Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were s...Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were selected for the study.TSH inhibition therapy was administered to the research group,while thyroxine replacement therapy was provided to the control group during the postoperative management phase.This allowed for a comparative analysis between the two groups.Results:In comparison with the control group,the research group exhibited significant decreases in serum TSH,T3,and T4 levels after treatment,while FT4 and FT3 levels significantly increased(P<0.05).Additionally,significant decreases in Tg,VEGF,TSGF,CD44V6,and sIL-2R levels were observed in the research group after treatment(P<0.05).No significant differences were found in pre-treatment thyroid function between the two groups(P>0.05).Conclusion:The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.展开更多
Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing ...Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data analysis.TSH suppression therapy was implemented during the postoperative period.Patients were grouped according to the TSH level:TSH<0.1,0.1≤TSH<0.5,and TSH≥0.5.Results:Among male patients,there were no significant differences in sex hormone levels at different dosing times and TSH levels(P>0.05).For female patients,testosterone levels at different dosing times showed no significant differences under the same circumstances(P>0.05).The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences(P>0.05).However,the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences(P<0.05),with the lowest levels observed at 0.1≤TSH<0.5.Conclusion:The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male patients.However,it has a significant impact on female patients.Therefore,preoperative sex hormone testing is recommended,and postoperative monitoring should include regular sex hormone testing.展开更多
The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of perturbation.However,the parameter design of the controller is a difficult problem.The traditional trial-and-er...The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of perturbation.However,the parameter design of the controller is a difficult problem.The traditional trial-and-error method is time-consuming and difficult to find optimal parameters.A parameter optimization strategy of control systems for uncertain WPT systems using the modified genetic algorithm(MGA)is proposed.Firstly,because the system has different characteristics at different periods,the simulation process is divided into three stages.The first one is the start-up stage,in which we mainly consider the overshoot and the rate of the voltage rise.The second one is the tracking stage,in which the tracking time and switching loss are mainly considered.The third one is the stabilisation stage,in which the steady-state error and switching loss are mainly considered.Secondly,three cost functions are designed according to the characteristics of the three stages,and then the optimal controller parameters of each stage are obtained by using MGA.Finally,the effectiveness of the proposed method is verified by simulation.The optimization results show that compared with the previous parameter optimization method,the optimal controller parameters obtained by the proposed method make the WPT system achieve better performance.展开更多
Needle-to-plane geometry has been widely investigated and used in underwater pulsed discharges.The position relationship between the needle tip and insulation layer significantly affects the discharge patterns.We carr...Needle-to-plane geometry has been widely investigated and used in underwater pulsed discharges.The position relationship between the needle tip and insulation layer significantly affects the discharge patterns.We carried out experiments on underwater pulsed discharge with the needle tip protruding from,recessing into,and flushing with the insulating tube.The results are as follows.First,underwater pulsed discharge has a strong randomness under the experimental conditions.Different discharge patterns appeared under the same experimental environment.Second,recession into the insulator surface led to a higher probability of occurrence but a lower strength of spark discharge than protrusion.Third,between the needle tip protruding from and recessing into the insulation material,the average speed of propagation of underwater pulsed spark discharge decreased by an order of magnitude.The study shows that the optimum length of needle tip protruding from the insulation layer is 1 mm to obtain a strong underwater pulsed spark discharge.展开更多
Dear Editor,By using cryo-electron microscopy and electrophysiology,this study characterizes the structural and functional dynamics of the K+outward-rectifying channel SKOR in Arabidopsis and the structural changes as...Dear Editor,By using cryo-electron microscopy and electrophysiology,this study characterizes the structural and functional dynamics of the K+outward-rectifying channel SKOR in Arabidopsis and the structural changes associated with a double mutation that transforms SKOR into an inward-rectifying K+channel,SKDM.These findings have implications for understanding and manipulating crop K+nutrition.展开更多
