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Tick-borne Pathogens in Shanxi Province, China 被引量:4
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作者 yang xiao na yang Hui Jun +5 位作者 ZHANG Lin HOU Xue Xia MIAO Guang Qing CAO Hong Bing HAO Rui E HAO Qin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2021年第5期410-415,共6页
Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates... Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates,including mammals,birds,amphibians.The numerous zoonotic pathogens transmitted by ticks are the causative agents of Lyme disease,rickettsiosis,ehrlichioses,relapsing fever,Q fever,and tularemia.Cases of tick-borne diseases are increasing around the world and some emerging or re-emerging pathogens are being discovered,which pose great challenges for prevention and control. 展开更多
关键词 PREVENTION SHANXI BIRDS
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Polymorphism of P66 in Borrelia Burgdorferi Strains in China
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作者 HAO Qin LIU Hui Xin +3 位作者 HOU Xue Xia ZHANG Lin yang xiao na WAN Kang Lin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2021年第5期364-371,共8页
Objective To study the polymorphism in P66 and its human B-cell epitopes of Borrelia burgdorferi strains in China.Methods Polymerase chain reaction(PCR)and sequencing were used to obtain the P66 sequences of59 Chinese... Objective To study the polymorphism in P66 and its human B-cell epitopes of Borrelia burgdorferi strains in China.Methods Polymerase chain reaction(PCR)and sequencing were used to obtain the P66 sequences of59 Chinese B.burgdorferi.Then the sequences were analyzed by MEGA 5.10 software and compared with the human B-cell epitope sequences from the Immune Epitope Database(IEDB)based on the reference strain of each genotype.Results Results showed that genetic and amino acid diversity presented in the 66 kD protein of all 59 Chinese strains,especially in Borrelia garinii(B.g)and Borrelia afzelii(B.a)strains.B.g strains were divided into three subclusters and two scattered strains JC1-7 and JC2-2 according to the amino acid sequences of P66.The P66 sequences of 15 Xinjiang strains represented by XI91-12 in the B.g subcluster1,changed from CAA to TAA codon at 508 aa position,resulting in early termination.Bases A and C were inserted at sequence position 1523 bp of strains FP1,LB20,LB21,and SZ21 in the B.a genotype,which resulted to early termination at position 511 aa.G base was inserted at 438 bp of LIP94-11 strain,which led to early termination at position 172 aa.Conclusion In P66 of 59 Chinese strains,polymorphisms were widely distributed.More importantly,the P66 amino acid sequences of B.g strains had a certain regional character.One of the characteristics of Xinjiang B.g isolates might be the variation at the 508 aa location in 15 Xinjiang B.g strains,which may be related to the strains’pathogenicity in this area. 展开更多
关键词 Borrelia burgdoferi P66 B-cell epitope POLYMORPHISM
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