Pulmonary Hypertension(PH)is a global health problem that affects about 1%of the global population.Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease.The present study...Pulmonary Hypertension(PH)is a global health problem that affects about 1%of the global population.Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease.The present study proposes a Kernel Extreme Learning Machine(KELM)model based on an improved Whale Optimization Algorithm(WOA)for predicting PH mouse models.The experimental results showed that the selected blood indicators,including Haemoglobin(HGB),Hematocrit(HCT),Mean,Platelet Volume(MPV),Platelet distribution width(PDW),and Platelet–Large Cell Ratio(P-LCR),were essential for identifying PH mouse models using the feature selection method proposed in this paper.Remarkably,the method achieved 100.0%accuracy and 100.0%specificity in classification,demonstrating that our method has great potential to be used for evaluating and identifying mouse PH models.展开更多
The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach tow...The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach towards ultrahigh-performance semiconductor lasers for many key novel applications,as either stand-alone sources or on-chip sources in photonic integrated circuits.However,the fabrication of conventional buried Bragg grating structures on GaAs,GaAs/Si,GaSb,and other material platforms has been met with major material regrowth difficulties.We report a novel and universal approach of introducing laterally coupled dielectric Bragg gratings to semiconductor lasers that allows highly controllable,reliable,and strong coupling between the grating and the optical mode.We implement such a grating structure in a low-loss amorphous silicon material alongside GaAs lasers with InAs/GaAs QD gain layers.The resulting DFB laser arrays emit at pre-designed 0.8 THz local area network wavelength division multiplexing frequency intervals in the 1300 nm band with record performance parameters,including sidemode suppression ratios as high as 52.7 dB,continuous-wave output power of 26.6 mW(room temperature)and 6 mW(at 55℃),and ultralow relative intensity noise(RIN)of<-165 dB/Hz(2.5-20 GHz).The devices are also capable of isolator-free operating under very high external reflection levels of up to-12.3 dB while maintaining high spectral purity and ultralow RIN qualities.These results validate the novel laterally coupled dielectric grating as a technologically superior and potentially cost-effective approach for fabricating DFB and DBR lasers free of their semiconductor material constraints,which are thus universally applicable across different material platforms and wavelength bands.展开更多
Summary of main observation and conclusion This work presents the synthesis, crystal structure and properties of a novel noncentrosymmetric (NCS) coordination polymer (CP), namely,(Me2NH2)3[BaLi(2,6-PyDC)3(H2O)](1)(2,...Summary of main observation and conclusion This work presents the synthesis, crystal structure and properties of a novel noncentrosymmetric (NCS) coordination polymer (CP), namely,(Me2NH2)3[BaLi(2,6-PyDC)3(H2O)](1)(2,6-PyDC = pyridine-2,6-dicarboxylate acid), which represents the first example of BaLi-CPs with 2,6-PyDC ligand. Single-crystal X-ray structural analysis reveals that the compound features a two-dimensional (2D) layered structure. The simplified structure of each layer belongs to the hcb topology. The second harmonic generation (SHG) response of 1 is about 0.5 times that of KH2PO4 (KDP) marker. What is more, 1 emits bright blue light upon the excitation of 365 nm UV light with the quantum yield (QX Ф) of 1.63%. The successful con struction of this compound convinces the feasibility of constructing NCS CPs via the combi nation of [BaL3] unit and Li(l) ion.展开更多
Two fluoride sulfates,K_(2)Mn_(3)(SO_(4))_(3)F_(2)·4H_(2)O(Ⅰ) and Rb_(2)Mn_(3)(SO_(4))_(3)F_(2)·2H_(2)O (Ⅱ) are obtained by water solution method.Single-crystal X-ray diffraction analysis indicated that th...Two fluoride sulfates,K_(2)Mn_(3)(SO_(4))_(3)F_(2)·4H_(2)O(Ⅰ) and Rb_(2)Mn_(3)(SO_(4))_(3)F_(2)·2H_(2)O (Ⅱ) are obtained by water solution method.Single-crystal X-ray diffraction analysis indicated that they crystallize in space groups of Cmc2_(1.)Their structures feature a pseudo-KTP structure consisting of interconnecting[Mn_(3)(SO_(4))3F_(2)(H_(2)O)2]_(∞) layers,which are further packing along the a axis with alkali metal cations balancing the charges.The structure relationships between the two compounds are discussed.Secondharmonic generation measurements manifest that Ⅰ and Ⅱ have similar second-harmonic generation responses of about 0.2 and 0.25 times that of KH_(2)PO_(4).展开更多
基金the National Natural Science Foundation of China(82003831,62076185 and U1809209)the Project of Health Commission of Zhejiang Province(2020KY177)+2 种基金the Wenzhou Technology Foundation(Y2020002)the Natural Science Foundation of Zhejiang Province(LZ22F020005)the First Affiliated Hospital of Wenzhou Medical University Youth Excellence Project(QNYC114).
