Objective: The main purpose was to investigate expression of CDH11 in pancreatic tissues and analyze its relations with clinical characteristics of patients with pancreatic cancer (PC). Methods: Expression of CDH11 in...Objective: The main purpose was to investigate expression of CDH11 in pancreatic tissues and analyze its relations with clinical characteristics of patients with pancreatic cancer (PC). Methods: Expression of CDH11 in cancerous tissues and cancer adjacent tissues were detected by immunohistochemistry staining, and their associations with clinical characteristics were analyzed. The text mining methods were used to assist the study of the effect of CDH11 on prognosis. Results: A total of 79 patients with PC were enrolled in the study, including 51 (64.6%) men and 28 (35.4%) women with a median age of 62 (41 - 84). The CDH11 expression in cancerous tissues was higher than that in adjacent tissues and the expression of CDH11 in both tissues was positively correlated (P 0.999;stage II vs III & IV, P = 0.308). A higher level of CDH11 expression correlated with worse overall survival (OS) time (P = 0.015). Conclusion: CDH11 may be involved in the development of early PC and lead to poor prognosis and could be a new target molecule for early diagnosis and treatment of PC.展开更多
Transformation acoustics(TA)has emerged as a powerful tool for designing several intriguing conceptual devices,which can manipulate acoustic waves in a flexible manner,yet their applications are limited in Hermitian m...Transformation acoustics(TA)has emerged as a powerful tool for designing several intriguing conceptual devices,which can manipulate acoustic waves in a flexible manner,yet their applications are limited in Hermitian materials.In this work,we propose the theory of complex-coordinate transformation acoustics(CCTA)and verify the effectiveness in realizing acoustic non-Hermitian metamaterials.Especially,we apply this theory for the first time to the design of acoustic parity-time(PT)and antisymmetric parity-time(APT)metamaterials and demonstrate two distinctive examples.First,we use this method to obtain the exceptional points(EPs)of the PT/APT system and observe the spontaneous phase transition of the scattering matrix in the transformation parameter space.Second,by selecting the Jacobian matrix's constitutive parameters,the PT/APT-symmetric system can also be configured to approach the zero and pole of the scattering matrix,behaving as an acoustic coherent perfect absorber and equivalent laser.We envision our proposed CCTAbased paradigm to open the way for exploring the non-Hermitian physics and finding application in the design of acoustic functional devices such as absorbers and amplifiers whose material parameters are hard to realize by using the conventional transformation method.展开更多
文摘Objective: The main purpose was to investigate expression of CDH11 in pancreatic tissues and analyze its relations with clinical characteristics of patients with pancreatic cancer (PC). Methods: Expression of CDH11 in cancerous tissues and cancer adjacent tissues were detected by immunohistochemistry staining, and their associations with clinical characteristics were analyzed. The text mining methods were used to assist the study of the effect of CDH11 on prognosis. Results: A total of 79 patients with PC were enrolled in the study, including 51 (64.6%) men and 28 (35.4%) women with a median age of 62 (41 - 84). The CDH11 expression in cancerous tissues was higher than that in adjacent tissues and the expression of CDH11 in both tissues was positively correlated (P 0.999;stage II vs III & IV, P = 0.308). A higher level of CDH11 expression correlated with worse overall survival (OS) time (P = 0.015). Conclusion: CDH11 may be involved in the development of early PC and lead to poor prognosis and could be a new target molecule for early diagnosis and treatment of PC.
基金the National Key Research and Development Program of China(Grant No.2022YFA1404402)the National Natural Science Foundation of China(Grant Nos.12174190,11634006,12074286,and 81127901)+1 种基金the High-Performance Computing Center of Collaborative Innovation Center of Advanced Microstructuresthe the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Transformation acoustics(TA)has emerged as a powerful tool for designing several intriguing conceptual devices,which can manipulate acoustic waves in a flexible manner,yet their applications are limited in Hermitian materials.In this work,we propose the theory of complex-coordinate transformation acoustics(CCTA)and verify the effectiveness in realizing acoustic non-Hermitian metamaterials.Especially,we apply this theory for the first time to the design of acoustic parity-time(PT)and antisymmetric parity-time(APT)metamaterials and demonstrate two distinctive examples.First,we use this method to obtain the exceptional points(EPs)of the PT/APT system and observe the spontaneous phase transition of the scattering matrix in the transformation parameter space.Second,by selecting the Jacobian matrix's constitutive parameters,the PT/APT-symmetric system can also be configured to approach the zero and pole of the scattering matrix,behaving as an acoustic coherent perfect absorber and equivalent laser.We envision our proposed CCTAbased paradigm to open the way for exploring the non-Hermitian physics and finding application in the design of acoustic functional devices such as absorbers and amplifiers whose material parameters are hard to realize by using the conventional transformation method.
