The skyrmion generator is one of the indispensable components for the future functional skyrmion devices,but the process of generating skyrmion cannot avoid mixing with other magnetic textures,such as skyrmionium and ...The skyrmion generator is one of the indispensable components for the future functional skyrmion devices,but the process of generating skyrmion cannot avoid mixing with other magnetic textures,such as skyrmionium and nested skyrmion bags.These mixed magnetic textures will inevitably lead to the blockage of skyrmion transport and even the distortion of data information.Therefore,the design of an efficient skyrmion filter is of great significance for the development of skyrmion-based spintronic devices.In this work,a skyrmion filter scheme is proposed,and the high-efficiency filtering function is demonstrated by micromagnetic simulations.The results show that the filtering effect of the scheme depends on the structure geometry and the spin current density that drives the skyrmion.Based on this scheme,the polarity of the filtered skyrmion can be controlled by switching the magnetization state at the output end,and the“cloning”of the skyrmion can be realized by geometric optimization of the structure.We believe that in the near future,the skyrmion filter will become one of the important components of skyrmion-based spintronic devices in the future.展开更多
Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluor...Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as autophagy.Subsequently,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic acid.Results:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell autophagy.It also targeted PTP1B and lowered PTP1B expression.However,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD cells.Conclusions:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.展开更多
BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective treatment.In surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to im...BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective treatment.In surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment effects.AIM To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic therapy.METHODS A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were grouped.The observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the operation.RESULTS White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(P<0.05).The hospital stay in the observation group was significantly shorter than that in the control group.The hospitalization cost in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P<0.05).CONCLUSION Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.展开更多
BACKGROUND Diagnosing and treating abdominal infection in children remains a challenge.Nucleic acid detection,as a rapid and accurate diagnosis tool,has great significance in this field.AIM To investigate the diagnosi...BACKGROUND Diagnosing and treating abdominal infection in children remains a challenge.Nucleic acid detection,as a rapid and accurate diagnosis tool,has great significance in this field.AIM To investigate the diagnosis and treatment of abdominal infection by nucleic acid detection and its possible correlation with psychological stress in children.METHODS A total of 50 pediatric patients diagnosed with abdominal infections between September 2020 and July 2021 were included in this study.Intra-abdominal pus samples were collected for pathogen culture,drug susceptibility testing,and broad-spectrum bacterial nucleic acid testing.Psychological stress,anxiety,depression,and coping styles were assessed using the coping with a disease(CODI)scale.RESULTS Based on susceptibility testing,a regimen of cefazoxime,piperacillin/tazobactam,and metronidazole or ornidazole achieved 100%effectiveness in treating appendicitis.Psychological assessments revealed a positive correlation between pressure level and both anxiety(r=0.324,P=0.001)and depressive disorders(r=0.325,P<0.001).Acceptance and distancing as coping strategies were negatively correlated with anxiety and depression,while negative emotional responses were strongly associated with increased anxiety(r=0.574,P<0.001)and depression(r=0.511,P=0.001).Coping strategies such as illusion and escape showed no significant correlation with emotional outcomes.CONCLUSION Nucleic acid testing helps in the diagnosis of abdominal infections in children,and also focuses on children's mental health.展开更多
We investigate asymmetric spin wave scattering behaviors caused by vortex chirality in a cross-shaped ferromagnetic system by using the micromagnetic simulations.In the system,four scattering behaviors are found:(i)as...We investigate asymmetric spin wave scattering behaviors caused by vortex chirality in a cross-shaped ferromagnetic system by using the micromagnetic simulations.In the system,four scattering behaviors are found:(i)asymmetric skew scattering,depending on the polarity of vortex core,(ii)back scattering(reflection),depending on the vortex core stiffness,(iii)side deflection scattering,depending on structural symmetry of the vortex circulation,and(iv)geometrical scattering,depending on waveguide structure.The first and second scattering behaviors are attributed to nonlinear topological magnon spin Hall effect related to magnon spin-transfer torque effect,which has value for magnonic exploration and application.展开更多
Background Fall and serious fall injuries have become a major health concern for elders. Many factors including blood pressure and anti-hypertensive medication application were reported as hazards of fall. The purpose...Background Fall and serious fall injuries have become a major health concern for elders. Many factors including blood pressure and anti-hypertensive medication application were reported as hazards of fall. The purpose of this study was to determine if age related systemic functional decline related with increased fall risks in elderly patients with hypertension. Methods A total of 342 elderly hypertension patients （age 79.5 ＋ 6.7 years, male 63.8%） were recruited to the study. Comprehensive geriatric assessment （CGA）, including measurements about activity of daily living （ADL）, nutrition, cognition, depression, numbers of prescription medication and number of clinical diagnosis, was conducted to evaluate the physical and mental status of each participants. Fall risk was evaluated by Morse fall scale, Tinetti perform- ance oriented mobility assessment （POMA） and history of fall in the recent years. Participants were grouped into tertiles according to CGA score. Correlation between CGA and fall risk was analyzed through SPSS 18.0. Results Participants with higher CGA score were likely to be older, had a lower body mass index （BMI）, and a higher prevalence of cardiovascular disease, chronic obstructive pulmonary disease （COPD）, cerebrovascular disease and osteoarthropathia. Participants in higher tertile of CGA score got increased prevalence of fall risk than those in lower tertile （P 〈 0.01 T3 vs. T1, P 〈 0.01 T3 vs. T2）. Correlation analysis and regression analysis showed significant association between CGA and Morse fall scale （P 〈 0.001）, as well as CGA and POMA （P 〈 0.001）. Meanwhile, CGA components also showed co-relationships with increase fall risks. After adjusting age, BMI, benzodiazepine use, cardiovascular disease, cerebrovascular disease, COPD and osteoarthropathia, both history of fall in the recent year and rising Morse fall scale were significantly associated with ADL im- pairment （OR： 2.748, 95%CI： 1.598-4.725）, （OR： 3.310, 95%CI： 1.893-5.788）. Decreased Tinetti POMA score was associated with Mini-Mental State Examination （MMSE） （OR： 4.035, 95%CI： 2.100-7.751）, ADL （OR： 2.380, 95%CI： 1.357-4.175） and shortened MNA form （MNA-SF） impairment （OR： 2.692, 95%CI： 1.147-6.319）. Conclusions In elderly adults with hypertension, impaired physical and mental function is associated with increased fall risk. Further study is required to investigate possible mediators for the association and effec- tive interventions.展开更多
