Objective:Inhibition of tumor angiogenesis has become a new targeted tumor therapy.In this study,we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-ta...Objective:Inhibition of tumor angiogenesis has become a new targeted tumor therapy.In this study,we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR.Methods:The targeted polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PEG-PLGA)modified with Asn–Gly–Arg(NGR)peptide was prepared and characterized by 1H nuclear magnetic resonance and Fourier-transform infrared spectrometry.NGR-PEG-PLGA was used to construct curcumin(Cur)-loaded micelles by the solvent evaporation method.The physicochemical properties of the micelles were also investigated.Additionally,we evaluated the antitumor efficacy of the polymer micelles(PM)using in vitro cytology experiments and in vivo animal studies.Results:The particle size of Cur-NGR-PM was 139.70±2.51 nm,and the drug-loading capacity was 14.37±0.06%.In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles,leading to the apoptosis of tumor cells.Then,in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe.Conclusions:NGR-modified micelles significantly optimized the therapeutic efficacy of Cur.This strategy offers a viable avenue for cancer treatment.展开更多
As the deployment of large Low Earth Orbiters(LEO)communication constellations,navigation from the LEO satellites becomes an emerging opportunity to enhance the existing satellite navigation systems.The LEO navigation...As the deployment of large Low Earth Orbiters(LEO)communication constellations,navigation from the LEO satellites becomes an emerging opportunity to enhance the existing satellite navigation systems.The LEO navigation augmentation(LEO-NA)systems require a centimeter to decimeter accuracy broadcast ephemeris to support high accuracy positioning applications.Thus,how to design the broadcast ephemeris becomes the key issue for the LEO-NA systems.In this paper,the temporal variation characteristics of the LEO orbit elements were analyzed via a spectrum analysis.A non-singular element set for orbit fitting was introduced to overcome the potential singularity problem of the LEO orbits.Based on the orbit characteristics,a few new parameters were introduced into the classical 16 parameter ephemeris set to improve the LEO orbit fitting accuracy.In order to identify the optimal parameter set,different parameter sets were tested and compared and the 21 parameters data set was recommended to make an optimal balance between the orbit accuracy and the bandwidth requirements.Considering the real-time broadcast ephemeris generation procedure,the performance of the LEO ephemeris based on the predicted orbit is also investigated.The performance of the proposed ephemeris set was evaluated with four in-orbit LEO satellites and the results indicate the proposed 21 parameter schemes improve the fitting accuracy by 87.4%subject to the 16 parameters scheme.The accuracy for the predicted LEO ephemeris is strongly dependent on the orbit altitude.For these LEO satellites operating higher than 500 km,10 cm signal-in-space ranging error(SISRE)is achievable for over 20 min prediction.展开更多
Modifying electrochemical surface area(ECSA)and surface chemistry are promising approaches to enhance the capacities of oxygen cathodes for lithium-oxygen(Li-O_(2))batteries.Although various chemical approaches have b...Modifying electrochemical surface area(ECSA)and surface chemistry are promising approaches to enhance the capacities of oxygen cathodes for lithium-oxygen(Li-O_(2))batteries.Although various chemical approaches have been successfully used to tune the cathode surface,versatile physical techniques including plasma etching etc.could be more effortless and effective than arduous chemical treatments.Herein,for the first time,we propose a facile oxygen plasma treatment to simultaneously etch and modify the surface of Co_(3)O_(4)nanosheet arrays(NAs)cathode for Li-O_(2)batteries.The oxygen plasma not only etches Co_(3)O_(4)nanosheets to enhance the ECSA but also lowers the oxygen vacancy concentration to enable a Co^(3+)-rich surface.In addition,the NA architecture enables the full exposure of oxygen vacancies and surface Co^(3+)that function as the catalytically active sites.Thus,the synergistic effects of enhanced ECSA,modest oxygen vacancy and high surface Co^(3+)achieve a significantly enhanced reversible capacity of 3.45 mAh/cm^(2)for Co_(3)O_(4)NAs.This work not only develops a promising high-capacity cathode for Li-O_(2)batteries,but also provides a facile physical method to simultaneously tune the nanostructure and surface chemistry of energy storage materials.展开更多
基金supported by Scientific Research Project of Tianjin Municipal Education Commission (No.2019KJ080).
