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芪丹通脉片调节TLR4信号通路抑制巨噬细胞泡沫化的研究 被引量:1
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作者 王南丁 马士航 +5 位作者 王文杰 刘兴林 胡乔斌 王新冰 郝伟 黄晓莉 《心脏杂志》 CAS 2019年第4期392-396,共5页
目的观察益气活血中药芪丹通脉片对氧化低密度脂蛋白(ox-LDL)诱导的RAW264.7细胞泡沫化进程、炎症指标及Toll样受体(TLR)4信号通路的影响。方法培养RAW264.7细胞,随机分为对照组、ox-LDL组及ox-LDL +芪丹通脉片(QDTM)组,各组细胞干预后... 目的观察益气活血中药芪丹通脉片对氧化低密度脂蛋白(ox-LDL)诱导的RAW264.7细胞泡沫化进程、炎症指标及Toll样受体(TLR)4信号通路的影响。方法培养RAW264.7细胞,随机分为对照组、ox-LDL组及ox-LDL +芪丹通脉片(QDTM)组,各组细胞干预后进行泡沫化诱导,分析各组细胞油红染色阳性面积,计算各组细胞泡沫化诱导率,收集细胞,ELISA法检测炎性因子肿瘤坏死因子(TNF)-α、白介素(IL)-6、C反应蛋白(CRP)表达水平,Real-time PCR及Western blot分析TLR4、分子核因子(NF)-κB表达水平。结果与对照组相比,ox-LDL组细胞泡沫化诱导率、TNF-α、IL-6、CRP水平显著升高(P < 0.05),TLR4、NF-κB表达水平明显上调,QDTM干预后,ox-LDL+QDTM组细胞泡沫化诱导率及TNF-α、IL-6、CRP水平较ox-LDL组显著下调(P < 0.05),同时TLR4、NF-κB表达水平较ox-LDL组明显下降。结论 QDTM能抑制TLR4信号通路及炎症反应、降低RAW264.7细胞泡沫化诱导率,抑制巨噬细胞泡沫化。 展开更多
关键词 不稳定斑块 芪丹通脉片 炎症反应 泡沫细胞 TLR4
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Micro-pinch formation and extreme ultraviolet emission of laser-induced discharge plasma
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作者 Jun-Wu wang xin-bing wang +1 位作者 Du-Luo Zuo Vassily S.Zakharov 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第9期355-363,共9页
Extreme ultraviolet(EUV)source produced by laser-induced discharge plasma(LDP)is a potential technical means in inspection and metrology.A pulsed Nd:YAG laser is focused on a tin plate to produce an initial plasma the... Extreme ultraviolet(EUV)source produced by laser-induced discharge plasma(LDP)is a potential technical means in inspection and metrology.A pulsed Nd:YAG laser is focused on a tin plate to produce an initial plasma thereby triggering a discharge between high-voltage electrodes in a vacuum system.The process of micro-pinch formation during the current rising is recorded by a time-resolved intensified charge couple device camera.The evolution of electron temperature and density of LDP are obtained by optical emission spectrometry.An extreme ultraviolet spectrometer is built up to investigate the EUV spectrum of Sn LDP at 13.5 nm.The laser and discharge parameters such as laser energy,voltage,gap distance,and anode shape can influence the EUV emission. 展开更多
关键词 laser-induced discharge plasma micro-pinch electron temperature and density extreme ultraviolet spectra
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Adaptive fractional window increment of TCP in multihop ad hoc networks
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作者 Liang-hui DING Wen-jun ZHANG +2 位作者 xin-bing wang Liang QIAN You-yun XU 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2009年第6期820-827,共8页
We propose an adaptive fractional window increasing algorithm (AFW) to improve the performance of the fractional window increment (FeW) in (Nahm et al., 2005). AFW fully utilizes the bandwidth when the network is idle... We propose an adaptive fractional window increasing algorithm (AFW) to improve the performance of the fractional window increment (FeW) in (Nahm et al., 2005). AFW fully utilizes the bandwidth when the network is idle, and limits the op-erating window when the network is congested. We evaluate AFW and compare the total throughput of AFW with that of FeW in different scenarios over chain, grid, random topologies and with hybrid traffics. Extensive simulation through ns2 shows that AFW obtains 5% higher throughput than FeW, whose throughput is significantly higher than that of TCP-Newreno, with limited modi-fications. 展开更多
关键词 TCP MULTIHOP Adaptive fractional window increasing algorithm (AFW)
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