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Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway
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作者 Tong-Tong Lin Chun-Yi Jiang +10 位作者 Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu Liang Hu xue-feng wu Yuan Han Wen-Tao Liu Yin-Bing Pan 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第9期2067-2074,共8页
Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory p... Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory pain,but its role in morphine tolerance is unclear.In this study,we established rat and mouse models of morphine tolerance by intrathecal injection of morphine for 7 consecutive days.We found that morphine induced rat spinal cord neurons to release a large amount of HMGB1.HMGB1 regulated nuclear factor κB p65 phosphorylation and interleukin-1β production by increasing Toll-like receptor 4receptor expression in microglia,thereby inducing morphine tolerance.Glycyrrhizin,an HMGB1 inhibito r,markedly attenuated chronic morphine tole rance in the mouse model.Finally,compound C(adenosine 5’-monophosphate-activated protein kinase inhibitor) and zinc protoporphyrin(heme oxygenase-1 inhibitor)alleviated the morphine-induced release of HMGB1 and reduced nuclear factor κB p65 phosphorylation and interleukin-1β production in a mouse model of morphine tolerance and an SH-SY5Y cell model of morphine tole rance,and alleviated morphine tolerance in the mouse model.These findings suggest that morphine induces HMGB1 release via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 signaling pathway,and that inhibiting this signaling pathway can effectively reduce morphine tole rance. 展开更多
关键词 adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 INTERLEUKIN-1Β MICROGLIA morphine tolerance NEUROINFLAMMATION neuron nuclear factor-κB p65 Toll-like receptor 4
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Atlas of dynamic spectra of fast radio burst FRB 20201124A
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作者 王铂钧 胥恒 +64 位作者 姜金辰 徐江伟 牛佳瑞 陈平 李柯伽 张冰 朱炜玮 东苏勃 张春风 傅海 周德江 张永坤 王培 冯毅 李晔 李冬子 鲁文宾 杨元培 RNCaballero 蔡策 陈卯蒸 戴子高 艾力·伊沙木丁 甘恒谦 韩金林 郝龙飞 黄玉祥 姜鹏 李承奎 李菂 李辉 李新乔 李志玄 刘志勇 罗睿 门云鹏 牛晨辉 彭文溪 钱磊 宋黎明 孙京海 王发印 汪敏 王娜 王维扬 吴雪峰 肖硕 熊少林 徐永华 徐仁新 杨俊 杨轩 姚蕊 易祁彬 岳友岭 于东俊 余文飞 袁建平 张彬彬 张松波 张双南 赵一 郑伟康 朱岩 邹金航 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第2期1-4,共4页
Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, ... Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the link https://www.doi.org/10.57760/sciencedb.j00113.00076. 展开更多
关键词 fast radio burst FAST
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New limits on the photon mass with radio pulsars in the Magellanic clouds 被引量:1
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作者 Jun-Jie Wei Er-Kang Zhang +1 位作者 Song-Bo Zhang xue-feng wu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2017年第2期17-21,共5页
A conservative constraint on the rest mass of the photon can be estimated under the assumption that the frequency dependence of dispersion from astronomical sources is mainly contributed by the nonzero photon mass eff... A conservative constraint on the rest mass of the photon can be estimated under the assumption that the frequency dependence of dispersion from astronomical sources is mainly contributed by the nonzero photon mass effect. Photon mass limits have been set earlier through the optical emissions of the Crab Nebula pulsar, but we demonstrate that these limits can be significantly improved with the dispersion measure(DM) measurements of radio pulsars in the Large and Small Magellanic Clouds.The combination of DM measurements of pulsars and distances of the Magellanic Clouds provides a strict upper limit on the photon mass as low as m_γ≤ 2.0 × 10^(-45) g, which is at least four orders of magnitude smaller than the constraint from the Crab Nebula pulsar. Although our limit is not as tight as the current best result(~ 10^(-47)g) from a fast radio burst(FRB 150418) at a cosmological distance,the cosmological origin of FRB 150418 remains under debate; and our limit can reach the same high precision of FRB 150418 when it has an extragalactic origin(~ 10^(-45)g). 展开更多
