Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardatio...Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life. This study was aimed to investigate the effects of lead exposure of pregnant mice on the expressions of insulin-degrading enzyme(IDE) and nerve growth factor(NGF) in the hippocampus of their offspring. Blood samples were collected from the tail vein, and after anesthetizing the pups, the brain was excised on postnatal day 21. Lead concentrations were determined by graphite furnace atomic absorption spectrophotometry, and the expressions of IDE and NGF were determined by immunohistochemistry and Western blotting. Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation.展开更多
Fluoride is widely distributed in nature,and it can lead to fluorosis if intake is excessive.In addition to its established effects on the skeleton and teeth,fluoride can also exert toxic effects on the kidneys.Fluori...Fluoride is widely distributed in nature,and it can lead to fluorosis if intake is excessive.In addition to its established effects on the skeleton and teeth,fluoride can also exert toxic effects on the kidneys.Fluoride can induce abnormal renal function in humans and other animals[1-3],but the mechanisms through which fluoride exerts such effects remain obscure.展开更多
基金supported by the National Natural Science Foundation of China(NSFC),No.31201878,81172716,and U1204804Post Doctoral Foundation of China,No.2015M572109Post Doctoral Fund of Henan province,No.2014049
文摘Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease(AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life. This study was aimed to investigate the effects of lead exposure of pregnant mice on the expressions of insulin-degrading enzyme(IDE) and nerve growth factor(NGF) in the hippocampus of their offspring. Blood samples were collected from the tail vein, and after anesthetizing the pups, the brain was excised on postnatal day 21. Lead concentrations were determined by graphite furnace atomic absorption spectrophotometry, and the expressions of IDE and NGF were determined by immunohistochemistry and Western blotting. Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation.
基金supported by the National Natural Science Foundation of China Grant No.81703230the Key Scientific Research Project of Universities in Henan Province Grant No.17A330005。
文摘Fluoride is widely distributed in nature,and it can lead to fluorosis if intake is excessive.In addition to its established effects on the skeleton and teeth,fluoride can also exert toxic effects on the kidneys.Fluoride can induce abnormal renal function in humans and other animals[1-3],but the mechanisms through which fluoride exerts such effects remain obscure.
