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Epigenetic disruption of cell signaling in nasopharyngeal carcinoma 被引量:9
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作者 Li-Li Li xing-sheng shu +2 位作者 Zhao-Hui Wang Ya Cao Qian Tao 《Chinese Journal of Cancer》 SCIE CAS CSCD 北大核心 2011年第4期231-239,共9页
Nasopharyngeal carcinoma(NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia.Alternative to genetic changes,aberrant epigenetic events disrupt multiple genes in... Nasopharyngeal carcinoma(NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia.Alternative to genetic changes,aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications.These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC.In this review,we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research.Developing pharmacologic strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy. 展开更多
关键词 细胞信号转导 鼻咽癌 全国人民代表大会 中断 DNA甲基化 基因变化 组蛋白修饰 信号调节器
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