关键词 pulsars:general Magellanic Clouds astroparticle physics
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Early afterglows from radially structured outflows and the application to X-ray shallow decays
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作者 Xue-Wen Liu xue-feng wu +1 位作者 Yuan-Chuan Zou Tan Lu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2009年第8期911-920,共10页
In the fireball model, it is more physically realistic that gamma-rayburst (GRB) ejecta have a range of bulk Lorentz factors (assuming M ∝Γ-s). The low Lorentz factor part of the ejecta will catch up with the high L... In the fireball model, it is more physically realistic that gamma-rayburst (GRB) ejecta have a range of bulk Lorentz factors (assuming M ∝Γ-s). The low Lorentz factor part of the ejecta will catch up with the high Lorentz factor part when the latter is decelerated by the surrounding medium to a comparable Lorentz factor. Such a process will develop a long-lasting weak reverse shock until the whole ejecta are shocked. Meanwhile, the forward shocked materials are gradually supplied with energy from the ejecta that are catching-up, and thus the temporal decay of the forward shock emission will be slower than that without an energy supply. However, the reverse shock may be strong. Here, we extend the standard reverse-forward shock model to the case of radially nonuniform ejecta. We show that this process can be classified into two cases: the thick shell case and the thin shell case. In the thin shell case, the reverse shock is weak and the temporal scaling law of the afterglow is the same as that in Sari & Me′sza′ros (2000). However, in the thick shell case, the reverse shock is strong and thus its emission dominates the afterglow in the high energy band. Our results also show slower decaying behavior of the afterglow due to the energy supply by low Lorentz factor materials, which may help the understanding of the plateau observed in the early optical and X-ray afterglows. 展开更多
关键词 放射状 衰变 X光 应用 外流 结构 早期 反向冲击
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Physical origin of multi-wavelength emission of GRB 100418A and implications for its progenitor
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作者 Lan-Wei Jia xue-feng wu +2 位作者 Hou-Jun Lti Shu-Jin Hou En-Wei Liang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第4期411-418,共8页
Swift GRB 100418A is a long burst at z = 0.624 without detection of any associated supernova (SN). Its light curves in both the prompt and afterglow phases are similar to GRB 060614, a nearby long GRB without an assoc... Swift GRB 100418A is a long burst at z = 0.624 without detection of any associated supernova (SN). Its light curves in both the prompt and afterglow phases are similar to GRB 060614, a nearby long GRB without an associated SN. We analyze the observational data of this event and discuss the possible origins of its multiwavelength emission. We show that its joint light curve at 1 keV derived from Swift BAT and XRT observations is composed of two distinguished components. The first component, whose spectrum is extremely soft (Γ = 4.32), ends with a steep decay segment, indicating the internal origin of this component. The second component is a slowly-rising, broad bump which peaks at ~ 10 5 s post the BAT trigger. Assuming that the late bump is due to onset of the afterglow, we derive the initial Lorentz factor (Γ 0 ) of the GRB fireball and find that it significantly deviates from the relation between the Γ 0 and isotropic gamma-ray energy derived from typical GRBs. We also check whether it follows the same anti-correlation between X-ray luminosity and the break time observed in the shallow decay phase of many typical GRBs, which is usually