The effect of microwave radiation on the nucleation and crystallization of tailing-based glass-ceramics was investigated using a 2.45 GHz multimode microwave cavity. Tailing-based glass samples were prepared fi＇om Sh...The effect of microwave radiation on the nucleation and crystallization of tailing-based glass-ceramics was investigated using a 2.45 GHz multimode microwave cavity. Tailing-based glass samples were prepared fi＇om Shandong gold tailings and Guyang iron tailings utilizing a conventional glass melting technique. For comparison, the tailing-based glass samples were crystallized using two different heat-treatment methods： conventional heating and hybrid microwave heating. The nucleation and crystallization temperatures were determined by performing a differential thermal analysis of the quenched tailing-based glass. The prepared glass-ceramic samples were further characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, thermal expansion coefficient measurements, and scanning electron microscopy. The results demonstrated that hybrid microwave heating could be successfully used to crystallize the tailing-based glass, reduce the processing time, and decrease the crystallization temperature. Furthermore, the results indicated that the nucleation and crystallization mechanism of the hybrid microwave heating process slightly differs fi＇om that of the conventional heating process.展开更多
We periodically modulate the lattice trapping potential of a ^(87)Sr optical clock to Floquet engineer the clock transition.In the context of atomic gases in lattices,Floquet engineering has been used to shape the dis...We periodically modulate the lattice trapping potential of a ^(87)Sr optical clock to Floquet engineer the clock transition.In the context of atomic gases in lattices,Floquet engineering has been used to shape the dispersion and topology of Bloch quasi-energy bands.Differently from these previous works manipulating the external(spatial)quasi-energies,we target the internal atomic degrees of freedom.We shape Floquet spin quasi-energies and measure their resonance profiles with Rabi spectroscopy.We provide the spectroscopic sensitivity of each band by measuring the Fisher information and show that this is not depleted by the Floquet dynamical modulation.The demonstration that the internal degrees of freedom can be selectively engineered by manipulating the external degrees of freedom inaugurates a novel device with potential applications in metrology,sensing and quantum simulations.展开更多
BACKGROUND:Hypothermia is associated with poor outcome in trauma patients;however,hemorrhagic shock(HS)model with anesthetized swine was different from that of clinical reality.To identify the effects of environmental...BACKGROUND:Hypothermia is associated with poor outcome in trauma patients;however,hemorrhagic shock(HS)model with anesthetized swine was different from that of clinical reality.To identify the effects of environmental hypothermia on HS,we investigated hemodynamics and oxygen dynamics in an unanesthetized swine model of HS under simulating hypothermia environment.METHODS:Totally 16 Bama pigs were randomly divided into ambient temperature group(group A)and low temperature group(group B),8 pigs in each group.Venous blood(30 mL/kg)was continuously withdrawn for more than 15 minutes in conscious swine to establish a hemorrhagic shock model.Pulmonary arterial temperature(Tp),heart rate(HR),mean arterial pressure(MAP),pulmonary arterial pressure(PAP),pulmonary arterial wedge pressure(PAWP),central venous pressure(CVP),cardiac output(CO),hemoglobin(Hb),saturation of mixed venous blood(SvO_2)and blood gas analysis were recorded at the baseline and different hemorrhagic shock time(HST).The whole body oxygen delivery indices,DO_2l and VO_2l,and the O_2 extraction ratio(O_2ER)were calculated.RESULTS:Core body temperature in group A decreased slightly after the hemorrhagic shock model was established,and environmental hypothermia decreased in core body temperature.The mortality rate was significantly higher in group B(50%)than in group A(0%).DO_2l and VO_2l decreased significantly after hemorrhage.No difference was found in hemodynamics,DO_2l and VO_2l between group A and group B,but the difference in pH,lactic acid and O_2ER was significant between the two groups.CONCLUSION:Environmental hypothermia aggravated the disorder of oxygen metabolism after hemorrhagic shock,which was associated with poor prognosis.展开更多
To investigate the dependence of large gradual solar energetic particle（SEP） events on the associated flares and coronal mass ejections（CMEs）, the correlation coefficients（CCs） between peak intensities of E 〉 1...To investigate the dependence of large gradual solar energetic particle（SEP） events on the associated flares and coronal mass ejections（CMEs）, the correlation coefficients（CCs） between peak intensities of E 〉 10 MeV（I10）, E 〉 30 MeV（I30） and E 〉 50 MeV（I50） protons and soft X-ray（SXR） emission of associated flares and the speeds of associated CMEs in the three longitudinal areas W0–W39, W40–W70（hereafter the well connected region） and W71–W90 have been calculated.Classical correlation analysis shows that CCs between SXR emission and peak intensities of SEP events always reach their largest value in the well connected region and then decline dramatically in the longitudinal area outside the well connected region, suggesting that they may contribute to the production of SEPs in large SEP events. Both classical and partial correlation analyses show that SXR fluence is a better parameter describing the relationship between flares and SEP events. For large SEP events with source location in the well connected region, the CCs between SXR fluence and I10, I30 and I50 are0.58±0.12, 0.80±0.06 and 0.83±0.06 respectively, while the CCs between CME speed and I10, I30 and I50 are 0.56±0.12, 0.52±0.13 and 0.48±0.13 respectively. The partial correlation analyses show that in the well connected region, both CME shock and SXR fluence can significantly affect I10, but SXR peak flux makes no additional contribution. For E 〉 30 MeV protons with source location in the well connected region, only SXR fluence can significantly affect I30, and the CME shock makes a small contribution to I30, but SXR peak flux makes no additional contribution. For E 〉 50 MeV protons with source location in the well connected region, only SXR fluence can significantly affect I50, but both CME shock and SXR peak flux make no additional contribution. We conclude that these findings provide statistical evidence that for SEP events with source locations in the well connected region, a CME shock is only an effective accelerator for E 〈 30 MeV protons. However, flares are not only effective accelerators for E 〈 30 MeV protons, but also for E 〉 30 MeV protons, and E 〉 30 MeV protons may be mainly accelerated by concurrent flares.展开更多
