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Application of Optical Hydrogels in Environmental Sensing
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作者 Shuo Yang Shruti Sarkar +2 位作者 xing xie Dan Li Jianmin Chen 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第3期311-336,共26页
The ever-increasing complexity of environmental pollutants urgently warrants the development of new detection technologies.Sensors based on the optical properties of hydrogels enabling fast and easy in situ detection ... The ever-increasing complexity of environmental pollutants urgently warrants the development of new detection technologies.Sensors based on the optical properties of hydrogels enabling fast and easy in situ detection are attracting increasing attention.In this paper,the data from 138 papers about different optical hydrogels(OHs)are extracted for statistical analysis.The detection performance and potential of various types of OHs in different environmental pollutant detection scenarios were evaluated and compared to those obtained using the standard detection method.Based on this analysis,the target recognition and sensing mechanisms of two main types of OHs are reviewed and discussed:photonic crystal hydrogels(PCHs)and fluorescent hydrogels(FHs).For PCHs,the environmental stimulus response,target receptors,inverse opal structures,and molecular imprinting techniques related to PCHs are reviewed and summarized.Furthermore,the different types of fluorophores(i.e.,compound probes,biomacromolecules,quantum dots,and luminescent microbes)of FHs are discussed.Finally,the potential academic research directions to address the challenges of applying and developing OHs in environmental sensing are proposed,including the fusion of various OHs,introduction of the latest technologies in various fields to the construction of OHs,and development of multifunctional sensor arrays. 展开更多
关键词 environmental sensors fluorescent hydrogel optical hydrogel photonic crystal hydrogel pollution detection
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Strong anharmonicity-assisted low lattice thermal conductivities and high thermoelectric performance in double-anion Mo_(2)AB_(2)(A=S,Se,Te;B=Cl,Br,I)semiconductors
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作者 廖海俊 黄乐 +4 位作者 谢兴 董华锋 吴福根 孙志鹏 李京波 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期600-608,共9页
The thermoelectric properties of layered Mo_(2)AB_(2)(A=S,Se,Te;B=Cl,Br,I)materials are systematically investigated by first-principles approach.Soft transverse acoustic modes and direct Mo d–Mo d couplings give rise... The thermoelectric properties of layered Mo_(2)AB_(2)(A=S,Se,Te;B=Cl,Br,I)materials are systematically investigated by first-principles approach.Soft transverse acoustic modes and direct Mo d–Mo d couplings give rise to strong anharmonicities and low lattice thermal conductivities.The double anions with distinctly different electronegativities of Mo_(2)AB_(2)monolayers can reduce the correlation between electron transport and phonon scattering,and further benefit much to their good thermoelectric properties.Thermoelectric properties of these Mo_(2)AB_(2)monolayers exhibit obvious anisotropies due to the direction-dependent chemical bondings and transport properties.Furthermore,their thermoelectric properties strongly depend on carrier type(n-type or p-type),carrier concentration and temperature.It is found that n-type Mo_(2)AB_(2)monolayers can be excellent thermoelectric materials with high electric conductivity,σ,and figures of merit,ZT.Choosing the types of A and B anions of Mo_(2)AB_(2)is an effective strategy to optimize their thermoelectric performance.These results provide rigorous understanding on thermoelectric properties of double-anions compounds and important guidance for achieving high thermoelectric performance in multi-anion compounds. 展开更多
关键词 THERMOELECTRICITY ANHARMONICITY lattice thermal conductivity anisotropy first-principles calculations
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Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China 被引量:4
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作者 Le Dang Linghua Kong +21 位作者 Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou xing xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2022年第5期496-509,共14页
Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 ... Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. 展开更多
关键词 Cervical cancer screening hrHPV-positive LBC triage strategy VIA/VILI
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Novel structures and mechanical properties of Zr_(2)N:Ab initio description under high pressures 被引量:1
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作者 Minru Wen xing xie +4 位作者 Zhixun xie Huafeng Dong Xin Zhang Fugen Wu Chong-Yu Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第1期434-442,共9页
