The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorat...The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy.After 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical testing.The results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid biosynthesis.Furthermore,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and microarchitecture.Mechanistically,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase 5b.Overall,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.展开更多
What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What ...What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What is added by this report?This study examines the long-term trend of genitourinary diseases'mortality across Chinese individuals of all genders and in various urban and rural regions.Additionally,it investigates the impact of age-period-cohort effects on this trend.What are the implications for public health practice?It is imperative to address genitourinary diseases,particularly among vulnerable populations such as rural older men.Policymakers should prioritize these individuals by providing necessary policy interventions and healthcare support.展开更多
Antibiotic abuse results in various antibiotic resistance among a number of foodborne bacteria,posing a severe threat to food safety.Antibiotic resistance genes are commonly detected in foodborne pathogens,which has s...Antibiotic abuse results in various antibiotic resistance among a number of foodborne bacteria,posing a severe threat to food safety.Antibiotic resistance genes are commonly detected in foodborne pathogens,which has sparked much interest in finding solutions to these issues.Various strategies against these drug-resistant pathogens have been studied,including new antibiotics and phages.Recently,a powerful tool has been introduced in the fight against drug-resistant pathogens,namely,clustered regularly interspaced short palindromic repeats-CRiSPR associated(CRISPR-Cas)system aggregated by a prokaryotic defense mechanism.This review summarizes the mechanism of antibiotic resistance in Salmonella and resistance to common antibiotics,analyzes the relationship between Salmonella CRiSPR-Cas and antibiotic resistance,discusses the changes in antibiotic resistance on the structure and function of CRiSPR-Cas,andfinally predicts the mechanism of CRISPR-Cas intervention in Salmonella antibiotic resistance.In the future,CRiSPR-Cas is expected to become an important tool to reduce the threat of antibiotic-resistant pathogens in food safety.展开更多
基金supported by the National Natural Science Foundation of China (32072191)Daxing District Major Scientific and Technological Achievements Transformation Project (2020006)+1 种基金Beijing Innovation Team Project of Livestock Industry Technology SystemBeijing Science and Technology Special Project (Z201100002620005)。
文摘The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy.After 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical testing.The results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid biosynthesis.Furthermore,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and microarchitecture.Mechanistically,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase 5b.Overall,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.
基金the Population and Aging Health Science Program(WH10022023035)the National Key Research and Development Program(SQ2022YFC3600291).
文摘What is already known about this topic?There has been a lack of attention to genitourinary diseases for an extended period,resulting in limited research on the mortality trends of genitourinary diseases in China.What is added by this report?This study examines the long-term trend of genitourinary diseases'mortality across Chinese individuals of all genders and in various urban and rural regions.Additionally,it investigates the impact of age-period-cohort effects on this trend.What are the implications for public health practice?It is imperative to address genitourinary diseases,particularly among vulnerable populations such as rural older men.Policymakers should prioritize these individuals by providing necessary policy interventions and healthcare support.
基金supported by the Graduate Innovative Fund of Wuhan Institute of Technology (No.CX2020347)the Key Projects of Science and Technology Research Plan of Hubei Provincial Department of Education (D202015001),China.
文摘Antibiotic abuse results in various antibiotic resistance among a number of foodborne bacteria,posing a severe threat to food safety.Antibiotic resistance genes are commonly detected in foodborne pathogens,which has sparked much interest in finding solutions to these issues.Various strategies against these drug-resistant pathogens have been studied,including new antibiotics and phages.Recently,a powerful tool has been introduced in the fight against drug-resistant pathogens,namely,clustered regularly interspaced short palindromic repeats-CRiSPR associated(CRISPR-Cas)system aggregated by a prokaryotic defense mechanism.This review summarizes the mechanism of antibiotic resistance in Salmonella and resistance to common antibiotics,analyzes the relationship between Salmonella CRiSPR-Cas and antibiotic resistance,discusses the changes in antibiotic resistance on the structure and function of CRiSPR-Cas,andfinally predicts the mechanism of CRISPR-Cas intervention in Salmonella antibiotic resistance.In the future,CRiSPR-Cas is expected to become an important tool to reduce the threat of antibiotic-resistant pathogens in food safety.