regarded as a signal of late energy injection from the GRB central engine. However, we find that it does not obey this correlation. We propose that the late bump could be contributed by a two-component jet. We fit the second component with an off-axis jet model for a constant medium density and find the late bump can be represented by the model. The derived jet half-opening angle is 0.30 rad and the viewing angle is 0.315 rad. The medium density is 0.05 cm 3 , possibly suggesting that it may be from a merger of compact stars. The similarity between GRBs 060614 and 100418A may indicate that the two GRBs are from the same population and the late bump observed in the two GRBs may be a signal of a two-component jet powered by the GRB central engine. 展开更多
关键词 多波长 起源 发射 伽玛射线暴 物理 组成部分 信号衰减 光变曲线
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Polarization of GRB prompt emission and its application to POLAR’s data
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作者 Mi-Xiang Lan xue-feng wu Zi-Gao Dai 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第3期43-56,共14页
Synchrotron emission polarization is very sensitive to the magnetic field configuration.Recently,polarization of synchrotron emission with a mixed(SM)magnetic field in the gamma-ray burst(GRB)afterglow phase has been ... Synchrotron emission polarization is very sensitive to the magnetic field configuration.Recently,polarization of synchrotron emission with a mixed(SM)magnetic field in the gamma-ray burst(GRB)afterglow phase has been developed.Here,we apply these SM models to the GRB prompt phase and compare their polarization properties with that of synchrotron emission in purely ordered(SO)magnetic field.We find that the polarization properties in an SM model are very similar to these in a corresponding SO model(e.g.,synchrotron emission in a mixed magnetic field with an aligned ordered part(SMA)and synchrotron emission with a purely ordered aligned magnetic field(SOA)),only with a lower polarization degree(PD).We also discuss the statistical properties of the models.We find PDs of the simulated bursts are concentrated around 25%for both SOA and synchrotron emission in a purely ordered toroidal magnetic field(SOT),while they can range from 0%to 25%for SMA and synchrotron emission in a mixed magnetic field with a toroidal ordered part(SMT),depending onξ_B value,i.e.,the ratio of magnetic reduction of the ordered magnetic field over that of random magnetic field.From statistics,if PDs of majority GRBs are non-zero,then it favors SO and SM models.Further,if there are some bright GRBs with prominently lower PDs than that of the majority GRBs,it favors SOT(SMT)models;if all the bright GRBs have comparable PDs with the majority ones,it favors SOA(SMA)models.Finally,we apply our results to POLAR’s data and find that~10%time-integrated PDs of the observed bursts favor SMA and SMT models,and theξ_B parameter of these bursts is constrained to be around 1.135. 展开更多
关键词 gamma-ray burst:general magnetic fields POLARIZATION radiation mechanisms:nonthermal
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快速射电暴X射线对应体的量子电动力学磁重联起源
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作者 谢雨 耿金军 +6 位作者 朱熹炜 赵忠海 雷柱 袁文强 赵刚 吴雪峰 乔宾 《Science Bulletin》 SCIE EI CAS CSCD 2023年第17期1857-1861,共5页
快速射电暴(FRB)是宇宙中短时标的射电闪耀现象.近期,来自于SGR 1935+2154的一个独特的FRB(FRB 200428)和非热X射线爆发的成协的天文探测,证实了FRB起源于磁坨星的可能性.然而,无论是快速射电暴还是非热X射线的物理起源都不确定.制约相... 快速射电暴(FRB)是宇宙中短时标的射电闪耀现象.近期,来自于SGR 1935+2154的一个独特的FRB(FRB 200428)和非热X射线爆发的成协的天文探测,证实了FRB起源于磁坨星的可能性.然而,无论是快速射电暴还是非热X射线的物理起源都不确定.制约相关研究进展的重要的原因之一是磁坨星磁层附近磁场强度接近施温格极限,此时量子电动力学(QED)效应(特别是正负电子对产生效应)主导了相对论等离子体过程,使其超快、超强的能量释放的过程异常复杂.本文针对这类磁陀星附近的非热X-ray产生机制提出了精确的理论模型,将小尺度的QED磁重联加速与大尺度的光子辐射以及多次康普顿散射自洽地耦合在一起,进行了跨尺度的数值模拟.其数值结果与我国慧眼卫星Insight-HXMT的观测数据的时间和光谱特征非常一致,表明与FRB成协的X射线暴可能来自磁陀星磁层内的QED重联过程.这类模拟方法可以推广到更为广泛、复杂的跨尺度天体物理现象的研究. 展开更多
关键词 量子电动力学 康普顿散射 正负电子对 X射线 磁重联 光子辐射 能量释放 对应体
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如何理解高能伽玛射线暴?
