Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2...Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.展开更多
Studies on urban energy have been growing in interest,and past research has mostly been focused on studies of urban solar potential or urban building energy consumption independently.However,holistic research on the c...Studies on urban energy have been growing in interest,and past research has mostly been focused on studies of urban solar potential or urban building energy consumption independently.However,holistic research on the combination of urban building energy consumption and solar potential at the urban block-scale is required in order to minimize energy use and maximize solar power generation simultaneously.The aim of this study is to comprehensively evaluate the impact of urban morphological factors on photovoltaic(PV)potential and building energy consumption.Firstly,58 residential blocks were classified into 6 categories by k-means clustering.Secondly,3 energy performance factors,which include the energy use intensity(EUI),the energy use intensity combined with PV potential(EUI-PV),and photovoltaic substitution rate(PSR)were calculated for these blocks.The study found that the EUI of the Small Length&High Height blocks was the lowest at around 30 kWh/(m^(2)·y),while the EUI-PV of the Small Length&Low Height blocks was the lowest at around 4.45 kWh/(m^(2)·y),and their PSR was the highest at 87%.Regression modelling was carried out,and the study concluded that the EUI of residential blocks was mainly affected by shape factor,building density and floor area ratio,while EUI-PV and PSR were mainly affected by height and sky view factor.In this study,the results and developed methodology are helpful to provide recommendations and strategies for sustainable planning of residential blocks in central China.展开更多
基金funded by the National Key Research and Development Program of China(2020YFD0900902)Zhejiang Province Public Welfare Technology Application Research Project(LGJ21C20001)Zhejiang Provincial Key Research and Development Project of China(2019C02076 and 2019C02075)。
文摘Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.
基金This research was supported by the program for HUST Academic Frontier Youth Team(No.2019QYTD10)the Fundamental Research Funds for the Central Universities(No.2019kfyXKJC029)the National Natural Science Foundation of China(No.51678261,No.51978296).
文摘Studies on urban energy have been growing in interest,and past research has mostly been focused on studies of urban solar potential or urban building energy consumption independently.However,holistic research on the combination of urban building energy consumption and solar potential at the urban block-scale is required in order to minimize energy use and maximize solar power generation simultaneously.The aim of this study is to comprehensively evaluate the impact of urban morphological factors on photovoltaic(PV)potential and building energy consumption.Firstly,58 residential blocks were classified into 6 categories by k-means clustering.Secondly,3 energy performance factors,which include the energy use intensity(EUI),the energy use intensity combined with PV potential(EUI-PV),and photovoltaic substitution rate(PSR)were calculated for these blocks.The study found that the EUI of the Small Length&High Height blocks was the lowest at around 30 kWh/(m^(2)·y),while the EUI-PV of the Small Length&Low Height blocks was the lowest at around 4.45 kWh/(m^(2)·y),and their PSR was the highest at 87%.Regression modelling was carried out,and the study concluded that the EUI of residential blocks was mainly affected by shape factor,building density and floor area ratio,while EUI-PV and PSR were mainly affected by height and sky view factor.In this study,the results and developed methodology are helpful to provide recommendations and strategies for sustainable planning of residential blocks in central China.
