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SWOT-AHP hybrid model for vehicle lubricants from CNPCLC,China 被引量:6
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作者 Jiang Qingzhe xuyanming +3 位作者 Xin Wenju Song Zhaozheng Song Qianqian Ke Ming 《Petroleum Science》 SCIE CAS CSCD 2012年第4期558-564,共7页
In recent years, owing to the strong increase in demand for lubricants, China is ranked second in the global lubricant market. With the rapid development of China's automobile industry, there is an increasing demand ... In recent years, owing to the strong increase in demand for lubricants, China is ranked second in the global lubricant market. With the rapid development of China's automobile industry, there is an increasing demand for vehicle lubricants and an increasing requirement for higher quality lubricants. While the demands for vehicle lubricants are increasing year by year in China, the quality grade of vehicle lubricant will be improved by leaps and bounds, and the high standard lubricant for automobile will be directly brought in line with international practice. At present, the market share of most high-end vehicle lubricant has been occupied by foreign lubricant brands. So for China National Petroleum Corporation Lubricant Company (CNPCLC), the urgent issue is that strategies must be made to respond to the stern challenges and to occupy more market share. In this paper, by using the analytic hierarchy process (AHP) technique that has the advantage of combining quantitative with qualitative analysis, a SWOT-AHP model for CNPCLC vehicle lubricants is developed, presenting a good tool for studying the competitive factors domestic and overseas for vehicle lubricants. Finally a strategic plan for CNPCLC vehicle lubricants is suggested. 展开更多
关键词 SWOT AHP CNPCLC vehicle lubricant strategic planning
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Specific targeted killing of ErbB2 positive breast cancer by retrovirus-mediated Immunocaspase-3 secreting T cells 被引量:5
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作者 ZHANGLihong JIALintao +7 位作者 ZHAOJing xuyanming WENWeihong BAOWei CAOYunxin SUChenazhi WANGChengji YANGAn-gang 《Chinese Science Bulletin》 SCIE EI CAS 2004年第13期1380-1385,共6页
In this study, lmmunocaspase-3 gene was transfected into Jurkat T lymphocytes and the targeted proapoptotic protein Immunocaspase-3 was stably secreted.Its entry to ErbB2 positive SKBr3 breast carcinoma cell line was ... In this study, lmmunocaspase-3 gene was transfected into Jurkat T lymphocytes and the targeted proapoptotic protein Immunocaspase-3 was stably secreted.Its entry to ErbB2 positive SKBr3 breast carcinoma cell line was observed by indirect immunofluorescence staining.Growth of SKBr3 cells was significantly inhibited when they were cultured with medium containing Immunocaspase-3.Next, lmmunocaspase-3 gene was cloned into retrovirus vector pLNCX, which was then transfected into PA317 cells to package. Packaged cells producing high titer pseudoviruses were acquired and the pseudoviruses were harvested to infect PBMCs, which had been stimulated to division. The latter were selected and administered to nude mice bearing SKBr3 tumors through tail vein. The results showed that the treatment contributed to an inhibition of tumor growth and prolonged the lifetime of nude mice bearing SKBr3 tumor.The efficiency of inhibition of tumor reached 73.25%, and the average lifetime of treated nude mice was 80.95% longerthan that of control group. Immunohistochemical examination revealed the exclusive distribution of Immunocaspase-3 proteins only in the tumor tissue samples; and TUNEL assay confirmed the occurrence of apoptosis in tumor calls. Thepresent study suggests that Immunocaspase-3 secreted by T lymphocytes can selectively bind and enter into ErbB2 positive breast cancer cells, where it exhibits a proapoptotic activity and causes tumor suppression in an in vivo tumor model. 展开更多
关键词 ERBB2 乳癌 逆转录酶病毒 免疫酶 T细胞 CASPASE-3 细胞凋亡 基因治疗
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