Some rock joints exhibit significant brittleness,characterized by a sharp decrease in shear stress upon reaching the peak strength.However,existing models often fail to accurately represent this behavior and are encum...Some rock joints exhibit significant brittleness,characterized by a sharp decrease in shear stress upon reaching the peak strength.However,existing models often fail to accurately represent this behavior and are encumbered by numerous parameters lacking clear mechanical significance.This study presents a new statistical damage constitutive model rooted in both damage mechanics and statistics,containing only three model parameters.The proposed model encompasses all stages of joint shearing,including the compaction stage,linear stage,plastic yielding stage,drop stage,strain softening stage,and residual strength stage.To derive the analytical expression of the constitutive model,three boundary conditions are introduced.Experimental data from both natural and artificial rock joints is utilized to validate the model,resulting in average absolute relative errors ranging from 3%to 8%.Moreover,a comparative analysis with established models illustrates that the proposed model captures stress drop and post-peak strain softening more effectively,with model parameters possessing clearer mechanical interpretations.Furthermore,parameter analysis is conducted to investigate the impacts of model parameters on the curves and unveil the relationship between these parameters and the mechanical properties of rock joints.Importantly,the proposed model is straightforward in form,and all model parameters can be obtained from direct shear tests,thus facilitating the utilization in numerical simulations.展开更多
To investigate the dynamic damage evolution characteristics of bank slopes with serrated structural planes,the shaking table model test and the numerical simulation were utilized.The main findings indicate that under ...To investigate the dynamic damage evolution characteristics of bank slopes with serrated structural planes,the shaking table model test and the numerical simulation were utilized.The main findings indicate that under continuous seismic loads,the deformation of the bank slope increased,particularly around the hydro-fluctuation belt,accompanying by the pore water pressure rising.The soil pressure increased and then decreased showed dynamic variation characteristics.As the undulation angle of the serrated structural planes increased(30°, 45°, and 60°),the failure modes were climbing,climbinggnawing,and gnawing respectively.The first-order natural frequency was used to calculate the damage degree(Dd)of the bank slope.During microseisms and small earthquakes,it was discovered that the evolution of Dd followed the“S”shape,which was fitted by a logic function.Additionally,the quadratic function was used to fit the Dd during moderately strong earthquakes.Through the numerical simulation,the variation characteristics of safety factors(Sf)for slopes with serrated structural planes and slopes with straight structural planes were compared.Under continuous seismic loads,the Sf of slopes with straight structural planes reduce stalely,whereas the Sf for slopes with serrated structural planes was greater than the former and the reduction rate was increasing.展开更多
Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two e...Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two experiments：（1） rhizobag filled with ＂clean＂ or metal-contaminated soil for analysis of Pb and Zn in plants and rhizosphere soils;and （2） applied deoxygenated solution for analyzing their rates of radial oxygen loss （ROL）.The results showed that the wetland plants with different ROL rates had significant effects on the mobility and chemical forms of Pb and Zn in rhizosphere under flooded conditions.These effects were varied with different metal elements and metal concentrations in the soils.Lead mobility in rhizosphere of the four plants both in the ＂clean＂ and contaminated soils was decreased,while Zn mobility was increased in the rhizosphere of the ＂clean＂ soil,but decreased in the contaminated soil.Among the four plants,V.serpyllifolia,with the highest ROL,formed the highest degree of Fe plaque on the root surface,immobilized more Zn in Fe plaque,and has the highest effects on the changes of Zn form （EXC-Zn） in rhizosphere under both ＂clean＂ and contaminated soil conditions.These results suggested that ROL of wetland plants could play an important role in Fe plaque formation and mobility and chemical changes of metals in rhizosphere soil under flood conditions.展开更多
Objective:To identify the causative adenomatous polyposis coli(APC)gene defects associated with a pedigree of familial adenomatous polyposis(FAP).Methods:FAP was diagnosed based on clinical manifestations,family histo...Objective:To identify the causative adenomatous polyposis coli(APC)gene defects associated with a pedigree of familial adenomatous polyposis(FAP).Methods:FAP was diagnosed based on clinical manifestations,family history,as well as endoscopic and pathological examinations.The blood samples of the FAP pedigree members,colonic polyp patients,and normal individuals were collected.Genomic DNA was then extracted from those samples.APC mutation analysis was conducted via direct polymerase chain reaction(PCR)sequencing.Results:Three synonymous mutations and a missense mutation were found:c.5034G>A(p.Glyl678Gly),c.5465T>A(p.Vall 822Asp),c.5880G>A(p.Prol960Pro),and c.5274T>G(p.Serl758Ser)・Among them,the homozygous mutation on APC gene c.5034G>A has been reported,while the other three mutations have not been reported in the Chinese Han population.Individuals with c.5465T>A(p.Vall822ASP)missense mutation eventually suffer from colon cancer and have poor prognosis.We found no mutation in patients with simple intestinal polyp and in normal individuals.In addition,there were homozygous and heterozygous mutations in different patients from the same family.Conclusion:Three new mutations of APC gene were firstly reported in Han population.The missense mutation of c.5465T>A(p.Vall 822Asp)may be the cause of carcinogenesis in this FAP pedigree with poor prognosis.展开更多
基金funded by the National Natural Science Foundation of China(No.41972266)Chongqing Natural Science Foundation(No.CSTB2024NSCQ-MSX0006).
