The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities.The hepatobiliary system originates from the foregut endoderm,in which cells undergo multiple events...The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities.The hepatobiliary system originates from the foregut endoderm,in which cells undergo multiple events of cell proliferation,migration,and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription factors.Studies on liver development and diseases have revealed that SRY-related high-mobility group box 9(SOx9)plays an important role in liver embryogenesis and the progression of hepatobiliary diseases.sox9 is not only a master regulator of cell fate determination and tissue morphogenesis,but also regulates various biological features of cancer,including cancer stemness,invasion,and drug resistance,making Sox9 a potential biomarker for tumor prognosis and progression.This review systematically summarizes the latest findings of sox9 in hepatobiliary development,homeostasis,and disease.We also highlight the value of sox9 as a novel biomarker and potential target for the clinical treatment of major liverdiseases.展开更多
Carrier migration path and driving forces are two crucial factors for charge separation of heterojunction with efficient photoelectric response from the thermodynamic and kinetic perspectives,respectively.Constructing...Carrier migration path and driving forces are two crucial factors for charge separation of heterojunction with efficient photoelectric response from the thermodynamic and kinetic perspectives,respectively.Constructing the S-scheme heterojunction and achieving an efficient migration path for space charge separation have aroused great interest,while a thorough insight into tuning interfacial band bending for S-scheme heterojunction is absent.Herein,we report a class of Zn atom-doped CeO_(2)/g-C_(3)N_(4) heterostructure for achieving a new carrier migration path conversion from inferior type-II to advanced S-scheme.Zn-dependent volcano-type plot for Zn-CeO_(2) is established to tune the Fermi level of CeO_(2).The built-in electric field for carrier flow dynamics strengthens when coupling with g-C_(3)N_(4),which significantly boosts the photoelectric response.Based on the intrinsic enzymelike activity of Zn-CeO_(2),we further demonstrate that the Zn-CeO_(2)/g-C_(3)N_(4) S-scheme heterojunction can be explored for constructing a sensitive nanozymatic photoelectrochemical biosensor for the detection of acetylcholinesterase.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82172895,81670516)the Funds for CreativeResearch Groups of China(No.81521091)the Clinical Research Plan of Shanghai Hospital Development Center(SHDC,China)(No.SHDC2020CR2011A).
文摘The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities.The hepatobiliary system originates from the foregut endoderm,in which cells undergo multiple events of cell proliferation,migration,and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription factors.Studies on liver development and diseases have revealed that SRY-related high-mobility group box 9(SOx9)plays an important role in liver embryogenesis and the progression of hepatobiliary diseases.sox9 is not only a master regulator of cell fate determination and tissue morphogenesis,but also regulates various biological features of cancer,including cancer stemness,invasion,and drug resistance,making Sox9 a potential biomarker for tumor prognosis and progression.This review systematically summarizes the latest findings of sox9 in hepatobiliary development,homeostasis,and disease.We also highlight the value of sox9 as a novel biomarker and potential target for the clinical treatment of major liverdiseases.
基金supported by the National Natural Science Foundation of China(22104114)the Natural Science Foundation of Hubei Province(2021CFB518)+1 种基金the Fundamental Research Funds for the Central Universities(CCNU22JC006)the Program of Introducing Talents of Discipline to Universities of China(111 Program,B17019)。
文摘Carrier migration path and driving forces are two crucial factors for charge separation of heterojunction with efficient photoelectric response from the thermodynamic and kinetic perspectives,respectively.Constructing the S-scheme heterojunction and achieving an efficient migration path for space charge separation have aroused great interest,while a thorough insight into tuning interfacial band bending for S-scheme heterojunction is absent.Herein,we report a class of Zn atom-doped CeO_(2)/g-C_(3)N_(4) heterostructure for achieving a new carrier migration path conversion from inferior type-II to advanced S-scheme.Zn-dependent volcano-type plot for Zn-CeO_(2) is established to tune the Fermi level of CeO_(2).The built-in electric field for carrier flow dynamics strengthens when coupling with g-C_(3)N_(4),which significantly boosts the photoelectric response.Based on the intrinsic enzymelike activity of Zn-CeO_(2),we further demonstrate that the Zn-CeO_(2)/g-C_(3)N_(4) S-scheme heterojunction can be explored for constructing a sensitive nanozymatic photoelectrochemical biosensor for the detection of acetylcholinesterase.