Nd content was varied in Nd13.2-xFe80.8+xB6(x = 0, 0.5, 1, and 1.5) to optimize the magnetic properties of sintered Nd–Fe–B/Tb–Fe–B composite magnets, which were prepared by mixing 9 g of Nd–Fe–B with 1 g of Tb1...Nd content was varied in Nd13.2-xFe80.8+xB6(x = 0, 0.5, 1, and 1.5) to optimize the magnetic properties of sintered Nd–Fe–B/Tb–Fe–B composite magnets, which were prepared by mixing 9 g of Nd–Fe–B with 1 g of Tb17Fe75B8 powder.In conventional magnets, by reducing Nd content, the coercivity of 10.4 kOe in Nd13.2Fe80.8B6 decreases to 7.2 kOe in Nd12.2Fe81.8B6;meanwhile, in Nd–Fe–B/Tb–Fe–B magnets the coercivity does not decrease when reducing Nd content.In the intergranular phase, the Tb content increases owing to the reducing Nd content of the Nd–Fe–B alloy in the sintered composite magnets.Therefore, the excess Tb in Tb17Fe75B8 enters the intergranular phase, and more Tb atoms can substitute for Nd at the grain boundary of the Nd–Fe–B phase, leading to a more significant increase in coercivity.The remanence increases with reducing Nd content, and the energy product of 39.1 MGOe with a high coercivity of 21.0 kOe is obtained in Nd12.2Fe81.8B6/Tb17Fe75B8 magnets.These investigations show that magnetic properties can be further improved by regulating the element distribution in sintered composite magnets.展开更多
To investigate the possible solar source of high-energy protons, correlation coefficients between the peak intensities of E ≥ 100 MeV protons, I100, and the peak flux and fluence of solar soft X-ray（SXR） emission, ...To investigate the possible solar source of high-energy protons, correlation coefficients between the peak intensities of E ≥ 100 MeV protons, I100, and the peak flux and fluence of solar soft X-ray（SXR） emission, and coronal mass ejection（CME） linear speed in the three longitudinal areas W0-W39, W40-W70 and W71-W90 have been calculated respectively. Classical correlation analysis shows that the correlation coefficients between CME speeds and I100 in the three longitudinal areas are0.28±0.21, 0.35±0.21 and 0.04±0.30 respectively. The classical correlation coefficients between I100 and SXR peak flux in the three longitudinal areas are 0.48±0.17, 0.72±0.13 and 0.02±0.30 respectively, while the correlation coefficients between I100 and SXR fluence in the three longitudinal areas are 0.25±0.21, 0.84±0.07 and 0.10±0.30 respectively. Partial correlation analysis shows that for solar proton events with source location in the well connected region（W40-W70）, only SXR fluence can significantly affect the peak intensity of E ≥ 100 MeV protons, but SXR peak flux has little influence on the peak intensities of E ≥ 100 MeV protons; moreover, CME speed has no influence on the peak intensities of E ≥ 100 MeV protons. We conclude that these findings provide statistical evidence that E ≥ 100 MeV protons may be mainly accelerated by concurrent flares.展开更多
AIM: To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-st...AIM: To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-step and multi-pathway processes of DLBCL tumorigenesis. METHODS: Maximum-weight branching and distancebased models were constructed based on the comparative genomic hybridization (CGH) data of 123 DLBCL samples using the established methods and software of Desper et al . A maximum likelihood tree model was also used to analyze the data. By comparing with the results reported in literature, values of tree models in the classification of DLBCL were elucidated. RESULTS: Both the branching and the distance-based trees classified DLBCL into three groups. We combined the classification methods of the two models and classified DLBCL into three categories according to their characteristics. The first group was marked by +Xq, +Xp, -17p and +13q; the second group by +3q, +18q and +18p; and the third group was marked by -6q and +6p. This chromosomal classification was consistent with cDNA classification. It indicated that -6q and +3q were two main events in the tumorigenesis of lymphoma. CONCLUSION: Tree models of lymphoma established from CGH data can be used in the classification of DLBCL. These models can suggest multi-gene, multistep and multi-pathway processes of tumorigenesis. Two pathways, -6q preceding +6q and +3q preceding+18q, may be important in understanding tumorigenesis of DLBCL. The pathway, -6q preceding +6q, may have a close relationship with the tumorigenesis of non-GCB DLBCL.展开更多
Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria.Methods: This study was conducted using epidemiologica...Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria.Methods: This study was conducted using epidemiological surveys and a multi-center randomized controlled clinical trial. A total of 3,011 subjects were studied, and the following indices were collected after their return to low altitude areas from the plateau: general health status, blood, urine and stool samples, myocardial enzyme levels, liver and kidney function, nerve function, sex hormone levels, microalbuminuria, electrocardiogram(ECG), echocardiography, pulmonary function, and hemorheological markers. These data were compared to those of randomized healthy subjects in the same age range who lived at the same altitude to determine the characteristics of high altitude deacclimatization syndrome. Based on these characteristics, diagnostic criteria for high altitude de-acclimatization syndrome were formulated.Results: This study demonstrated that the incidence of high altitude de-acclimatization syndrome was 84.36%. Sixty percent of the cases were mild, 30% were medium, and 10% were severe. The incidence was higher among those who returned to a place of lower altitude, resided at a high altitude for a longer period of time, or engaged in heavy labor while at high altitude. Patients with high altitude de-acclimatization syndrome manifested hematological abnormalities and abnormal ventricular function, notably a right ventricular diastolic function, which recovered to baseline function after one to five years. Exposure to long-term hypoxia often caused obvious changes in cardiac morphology, i.e., left and right ventricular hypertrophy, particularly within the right ventricle. In addition, patients with high altitude de-acclimatization syndrome often presented with low blood pressure, low pulse pressure, and microalbuminuria. A few patients presented with occult blood in their feces. The diagnosis of high altitude deacclimatization syndrome can be made if a patient who recently returns to the plain from the plateau complains of dizziness, weakness, sleepiness, chest tightness, edema, memory loss, and other symptoms and signs that do not alleviate under short-term rehabilitation or symptomatic treatment, and if organic diseases of the heart, lung, kidney, and other organs have been excluded.Conclusion: The diagnosis of high altitude de-acclimatization syndrome should be made after a comprehensive analysis of the patient's clinical symptoms and signs.展开更多
Designing multicomponent integration catalysts(MICs)has been a promising strategy for improving electrocatalytic hydrogen evolution reaction(HER)due to the highly active interfaces as well as electronic synergy.Nevert...Designing multicomponent integration catalysts(MICs)has been a promising strategy for improving electrocatalytic hydrogen evolution reaction(HER)due to the highly active interfaces as well as electronic synergy.Nevertheless,many fundamental questions such as their actual active species and the influence on long-term stability remain to be answered.Herein,we present the structural evolution from a pseudotri-component electrocatalyst of nitrogen-doped carbon supported nickel/vanadium nitride/vanadium oxide(Ni-VN-V_(2)O_(3)/NC)nanorods to the heterostructural nickel/vanadium nitride(Ni-VN/NC)nanosheets during chemical or electrochemical processes.The self-reconstructed Ni-VN/NC exhibits a robust stability under alkaline conditions,while maintaining initial efficient HER activity with a low overpotential of 76 mV at the current density of 10 mA cm^(-2).Theoretical calculations and quasi-in-situ spectroscopic technology unveil the redistribution of electrons on the synergistic active interface,which synchronously optimizes the affinities for hydrogen,hydroxide,and water molecules,thereby remarkably accelerating the HER kinetics by reducing the barrier of Volmer step.展开更多
Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myo...Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.展开更多
Ammonia borane(NH_(3)BH_(3),AB)has been regarded as a promising chemical hydrogen storage material owing to its high hydrogen density and superior stability.Thus,the development of low-cost and high-efficient heteroge...Ammonia borane(NH_(3)BH_(3),AB)has been regarded as a promising chemical hydrogen storage material owing to its high hydrogen density and superior stability.Thus,the development of low-cost and high-efficient heterogeneous catalysts for the dehydrogenation of AB has attracted considerable scholarly attention.In this study,heterostructured Co_(3)O_(4)-SnO_(2)catalysts containing oxygen vacancy(V_(o))with different Co/Sn atomic ratios(designated as V_(o)-Co-Sn_(5:x))were synthesized via a simple coprecipitation-calcination method under mild reaction conditions.The catalyst containing an optimized Co/Sn atomic ratio of 5:2(V_(o)-Co-Sn_(5:2))exhibited robust catalytic performance with a turnover frequency value of 17.6mol_(H2)·mol^(-1)_(metal)·min^(-1).Moreover,82.6%of the original activity of the catalyst was retained after 14 catalytic cycles,indicating the high stability of the catalyst.Diversified characterization combined with the density functional theory(DFT)calculation confirmed the transfer of electrons from Co_(3)O_(4)to Sn O_(2)and the distribution of the separated charges on SnO_(2)-Co_(3)O_(4)interface.The transfer of electrons and the distribution of charges facilitated the adsorption and activation of water on the catalyst,thus accelerating the dissociation of H_(2)O molecule(the ratedetermining step of AB hydrolysis).It was found that the V_(o)adjusted the electron structure of the catalysts rather than acted as active sites.These findings will provide researchers with useful information for designing cheap and highly efficient catalysts for catalytic AB hydrolysis.展开更多
In this study, the effect of wheel speed and mischmetal（MM） content on the magnetic properties of MMFeB ribbons was investigated. The samples were prepared via direct solidification technique. The nominal compositio...In this study, the effect of wheel speed and mischmetal（MM） content on the magnetic properties of MMFeB ribbons was investigated. The samples were prepared via direct solidification technique. The nominal composition of the alloy ingots is MM;Fe;B;with x varying from 9 to 15 in steps of 2. Experimental results show the overall magnetic properties of the ribbons.Analysis of the results shows that the magnetic properties first improve and then degrade with the wheel speed and MM content increasing. Increase in MM content leads to better formation of crystal texture in the ribbons, indicating that the a-Fe phase might undermine the formation of crystal texture. Magnetic properties results show that the coercivity of the ribbons rises with an appropriate increase in both MM content and wheel speed during melt-spun process. The strongest magnetic properties of the ribbons(remanence of M;= 0.72 T, intrinsic coercivity of H;= 352.58 kA·m;, and maximum energy product of（BH）;=72.14 kJ·m;) are obtained for compositions where x = 13 and a wheel speed of v = 20 m·s;.展开更多
The isotropic nanocrystalline[(PrNd)0.8MM0.2]29.8Fe68.7Al0.1Cu0.12Co0.88B magnets(MM:mischmetal)were prepared by single-main phase and double-main phase methods using spark plasma sintering(SPS).Melt-spinning method w...The isotropic nanocrystalline[(PrNd)0.8MM0.2]29.8Fe68.7Al0.1Cu0.12Co0.88B magnets(MM:mischmetal)were prepared by single-main phase and double-main phase methods using spark plasma sintering(SPS).Melt-spinning method was used to prepare initial powder and avoid component deviations caused by longtime ball milling.The magnetic properties of the magnet prepared by double-main phase method(called double-main phase magnet,DMP magnet)are remanence of Br=0.75 T,intrinsic coercivity of Hcj=909.83 kA·m-1,maximum magnetic energy product of(BH)max=95.48 kJ·m-3,which are better than those of the magnet prepared by single-main phase method(called singlemain phase magnet,SMP magnet).The diffraction peaks of the main phase of DMP magnet split in X-ray diffractometer(XRD)pattern,indicating that R2 Fe14B phases with different distributions of La/Ce elements exist in the magnet.This speculation is confirmed by transmission electron microscopy(TEM)observation.The La/Ce-rich main phase and La/Celean main phase are present in DMP magnets.The heterogeneity of rare earth elements suppresses the magnetic dilution effect in DMP magnet,and the magnetic properties are improved.Though the DMP magnet contains different main phases,it presents unitary Curie temperature(TC)of 577 K,which is higher than that of SMP magnet.This result suggests that the TC of the magnets can be promoted by double-main phase method and SPS.展开更多
Adsorptive separation of p-xylene(pX)from xylene isomers is a key process in chemical industry,but known adsorbents cannot simultaneously achieve high adsorption selectivity,capacity,and rate.Here,we demonstrate gatin...Adsorptive separation of p-xylene(pX)from xylene isomers is a key process in chemical industry,but known adsorbents cannot simultaneously achieve high adsorption selectivity,capacity,and rate.Here,we demonstrate gating ultramicropore as a solution for this challenge.Slight modification of the synthetic condition gives rise to isomeric metal-organic frameworksα-[Zn(pba)](MAF-88,H2pba=4-(1H-pyrazol-4-yl)benzoic acid)andβ-[Zn(pba)](MAF-89)possessing similar pillared-column structures,porosities,and high pX capacities of 2.0 mmol g^(−1),but very different framework/pore topologies,pore sizes,and pX selectivities.For binary and ternary mixtures of liquid xylene isomers,MAF-88 with narrow one-dimensional(1D)channels shows pX selectivity of 11 and 1.6,while MAF-89 with 3D-connected quasi-discrete pores shows pX selectivity up to 221 and 46,respectively.Thermogravimetry,differential scanning calorimetry,and time-dependent separation experiments reveal that the kinetic effects of the gating pores play more important roles than the thermodynamic effects,which is further confirmed by single-crystal X-ray diffraction and computational simulations.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12364020)the Scientific and Technological Development Plan of Jilin Province,China(Grant No.20240101295JC)+1 种基金the Science and Technology Research and Planning Project of Jilin Provincial Department of Education(Grant No.JJKH20230611KJ)the Applied Foundation Research Project(Talent Funding Project)of Yanbian University(Grant No.ydkj202241).
文摘The skyrmion generator is one of the indispensable components for the future functional skyrmion devices,but the process of generating skyrmion cannot avoid mixing with other magnetic textures,such as skyrmionium and nested skyrmion bags.These mixed magnetic textures will inevitably lead to the blockage of skyrmion transport and even the distortion of data information.Therefore,the design of an efficient skyrmion filter is of great significance for the development of skyrmion-based spintronic devices.In this work,a skyrmion filter scheme is proposed,and the high-efficiency filtering function is demonstrated by micromagnetic simulations.The results show that the filtering effect of the scheme depends on the structure geometry and the spin current density that drives the skyrmion.Based on this scheme,the polarity of the filtered skyrmion can be controlled by switching the magnetization state at the output end,and the“cloning”of the skyrmion can be realized by geometric optimization of the structure.We believe that in the near future,the skyrmion filter will become one of the important components of skyrmion-based spintronic devices in the future.