文摘Some rock joints exhibit significant brittleness,characterized by a sharp decrease in shear stress upon reaching the peak strength.However,existing models often fail to accurately represent this behavior and are encumbered by numerous parameters lacking clear mechanical significance.This study presents a new statistical damage constitutive model rooted in both damage mechanics and statistics,containing only three model parameters.The proposed model encompasses all stages of joint shearing,including the compaction stage,linear stage,plastic yielding stage,drop stage,strain softening stage,and residual strength stage.To derive the analytical expression of the constitutive model,three boundary conditions are introduced.Experimental data from both natural and artificial rock joints is utilized to validate the model,resulting in average absolute relative errors ranging from 3%to 8%.Moreover,a comparative analysis with established models illustrates that the proposed model captures stress drop and post-peak strain softening more effectively,with model parameters possessing clearer mechanical interpretations.Furthermore,parameter analysis is conducted to investigate the impacts of model parameters on the curves and unveil the relationship between these parameters and the mechanical properties of rock joints.Importantly,the proposed model is straightforward in form,and all model parameters can be obtained from direct shear tests,thus facilitating the utilization in numerical simulations.
基金supported by the National Natural Science Foundation of China(No.41972266)the China Postdoctoral Science Foundation(No.2023M730432)+1 种基金the Special Funding for Chongqing Postdoctoral Research Project(No.2022CQBSHTB1010)the Chongqing Postdoctoral Science Foundation(No.CSTB2023NSCQBHX0223).
文摘To investigate the dynamic damage evolution characteristics of bank slopes with serrated structural planes,the shaking table model test and the numerical simulation were utilized.The main findings indicate that under continuous seismic loads,the deformation of the bank slope increased,particularly around the hydro-fluctuation belt,accompanying by the pore water pressure rising.The soil pressure increased and then decreased showed dynamic variation characteristics.As the undulation angle of the serrated structural planes increased(30°, 45°, and 60°),the failure modes were climbing,climbinggnawing,and gnawing respectively.The first-order natural frequency was used to calculate the damage degree(Dd)of the bank slope.During microseisms and small earthquakes,it was discovered that the evolution of Dd followed the“S”shape,which was fitted by a logic function.Additionally,the quadratic function was used to fit the Dd during moderately strong earthquakes.Through the numerical simulation,the variation characteristics of safety factors(Sf)for slopes with serrated structural planes and slopes with straight structural planes were compared.Under continuous seismic loads,the Sf of slopes with straight structural planes reduce stalely,whereas the Sf for slopes with serrated structural planes was greater than the former and the reduction rate was increasing.
基金supported by the National Natural Science Foundation of China (No. 30570345,30770417)the Guangdong Natural Science Group Foundation (No.06202438)the Specialized Research Fund for the Doctoral Program of Higher Education,China (No. 20558097)
文摘Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two experiments：（1） rhizobag filled with ＂clean＂ or metal-contaminated soil for analysis of Pb and Zn in plants and rhizosphere soils;and （2） applied deoxygenated solution for analyzing their rates of radial oxygen loss （ROL）.The results showed that the wetland plants with different ROL rates had significant effects on the mobility and chemical forms of Pb and Zn in rhizosphere under flooded conditions.These effects were varied with different metal elements and metal concentrations in the soils.Lead mobility in rhizosphere of the four plants both in the ＂clean＂ and contaminated soils was decreased,while Zn mobility was increased in the rhizosphere of the ＂clean＂ soil,but decreased in the contaminated soil.Among the four plants,V.serpyllifolia,with the highest ROL,formed the highest degree of Fe plaque on the root surface,immobilized more Zn in Fe plaque,and has the highest effects on the changes of Zn form （EXC-Zn） in rhizosphere under both ＂clean＂ and contaminated soil conditions.These results suggested that ROL of wetland plants could play an important role in Fe plaque formation and mobility and chemical changes of metals in rhizosphere soil under flood conditions.
文摘Objective:To identify the causative adenomatous polyposis coli(APC)gene defects associated with a pedigree of familial adenomatous polyposis(FAP).Methods:FAP was diagnosed based on clinical manifestations,family history,as well as endoscopic and pathological examinations.The blood samples of the FAP pedigree members,colonic polyp patients,and normal individuals were collected.Genomic DNA was then extracted from those samples.APC mutation analysis was conducted via direct polymerase chain reaction(PCR)sequencing.Results:Three synonymous mutations and a missense mutation were found:c.5034G>A(p.Glyl678Gly),c.5465T>A(p.Vall 822Asp),c.5880G>A(p.Prol960Pro),and c.5274T>G(p.Serl758Ser)・Among them,the homozygous mutation on APC gene c.5034G>A has been reported,while the other three mutations have not been reported in the Chinese Han population.Individuals with c.5465T>A(p.Vall822ASP)missense mutation eventually suffer from colon cancer and have poor prognosis.We found no mutation in patients with simple intestinal polyp and in normal individuals.In addition,there were homozygous and heterozygous mutations in different patients from the same family.Conclusion:Three new mutations of APC gene were firstly reported in Han population.The missense mutation of c.5465T>A(p.Vall 822Asp)may be the cause of carcinogenesis in this FAP pedigree with poor prognosis.