With the formation of structural vacancies,zirconium nitrides(key materials for cutting coatings,super wearresistance,and thermal barrier coatings) display a variety of compositions and phases featuring both cation an... With the formation of structural vacancies,zirconium nitrides(key materials for cutting coatings,super wearresistance,and thermal barrier coatings) display a variety of compositions and phases featuring both cation and nitrogen enrichment.This study presents a systematic exploration of the stable crystal structures of zirconium heminitride combining the evolutionary algorithm method and ab initio density functional theory calculations at pressures of 0 GPa,30 GPa,60 GPa,90 GPa,120 GPa,150 GPa,and 200 GPa.In addition to the previously proposed phases P42/mnm-,Pnnn-,and Cmcm-Zr2 N,five new high-pressure Zr_(2)N phases of PA/nmm,IA/mcm,P2_(1)/m,P3 m1,and C2/m are discovered.An enthalpy study of these candidate configurations reveals various structural phase transformations of Zr2 N under pressure.By calculating the elastic constants and phonon dispersion,the mechanical and dynamical stabilities of all predicted structures are examined at ambient and high pressures.To understand the structure-property relationships,the mechanical properties of all Zr_(2)N compounds are investigated,including the elastic moduli,Vickers hardness,and directional dependence of Young’s modulus.The Cmncm-Zr2 N phase is found to belong to the brittle materials and has the highest Vickers hardness(12.9 GPa) among all candidate phases,while the I4/mcm-Zr2 N phase is the most ductile and has the lowest Vickers hardness(2.1 GPa).Furthermore,the electronic mechanism underlying the diverse mechanical behaviors of Zr2 N structures is discussed by analyzing the partial density of states. 展开更多
关键词 phase transition phonon dispersion Zr_(2)N first-principles calculations
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Boron at tera-Pascal pressures
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作者 Peiju Hu Junhao Peng +4 位作者 xing xie Minru Wen Xin Zhang Fugen Wu Huafeng Dong 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第3期444-448,共5页
The study of boron structure is fascinating because boron has various allotropes containing boron icosahedrons under pressure. Here, we propose a new boron structure(space group Fm3m) that is dynamically stable at 1.4... The study of boron structure is fascinating because boron has various allotropes containing boron icosahedrons under pressure. Here, we propose a new boron structure(space group Fm3m) that is dynamically stable at 1.4 tera-Pascal(TPa)using density functional theory and an evolutionary algorithm. The unit cell of this structure can be viewed as a structure with a boron atom embedded in the icosahedron. This structure behaves as a metal, and cannot be stable under ambient pressure. Furthermore, we found electrons gather in lattice interstices, which is similar to that of the semiconductor Na or Ca_(2)N-Ⅱ under high pressure. The discovery of this new structure expands our comprehension of high-pressure condensed matter and contributes to the further development of high-pressure science. 展开更多
关键词 BORON high-pressure prediction first principles USPEX
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Dependence of mechanical properties on the site occupancy of ternary alloying elements in γ'-Ni3Al: Ab initio description for shear and tensile deformation
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作者 Minru Wen xing xie +2 位作者 Huafeng Dong Fugen Wu Chong-Yu Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第7期560-566,共7页
The site occupancy behavior of ternary alloying elements inγ'-Ni3Al(a key strengthening phase of commercial Ni-based single-crystal superalloys)can change with temperature and alloy composition owing to the effec... The site occupancy behavior of ternary alloying elements inγ'-Ni3Al(a key strengthening phase of commercial Ni-based single-crystal superalloys)can change with temperature and alloy composition owing to the effect of entropy.Using a total-energy method based on density functional theory,the dependence of tensile and shear behaviors on the site preference of alloying elements inγ'-Ni3Al were investigated in detail.Our results demonstrate that Fe,Ru,and Ir can significantly improve the ideal tensile and shear strength of theγ'phase when occupying the Al site,with Ru resulting in the strongest enhancement.In contrast,elements with fully filled d orbitals(i.e.,Cu,Zn,Ag,and Cd)are expected to reduce the ideal tensile and shear strength.The calculated stress-strain relationships of Ni3Al alloys indicate that none of the alloying elements can simultaneously increase the ideal strength of theγ'phase for both Ni1-site and Ni2-site substitutions.In addition,the charge redistribution and the bond length of the alloying elements and host atoms during the tensile and shear processes are analyzed to unveil the underlying electronic mechanisms. 展开更多
关键词 stress-strain relations transition-metal elements γ'-Ni3Al first-principles calculations
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Observation of robust anisotropy in WS_(2)/BP heterostructures 被引量:1