基金supported by the Zhejiang Province Traditional Chinese Medicine Health Science and Technology Program(2023ZL570).
文摘Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as autophagy.Subsequently,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic acid.Results:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell autophagy.It also targeted PTP1B and lowered PTP1B expression.However,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD cells.Conclusions:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.
基金Zhangjiakou Science and Technology Tackling Program,No.2021099D.
文摘BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective treatment.In surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment effects.AIM To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic therapy.METHODS A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were grouped.The observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the operation.RESULTS White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(P<0.05).The hospital stay in the observation group was significantly shorter than that in the control group.The hospitalization cost in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P<0.05).CONCLUSION Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.
基金Supported by Zhangjiakou Science and Technology Tackling Program,No.2021099D。
文摘BACKGROUND Diagnosing and treating abdominal infection in children remains a challenge.Nucleic acid detection,as a rapid and accurate diagnosis tool,has great significance in this field.AIM To investigate the diagnosis and treatment of abdominal infection by nucleic acid detection and its possible correlation with psychological stress in children.METHODS A total of 50 pediatric patients diagnosed with abdominal infections between September 2020 and July 2021 were included in this study.Intra-abdominal pus samples were collected for pathogen culture,drug susceptibility testing,and broad-spectrum bacterial nucleic acid testing.Psychological stress,anxiety,depression,and coping styles were assessed using the coping with a disease(CODI)scale.RESULTS Based on susceptibility testing,a regimen of cefazoxime,piperacillin/tazobactam,and metronidazole or ornidazole achieved 100%effectiveness in treating appendicitis.Psychological assessments revealed a positive correlation between pressure level and both anxiety(r=0.324,P=0.001)and depressive disorders(r=0.325,P<0.001).Acceptance and distancing as coping strategies were negatively correlated with anxiety and depression,while negative emotional responses were strongly associated with increased anxiety(r=0.574,P<0.001)and depression(r=0.511,P=0.001).Coping strategies such as illusion and escape showed no significant correlation with emotional outcomes.CONCLUSION Nucleic acid testing helps in the diagnosis of abdominal infections in children,and also focuses on children's mental health.
基金Project supported by the Basic Science Research Program of the National Research Foundation of Korea(Grant No.2021R1F1A1050539)the Yanbian University Research Project(Grant No.482022104)the Yichang Natural Science Research Project(Grant No.A22-3-010)。
文摘We investigate asymmetric spin wave scattering behaviors caused by vortex chirality in a cross-shaped ferromagnetic system by using the micromagnetic simulations.In the system,four scattering behaviors are found:(i)asymmetric skew scattering,depending on the polarity of vortex core,(ii)back scattering(reflection),depending on the vortex core stiffness,(iii)side deflection scattering,depending on structural symmetry of the vortex circulation,and(iv)geometrical scattering,depending on waveguide structure.The first and second scattering behaviors are attributed to nonlinear topological magnon spin Hall effect related to magnon spin-transfer torque effect,which has value for magnonic exploration and application.
文摘Background Fall and serious fall injuries have become a major health concern for elders. Many factors including blood pressure and anti-hypertensive medication application were reported as hazards of fall. The purpose of this study was to determine if age related systemic functional decline related with increased fall risks in elderly patients with hypertension. Methods A total of 342 elderly hypertension patients （age 79.5 ＋ 6.7 years, male 63.8%） were recruited to the study. Comprehensive geriatric assessment （CGA）, including measurements about activity of daily living （ADL）, nutrition, cognition, depression, numbers of prescription medication and number of clinical diagnosis, was conducted to evaluate the physical and mental status of each participants. Fall risk was evaluated by Morse fall scale, Tinetti perform- ance oriented mobility assessment （POMA） and history of fall in the recent years. Participants were grouped into tertiles according to CGA score. Correlation between CGA and fall risk was analyzed through SPSS 18.0. Results Participants with higher CGA score were likely to be older, had a lower body mass index （BMI）, and a higher prevalence of cardiovascular disease, chronic obstructive pulmonary disease （COPD）, cerebrovascular disease and osteoarthropathia. Participants in higher tertile of CGA score got increased prevalence of fall risk than those in lower tertile （P 〈 0.01 T3 vs. T1, P 〈 0.01 T3 vs. T2）. Correlation analysis and regression analysis showed significant association between CGA and Morse fall scale （P 〈 0.001）, as well as CGA and POMA （P 〈 0.001）. Meanwhile, CGA components also showed co-relationships with increase fall risks. After adjusting age, BMI, benzodiazepine use, cardiovascular disease, cerebrovascular disease, COPD and osteoarthropathia, both history of fall in the recent year and rising Morse fall scale were significantly associated with ADL im- pairment （OR： 2.748, 95%CI： 1.598-4.725）, （OR： 3.310, 95%CI： 1.893-5.788）. Decreased Tinetti POMA score was associated with Mini-Mental State Examination （MMSE） （OR： 4.035, 95%CI： 2.100-7.751）, ADL （OR： 2.380, 95%CI： 1.357-4.175） and shortened MNA form （MNA-SF） impairment （OR： 2.692, 95%CI： 1.147-6.319）. Conclusions In elderly adults with hypertension, impaired physical and mental function is associated with increased fall risk. Further study is required to investigate possible mediators for the association and effec- tive interventions.
基金financially supported by the Fundamental Research and Key Technologies Fund for the Integrated Utilization of Bayan Obo Mine Resources with High Added Value (No. 41402060901)the National Natural Science Foundation of China (No. 11564013)the Inner Mongolia University of Science and Technology Innovation Fund (Nos. 2014QNGG09 and 2014QDL042).
文摘The effect of microwave radiation on the nucleation and crystallization of tailing-based glass-ceramics was investigated using a 2.45 GHz multimode microwave cavity. Tailing-based glass samples were prepared fi＇om Shandong gold tailings and Guyang iron tailings utilizing a conventional glass melting technique. For comparison, the tailing-based glass samples were crystallized using two different heat-treatment methods： conventional heating and hybrid microwave heating. The nucleation and crystallization temperatures were determined by performing a differential thermal analysis of the quenched tailing-based glass. The prepared glass-ceramic samples were further characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, thermal expansion coefficient measurements, and scanning electron microscopy. The results demonstrated that hybrid microwave heating could be successfully used to crystallize the tailing-based glass, reduce the processing time, and decrease the crystallization temperature. Furthermore, the results indicated that the nucleation and crystallization mechanism of the hybrid microwave heating process slightly differs fi＇om that of the conventional heating process.