Due to the advantages of low propagation loss,wide operation bandwidth,continuous delay tuning,fast tuning speed,and compact footprints,chirped Bragg grating waveguide has great application potential in wideband phase...Due to the advantages of low propagation loss,wide operation bandwidth,continuous delay tuning,fast tuning speed,and compact footprints,chirped Bragg grating waveguide has great application potential in wideband phased array beamforming systems.However,the disadvantage of large group delay error hinders their practical applications.The nonlinear group delay spectrum is one of the main factors causing large group delay errors.To solve this problem,waveguides with nonlinear gradient widths are adopted in this study to compensate for the nonlinear efect of the grating apodization on the mode efective index.As a result,a linear group delay spectrum is obtained in the experiment,and the group delay error is halved.展开更多
An integrated microwave photonic mixer based on silicon photonic platforms is proposed,which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector.The modulated optical signals from microwave ph...An integrated microwave photonic mixer based on silicon photonic platforms is proposed,which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector.The modulated optical signals from microwave photonic links can be directly demodulated and down-converted to intermediate frequency(IF)signals by the photonic mixer.The converted signal is obtained by conducting of-chip subtraction of the outputs from the balanced photodetector,and subsequent fltering of the high frequency items by an electrical low-pass flter.Benefting from balanced detection,the conversion gain of the IF signal is improved by 6 dB,and radio frequency leakage and common-mode noise are suppressed signifcantly.System-level simulations show that the frequency mixing system has a spurious-free dynamic range of 89 dB·Hz^(2/3),even with deteriorated linearity caused by the two cascaded modulators.The spur suppression ratio of the photonic mixer remains higher than 40 dB when the IF varies from 0.5 to 4 GHz.The electrical-electrical 3 dB bandwidth of frequency conversion is 11 GHz.The integrated frequency mixing approach is quite simple,requiring no extra optical flters or electrical 90°hybrid coupler,which makes the system more stable and with broader bandwidth so that it can meet the potential demand in practical applications.展开更多
As the complexity of flight missions continues to increase,sending a timely warning or providing assistance to pilots helps to reduce the probability of operational errors and flight accidents.Monitoring pilots’physi...As the complexity of flight missions continues to increase,sending a timely warning or providing assistance to pilots helps to reduce the probability of operational errors and flight accidents.Monitoring pilots’physiological data,real-time evaluation of mission load is a feasible technical way to achieve this.In this paper,a set of flight tasks including aircraft control,humancomputer interaction and mental arithmetic tests are designed to simulate five mission loads at different flight difficulty levels.A sensitivity analysis method based on a comprehensive test is proposed to select a set of sensitive physiological factors.Then,based on the SVM hierarchical combination classification method,the pilot mission load real-time evaluation model is established.The test results show significant differences in EMG,respiration rate(abdomen),heart rate,blood oxygen saturation,pupil area,fixation duration,number of fixations,and saccades.The high accuracy obtained from experiments proved that the proposed real-time evaluation model is applicable to meet the requirements of real working environments.The findings can provide methodological references for mission load evaluation research in other fields.展开更多
In this paper, we introduce and study differential graded(DG for short) polynomial algebras. In brief, a DG polynomial algebra A is a connected cochain DG algebra such that its underlying graded algebra A~# is a polyn...In this paper, we introduce and study differential graded(DG for short) polynomial algebras. In brief, a DG polynomial algebra A is a connected cochain DG algebra such that its underlying graded algebra A~# is a polynomial algebra K[x_1, x_2,..., x_n] with |xi| = 1 for any i ∈ {1, 2,..., n}. We describe all possible differential structures on DG polynomial algebras, compute their DG automorphism groups, study their isomorphism problems, and show that they are all homologically smooth and Gorenstein DG algebras. Furthermore, it is proved that the DG polynomial algebra A is a Calabi-Yau DG algebra when its differential ?_A≠ 0 and the trivial DG polynomial algebra(A, 0) is Calabi-Yau if and only if n is an odd integer.展开更多
文摘Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were selected for the study.TSH inhibition therapy was administered to the research group,while thyroxine replacement therapy was provided to the control group during the postoperative management phase.This allowed for a comparative analysis between the two groups.Results:In comparison with the control group,the research group exhibited significant decreases in serum TSH,T3,and T4 levels after treatment,while FT4 and FT3 levels significantly increased(P<0.05).Additionally,significant decreases in Tg,VEGF,TSGF,CD44V6,and sIL-2R levels were observed in the research group after treatment(P<0.05).No significant differences were found in pre-treatment thyroid function between the two groups(P>0.05).Conclusion:The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.