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作者 Xinran Li xing xie +6 位作者 Biao Wu Junying Chen Shaofei Li Jun He Zongwen Liu Jian-Tao Wang Yanping Liu 《Nano Research》 SCIE EI CSCD 2024年第7期6749-6756,共8页
Two-dimensional(2D)anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical,optical,thermal,and mechanical properties.While extens... Two-dimensional(2D)anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical,optical,thermal,and mechanical properties.While extensive research has delved into the optical and electrical characteristics of these materials,there remains a need for further exploration to identify novel materials and structures capable of fulfilling device requirements under various conditions.Here,we employ heterojunction interface engineering with black phosphorus(BP)to disrupt the C_(3) rotational symmetry of monolayer WS_(2).The resulting WS_(2)/BP heterostructure exhibits pronounced anisotropy in exciton emissions,with a measured anisotropic ratio of 1.84 for neutral excitons.Through a comprehensive analysis of magnetic-field-dependent and temperature-evolution photoluminescence spectra,we discern varying trends in the polarization ratio,notably observing a substantial anisotropy ratio of 1.94 at a temperature of 1.6 K and a magnetic field of 9 T.This dynamic behavior is attributed to the susceptibility of the WS_(2)/BP heterostructure interface strain to fluctuations in magnetic fields and temperatures.These findings provide valuable insights into the design of anisotropic optoelectronic devices capable of adaptation to a range of magnetic fields and temperatures,thereby advancing the frontier of material-driven device engineering. 展开更多
关键词 two-dimensional materials in-plane anisotropy black phosphorus HETEROJUNCTIONS optoelectronic devices photoluminescence spectra
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Progress and prospects of Moiré superlattices in twisted TMD heterostructures
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作者 Syed Jamal Shah Junying Chen +6 位作者 xing xie Xinyu Oyang Fangping Ouyang Zongwen Liu Jian-Tao Wang Jun He Yanping Liu 《Nano Research》 SCIE EI CSCD 2024年第11期10134-10161,共28页
Moiré superlattices based on twisted transition metal dichalcogenide (TMD) heterostructures have recently emerged as a promising platform for probing novel and distinctive electronic phenomena in two-dimensional ... Moiré superlattices based on twisted transition metal dichalcogenide (TMD) heterostructures have recently emerged as a promising platform for probing novel and distinctive electronic phenomena in two-dimensional (2D) materials. By stacking TMD monolayers with a small twist angle, these superlattices create a periodic modulation of the electronic density of states, leading to the formation of mini bands. These mini bands can exhibit intriguing properties such as flat bands, correlated electron behavior, and unconventional superconductivity. This review provides a comprehensive overview of recent progress in Moiré superlattices formed from twisted TMD heterostructures. It covers the theoretical principles and experimental techniques for creating and studying these superlattices, and explores their potential applications in optoelectronics, quantum computing, and energy harvesting. The review also addresses key challenges, such as improving the scalability and reproducibility of the fabrication process, emphasizing the exciting opportunities and ongoing hurdles in this rapidly evolving field. 展开更多
关键词 Moirésuperlattices twisted transition metal dichalcogenides HETEROSTRUCTURES electronic properties optical properties transport properties valleytronics OPTOELECTRONICS quantum information processing
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Synthesis and modification of nanowires anchored on electrodes for electrochemical and electrophysical applications
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作者 Feiyang Mo Zhitao Chen +1 位作者 Nian Liu xing xie 《Nano Research》 SCIE EI CSCD 2024年第10期8863-8884,共22页
The integration of nanowires onto electrode surfaces marks a significant advancement over traditional electrode materials,conferring upon nanowire-modified electrodes a vast array of applications within electrochemica... The integration of nanowires onto electrode surfaces marks a significant advancement over traditional electrode materials,conferring upon nanowire-modified electrodes a vast array of applications within electrochemical and electrophysical domains.The nanowires used for electrode modification can be catalogized into two distinct types:anchored nanowires and free-standing nanowires.A critical advantage of anchored nanowires lies in their enhanced electrical connectivity with the substrate,which reduces electrode resistance and facilitates charge transport.Furthermore,the anchorage of nanowires onto electrodes provides additional mechanical support,bolstering the structural stability of the nanowire assembly.Here,we review the development of anchored nanowires designed for applications in energy storage,electrocatalysis,and electric field treatment(EFT)over the past decade.We focus on the synthesis and modification strategies employed for anchored nanowires,culminating in the evaluation of these fabrication and enhancement techniques.Through this analysis,we aim to furnish comprehensive insights into the preparation of anchored nanowires,guiding the selection of appropriate fabrication processes and subsequent functional modifications. 展开更多