基金Supported by the National Natural Science Foundation of China(Grant Nos.61775220,11804034,11874094,12047564,11874247,11874246)the Key Research Project of Frontier Science of the Chinese Academy of Sciences(Grant No.QYZDB-SSW-JSC004)+5 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDB21030100 and XDB35010202)the Special Foundation for Theoretical Physics Research Program of China(Grant No.11647165)the Fundamental Research Funds for the Central Universities(Grant No.2020CDJQY-Z003)the National Key R&D Program of China(Grant No.2017YFA0304501),the 111 Project(Grant No.D18001)the Hundred Talent Program of the Shanxi Province(2018)the EMPIR-USOQS,EMPIR Project co-funded by the European Unions Horizon2020 Research and Innovation Programme and the EMPIR Participating States.
文摘We periodically modulate the lattice trapping potential of a ^(87)Sr optical clock to Floquet engineer the clock transition.In the context of atomic gases in lattices,Floquet engineering has been used to shape the dispersion and topology of Bloch quasi-energy bands.Differently from these previous works manipulating the external(spatial)quasi-energies,we target the internal atomic degrees of freedom.We shape Floquet spin quasi-energies and measure their resonance profiles with Rabi spectroscopy.We provide the spectroscopic sensitivity of each band by measuring the Fisher information and show that this is not depleted by the Floquet dynamical modulation.The demonstration that the internal degrees of freedom can be selectively engineered by manipulating the external degrees of freedom inaugurates a novel device with potential applications in metrology,sensing and quantum simulations.
基金supported by a grant from 11th Five-Year Plan Medical Science Scientific Research Fund of the Chinese People's Liberation Army(08G002)
文摘BACKGROUND:Hypothermia is associated with poor outcome in trauma patients;however,hemorrhagic shock(HS)model with anesthetized swine was different from that of clinical reality.To identify the effects of environmental hypothermia on HS,we investigated hemodynamics and oxygen dynamics in an unanesthetized swine model of HS under simulating hypothermia environment.METHODS:Totally 16 Bama pigs were randomly divided into ambient temperature group(group A)and low temperature group(group B),8 pigs in each group.Venous blood(30 mL/kg)was continuously withdrawn for more than 15 minutes in conscious swine to establish a hemorrhagic shock model.Pulmonary arterial temperature(Tp),heart rate(HR),mean arterial pressure(MAP),pulmonary arterial pressure(PAP),pulmonary arterial wedge pressure(PAWP),central venous pressure(CVP),cardiac output(CO),hemoglobin(Hb),saturation of mixed venous blood(SvO_2)and blood gas analysis were recorded at the baseline and different hemorrhagic shock time(HST).The whole body oxygen delivery indices,DO_2l and VO_2l,and the O_2 extraction ratio(O_2ER)were calculated.RESULTS:Core body temperature in group A decreased slightly after the hemorrhagic shock model was established,and environmental hypothermia decreased in core body temperature.The mortality rate was significantly higher in group B(50%)than in group A(0%).DO_2l and VO_2l decreased significantly after hemorrhage.No difference was found in hemodynamics,DO_2l and VO_2l between group A and group B,but the difference in pH,lactic acid and O_2ER was significant between the two groups.CONCLUSION:Environmental hypothermia aggravated the disorder of oxygen metabolism after hemorrhagic shock,which was associated with poor prognosis.
基金funded by the National Basic Research Program of China (973 Program,Grants 2012CB957801 and 2014CB744203)the National Natural Science Foundation of China (Grant Nos.41074132,41274193,41474166,41304144,11303017 and 11533005)the National Standard Research Program (Grant 200710123)
文摘To investigate the dependence of large gradual solar energetic particle（SEP） events on the associated flares and coronal mass ejections（CMEs）, the correlation coefficients（CCs） between peak intensities of E 〉 10 MeV（I10）, E 〉 30 MeV（I30） and E 〉 50 MeV（I50） protons and soft X-ray（SXR） emission of associated flares and the speeds of associated CMEs in the three longitudinal areas W0–W39, W40–W70（hereafter the well connected region） and W71–W90 have been calculated.Classical correlation analysis shows that CCs between SXR emission and peak intensities of SEP events always reach their largest value in the well connected region and then decline dramatically in the longitudinal area outside the well connected region, suggesting that they may contribute to the production of SEPs in large SEP events. Both classical and partial correlation analyses show that SXR fluence is a better parameter describing the relationship between flares and SEP events. For large SEP events with source location in the well connected region, the CCs between SXR fluence and I10, I30 and I50 are0.58±0.12, 0.80±0.06 and 0.83±0.06 respectively, while the CCs between CME speed and I10, I30 and I50 are 0.56±0.12, 0.52±0.13 and 0.48±0.13 respectively. The partial correlation analyses show that in the well connected region, both CME shock and SXR fluence can significantly affect I10, but SXR peak flux makes no additional contribution. For E 〉 30 MeV protons with source location in the well connected region, only SXR fluence can significantly affect I30, and the CME shock makes a small contribution to I30, but SXR peak flux makes no additional contribution. For E 〉 50 MeV protons with source location in the well connected region, only SXR fluence can significantly affect I50, but both CME shock and SXR peak flux make no additional contribution. We conclude that these findings provide statistical evidence that for SEP events with source locations in the well connected region, a CME shock is only an effective accelerator for E 〈 30 MeV protons. However, flares are not only effective accelerators for E 〈 30 MeV protons, but also for E 〉 30 MeV protons, and E 〉 30 MeV protons may be mainly accelerated by concurrent flares.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51861030 and 51571126)the National Key Research and Development Program of China(Grant No.2016YFB0700900)
文摘Nd content was varied in Nd13.2-xFe80.8+xB6(x = 0, 0.5, 1, and 1.5) to optimize the magnetic properties of sintered Nd–Fe–B/Tb–Fe–B composite magnets, which were prepared by mixing 9 g of Nd–Fe–B with 1 g of Tb17Fe75B8 powder.In conventional magnets, by reducing Nd content, the coercivity of 10.4 kOe in Nd13.2Fe80.8B6 decreases to 7.2 kOe in Nd12.2Fe81.8B6;meanwhile, in Nd–Fe–B/Tb–Fe–B magnets the coercivity does not decrease when reducing Nd content.In the intergranular phase, the Tb content increases owing to the reducing Nd content of the Nd–Fe–B alloy in the sintered composite magnets.Therefore, the excess Tb in Tb17Fe75B8 enters the intergranular phase, and more Tb atoms can substitute for Nd at the grain boundary of the Nd–Fe–B phase, leading to a more significant increase in coercivity.The remanence increases with reducing Nd content, and the energy product of 39.1 MGOe with a high coercivity of 21.0 kOe is obtained in Nd12.2Fe81.8B6/Tb17Fe75B8 magnets.These investigations show that magnetic properties can be further improved by regulating the element distribution in sintered composite magnets.