文摘Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data analysis.TSH suppression therapy was implemented during the postoperative period.Patients were grouped according to the TSH level:TSH<0.1,0.1≤TSH<0.5,and TSH≥0.5.Results:Among male patients,there were no significant differences in sex hormone levels at different dosing times and TSH levels(P>0.05).For female patients,testosterone levels at different dosing times showed no significant differences under the same circumstances(P>0.05).The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences(P>0.05).However,the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences(P<0.05),with the lowest levels observed at 0.1≤TSH<0.5.Conclusion:The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male patients.However,it has a significant impact on female patients.Therefore,preoperative sex hormone testing is recommended,and postoperative monitoring should include regular sex hormone testing.
基金Startup Foundation for Introducing Talent of NUISTNational Natural Science Foundation of China,Grant/Award Number:62006124+1 种基金Nature Science Foundation of Jiangsu Province,Grant/Award Number:BK20200811Natural Science Foundation of the Jiangsu Higher Edu-cation Institutions of China,Grant/Award Number:20KJB520006。
文摘The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of perturbation.However,the parameter design of the controller is a difficult problem.The traditional trial-and-error method is time-consuming and difficult to find optimal parameters.A parameter optimization strategy of control systems for uncertain WPT systems using the modified genetic algorithm(MGA)is proposed.Firstly,because the system has different characteristics at different periods,the simulation process is divided into three stages.The first one is the start-up stage,in which we mainly consider the overshoot and the rate of the voltage rise.The second one is the tracking stage,in which the tracking time and switching loss are mainly considered.The third one is the stabilisation stage,in which the steady-state error and switching loss are mainly considered.Secondly,three cost functions are designed according to the characteristics of the three stages,and then the optimal controller parameters of each stage are obtained by using MGA.Finally,the effectiveness of the proposed method is verified by simulation.The optimization results show that compared with the previous parameter optimization method,the optimal controller parameters obtained by the proposed method make the WPT system achieve better performance.
基金supported by the Science and Technology Research Project of the Hebei Higher Education Institutions of China No.ZD2014031。
文摘Needle-to-plane geometry has been widely investigated and used in underwater pulsed discharges.The position relationship between the needle tip and insulation layer significantly affects the discharge patterns.We carried out experiments on underwater pulsed discharge with the needle tip protruding from,recessing into,and flushing with the insulating tube.The results are as follows.First,underwater pulsed discharge has a strong randomness under the experimental conditions.Different discharge patterns appeared under the same experimental environment.Second,recession into the insulator surface led to a higher probability of occurrence but a lower strength of spark discharge than protrusion.Third,between the needle tip protruding from and recessing into the insulation material,the average speed of propagation of underwater pulsed spark discharge decreased by an order of magnitude.The study shows that the optimum length of needle tip protruding from the insulation layer is 1 mm to obtain a strong underwater pulsed spark discharge.
基金supported by the National Natural Science Foundation of China(32171188 to G.Y.)the National Key R&D Program of China(2022YFA1303400)+3 种基金the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(to G.Y.)the Chinese Universities Scientific Fund(2023RC012 and 2023TC190 to G.Y.)the Pinduoduo-China Agricultural University Research Fund(grant no.PC2023B01010)China Agricultural University Young Talent Program in Life Science(Grant No.008).
文摘Dear Editor,By using cryo-electron microscopy and electrophysiology,this study characterizes the structural and functional dynamics of the K+outward-rectifying channel SKOR in Arabidopsis and the structural changes associated with a double mutation that transforms SKOR into an inward-rectifying K+channel,SKDM.These findings have implications for understanding and manipulating crop K+nutrition.