文摘Objective:Inhibition of tumor angiogenesis has become a new targeted tumor therapy.In this study,we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR.Methods:The targeted polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PEG-PLGA)modified with Asn–Gly–Arg(NGR)peptide was prepared and characterized by 1H nuclear magnetic resonance and Fourier-transform infrared spectrometry.NGR-PEG-PLGA was used to construct curcumin(Cur)-loaded micelles by the solvent evaporation method.The physicochemical properties of the micelles were also investigated.Additionally,we evaluated the antitumor efficacy of the polymer micelles(PM)using in vitro cytology experiments and in vivo animal studies.Results:The particle size of Cur-NGR-PM was 139.70±2.51 nm,and the drug-loading capacity was 14.37±0.06%.In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles,leading to the apoptosis of tumor cells.Then,in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe.Conclusions:NGR-modified micelles significantly optimized the therapeutic efficacy of Cur.This strategy offers a viable avenue for cancer treatment.
基金the National Natural Science Foundation of China[grant number 42074036]the Fundamental Research Funds for the Central Universities.
文摘As the deployment of large Low Earth Orbiters(LEO)communication constellations,navigation from the LEO satellites becomes an emerging opportunity to enhance the existing satellite navigation systems.The LEO navigation augmentation(LEO-NA)systems require a centimeter to decimeter accuracy broadcast ephemeris to support high accuracy positioning applications.Thus,how to design the broadcast ephemeris becomes the key issue for the LEO-NA systems.In this paper,the temporal variation characteristics of the LEO orbit elements were analyzed via a spectrum analysis.A non-singular element set for orbit fitting was introduced to overcome the potential singularity problem of the LEO orbits.Based on the orbit characteristics,a few new parameters were introduced into the classical 16 parameter ephemeris set to improve the LEO orbit fitting accuracy.In order to identify the optimal parameter set,different parameter sets were tested and compared and the 21 parameters data set was recommended to make an optimal balance between the orbit accuracy and the bandwidth requirements.Considering the real-time broadcast ephemeris generation procedure,the performance of the LEO ephemeris based on the predicted orbit is also investigated.The performance of the proposed ephemeris set was evaluated with four in-orbit LEO satellites and the results indicate the proposed 21 parameter schemes improve the fitting accuracy by 87.4%subject to the 16 parameters scheme.The accuracy for the predicted LEO ephemeris is strongly dependent on the orbit altitude.For these LEO satellites operating higher than 500 km,10 cm signal-in-space ranging error(SISRE)is achievable for over 20 min prediction.
基金supported by grants from the National Natural Science Foundation of China(Nos.22075219 and 51972257)the National Key Research Program of China(No.2016YFA0202602)the Research Start-Up Fund from Wuhan University of Technology.
文摘Modifying electrochemical surface area(ECSA)and surface chemistry are promising approaches to enhance the capacities of oxygen cathodes for lithium-oxygen(Li-O_(2))batteries.Although various chemical approaches have been successfully used to tune the cathode surface,versatile physical techniques including plasma etching etc.could be more effortless and effective than arduous chemical treatments.Herein,for the first time,we propose a facile oxygen plasma treatment to simultaneously etch and modify the surface of Co_(3)O_(4)nanosheet arrays(NAs)cathode for Li-O_(2)batteries.The oxygen plasma not only etches Co_(3)O_(4)nanosheets to enhance the ECSA but also lowers the oxygen vacancy concentration to enable a Co^(3+)-rich surface.In addition,the NA architecture enables the full exposure of oxygen vacancies and surface Co^(3+)that function as the catalytically active sites.Thus,the synergistic effects of enhanced ECSA,modest oxygen vacancy and high surface Co^(3+)achieve a significantly enhanced reversible capacity of 3.45 mAh/cm^(2)for Co_(3)O_(4)NAs.This work not only develops a promising high-capacity cathode for Li-O_(2)batteries,but also provides a facile physical method to simultaneously tune the nanostructure and surface chemistry of energy storage materials.
