期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Transporters(OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription 被引量:6
1
作者 Ze Wang Haihua Shang +12 位作者 Yazhuo Li Chen Zhang Yan Dong Tao Cui Hongbing Zhang xiaoyan ci Xiulin Yi Tiejun Zhang Fengying Yan Yaping Zhang Xing Huang Weidang Wu Changxiao Liu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第9期1646-1657,共12页
Various medicinal ingredients with different tastes are combined according to the theory of compatibility in Chinese materia medica to achieve a better efficacy,while the mechanism was not very clear.Here,the authors ... Various medicinal ingredients with different tastes are combined according to the theory of compatibility in Chinese materia medica to achieve a better efficacy,while the mechanism was not very clear.Here,the authors studied the interaction between ingredients and human transporters such as the kidney transporters OAT1 and OAT3,the liver transporters OATP1 B1 and OATP1 B3,and the intestine transporter OATP2 B1 to discern the compatibility mechanism of ingredients with different tastes in the Yuanhuzhitong preparation(YHP)comprising Corydalis yanhusuo(CYH)and Angelica dahurica(AD),which could relieve pain by restraining the central system.The results show that tetrahydropalmatine(TDE),the major component of CYH,could be transported by OAT3 into kidney,OATP1 B1 and OATP1 B3 into liver,while imperatorin(IPT)and isoimperatorin(ISP),the two key components of AD,and AD extract showed strong inhibition to OAT1 and OAT3.What’s more,AD extract also exerted strongly inhibition to human transporters OATP1 B1 and OATP1 B3.It was also detected that IPT,ISP,and AD extract significantly downregulated the expression of Oatplal,Oafp1 a4,and Oatp1 b2 of liver in mice.The in vivo results show that the concentration of TDE in liver and kidney significantly decreased,while the TDE concentration in blood and brain were both significantly enhanced in the presence of IPT,ISP,and AD extract.These results suggest that the ingredients in AD with pungent taste could enhance the exposure of TDE in blood and brain by inhibiting the uptake of TDE in liver and kidney.That is to say,TDE with bitter taste could"flood up"into the central nervous system to play its therapeutic effect by the cut-off of that into liver and kidney in the presence of ingredients within AD.This paper not only proves the meridian distribution of CYH in liver and kidney with the role of OAT3,OATP1 B1,and OATP1 B3,but also illustrates how to improve the efficacy of CYH by reasonable compatibility with AD.This study may offer a valuable clue to illustrate the mechanism of compatibility theory. 展开更多
关键词 Transporters Drug-drug interaction Yuanhuzhitong prescription OAT1 OAT3 OATP1B1 OATP1B3 OATP2B1
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部