基金supported by the key research and development program of Anhui province(202104a05020052,2022a05020027)open project program of Wuhan national laboratory for optoelectronics(2020WNL0KF005).
文摘Due to the advantages of low propagation loss,wide operation bandwidth,continuous delay tuning,fast tuning speed,and compact footprints,chirped Bragg grating waveguide has great application potential in wideband phased array beamforming systems.However,the disadvantage of large group delay error hinders their practical applications.The nonlinear group delay spectrum is one of the main factors causing large group delay errors.To solve this problem,waveguides with nonlinear gradient widths are adopted in this study to compensate for the nonlinear efect of the grating apodization on the mode efective index.As a result,a linear group delay spectrum is obtained in the experiment,and the group delay error is halved.
基金supported by the Key Research and Development Program of Anhui Province(Nos.2022a05020027 and 202104a05020052)Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNL0KF005).
文摘An integrated microwave photonic mixer based on silicon photonic platforms is proposed,which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector.The modulated optical signals from microwave photonic links can be directly demodulated and down-converted to intermediate frequency(IF)signals by the photonic mixer.The converted signal is obtained by conducting of-chip subtraction of the outputs from the balanced photodetector,and subsequent fltering of the high frequency items by an electrical low-pass flter.Benefting from balanced detection,the conversion gain of the IF signal is improved by 6 dB,and radio frequency leakage and common-mode noise are suppressed signifcantly.System-level simulations show that the frequency mixing system has a spurious-free dynamic range of 89 dB·Hz^(2/3),even with deteriorated linearity caused by the two cascaded modulators.The spur suppression ratio of the photonic mixer remains higher than 40 dB when the IF varies from 0.5 to 4 GHz.The electrical-electrical 3 dB bandwidth of frequency conversion is 11 GHz.The integrated frequency mixing approach is quite simple,requiring no extra optical flters or electrical 90°hybrid coupler,which makes the system more stable and with broader bandwidth so that it can meet the potential demand in practical applications.
基金co-supported by the Aeronautical Science Foundation of China(No.2020Z023053002)the National Natural Science Foundation of China(No.61305133。
文摘As the complexity of flight missions continues to increase,sending a timely warning or providing assistance to pilots helps to reduce the probability of operational errors and flight accidents.Monitoring pilots’physiological data,real-time evaluation of mission load is a feasible technical way to achieve this.In this paper,a set of flight tasks including aircraft control,humancomputer interaction and mental arithmetic tests are designed to simulate five mission loads at different flight difficulty levels.A sensitivity analysis method based on a comprehensive test is proposed to select a set of sensitive physiological factors.Then,based on the SVM hierarchical combination classification method,the pilot mission load real-time evaluation model is established.The test results show significant differences in EMG,respiration rate(abdomen),heart rate,blood oxygen saturation,pupil area,fixation duration,number of fixations,and saccades.The high accuracy obtained from experiments proved that the proposed real-time evaluation model is applicable to meet the requirements of real working environments.The findings can provide methodological references for mission load evaluation research in other fields.
基金supported by National Natural Science Foundation of China (Grant No. 11001056)the China Postdoctoral Science Foundation (Grant Nos. 20090450066 and 201003244)+1 种基金the Key Disciplines of Shanghai Municipality (Grant No. S30104)the Innovation Program of Shanghai Municipal Education Commission (Grant No. 12YZ031)
文摘In this paper, we introduce and study differential graded(DG for short) polynomial algebras. In brief, a DG polynomial algebra A is a connected cochain DG algebra such that its underlying graded algebra A~# is a polynomial algebra K[x_1, x_2,..., x_n] with |xi| = 1 for any i ∈ {1, 2,..., n}. We describe all possible differential structures on DG polynomial algebras, compute their DG automorphism groups, study their isomorphism problems, and show that they are all homologically smooth and Gorenstein DG algebras. Furthermore, it is proved that the DG polynomial algebra A is a Calabi-Yau DG algebra when its differential ?_A≠ 0 and the trivial DG polynomial algebra(A, 0) is Calabi-Yau if and only if n is an odd integer.
