Objective:To study the omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its correlation with maternal endothelial injury and placental trophoblast invasion.Methods: The subj...Objective:To study the omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its correlation with maternal endothelial injury and placental trophoblast invasion.Methods: The subjects who were diagnosed with severe preeclampsia and gave birth in Wuhan No.1 Hospital between November 2015 and October 2017 were selected as the PE group, while healthy subjects who gave birth in Wuhan No.1 Hospital during the same period were selected as control group. The omentin expression in neonatal umbilical cord, endothelial injury index contents in maternal blood and invasion gene expression in placenta were determined.Results: The omentin expression in neonatal umbilical cord, VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expressions in placenta of PE group were significantly lower than those of control group whereas IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45 and E-cadherin mRNA expressions in placenta were significantly higher than those of control group;IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45 and E-cadherin mRNA expressions in placenta of patients with high omentin expression were significantly lower than those of patients with low omentin expression whereas VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expressions in placenta were significantly higher than those of patients with low omentin expression.Conclusion: The low expression of omentin in neonatal umbilical cord of patients with severe preeclampsia is closely related to the maternal endothelial injury and insufficient placental trophoblast invasion.展开更多
Objective: To investigate the correlation of AP-2 with trophoblast apoptosis and invasion in placental tissues of preeclampsia. Methods: A total of 68 puerperae with preeclampsia who gave birth in our hospital between...Objective: To investigate the correlation of AP-2 with trophoblast apoptosis and invasion in placental tissues of preeclampsia. Methods: A total of 68 puerperae with preeclampsia who gave birth in our hospital between November 2015 and October 2017 were selected as preeclampsia group, and 60 healthy puerperae who gave birth in our hospital during the same period were selected as normal control group. The differences in expression of AP-2 gene, apoptosis-related genes and invasion-related genes in placenta tissue were compared between the two groups, and the inner link of AP-2 gene expression with trophoblast apoptosis and invasion activity in placental tissues of preeclampsia was further analyzed. Results: AP-2 mRNA expression in placental tissue of preeclampsia group was higher than that of control group;apoptosis-related genes Bcl and Cx43 mRNA expression were lower than those of control group whereas Bax, Caspase7 and metastin mRNA expression were higher than those of control group;invasion-related genes HIF-1α, GPR30, MEST and Snail mRNA expression were lower than those of control group whereas PEDF and RECK mRNA expression were higher than those of control group. Pearson test showed that the AP-2 gene expression in the placental tissues of preeclampsia was directly correlated with the expression of trophoblast apoptosis-related genes and invasion-related genes. Conclusion: AP-2 gene expression significantly increases in the placental tissue of puerperae with preeclampsia, and it can positively regulate the trophoblast apoptosis activity and negatively regulate its invasion activity.展开更多
Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug react...Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.展开更多
文摘Objective:To study the omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its correlation with maternal endothelial injury and placental trophoblast invasion.Methods: The subjects who were diagnosed with severe preeclampsia and gave birth in Wuhan No.1 Hospital between November 2015 and October 2017 were selected as the PE group, while healthy subjects who gave birth in Wuhan No.1 Hospital during the same period were selected as control group. The omentin expression in neonatal umbilical cord, endothelial injury index contents in maternal blood and invasion gene expression in placenta were determined.Results: The omentin expression in neonatal umbilical cord, VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expressions in placenta of PE group were significantly lower than those of control group whereas IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45 and E-cadherin mRNA expressions in placenta were significantly higher than those of control group;IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45 and E-cadherin mRNA expressions in placenta of patients with high omentin expression were significantly lower than those of patients with low omentin expression whereas VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expressions in placenta were significantly higher than those of patients with low omentin expression.Conclusion: The low expression of omentin in neonatal umbilical cord of patients with severe preeclampsia is closely related to the maternal endothelial injury and insufficient placental trophoblast invasion.
文摘Objective: To investigate the correlation of AP-2 with trophoblast apoptosis and invasion in placental tissues of preeclampsia. Methods: A total of 68 puerperae with preeclampsia who gave birth in our hospital between November 2015 and October 2017 were selected as preeclampsia group, and 60 healthy puerperae who gave birth in our hospital during the same period were selected as normal control group. The differences in expression of AP-2 gene, apoptosis-related genes and invasion-related genes in placenta tissue were compared between the two groups, and the inner link of AP-2 gene expression with trophoblast apoptosis and invasion activity in placental tissues of preeclampsia was further analyzed. Results: AP-2 mRNA expression in placental tissue of preeclampsia group was higher than that of control group;apoptosis-related genes Bcl and Cx43 mRNA expression were lower than those of control group whereas Bax, Caspase7 and metastin mRNA expression were higher than those of control group;invasion-related genes HIF-1α, GPR30, MEST and Snail mRNA expression were lower than those of control group whereas PEDF and RECK mRNA expression were higher than those of control group. Pearson test showed that the AP-2 gene expression in the placental tissues of preeclampsia was directly correlated with the expression of trophoblast apoptosis-related genes and invasion-related genes. Conclusion: AP-2 gene expression significantly increases in the placental tissue of puerperae with preeclampsia, and it can positively regulate the trophoblast apoptosis activity and negatively regulate its invasion activity.
基金Key Research Project of Scientific and Educational Innovation in the Institute of Educational Science,Chinese Academy of Management Sciences(Grant No:KJCX5406).
文摘Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.
