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基于GC-MS技术结合网络药理学和分子对接探究扎冲十三挥发油治疗缺血性脑卒中的成分及作用机制 被引量:1
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作者 杨胜男 顾艳丽 +4 位作者 郭慧青 祖文 周雪梅 杨彩静 吉日木巴图 《药物流行病学杂志》 CAS 2023年第3期280-293,共14页
目的基于气相色谱-质谱联用(GC-MS)技术对扎冲十三方剂中8味植物药挥发油的主要化学成分进行分析,并运用网络药理学方法探究其成分对缺血性脑卒中可能作用机制。方法利用GC-MS技术分析挥发油后,借助多个数据库预测分析化学成分作用靶点... 目的基于气相色谱-质谱联用(GC-MS)技术对扎冲十三方剂中8味植物药挥发油的主要化学成分进行分析,并运用网络药理学方法探究其成分对缺血性脑卒中可能作用机制。方法利用GC-MS技术分析挥发油后,借助多个数据库预测分析化学成分作用靶点和疾病靶点,构建“化学成分-作用靶点”网络并由共同靶点得到蛋白质-蛋白质相互作用关系,将其可视化,根据筛选到的关键作用靶点完成基因本体(GO)功能和京都基因与基因组百科全书(KEGG)通路富集分析;在Discovery Studio软件上实施关键靶点与活性成分的分子对接验证。结果GC-MS确认出44个化合物,占总含量的94.14%,含量最高的为丁香酚;检索出扎冲十三挥发油关于缺血性脑卒中的42个活性成分,159个潜在作用靶点;得到369个GO功能条目,126个KEGG信号通路条目,涉及癌症通路、脂质和动脉粥样硬化等。分子对接数据显示丁香酚等活性成分与缺氧诱导因子1α、基质金属蛋白酶9、信号转导与转录激活因子3等关键靶点具备较强的结合性能。结论该实验探究了扎冲十三挥发油通过多成分、多靶点、多途径协同用于治疗缺血性脑卒中的可能作用机制,为进一步研究扎冲十三挥发油对缺血性脑卒中的作用提供一定参考。 展开更多
关键词 扎冲十三挥发油 气相色谱-质谱联用 缺血性脑卒中 网络药理学 分子对接
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Th–U cycle performance analysis based on molten chloride salt and molten fluoride salt fast reactors 被引量:1
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作者 Liao-Yuan He Shao-Peng Xia +4 位作者 xue-mei zhou Jin-Gen Chen Gui-Min Liu Yang Zou Rui Yan 《Nuclear Science and Techniques》 SCIE CAS CSCD 2020年第8期116-128,共13页
The recent development of molten salt fast reactors has generated a renewed interest in them. As compared to traditional solid fuel fast neutron systems, it has many unique advantages, e.g., lower fissile inventory,no... The recent development of molten salt fast reactors has generated a renewed interest in them. As compared to traditional solid fuel fast neutron systems, it has many unique advantages, e.g., lower fissile inventory,no initial criticality reserve, waste reduction, and a simplified fuel cycle. It has been recognized as an ideal reactor for achieving a closed Th–U cycle. Based on the carrier salt, molten salt fast reactors could be divided into either a molten chloride salt fast reactor(MCFR) or a molten fluoride salt fast reactor(MFFR);to compare their Th–U cycle performance, the neutronic parameters in a breeding and burning(B&B) transition scenario were studied based on similar core geometry and power. The results demonstrated that the required reprocessing rate for an MCFR to achieve self-breeding was lower than that of an MFFR.Moreover, the breeding capability of an MCFR was better than that of an MFFR;at a reprocessing rate of 40 L/day,using LEU and Pu as start-up fissile materials, the doubling time(DT) of an MFFR and MCFR were 88.0 years and 48.0 years, and 16.5 years and 16.2 years, respectively.Besides, an MCFR has lower radio-toxicity due to lower buildup of fission products(FPs) and transuranium(TRU),while an MFFR has a larger, delayed neutron fraction with smaller changes during the entire operation. 展开更多
关键词 Th–U cycle Molten salt fast reactor Breeding capability Doubling time
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