基金jointly funded by the National Basic Research Program of China (973 Program, Grants 2012CB957801 and 2014CB744203)the National Natural Science Foundation of China (Grants 41074132, 41274193, 41474166, 41304144, 11303017 and 11533005)the National Standard Research Program (Grant 200710123)
文摘To investigate the possible solar source of high-energy protons, correlation coefficients between the peak intensities of E ≥ 100 MeV protons, I100, and the peak flux and fluence of solar soft X-ray（SXR） emission, and coronal mass ejection（CME） linear speed in the three longitudinal areas W0-W39, W40-W70 and W71-W90 have been calculated respectively. Classical correlation analysis shows that the correlation coefficients between CME speeds and I100 in the three longitudinal areas are0.28±0.21, 0.35±0.21 and 0.04±0.30 respectively. The classical correlation coefficients between I100 and SXR peak flux in the three longitudinal areas are 0.48±0.17, 0.72±0.13 and 0.02±0.30 respectively, while the correlation coefficients between I100 and SXR fluence in the three longitudinal areas are 0.25±0.21, 0.84±0.07 and 0.10±0.30 respectively. Partial correlation analysis shows that for solar proton events with source location in the well connected region（W40-W70）, only SXR fluence can significantly affect the peak intensity of E ≥ 100 MeV protons, but SXR peak flux has little influence on the peak intensities of E ≥ 100 MeV protons; moreover, CME speed has no influence on the peak intensities of E ≥ 100 MeV protons. We conclude that these findings provide statistical evidence that E ≥ 100 MeV protons may be mainly accelerated by concurrent flares.
基金Science and Technology Project of Guangzhou, No. 2002Z3-E4016 No. B30101, China
文摘AIM: To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-step and multi-pathway processes of DLBCL tumorigenesis. METHODS: Maximum-weight branching and distancebased models were constructed based on the comparative genomic hybridization (CGH) data of 123 DLBCL samples using the established methods and software of Desper et al . A maximum likelihood tree model was also used to analyze the data. By comparing with the results reported in literature, values of tree models in the classification of DLBCL were elucidated. RESULTS: Both the branching and the distance-based trees classified DLBCL into three groups. We combined the classification methods of the two models and classified DLBCL into three categories according to their characteristics. The first group was marked by +Xq, +Xp, -17p and +13q; the second group by +3q, +18q and +18p; and the third group was marked by -6q and +6p. This chromosomal classification was consistent with cDNA classification. It indicated that -6q and +3q were two main events in the tumorigenesis of lymphoma. CONCLUSION: Tree models of lymphoma established from CGH data can be used in the classification of DLBCL. These models can suggest multi-gene, multistep and multi-pathway processes of tumorigenesis. Two pathways, -6q preceding +6q and +3q preceding+18q, may be important in understanding tumorigenesis of DLBCL. The pathway, -6q preceding +6q, may have a close relationship with the tumorigenesis of non-GCB DLBCL.
基金supported by the National Key Technology Research and Development Program of China (2009BAI85B03)Health Subject of Chinese PLA (2013BJZ032)
文摘Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria.Methods: This study was conducted using epidemiological surveys and a multi-center randomized controlled clinical trial. A total of 3,011 subjects were studied, and the following indices were collected after their return to low altitude areas from the plateau: general health status, blood, urine and stool samples, myocardial enzyme levels, liver and kidney function, nerve function, sex hormone levels, microalbuminuria, electrocardiogram(ECG), echocardiography, pulmonary function, and hemorheological markers. These data were compared to those of randomized healthy subjects in the same age range who lived at the same altitude to determine the characteristics of high altitude deacclimatization syndrome. Based on these characteristics, diagnostic criteria for high altitude de-acclimatization syndrome were formulated.Results: This study demonstrated that the incidence of high altitude de-acclimatization syndrome was 84.36%. Sixty percent of the cases were mild, 30% were medium, and 10% were severe. The incidence was higher among those who returned to a place of lower altitude, resided at a high altitude for a longer period of time, or engaged in heavy labor while at high altitude. Patients with high altitude de-acclimatization syndrome manifested hematological abnormalities and abnormal ventricular function, notably a right ventricular diastolic function, which recovered to baseline function after one to five years. Exposure to long-term hypoxia often caused obvious changes in cardiac morphology, i.e., left and right ventricular hypertrophy, particularly within the right ventricle. In addition, patients with high altitude de-acclimatization syndrome often presented with low blood pressure, low pulse pressure, and microalbuminuria. A few patients presented with occult blood in their feces. The diagnosis of high altitude deacclimatization syndrome can be made if a patient who recently returns to the plain from the plateau complains of dizziness, weakness, sleepiness, chest tightness, edema, memory loss, and other symptoms and signs that do not alleviate under short-term rehabilitation or symptomatic treatment, and if organic diseases of the heart, lung, kidney, and other organs have been excluded.Conclusion: The diagnosis of high altitude de-acclimatization syndrome should be made after a comprehensive analysis of the patient's clinical symptoms and signs.
基金supported by the National Natural Science Foundation of China(21901089,21901088,22161021 and 91622105)the Jiangxi Provincial Department of Science and Technology(20192BBEL50017,20172BCB22008 and 20192ACB20013)+1 种基金the support of Jiangxi Province(jxsq2018106041)the‘‘Young Elite Scientists Sponsorship Program”by CAST。
文摘Designing multicomponent integration catalysts(MICs)has been a promising strategy for improving electrocatalytic hydrogen evolution reaction(HER)due to the highly active interfaces as well as electronic synergy.Nevertheless,many fundamental questions such as their actual active species and the influence on long-term stability remain to be answered.Herein,we present the structural evolution from a pseudotri-component electrocatalyst of nitrogen-doped carbon supported nickel/vanadium nitride/vanadium oxide(Ni-VN-V_(2)O_(3)/NC)nanorods to the heterostructural nickel/vanadium nitride(Ni-VN/NC)nanosheets during chemical or electrochemical processes.The self-reconstructed Ni-VN/NC exhibits a robust stability under alkaline conditions,while maintaining initial efficient HER activity with a low overpotential of 76 mV at the current density of 10 mA cm^(-2).Theoretical calculations and quasi-in-situ spectroscopic technology unveil the redistribution of electrons on the synergistic active interface,which synchronously optimizes the affinities for hydrogen,hydroxide,and water molecules,thereby remarkably accelerating the HER kinetics by reducing the barrier of Volmer step.
