Objective:To retrospectively evaluate efficacy and safety of 0.05%halometasone/1%triclosan cream(Hal/TCS)in treating truncal vitiligo of children and adolescents.Methods:We retrospectively reviewed the records of chil...Objective:To retrospectively evaluate efficacy and safety of 0.05%halometasone/1%triclosan cream(Hal/TCS)in treating truncal vitiligo of children and adolescents.Methods:We retrospectively reviewed the records of children and adolescents with truncal vitiligo treated only with topical Hal/TCS twice daily or only with topical 0.1%mometasone furoate cream(mometasone)twice daily for at least 3 months,and collected relevant data.Efficacy outcomes included patients’mean repigmentation score after 1-and 3-month treatment calculated based on patients’repigmentation percentage,and effective rate(percentage of patients with≥50%repigmentation).Subgroup analyses of patients’mean repigmentation score based on their age,vitiligo stage,and duration were conducted.Rate of adverse events were calculated.Results:One hundred and twenty-two eligible patients were included,among them,63 and 59 patients were in the Hal/TCS group and the mometasone group,respectively.After 3 months of treatment,the Hal/TCS group had significantly higher mean repigmentation score and effective rate than the mometasone group(53.49±28.33vs.41.46±27.16,P=0.02;53.97%vs.35.59%,P=0.04,respectively).Patients with shorter disease duration(≤12 months)and patients with progressive vitiligo responded significantly better to the Hal/TCS treatment than patients with longer disease duration and patients with stable vitiligo,respectively.Both treatments were well tolerated and the two treatment groups had comparable rates of adverse events.Conclusions:Short-term Hal/TCS treatment was effective,well-tolerated,and safe in treating vitiligo in the trunk of children and adolescents.展开更多
Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the bo...Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical diagnosis.Case report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three years.Based on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet disease.Discussion:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers.Other clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases.Conclusion:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis.展开更多
Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of por...Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of porokeratosis which is often eruptive and pruritic.Case report: A 72 years-old Chinese man presented to our hospital with intensively pruritic papular lesions on his trunk and limbs. Physical examination showed numerous scattered keratotic papules measuring 35 mm in diameter on his trunk and extremities. Some coalesced into anannular lesion with a slightly raised peripheral red rim. A tissue biopsy revealed the presence of a cornoid lamella. The patient was diagnosed with EPPP. After 3-months’ treatment of antihistamines and topical steroid agents, the lesions and the pruritus were diminished.Discussion: EPPP predominantly happens in an old male demographic. Patients with EPPP often develop pruritic papules spread on the body with or without preexisting typical porokeratosis lesions, and the lesions can subside within few months, leaving small brown spots or annular lesions. EPPP has the unique histological characteristic of porokeratosis cornoid lamella. The mechanism of EPPP is still unknown. It is important for clinicians to be aware of a disseminated pruritic papules as a manifestation of EPPP.Conclusion: The lesion of porokeratosis can be manifested as eruptive papules with intensive itch. When a patient develops eruptive pruritic papules, it is necessary to consider the possibility of EPPP. Histopathology is necessary for diagnosis.展开更多
Introduction Tufted angioma (TA) is an uncommon vascular tumor.It most presents variable clinical appearances during infancy and early childhood.TA usually presents clinically as a large,plaque-like,red or dusky blue-...Introduction Tufted angioma (TA) is an uncommon vascular tumor.It most presents variable clinical appearances during infancy and early childhood.TA usually presents clinically as a large,plaque-like,red or dusky blue-purple,infiltrated lesion,or an exophytic,firm,violaceous,cutaneous nodule.TA is commonly solitary,but multifocal cases have been reported[1].Histologically,TA demonstrates vascular tufts of tightly packed capillaries,randomly dispersed throughout the dermis in a typical model of 'cannonball distribution' with crescent spaces surrounding the vascular tufts and lymphatic-like spaces within the tumor stromal.展开更多
文摘Objective:To retrospectively evaluate efficacy and safety of 0.05%halometasone/1%triclosan cream(Hal/TCS)in treating truncal vitiligo of children and adolescents.Methods:We retrospectively reviewed the records of children and adolescents with truncal vitiligo treated only with topical Hal/TCS twice daily or only with topical 0.1%mometasone furoate cream(mometasone)twice daily for at least 3 months,and collected relevant data.Efficacy outcomes included patients’mean repigmentation score after 1-and 3-month treatment calculated based on patients’repigmentation percentage,and effective rate(percentage of patients with≥50%repigmentation).Subgroup analyses of patients’mean repigmentation score based on their age,vitiligo stage,and duration were conducted.Rate of adverse events were calculated.Results:One hundred and twenty-two eligible patients were included,among them,63 and 59 patients were in the Hal/TCS group and the mometasone group,respectively.After 3 months of treatment,the Hal/TCS group had significantly higher mean repigmentation score and effective rate than the mometasone group(53.49±28.33vs.41.46±27.16,P=0.02;53.97%vs.35.59%,P=0.04,respectively).Patients with shorter disease duration(≤12 months)and patients with progressive vitiligo responded significantly better to the Hal/TCS treatment than patients with longer disease duration and patients with stable vitiligo,respectively.Both treatments were well tolerated and the two treatment groups had comparable rates of adverse events.Conclusions:Short-term Hal/TCS treatment was effective,well-tolerated,and safe in treating vitiligo in the trunk of children and adolescents.
文摘Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are uncommon.Here,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical diagnosis.Case report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three years.Based on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet disease.Discussion:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers.Other clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases.Conclusion:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis.
文摘Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been reported.Here, we reported an old man with this rare kind of porokeratosis which is often eruptive and pruritic.Case report: A 72 years-old Chinese man presented to our hospital with intensively pruritic papular lesions on his trunk and limbs. Physical examination showed numerous scattered keratotic papules measuring 35 mm in diameter on his trunk and extremities. Some coalesced into anannular lesion with a slightly raised peripheral red rim. A tissue biopsy revealed the presence of a cornoid lamella. The patient was diagnosed with EPPP. After 3-months’ treatment of antihistamines and topical steroid agents, the lesions and the pruritus were diminished.Discussion: EPPP predominantly happens in an old male demographic. Patients with EPPP often develop pruritic papules spread on the body with or without preexisting typical porokeratosis lesions, and the lesions can subside within few months, leaving small brown spots or annular lesions. EPPP has the unique histological characteristic of porokeratosis cornoid lamella. The mechanism of EPPP is still unknown. It is important for clinicians to be aware of a disseminated pruritic papules as a manifestation of EPPP.Conclusion: The lesion of porokeratosis can be manifested as eruptive papules with intensive itch. When a patient develops eruptive pruritic papules, it is necessary to consider the possibility of EPPP. Histopathology is necessary for diagnosis.
文摘Introduction Tufted angioma (TA) is an uncommon vascular tumor.It most presents variable clinical appearances during infancy and early childhood.TA usually presents clinically as a large,plaque-like,red or dusky blue-purple,infiltrated lesion,or an exophytic,firm,violaceous,cutaneous nodule.TA is commonly solitary,but multifocal cases have been reported[1].Histologically,TA demonstrates vascular tufts of tightly packed capillaries,randomly dispersed throughout the dermis in a typical model of 'cannonball distribution' with crescent spaces surrounding the vascular tufts and lymphatic-like spaces within the tumor stromal.