关键词 electrode modification direct growth ETCHING energy storage ELECTROCATALYSIS electric field treatment
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Pressure-driven layer-dependent phase transitions and enhanced interlayer coupling in PdSe_(2) crystals
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作者 Junnan Ding xing xie +6 位作者 Xinyu Ouyang Junying Chen Fangping Ouyang Zongwen Liu Jian-Tao Wang Jun He Yanping Liu 《Nano Research》 SCIE EI CSCD 2024年第11期10170-10178,共9页
Pressure exerts a profound influence on atomic configurations and interlayer interactions, thereby modulating the electronic and structural properties of materials. While high pressure has been observed to induce a st... Pressure exerts a profound influence on atomic configurations and interlayer interactions, thereby modulating the electronic and structural properties of materials. While high pressure has been observed to induce a structural phase transition in bulk PdSe_(2) crystals, leading to a transition from semiconductor to metal, the high-pressure behavior of few-layer PdSe_(2) remains elusive. Here, employing diamond anvil cell (DAC) techniques and high-pressure Raman spectroscopy, we investigate the structural evolution of layer-dependent PdSe_(2) under high pressure. We reveal that pressure significantly enhances interlayer coupling in PdSe_(2), driving structural phase transitions from an orthorhombic to a cubic phase. We demonstrate that PdSe_(2) crystals exhibit distinct layer-dependent pressure thresholds during the phase transition, with the decrease of transition pressure as the thickness of PdSe_(2) increases. Furthermore, our results of polarized Raman spectra confirm a reduction in material anisotropy with increasing pressure. This study offers crucial insights into the structural evolution of layer-dependent van der Waals materials under pressure, advancing our understanding of their pressure-induced behaviors. 展开更多
关键词 palladium diselenide high pressure phase transition diamond anvil cell ANISOTROPY
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RAD51B-AS1 promotes the malignant biological behavior of ovarian cancer through upregulation of RAD51B
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作者 Xinyi WEI Conghui WANG +8 位作者 Sangsang TANG Qian YANG Zhangjin SHEN Jiawei ZHU Xiaodong CHENG Xinyu WANG xing xie Junfen XU Weiguo LU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2024年第7期581-593,共13页
Long non-coding RNAs(lncRNAs)play an indispensable role in the occurrence and development of ovarian cancer(OC).However,the potential involvement of lncRNAs in the progression of OC is largely unknown.To investigate t... Long non-coding RNAs(lncRNAs)play an indispensable role in the occurrence and development of ovarian cancer(OC).However,the potential involvement of lncRNAs in the progression of OC is largely unknown.To investigate the detailed roles and mechanisms of RAD51 homolog B-antisense 1(RAD51B-AS1),a novel lncRNA in OC,reverse transcription-quantitative polymerase chain reaction(RT-qPCR)was performed to verify the expression of RAD51B-AS1.Cellular proliferation,metastasis,and apoptosis were detected using the cell counting kit-8(CCK-8),colony-formation,transwell,and flow cytometry assays.Mouse xenograft models were established for the detection of tumorigenesis.The results revealed that RAD51B-AS1 was significantly upregulated in a highly metastatic human OC cell line and OC tissues.RAD51B-AS1 significantly increased the proliferation and metastasis of OC cells and enhanced their resistance to anoikis.Biogenetics prediction analysis revealed that the only target gene of RAD51B-AS1 was RAD51B.Subsequent gene function experiments revealed that RAD51B exerts the same biological effects as RAD51B-AS1.Rescue experiments demonstrated that the malignant biological behaviors promoted by RAD51B-AS1 overexpression were partially or completely reversed by RAD51B silencing in vitro and in vivo.Thus,RAD51B-AS1 promotes the malignant biological behaviors of OC and activates the protein kinase B(Akt)/B cell lymphoma protein-2(Bcl-2)signaling pathway,and these effects may be associated with the positive regulation of RAD51B expression.RAD51B-AS1 is expected to serve as a novel molecular biomarker for the diagnosis and prediction of poor prognosis in OC,and as a potential therapeutic target for disease management. 展开更多
关键词 Ovarian cancer(OC) Long non-coding RNA(LncRNA) Metastasis ANOIKIS