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作者 戴子高 吴雪峰 梁恩维 《科学通报》 EI CAS CSCD 北大核心 2018年第24期2450-2464,共15页
伽玛射线暴(简称伽玛暴或gamma ray burst,GRB)是来自宇宙深处的、短时标的伽玛射线突然增强的现象,是宇宙大爆炸之后最猛烈的爆发现象.伽玛暴可分为长暴(持续时间T_(90)>2 s)和短暴(T_(90)<2 s).观测发现,长暴起源于大质量恒星... 伽玛射线暴(简称伽玛暴或gamma ray burst,GRB)是来自宇宙深处的、短时标的伽玛射线突然增强的现象,是宇宙大爆炸之后最猛烈的爆发现象.伽玛暴可分为长暴(持续时间T_(90)>2 s)和短暴(T_(90)<2 s).观测发现,长暴起源于大质量恒星的塌缩,而短暴起源于双致密星的并合.除了瞬时伽玛辐射,伽玛暴分别在暴后周、月和年时间量级上还会产生X射线、光学和射电余辉.理论上,伽玛暴的瞬时辐射被认为产生于相对论喷流内部的能量耗散过程,而多波段的余辉则产生于相对论喷流与外部介质之间的相互碰撞引起的外激波.因此,伽玛暴是研究致密天体(恒星级质量黑洞和中子星)诞生、引力波辐射、相对论激波、极高能宇宙线、高能中微子等极端物理现象以及高精度检验基本物理原理的天文实验室,也是早期宇宙恒星形成和演化、高红移星系、高红移宇宙学的重要探针.伽玛暴的研究横跨当今天文学、宇宙学、物理学等学科,是当前国际竞争最激烈的自然科学基础研究领域之一.2017年8月17日,LIGO(laser interferometer gravitational wave observatory)/Virgo引力波天文台和Fermi卫星同时分别探测到引力波事件GW170817和短时标伽玛暴GRB170817A,开辟了多信使天文学的新时代.本文结合相关的关键科学问题评述了伽玛暴和引力波电磁对应体研究领域的最新研究进展,并基于伽玛暴学科领域的发展态势和我国现有的研究基础,讨论如何抓住机遇、布局跨学科的重大研究计划,促进国内与伽玛暴相关科学设备成果的最大化,全面提升我国在这个领域的国际影响力. 展开更多
关键词 伽玛射线暴 高能天体物理 引力波 多信使 基本物理
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Testing fundamental physics with astrophysical transients 被引量:1
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作者 Jun-Jie Wei xue-feng wu 《Frontiers of physics》 CSCD 2021年第4期1-25,共25页
Explosive astrophysical transients at cosmological distances can be used to place precision tests of the basic assumptions of relativity theory,such as Lorentz invariance,the photon zero-mass hypothesis,and the weak e... Explosive astrophysical transients at cosmological distances can be used to place precision tests of the basic assumptions of relativity theory,such as Lorentz invariance,the photon zero-mass hypothesis,and the weak equivalence principle(WEP).Signatures of Lorentz invariance violations(LIV)include vacuum dispersion and vacuum birefringence.Sensitive searches for LIV using astrophysical sources such as gamma-ray bursts,active galactic nuclei,and pulsars are discussed.The most direct consequence of a nonzero photon rest mass is a frequency dependence in the velocity of light propagating in vacuum.A detailed representation of how to obtain a combined severe limit on the photon mass using fast radio bursts at different redshifts through the dispersion method is presented.The accuracy of the WEP has been well tested based on the Shapiro time delay of astrophysical messengers traveling through a gravitational field.Some caveats of Shapiro delay tests are discussed.In this article,we review and update the status of astrophysical tests of fundamental physics. 展开更多
关键词 astroparticle physics GRAVITATION astrophysical transients
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Self-organized criticality in multi-pulse gamma-ray bursts
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作者 Fen Lyu Ya-Ping Li +3 位作者 Shu-Jin Hou Jun-Jie Wei Jin-Jun Geng xue-feng wu 《Frontiers of physics》 SCIE CSCD 2021年第1期91-98,共8页
