ner...Picornaviridae are a family of small positive-strand RNA viruses,and transmitted via the respiratory or fecal-oral route.The neurotropic picornaviruses can induce acute or late recurrent seizures following central nervous system infection,by infecting the peripheral nerve,crossing the blood-brain barrier and migrating in the Trojan-horse method.Theiler’s murine encephalomyelitis virus(TMEV),as a member of Picornaviridae family,can cause encephalitis,leading to chronic spontaneous seizures.TMEV-infected C57BL/6 mice have been used as an animal model for exploring the mechanism of epileptogenesis and assessing new antiepileptic drugs.Astrogliosis,neuronal death and microglial recruitment have been detected in the hippocampus following the picornaviruse-induced encephalitis.The macrophages,monocytes,neutrophils,as well as IL-6 and TNF-αreleased by them,play an important role in the epileptogenesis.In this review,we summarize the clinical characteristics of picornavirus infection,and the immunopathology involved in the TMEV-induced epilepsy.展开更多
Background:Emerging evidence has implied that the GABRG2 gene play a role in the mechanism of febrile seizure(FS),however,the relationship between GABRG2 rs211037 polymorphism and the risk of FS remains controversial....Background:Emerging evidence has implied that the GABRG2 gene play a role in the mechanism of febrile seizure(FS),however,the relationship between GABRG2 rs211037 polymorphism and the risk of FS remains controversial.This meta-analysis was conducted to investigate the relationship of GABRG2 rs211037 polymorphism with the susceptibility to FS.Methods:MEDLINE,Embase,Cochrane Library and CNKI databases were searched(until April 6,2019)for eligible studies on the relationship between GABRG2 rs211037 polymorphism and FS.We calculated the odds ratios(ORs)by a fixed or random model with the STATA 15.0 software.Subgroup analyses for the ethnicity,the source of the control,and age and sex matching of controls were conducted.Results:A total of 8 studies consisting of 775 FS patients and 5162 controls were included in this study.Based on the overall data,he GABRG2 rs211037 polymorphism was not significantly associated with the risk of FS(TT+CT vs CC:OR=0.95,95%CI 0.64–1.41,P=0.80).Notably,the GABRG2 rs211037 variant was significantly associated with decreased risk of FS in Asian populations(TT vs CT+CC:OR=0.63,95%CI 0.45–0.88,P=0.006),but increased risk in Caucasian populations(CT vs CC:OR=1.56,95%CI 1.14–2.15,P=0.006).Significant associations were also detected when healthy controls out of the whole controls were employed for comparison(TT vs CT+CC:OR=0.59,95%CI 0.45–0.77,P<0.001)and when data from studies with age-and sex-matched controls were used(TT+CT vs CC:OR=0.60,95%CI 0.43–0.86,P=0.001).Conclusion:The GABRG2 rs211037 polymorphism may decrease the risk of FS in Asian populations,while increasing the risk in Caucasian populations.Further well-designed studies with large sample sizes are essential to verify the conclusions in other ethnicities.展开更多
基金supported by the National Natural Science Foundation of Shandong,China(item number ZR2019PH040)the National Natural Science Foundation of China(item number 81901321).
文摘Background:We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and the risk for idiopathic generalized epilepsies(IGEs).Methods:Medline,Embase,Cochrane Library and Chinese National Knowledge Infrastructure(CNKI)databases were searched for eligible studies(until May 5,2020)on the association between GABRG2 rs211037 polymorphism and IGE.The odds ratios were calculated using a fixed or random model in STATA 15.0 software.Subgroup analyses for ethnicity,age,source of controls,type of seizure syndrome and therapeutic responses were conducted.Results:We found no significant associations between GABRG2 rs211037 polymorphism and the susceptibility to IGEs.In addition,no significant association was detected between GABRG2 rs211037 polymorphism and drug resistance in IGE patients.The results did not change after stratification by Asian population,healthy controls,children,juvenile myoclonic epilepsy,and childhood absence epilepsy.Conclusion:The current studies indicated that the GABRG2 rs211037 polymorphism was not related to susceptibility or drug resistance of IGE.Further well-designed studies are needed to verify the results.
基金supported by the National Natural Science Foundation of Shandong,China(ZR2019PH040)the National Natural Science Foundation of China(81901321).
文摘Picornaviridae are a family of small positive-strand RNA viruses,and transmitted via the respiratory or fecal-oral route.The neurotropic picornaviruses can induce acute or late recurrent seizures following central nervous system infection,by infecting the peripheral nerve,crossing the blood-brain barrier and migrating in the Trojan-horse method.Theiler’s murine encephalomyelitis virus(TMEV),as a member of Picornaviridae family,can cause encephalitis,leading to chronic spontaneous seizures.TMEV-infected C57BL/6 mice have been used as an animal model for exploring the mechanism of epileptogenesis and assessing new antiepileptic drugs.Astrogliosis,neuronal death and microglial recruitment have been detected in the hippocampus following the picornaviruse-induced encephalitis.The macrophages,monocytes,neutrophils,as well as IL-6 and TNF-αreleased by them,play an important role in the epileptogenesis.In this review,we summarize the clinical characteristics of picornavirus infection,and the immunopathology involved in the TMEV-induced epilepsy.
基金supported by the National Natural Science Foundation of Shandong,China(ZR2019PH040)the National Natural Science Foundation of China(81901321).
文摘Background:Emerging evidence has implied that the GABRG2 gene play a role in the mechanism of febrile seizure(FS),however,the relationship between GABRG2 rs211037 polymorphism and the risk of FS remains controversial.This meta-analysis was conducted to investigate the relationship of GABRG2 rs211037 polymorphism with the susceptibility to FS.Methods:MEDLINE,Embase,Cochrane Library and CNKI databases were searched(until April 6,2019)for eligible studies on the relationship between GABRG2 rs211037 polymorphism and FS.We calculated the odds ratios(ORs)by a fixed or random model with the STATA 15.0 software.Subgroup analyses for the ethnicity,the source of the control,and age and sex matching of controls were conducted.Results:A total of 8 studies consisting of 775 FS patients and 5162 controls were included in this study.Based on the overall data,he GABRG2 rs211037 polymorphism was not significantly associated with the risk of FS(TT+CT vs CC:OR=0.95,95%CI 0.64–1.41,P=0.80).Notably,the GABRG2 rs211037 variant was significantly associated with decreased risk of FS in Asian populations(TT vs CT+CC:OR=0.63,95%CI 0.45–0.88,P=0.006),but increased risk in Caucasian populations(CT vs CC:OR=1.56,95%CI 1.14–2.15,P=0.006).Significant associations were also detected when healthy controls out of the whole controls were employed for comparison(TT vs CT+CC:OR=0.59,95%CI 0.45–0.77,P<0.001)and when data from studies with age-and sex-matched controls were used(TT+CT vs CC:OR=0.60,95%CI 0.43–0.86,P=0.001).Conclusion:The GABRG2 rs211037 polymorphism may decrease the risk of FS in Asian populations,while increasing the risk in Caucasian populations.Further well-designed studies with large sample sizes are essential to verify the conclusions in other ethnicities.