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Unveiling optical anisotropy in disrupted symmetry WSe_(2)/SiP heterostructures
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作者 Biqi Hu xing xie +6 位作者 Xinyu Ouyang Junying Chen Shaofei Li Jun He Zongwen Liu Jian-Tao Wang Yanping Liu 《Nano Research》 SCIE EI CSCD 2024年第9期8585-8591,共7页
Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered considerable attention for their promising applications in sensors and optoelectronic devices,owing to their exceptional optical,electronic,and op... Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered considerable attention for their promising applications in sensors and optoelectronic devices,owing to their exceptional optical,electronic,and optoelectronic properties.However,the inherent high symmetry of TMD lattices imposes limitations on their functional versatility.Here,we present a strategy to disrupt the C_(3)rotational symmetry of monolayer WSe_(2)by fabricating a heterostructure incorporating WSe_(2)and SiP flakes.Through comprehensive experimental investigations and first-principle calculations,we elucidate that in the WSe_(2)/SiP heterostructure,excitons-both neutral and charged-emanating from WSe_(2)exhibit pronounced anisotropy,which remains robust against temperature variations.Notably,we observe an anisotropic ratio reaching up to 1.5,indicating a substantial degree of anisotropy.Furthermore,we demonstrate the tunability of exciton anisotropy through the application of a magnetic field,resulting in a significant reduction in the anisotropic ratio with increasing field strength,from 1.57 to 1.18.Remarkably,the change in heterojunction anisotropy ratio reaches 24.8%as the magnetic field increases.Our findings elucidate that the perturbation of the C_(3)rotational symmetry of the WSe_(2)monolayer arises from a non-uniform charge density distribution within the layer,exhibiting mirror symmetry.These results underscore the potential of heterostructure engineering in tailoring the properties of isotropic materials and provide a promising avenue for advancing the application of anisotropic devices across various fields. 展开更多
关键词 symmetry breaking heterostructure engineering ANISOTROPY optical spectroscopy
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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial 被引量:2
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作者 Danhui Weng Huihua Xiong +35 位作者 Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong xing xie Ding Ma 《Frontiers of Medicine》 SCIE CSCD 2023年第1期93-104,共12页
We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 sta... We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. 展开更多
关键词 CHEMOTHERAPY cervical cancer lymph node metastasis concurrent chemoradiotherapy quality of life
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Platelet RNA enables accurate detection of ovarian cancer:an intercontinental,biomarker identification study 被引量:2
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作者 Yue Gao Chun-Jie Liu +33 位作者 Hua-Yi Li Xiao-Ming Xiong Gui-Ling Li Sjors G.J.G.In't Veld Guang-Yao Cai Gui-Yan xie Shao-Qing Zeng Yuan Wu Jian-Hua Chi Jia-Hao Liu Qiong Zhang Xiao-Fei Jiao Lin-Li Shi Wan-Rong Lu Wei-Guo Lv xing-Sheng Yang Jurgen M.J.Piek Cornelis D de Kroon C.A.R.Lok Anna Supernat Sylwia Łapińska-Szumczyk Anna Łojkowska Anna J Żaczek Jacek Jassem Bakhos A.Tannous Nik Sol Edward Post Myron G.Best Bei-Hua Kong xing xie Ding Ma Thomas Wurdinger An-Yuan Guo Qing-Lei Gao 《Protein & Cell》 SCIE CSCD 2023年第8期579-590,共12页
Platelets are reprogrammed by cancer via a process called education,which favors cancer development.The transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer detection... Platelets are reprogrammed by cancer via a process called education,which favors cancer development.The transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer detection.This intercontinental,hospital-based,diagnostic study included 761 treatment-naive inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers(China,n=3;Netherlands,n=5;Poland,n=1)between September 2016 and May 2019.The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese(VC1 and VC2)and the European(VC3)validation cohorts collectively and independently.Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets.The AUCs for TEPs in the combined validation cohort,VC1,VC2,and VC3 were 0.918(95%CI 0.889-0.948),0.923(0.855-0.990),0.918(0.872-0.963),and 0.887(0.813-0.960),respectively.Combination of TEPs and CA125 demonstrated an AUC of 0.922(0.889-0.955)in the combined validation cohort;0.955(0.912-0.997)in VC1;0.939(0.901-0.977)in VC2;0.917(0.824-1.000)in VC3.For subgroup analysis,TEPs exhibited an AUC of o.858,0.859,and 0.920 to detect early-stage,borderline,non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis.TEPs had robustness,compatibility,and universality for preop.erative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities,heterogeneous histoiogical subtypes,and early-stage ovarian cancer.However,these observations warrant prospective validations in a larger population beforeclinicalutilities. 展开更多