The variability in multi-pulse gamma-ray bursts(GRBs)may help to reveal the mechanism of underlying processes from the central engine.To investigate whether the self-organized criticality(SOC)phenomena exist in the pr... The variability in multi-pulse gamma-ray bursts(GRBs)may help to reveal the mechanism of underlying processes from the central engine.To investigate whether the self-organized criticality(SOC)phenomena exist in the prompt phase of GRBs,we statistically study the proper ties of GRBs with more than 3 pulses in each burst by fitting the distributions of several observed physical variables with a Markov Chain Monte Carlo approach,including the isotropic energy E_(iso),the duration time T,and the peak count rate P of each pulse.Our sample consists of 454 pulses in 93 GRBs observed by the CGRO/BATSE satellite.The best-fitting values and uncertainties for these power-law indices of the differential frequency distributions are:α_(E)^(d)=1.54±0.09,α_(T)^(d)=1.82_(-0.15)^(+0.14)andα_(P)^(d)=2.09_(-0.19)^(0.18),while the power-law indices in the cumulative frequency distributions are:α_(E)^(c)=1.44_(-0.10)^(+0.08),α_(T)^(c)=1.75_(-0.13)^(0.11)andα_(P)^(c)=1.99_(-0.19)^(+0.16).We find that these distributions are roughly consistent with the physical framework of a Fractal-Diffusive,Self^Organized Criticality(FD-SOC)system with the spatial dimension S=3 and the classical diffusionβ=1.Our results support that the jet responsible for the GRBs should be magnetically dominated and magnetic instabilities(e.g.,kink model,or tearing-model instability)lead the GRB emission region into the SOC state. 展开更多
关键词 gamma-ray burst general methods STATISTICAL
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A comparison between repeating bursts of FRB 121102 an giant pulses from Crab pulsar and its applications
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作者 Fen Lyu Yan-Zhi Meng +6 位作者 Zhen-Fan Tang Ye Li Jun-Jie Wei Jin-Jun Geng Lin Lin Can-Min Deng xue-feng wu 《Frontiers of physics》 SCIE CSCD 2021年第2期201-207,共7页
There are some similarities between bursts of repeating fast radio bursts(FRBs)and giant pulses(GPs)of pulsars.To explore possible relations between them,we study the cumulative energy distributions of these two pheno... There are some similarities between bursts of repeating fast radio bursts(FRBs)and giant pulses(GPs)of pulsars.To explore possible relations between them,we study the cumulative energy distributions of these two phenomena using the observations of repeating FRB 121102 and the GPs of Crab pulsar.We find that the power-law slope of GPs(with fuence≥130 Jy.ms)is 2.85±0.10.The energy distribution of FRB 121102 can be well fitted by a smooth broken power-law function.For the bursts of FRB 121102 above the break energy(1.22×10^(37)erg),the best-ftting slope is 2.90^(+0.55)_(-0344),similar to the index of GPs at the same observing frequency(~1.4 GHz).We further discuss the physical origin of the repeating FRB 121102 in the framework of the super GPs model.And we find that the super GPs model involving a millisecond pulsar is workable and favored for explaining FRB 121102 despite that the magnetar burst model is more popular. 展开更多
关键词 PULSARS radio sources general-methods:statistical
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