Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the an...Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.展开更多
Despite the dazzling theoretical capacity,the devasting electrochemical activity of Li_(2)MnO_(3)(LMO)caused by the difficult oxidation of Mn4+impedes its practical application as the lithium-ion battery(LIB)cathode.T...Despite the dazzling theoretical capacity,the devasting electrochemical activity of Li_(2)MnO_(3)(LMO)caused by the difficult oxidation of Mn4+impedes its practical application as the lithium-ion battery(LIB)cathode.The efficacious activation of the Li_(2)MnO_(3) by importing electrochemically active Mn3+ions or morphological engineering is instrumental to its lithium storage activity and structural integrity upon cycling.Herein,we propose a conceptual strategy with metal-organic frameworks(MOFs)as self-sacrificial templates to prepare oxygen-deficient Li_(2)MnO_(3)(O_v-LMO)for exalted lithium storage performance.Attributed to optimized morphological features,LMO materials derived from Mn-BDC(H_(2)BDC=1,4-dicarboxybenzene)delivered superior cycling/rate performances compared with their counterparts derived from Mn-BTC(H_(3)BTC=1,3,5-benzenetricarboxylicacid)and Mn-PTC(H_(4)PTC=pyromellitic acid).Both experimental and theoretical studies elucidate the efficacious activation of primitive LMO materials toward advanced lithium storage by importing oxygen deficiencies.Impressively,O_v-LMO derived from Mn-BDC(O_v-BDC-LMO)delivered intriguing reversible capacities(179.2 mA h g^(-1)at 20 mA g^(-1)after 200 cycles and 100.1 mA h g^(-1)at 80 mA g^(-1)after 300 cycles),which can be attributed to the small particle size that shortens pathways for Li+/electron transport,the enhanced redox activity induced by abundant oxygen vacancies,and the optimized electronic configuration that contributes to the faster lithium diffusivity.This work provides insights into the rational design of LMO by morphological and atomic modulation to direct its activation and practical application as an advanced LIB cathode.展开更多
This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed...This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed into a set of algebraic equations by operational matrix of block pulse functions. Then, we give error analysis and prove that the rate of convergence of this method is efficient. Lastly, a numerical example is given to confirm the method.展开更多
基金supported by the open project of the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,China (GMU-2022-HJZ-06)。
文摘Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.
基金the financial support from the Special Funds for the Cultivation of Guangdong College Students’Scientific and Technological Innovation(“Climbing Program”Special Funds,pdjh2023b0145)the Research and Development Plan Project in Key Fields of Guangdong Province(2020B0101030005)+1 种基金the Applied special project of Guangdong Provincial Science and Technology Plan(2017B090917002)the Basic and Applied Basic Research Fund of Guangdong Province(2019B1515120027)。
文摘Despite the dazzling theoretical capacity,the devasting electrochemical activity of Li_(2)MnO_(3)(LMO)caused by the difficult oxidation of Mn4+impedes its practical application as the lithium-ion battery(LIB)cathode.The efficacious activation of the Li_(2)MnO_(3) by importing electrochemically active Mn3+ions or morphological engineering is instrumental to its lithium storage activity and structural integrity upon cycling.Herein,we propose a conceptual strategy with metal-organic frameworks(MOFs)as self-sacrificial templates to prepare oxygen-deficient Li_(2)MnO_(3)(O_v-LMO)for exalted lithium storage performance.Attributed to optimized morphological features,LMO materials derived from Mn-BDC(H_(2)BDC=1,4-dicarboxybenzene)delivered superior cycling/rate performances compared with their counterparts derived from Mn-BTC(H_(3)BTC=1,3,5-benzenetricarboxylicacid)and Mn-PTC(H_(4)PTC=pyromellitic acid).Both experimental and theoretical studies elucidate the efficacious activation of primitive LMO materials toward advanced lithium storage by importing oxygen deficiencies.Impressively,O_v-LMO derived from Mn-BDC(O_v-BDC-LMO)delivered intriguing reversible capacities(179.2 mA h g^(-1)at 20 mA g^(-1)after 200 cycles and 100.1 mA h g^(-1)at 80 mA g^(-1)after 300 cycles),which can be attributed to the small particle size that shortens pathways for Li+/electron transport,the enhanced redox activity induced by abundant oxygen vacancies,and the optimized electronic configuration that contributes to the faster lithium diffusivity.This work provides insights into the rational design of LMO by morphological and atomic modulation to direct its activation and practical application as an advanced LIB cathode.
基金NSF Grants 11471105 of China, NSF Grants 2016CFB526 of Hubei Province, Innovation Team of the Educational Department of Hubei Province T201412, and Innovation Items of Hubei Normal University 2018032 and 2018105
文摘This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed into a set of algebraic equations by operational matrix of block pulse functions. Then, we give error analysis and prove that the rate of convergence of this method is efficient. Lastly, a numerical example is given to confirm the method.