关键词 tumor-educated platelets ovarian cancer liquid biopsy preoperative diagnosis
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Highly degradable chitosan-montmorillonite (MMT) nanocomposite hydrogel for controlled fertilizer release 被引量:1
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作者 Zeou Dou Maria Vitoria Bini Farias +3 位作者 Wensi Chen Dongjing He Yuhang Hu xing xie 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2023年第5期1-11,共11页
Fertilizer consumption is increasing drastically along with the rapid expansion of farming in response to the ever-growing population. However, a significant portion of the nutrients in traditional fertilizers is lost... Fertilizer consumption is increasing drastically along with the rapid expansion of farming in response to the ever-growing population. However, a significant portion of the nutrients in traditional fertilizers is lost during leaching and runoff causing economic loss and environmental threats. Polymer-modified controlled-release fertilizers provide an opportunity for mitigating adverse environmental effects and increasing the profitability of crop production. Here, we present a cheap and easy-to-fabricate controlled-release fertilizer excipient based on hydrogels scaffolded by safe and biodegradable chitosan and montmorillonite (MMT) nanoclays. By introducing elastic and flexible physical crosslinking induced by 2-dimensional (2D) MMT nanoflakes into the chitosan hydrogel, highly swellable and degradable chitosan-MMT nanocomposites were fabricated. The addition of MMT into the chitosan hydrogels enhanced the total release of phosphorous (P) and potassium (K), from 22.0 % to 94.9 % and 9.6% to 31.4 %, respectively, compared to the pure chitosan gel. The chitosan-MMT nanocomposite hydrogel achieved a well-controlled overall fertilizer release in soil. A total of 55.3 % of loaded fertilizer was released over 15 d with a daily release of 2.8 %. For the traditional fertilizer podwer, 89.2 % of the fertilizer was washed out during the first irrigation under the same setup. In the meantime, the nanocomposites improved the water retention of the soil, thanks to its excellent water absorbency. Moreover, the chitosan-MMT nanocomposite hydrogels exhibited high degradation of 57 % after swelling in water for 20 d. Such highly degradable fertilizer excipient poses minimal threat to the long-term fertility of the soil. The engineered Chitosan-MMT biopolymer scaffold as a controlled-release fertilizer excipient provides a promising opportunity for advancing sustainable agriculture. 展开更多
关键词 BIOPOLYMER Hydrogel Controlled-release fertilizer NANOCLAY Nanocomposite
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Salinity exchange between seawater/brackish water and domestic wastewater through electrodialysis for potable water 被引量:1
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作者 Mourin Jarin Zeou Dou +2 位作者 Haiping Gao Yongsheng Chen xing xie 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2023年第2期19-28,共10页
Two-thirds of the world’s population has limited access to potable water.As we continue to use up our freshwater resources,new and improved techniques for potable water production are warranted.Here,we present a gene... Two-thirds of the world’s population has limited access to potable water.As we continue to use up our freshwater resources,new and improved techniques for potable water production are warranted.Here,we present a general concept called“salinity exchange”that transfers salts from seawater or brackish water to treated wastewater until their salinity values approximately switch,thus producing wastewater with an increased salinity for discharge and desalinated seawater as the potable water source.We have demonstrated this process using electrodialysis.Salinity exchange has been successfully achieved between influents of different salinities under various operating conditions.Laboratory-scale salinity exchange electrodialysis(SEE)systems can produce high-quality desalinated water at~1 mL/min with an energy consumption less than 1 kWh/m3.SEE has also been operated using real water,and the challenges of its implementation at a larger scale are evaluated. 展开更多
关键词 DESALINATION Potable water reuse Ion-exchange membrane Salinity gradient energy Wastewater discharge
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Correction to: Highly degradable chitosan-montmorillonite (MMT) nanocomposite hydrogel for controlled fertilizer release
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作者 Zeou Dou Maria Vitoria Bini Farias +3 位作者 Wensi Chen Dongjing He Yuhang Hu xing xie 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2023年第8期167-167,共1页