基金supported by grants from Excellent Youth Foundation of BUCM (No. BUCM-2019-JCRC005)Beijing Excellent Talent Support Project (No. 2017000020124G294)。
文摘Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.
基金financially supported by the Professorial and Doctoral Scientific Research Foundation of Huizhou University(Nos.2018JB036,2020JB046 and 2022JB009)the Major and Special Project in the Field of Intelligent Manufacturing of the Universities in Guangdong Province(No.2020ZDZX2067)+3 种基金the Natural Science Foundation of Huizhou University(No.HZU202004)Open Project Program of Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices,Huizhou University(Nos.EFMDN2021001Z and EFMDN2021004M)Youth Innovative Talents Project in Collegesand Universities in Guangdong Province(No.2019KQNCX151)Basic and Applied Basic Research Fund of Guangdong Province(No.2020A1515110038)。
文摘Ammonia borane(NH_(3)BH_(3),AB)has been regarded as a promising chemical hydrogen storage material owing to its high hydrogen density and superior stability.Thus,the development of low-cost and high-efficient heterogeneous catalysts for the dehydrogenation of AB has attracted considerable scholarly attention.In this study,heterostructured Co_(3)O_(4)-SnO_(2)catalysts containing oxygen vacancy(V_(o))with different Co/Sn atomic ratios(designated as V_(o)-Co-Sn_(5:x))were synthesized via a simple coprecipitation-calcination method under mild reaction conditions.The catalyst containing an optimized Co/Sn atomic ratio of 5:2(V_(o)-Co-Sn_(5:2))exhibited robust catalytic performance with a turnover frequency value of 17.6mol_(H2)·mol^(-1)_(metal)·min^(-1).Moreover,82.6%of the original activity of the catalyst was retained after 14 catalytic cycles,indicating the high stability of the catalyst.Diversified characterization combined with the density functional theory(DFT)calculation confirmed the transfer of electrons from Co_(3)O_(4)to Sn O_(2)and the distribution of the separated charges on SnO_(2)-Co_(3)O_(4)interface.The transfer of electrons and the distribution of charges facilitated the adsorption and activation of water on the catalyst,thus accelerating the dissociation of H_(2)O molecule(the ratedetermining step of AB hydrolysis).It was found that the V_(o)adjusted the electron structure of the catalysts rather than acted as active sites.These findings will provide researchers with useful information for designing cheap and highly efficient catalysts for catalytic AB hydrolysis.
基金financially supported by the National Natural Science Foundation of China (Nos. 51461033, 51571126, 51541105, and 11547032)the Inner Mongolia Innovative Research Team (No. 3400102)+3 种基金the Inner Mongolia Science Foundation (No. 2013MS0110)the Provincial Major Science and Technology Project of Inner Mongolia (No. 2009J1006)the Baotou Major Research Project Special for Rare Earth (No. 2012R1006)the Inner Mongolia University of Science and Technology Innovation Fund
文摘In this study, the effect of wheel speed and mischmetal（MM） content on the magnetic properties of MMFeB ribbons was investigated. The samples were prepared via direct solidification technique. The nominal composition of the alloy ingots is MM;Fe;B;with x varying from 9 to 15 in steps of 2. Experimental results show the overall magnetic properties of the ribbons.Analysis of the results shows that the magnetic properties first improve and then degrade with the wheel speed and MM content increasing. Increase in MM content leads to better formation of crystal texture in the ribbons, indicating that the a-Fe phase might undermine the formation of crystal texture. Magnetic properties results show that the coercivity of the ribbons rises with an appropriate increase in both MM content and wheel speed during melt-spun process. The strongest magnetic properties of the ribbons(remanence of M;= 0.72 T, intrinsic coercivity of H;= 352.58 kA·m;, and maximum energy product of（BH）;=72.14 kJ·m;) are obtained for compositions where x = 13 and a wheel speed of v = 20 m·s;.
基金financially supported by the National Key Research and Development Program of China(No.2016YFB0700903)the National Natural Science Foundation of China(Nos.51571064 and 51571126).
文摘The isotropic nanocrystalline[(PrNd)0.8MM0.2]29.8Fe68.7Al0.1Cu0.12Co0.88B magnets(MM:mischmetal)were prepared by single-main phase and double-main phase methods using spark plasma sintering(SPS).Melt-spinning method was used to prepare initial powder and avoid component deviations caused by longtime ball milling.The magnetic properties of the magnet prepared by double-main phase method(called double-main phase magnet,DMP magnet)are remanence of Br=0.75 T,intrinsic coercivity of Hcj=909.83 kA·m-1,maximum magnetic energy product of(BH)max=95.48 kJ·m-3,which are better than those of the magnet prepared by single-main phase method(called singlemain phase magnet,SMP magnet).The diffraction peaks of the main phase of DMP magnet split in X-ray diffractometer(XRD)pattern,indicating that R2 Fe14B phases with different distributions of La/Ce elements exist in the magnet.This speculation is confirmed by transmission electron microscopy(TEM)observation.The La/Ce-rich main phase and La/Celean main phase are present in DMP magnets.The heterogeneity of rare earth elements suppresses the magnetic dilution effect in DMP magnet,and the magnetic properties are improved.Though the DMP magnet contains different main phases,it presents unitary Curie temperature(TC)of 577 K,which is higher than that of SMP magnet.This result suggests that the TC of the magnets can be promoted by double-main phase method and SPS.
基金supported by the National Natural Science Foundation of China(21731007,22090061,21821003,22161021)the support of Jiangxi Province(jxsq2018106041)the“Young Elite Scientists Sponsorship Program”by CAST。
文摘Adsorptive separation of p-xylene(pX)from xylene isomers is a key process in chemical industry,but known adsorbents cannot simultaneously achieve high adsorption selectivity,capacity,and rate.Here,we demonstrate gating ultramicropore as a solution for this challenge.Slight modification of the synthetic condition gives rise to isomeric metal-organic frameworksα-[Zn(pba)](MAF-88,H2pba=4-(1H-pyrazol-4-yl)benzoic acid)andβ-[Zn(pba)](MAF-89)possessing similar pillared-column structures,porosities,and high pX capacities of 2.0 mmol g^(−1),but very different framework/pore topologies,pore sizes,and pX selectivities.For binary and ternary mixtures of liquid xylene isomers,MAF-88 with narrow one-dimensional(1D)channels shows pX selectivity of 11 and 1.6,while MAF-89 with 3D-connected quasi-discrete pores shows pX selectivity up to 221 and 46,respectively.Thermogravimetry,differential scanning calorimetry,and time-dependent separation experiments reveal that the kinetic effects of the gating pores play more important roles than the thermodynamic effects,which is further confirmed by single-crystal X-ray diffraction and computational simulations.
