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Effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer
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作者 xue-gang li Bing-Xiong liu 《Journal of Hainan Medical University》 2017年第22期57-61,共5页
Objective: To investigate the effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer. Methods: A total of 98 patient... Objective: To investigate the effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer. Methods: A total of 98 patients with primary breast cancer who were diagnosed and treated in the hospital between December 2015 and February 2017 were collected and divided into control group and Xiaoaiping group by random number table, each with 49 cases. Control group received neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy, and Xiaoaiping group received Xiaoaiping + neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy. The differences in pro-proliferation gene expression in intraoperative breast cancer tissue as well as the differences in serum levels of Th1/Th2 cytokines and Th17/Treg cytokines before chemotherapy started (T0) and 1 week after neoadjuvant chemotherapy ended (T1) were compared between the two groups of patients. Results: MTA2, NRP-1, PKM2, TM4SF1 and ZIC1 mRNA expression in breast cancer tissue of Xiaoaiping group were lower than those of control group. At T1, serum IFN-γ and TNF-α levels of Xiaoaiping group were higher than those of control group whereas IL-4, IL-10, IL-17, IL-22, IL-35 and TGF-β levels were lower than those of control group. Conclusion: Xiaoaiping combined with neoadjuvant chemotherapy can effectively improve the curative effect of preoperative chemotherapy, and also significantly inhibit the proliferation activity of breast cancer cells and balance the immune function of the body. 展开更多
关键词 Breast cancer XIAOAIPING NEOADJUVANT chemotherapy Pro-proliferation MOLECULE Immune function
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Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guerin vaccine revaccinated in Chinese infants 被引量:5
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作者 Ying Zheng xue-gang li +6 位作者 Qiu-Zhen Wang Ai-Guo Ma Ib Christian Bygbjerg Yong-Ye Sun Yong li Ming-Ci Zheng Xi Wang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第2期130-135,共6页
Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPD)reaction anil to determine whether vitamin A(VA)combined vita... Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPD)reaction anil to determine whether vitamin A(VA)combined vitamin I)(VD)supplementation influences the immune response to BCG revueeinated in Chinese infants.Methods:A cross-section and 3-month community-randomised trial was conducted.A total of 5 629 infants at 3,6 and 12 months of age in Junan County of China were examined for BCG scar fonnation.Then,597 revuccinated infants were randomly assigned to supplementation(n=307)and control(n=290)groups.The supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 months.Then all infants were subjected to skin test with PPD.Results:The diameter of BCG sears was positively con-elated with diameter of skin indurations of PPD(r=0.17,P<0.05)in the 5 629 infants.The rate of positive response to PP1)was higher in the supplementation group than in the control group(96.1%versus 89.7%,P<0.05,prevalence ratio 1.07.95%CI 1.02-1.12).The prevalence ralio of PPD response for the supplementation group compared with that for the control group was 1.07(95%CI 1.01-1.13)for the males and 1.08(95%CI 1.00-1.17)for the females.For the supplementation group,the males got larger tuberculin induration than the females[(0.73±0.2l)cm versus(0.67±0.20)cm.P<0.05)after intervention.Conclusions:The diameter of BCG scars was effectively correlated with PPD response,which indicates BCG scar formation may be an useful tool Io evaluate the effect of tuberculosis prevention.VA combined VD supplementation may play an immunoregulatory rale in BCG revuecination.This may contribute to the prevention of childhood tuberculosis. 展开更多
关键词 TUBERCULOSIS Bacille CALMETTE-GUERIN Purified protein derivative VITAMIN A VITAMIN D REVACCINATION
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Correlation of BRD4 and Skp2 expression levels in ultrasound-guided thyroid nodule fine needle aspiration biopsy tissue with the pathological features of nodules
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作者 Bing-Xiong liu xue-gang li 《Journal of Hainan Medical University》 2019年第14期53-56,共4页
Objective:To study the correlation of bromodomain-containing protein 4(BRD4)and S-phase kinase-associated protein 2(Skp2)expression levels in ultrasound-guided thyroid nodule fine needle aspiration biopsy tissue with ... Objective:To study the correlation of bromodomain-containing protein 4(BRD4)and S-phase kinase-associated protein 2(Skp2)expression levels in ultrasound-guided thyroid nodule fine needle aspiration biopsy tissue with the pathological features of nodules.Methods:The tissues obtained in ultrasound-guided thyroid nodule fine needle aspiration biopsy in our hospital between March 2015 and March 2018 was selected and divided into malignant group and benign group according to the pathological results,and the expression levels of BRD4,Skp2,proliferation genes and angiogenesis genes were detected.Results:The BRD4 and Skp2 mRNA expression in thyroid nodules of the malignant group were significantly higher than those of the benign group,and the BRD4 and Skp2 mRNA expression in the malignant group of thyroid nodules with TNM III-IV,capsular invasion and lymph node metastasis were significantly higher than those in the thyroid nodules with TNM I-II,without capsular invasion and without lymph node metastasis;cyclin D1(CCND1),β-catenin,proliferation cell nuclear antigen(PCNA),vascular endothelial growth factor(VEGF),endothelial cell specific molecule-1(ESM-1),Survivin and cyclooxygenase 2(COX2)mRNA expression in thyroid nodules of the malignant group were obviously higher than those of the benign group and positively correlated with BRD4 and Skp2 while cyclin G2(CCNG2)and endostatin(ES)mRNA expression were significantly lower than those of the benign group and negatively correlated with BRD4 and Skp2.Conclusion:The high expression of BRD4 and Skp2 in malignant thyroid nodules is correlated with the pathological changes and can change the expression of proliferation genes and angiogenesis genes. 展开更多
关键词 Malignant thyroid NODULE Bromodomain-containing PROTEIN 4 S-PHASE kinase-associated PROTEIN 2 Proliferation Angiogenesis
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