The authors regret that there is an error in Fig.4(a)of the original version of the above article.The“GA weight”values in the legend should be half.For example,2.3%should be 1.15%.The corrected Fig.4 is below.In add... The authors regret that there is an error in Fig.4(a)of the original version of the above article.The“GA weight”values in the legend should be half.For example,2.3%should be 1.15%.The corrected Fig.4 is below.In addition,the“2.3 wt%GA”in the second line of the caption for Fig.2 should be“1.15 wt%GA”.The cause of these errors was that the glutaraldehyde(GA)stock solution we purchased and used to in our experiment was 50 wt%GA in water rather than 100 wt%GA.The authors would like to apologize for any inconvenience caused. 展开更多
关键词 HIGHLY RELEASE gradable
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Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospective analysis 被引量:13
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作者 Yuya Dou Xiaodan Zhang +3 位作者 Yang Li Fenfen Wang xing xie Xinyu Wang 《Frontiers of Medicine》 SCIE CAS CSCD 2017年第2期223-228,共6页
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patien... The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses. Among a total of 119 patients, 56 (47.06%) patients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical carcinoma (3 stage IA1 and 1 stage IA2 patients). Univariate analysis showed that patient age 〉 35 years (P = 0.005), menopausal period 〉 5 years (P = 0.0035), and multiple- quadrant involvement (P=0.001) were significantly correlated with residual disease; however, multivariate analysis revealed that multiple-quadrant involvement (P=0.001; OR, 3.701; 95%CI, 1.496-9.154) was an independent risk factor for residua! disease. Nearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgical specimens, and those with multiple positive margins may consider re- conization or re-assessment. 展开更多
关键词 cervical high-grade squamous intraepithelial lesion CONIZATION positive surgical margin HYSTERECTOMY
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Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology 被引量:7
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作者 Jing YE Bei CHENG +4 位作者 Yi-fan CHENG Ye-li YAO xing xie Wei-guo LU Xiao-dong CHENG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2017年第3期249-255,共7页
Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separat... Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus (HPV) 16/18 genotyping in 273 patients with LSIL/CINI. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV (hrHPV) were referred for colposcopy. Enrollment cytology, HPV16/18 genotyping, and questionnaire-obtained factors were linked to the 2-year cumulative progression rate. Univariate and multivariate analyses were performed taking into account time-to-event with Cox proportional hazard regression. The results showed that 190 cases (69.6%) regressed, 37 (13.6%) persisted, and 46 (16.8%) progressed. HPV16/18 positivity (hazard ratio (HR), 2.708; 95% confidence interval (CI), 1.432-5.121; P=-0.002) is significantly associated with higher 2-year cumulative progression rate. Sub-analysis by enrollment cytology and age restricted the positive association among patients preceded by mildly abnormal cytology and aged 30 years or older. Immediate treatment is a rational recommendation for the high-risk subgroup, when good compliance is not assured. 展开更多
关键词 Low-grade squamous intraepithelial lesion (LSIL) Cervical intraepithelial neoplasia grade 1 (CIN1) Human papillomavirus (HPV) HPV16/18 genotyping Prognostic value Prospective study
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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective study of 251 cases 被引量:8
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作者 Yunfeng Fu Xinyu Wang +1 位作者 Zimin Pan xing xie 《Frontiers of Medicine》 SCIE CAS CSCD 2014年第1期91-95,共5页
A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly th... A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinico- pathological parameters, including progression-free survival (PFS) and overall survival (OS), were also analyzed. The median follow-up period from the end of initial treatment to June 2010 was 58 months. The three-year PFS rate was 61.7% for International Federation of Gynecology and Obstetrics (FIGO) I-II, 19.9% for FIGO III-IV, and 33.9% for all stages. By comparison, the five-year PFS rate was 44.6% for FIGO I-II, 17.7% for FIGO III-IV, and 28.3% for all stages. The three-year OS rate was 67.9% for FIGO I-II, 41.7% for FIGO III IV, and 50.2% for all stages. The five-year OS rate was 52.7% for FIGO I-II, 30.8% for FIGO III-IV, and 39.2% for all stages. Univariate analysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significant factors affecting PFS and OS. In multivariate analysis, PFS was significantly influenced by FIGO stage and suboptimal debulking. However, OS was significantly influenced by advanced FIGO stage only. Our study confirms the efficacy of surgery followed by platinum-based chemotherapy for EOC. FIGO stage is considered as one of the most reliable predictors of the prognosis of patients with EOC. 展开更多
关键词 ovarian carcinoma prognostic factors SURGERY CHEMOTHERAPY SURVIVAL
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