ABSTRACT： Peroxisome proliferator-activated re- ceptor-Υ （PPAR-T） plays a pivotal role in controlling adipogenesis. We hypothesized that changes in dietary energy density might alter fat deposition in finishing pi...ABSTRACT： Peroxisome proliferator-activated re- ceptor-Υ （PPAR-T） plays a pivotal role in controlling adipogenesis. We hypothesized that changes in dietary energy density might alter fat deposition in finishing pigs via modulation of the expression of PPAR-Υ . To test this hypothesis, thirty female finishing pigs were fed diets containing low （ LD ）, medium （ MD ） or high （HD） energy density. Blood samples were col- lected on day 53, and then the pigs were sacrificed to collect samples of the dorsal subcutaneous （ ST）, ab- dominal （AT） and mesenteric （MT） adipose tissue. Compared with pigs fed the MD diet, malate dehydro- genase activity was increased in the ST and MT of pigs fed the HD diet, while activity was decreased in the MT of pigs fed the LD diet （P 〈 0.05）. Glucose- 6-phosphate dehydrogenase activity was increased in all three fat depots of pigs fed the HD diet （P 〈0.05） in comparison with pigs fed the MD diet. Both HD and LD diets increased the size of the adipocytes in the AT and MT （ P 〈 0.05 ）. Pigs fed the HI） diet had a higher cell proliferation index in the ST com- pared with pigs fed the other two diets （P 〈 0.05 ）. Compared with pigs fed the MD diet, a decreased ap- optosis index was seen in the ST of pigs fed the HD diet, and in the AT of pigs fed the LD diet, as well as in the MT of both HD and LD fed pigs （ P 〈 0.05）. PPAR-Υ positive percentage was elevated in the ST and MT of HD fed pigs compared with pigs fed the MD and LD diets, while it was decreased in the ST of LD compared with MD fed pigs （ P 〈 0.05 ）. These results suggest that dietary energy density may regu- late fat deposition in fmishing pigs. It is possible that feeding a high energy diet may induce fat deposition via up-regulation of PPAR-Υ expression.展开更多
The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics community.It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of...The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics community.It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or higher.The STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard Model.The STCF project in China is under development with an extensive R&D program.This document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.展开更多
基金the National Basic Research Program of China (2004CB117504)for the financial support
文摘ABSTRACT： Peroxisome proliferator-activated re- ceptor-Υ （PPAR-T） plays a pivotal role in controlling adipogenesis. We hypothesized that changes in dietary energy density might alter fat deposition in finishing pigs via modulation of the expression of PPAR-Υ . To test this hypothesis, thirty female finishing pigs were fed diets containing low （ LD ）, medium （ MD ） or high （HD） energy density. Blood samples were col- lected on day 53, and then the pigs were sacrificed to collect samples of the dorsal subcutaneous （ ST）, ab- dominal （AT） and mesenteric （MT） adipose tissue. Compared with pigs fed the MD diet, malate dehydro- genase activity was increased in the ST and MT of pigs fed the HD diet, while activity was decreased in the MT of pigs fed the LD diet （P 〈 0.05）. Glucose- 6-phosphate dehydrogenase activity was increased in all three fat depots of pigs fed the HD diet （P 〈0.05） in comparison with pigs fed the MD diet. Both HD and LD diets increased the size of the adipocytes in the AT and MT （ P 〈 0.05 ）. Pigs fed the HI） diet had a higher cell proliferation index in the ST com- pared with pigs fed the other two diets （P 〈 0.05 ）. Compared with pigs fed the MD diet, a decreased ap- optosis index was seen in the ST of pigs fed the HD diet, and in the AT of pigs fed the LD diet, as well as in the MT of both HD and LD fed pigs （ P 〈 0.05）. PPAR-Υ positive percentage was elevated in the ST and MT of HD fed pigs compared with pigs fed the MD and LD diets, while it was decreased in the ST of LD compared with MD fed pigs （ P 〈 0.05 ）. These results suggest that dietary energy density may regu- late fat deposition in fmishing pigs. It is possible that feeding a high energy diet may induce fat deposition via up-regulation of PPAR-Υ expression.
基金supported by the National Key R&D Program of China under Contract No.2022YFA1602200the International Partnership Program of the Chineses Academy of Sciences under Grant No.211134KYSB20200057the STCF Key Technology Research and Development Project.
文摘The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics community.It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or higher.The STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard Model.The STCF project in China is under development with an extensive R&D program.This document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.