文摘Pulmonary Hypertension(PH)is a global health problem that affects about 1%of the global population.Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease.The present study proposes a Kernel Extreme Learning Machine(KELM)model based on an improved Whale Optimization Algorithm(WOA)for predicting PH mouse models.The experimental results showed that the selected blood indicators,including Haemoglobin(HGB),Hematocrit(HCT),Mean,Platelet Volume(MPV),Platelet distribution width(PDW),and Platelet–Large Cell Ratio(P-LCR),were essential for identifying PH mouse models using the feature selection method proposed in this paper.Remarkably,the method achieved 100.0%accuracy and 100.0%specificity in classification,demonstrating that our method has great potential to be used for evaluating and identifying mouse PH models.
基金National Key Research and Development Program of China(2018YFB2200201)Science and Technology Program of Guangzhou(202103030001)+2 种基金National Key R&D Program of Guangdong Province(2020B0303020001)Science Foundation of Guangzhou City for the Pearl River Star(201906010090)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01121).
文摘The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach towards ultrahigh-performance semiconductor lasers for many key novel applications,as either stand-alone sources or on-chip sources in photonic integrated circuits.However,the fabrication of conventional buried Bragg grating structures on GaAs,GaAs/Si,GaSb,and other material platforms has been met with major material regrowth difficulties.We report a novel and universal approach of introducing laterally coupled dielectric Bragg gratings to semiconductor lasers that allows highly controllable,reliable,and strong coupling between the grating and the optical mode.We implement such a grating structure in a low-loss amorphous silicon material alongside GaAs lasers with InAs/GaAs QD gain layers.The resulting DFB laser arrays emit at pre-designed 0.8 THz local area network wavelength division multiplexing frequency intervals in the 1300 nm band with record performance parameters,including sidemode suppression ratios as high as 52.7 dB,continuous-wave output power of 26.6 mW(room temperature)and 6 mW(at 55℃),and ultralow relative intensity noise(RIN)of<-165 dB/Hz(2.5-20 GHz).The devices are also capable of isolator-free operating under very high external reflection levels of up to-12.3 dB while maintaining high spectral purity and ultralow RIN qualities.These results validate the novel laterally coupled dielectric grating as a technologically superior and potentially cost-effective approach for fabricating DFB and DBR lasers free of their semiconductor material constraints,which are thus universally applicable across different material platforms and wavelength bands.
基金the National Natural Science Foundation of China (No. 21601181)NSF of Fujian Province (No. 2016J05054).
文摘Summary of main observation and conclusion This work presents the synthesis, crystal structure and properties of a novel noncentrosymmetric (NCS) coordination polymer (CP), namely,(Me2NH2)3[BaLi(2,6-PyDC)3(H2O)](1)(2,6-PyDC = pyridine-2,6-dicarboxylate acid), which represents the first example of BaLi-CPs with 2,6-PyDC ligand. Single-crystal X-ray structural analysis reveals that the compound features a two-dimensional (2D) layered structure. The simplified structure of each layer belongs to the hcb topology. The second harmonic generation (SHG) response of 1 is about 0.5 times that of KH2PO4 (KDP) marker. What is more, 1 emits bright blue light upon the excitation of 365 nm UV light with the quantum yield (QX Ф) of 1.63%. The successful con struction of this compound convinces the feasibility of constructing NCS CPs via the combi nation of [BaL3] unit and Li(l) ion.
基金financially supported by the National Natural Science Foundation of China(Nos.21833010,21525104,21971238,61975207,21921001)the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(No.ZDBS-LYSLH024)+1 种基金Key Laboratory of Functional Crystals and Laser Technology,TIPC,CAS(No.FCLT 202003)Key Laboratory of New Processing Technology for Nonferrous Metal&Materials,Ministry of Education/Guangxi Key Laboratory of Optical and Electronic Materials and Devices(No.20KF-11)。
文摘Two fluoride sulfates,K_(2)Mn_(3)(SO_(4))_(3)F_(2)·4H_(2)O(Ⅰ) and Rb_(2)Mn_(3)(SO_(4))_(3)F_(2)·2H_(2)O (Ⅱ) are obtained by water solution method.Single-crystal X-ray diffraction analysis indicated that they crystallize in space groups of Cmc2_(1.)Their structures feature a pseudo-KTP structure consisting of interconnecting[Mn_(3)(SO_(4))3F_(2)(H_(2)O)2]_(∞) layers,which are further packing along the a axis with alkali metal cations balancing the charges.The structure relationships between the two compounds are discussed.Secondharmonic generation measurements manifest that Ⅰ and Ⅱ have similar second-harmonic generation responses of about 0.2 and 0.25 times that of KH_(2)PO_(4).
