血小板减少症和肝损伤是肿瘤患者常见且严重的临床问题。肿瘤合并肝损伤患者血小板减少症(thrombocytopenia in cancer patients with liver injury,TCLI)的病因更加复杂,但常见于肝损伤和肿瘤治疗。肿瘤治疗所致血小板减少症的管理已...血小板减少症和肝损伤是肿瘤患者常见且严重的临床问题。肿瘤合并肝损伤患者血小板减少症(thrombocytopenia in cancer patients with liver injury,TCLI)的病因更加复杂,但常见于肝损伤和肿瘤治疗。肿瘤治疗所致血小板减少症的管理已逐渐形成规范,肝损伤相关血小板减少症随着相关药物的获批上市,管理日益明晰。但肿瘤合并肝损伤患者血小板减少症的管理仍是空白,血小板减少症和肝损伤的叠加进一步增加了肿瘤治疗的难度。为此,中国抗癌协会肿瘤支持治疗专业委员会组织专家对文献进行分析和讨论,形成肿瘤合并肝损伤患者血小板减少症管理中国专家共识(2022版),以指导临床实践。展开更多
Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ an...Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ and IVA stage） were divided into two groups randomly： group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively. Results： MVD （median） in group A was significantly reduced as compared with group B （P=0.001）. A-LI （median） in group A was significantly increased as compared with group B （P=0.034）. T0.5 in group A was significantly shorter than that in group B （P=0.018）. The reduction of MVD in group A was negatively correlated with T0.5 （r=-0.628）. There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion： Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.展开更多
目的探讨角色扮演教学法在临床医学专业(bachelor of medicine&bachelor of surgery,MBBS)留学生老年医学临床教学中的应用。方法本研究采用试验对照方法。选取昆明医科大学2014级六年制49名MBBS留学生为研究对象,将其随机分为试验...目的探讨角色扮演教学法在临床医学专业(bachelor of medicine&bachelor of surgery,MBBS)留学生老年医学临床教学中的应用。方法本研究采用试验对照方法。选取昆明医科大学2014级六年制49名MBBS留学生为研究对象,将其随机分为试验组24人和对照组25人,试验组采用全英文标准化病人(English standardized patients,ESP)的角色扮演教学法进行授课,对照组采用传统教学方法进行授课,采用期末理论考试成绩和问卷调查的形式对两种教学方法进行评估。结果两组MBBS留学生期末理论考试成绩差异无统计学意义[(81.43±1.43)分比(81.25±1.25)分,P=0.91],但试验组MBBS留学生问卷小测验成绩明显高于对照组MBBS留学生,其差异有统计学意义[(6.71±0.71)分比(5.39±0.39)分,P<0.01]。对教学满意度评价,试验组MBBS留学生满意率之和[87.5%(21/25)]高于对照组MBBS留学生[82.6%(19/24)],其差异无统计学意义(χ^2=2.909,P=0.573)。结论采用ESP方式的角色扮演教学法在MBBS留学生老年医学教学中取得了良好的教学效果。展开更多
文摘血小板减少症和肝损伤是肿瘤患者常见且严重的临床问题。肿瘤合并肝损伤患者血小板减少症(thrombocytopenia in cancer patients with liver injury,TCLI)的病因更加复杂,但常见于肝损伤和肿瘤治疗。肿瘤治疗所致血小板减少症的管理已逐渐形成规范,肝损伤相关血小板减少症随着相关药物的获批上市,管理日益明晰。但肿瘤合并肝损伤患者血小板减少症的管理仍是空白,血小板减少症和肝损伤的叠加进一步增加了肿瘤治疗的难度。为此,中国抗癌协会肿瘤支持治疗专业委员会组织专家对文献进行分析和讨论,形成肿瘤合并肝损伤患者血小板减少症管理中国专家共识(2022版),以指导临床实践。
文摘Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ and IVA stage） were divided into two groups randomly： group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively. Results： MVD （median） in group A was significantly reduced as compared with group B （P=0.001）. A-LI （median） in group A was significantly increased as compared with group B （P=0.034）. T0.5 in group A was significantly shorter than that in group B （P=0.018）. The reduction of MVD in group A was negatively correlated with T0.5 （r=-0.628）. There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion： Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.
文摘目的探讨角色扮演教学法在临床医学专业(bachelor of medicine&bachelor of surgery,MBBS)留学生老年医学临床教学中的应用。方法本研究采用试验对照方法。选取昆明医科大学2014级六年制49名MBBS留学生为研究对象,将其随机分为试验组24人和对照组25人,试验组采用全英文标准化病人(English standardized patients,ESP)的角色扮演教学法进行授课,对照组采用传统教学方法进行授课,采用期末理论考试成绩和问卷调查的形式对两种教学方法进行评估。结果两组MBBS留学生期末理论考试成绩差异无统计学意义[(81.43±1.43)分比(81.25±1.25)分,P=0.91],但试验组MBBS留学生问卷小测验成绩明显高于对照组MBBS留学生,其差异有统计学意义[(6.71±0.71)分比(5.39±0.39)分,P<0.01]。对教学满意度评价,试验组MBBS留学生满意率之和[87.5%(21/25)]高于对照组MBBS留学生[82.6%(19/24)],其差异无统计学意义(χ^2=2.909,P=0.573)。结论采用ESP方式的角色扮演教学法在MBBS留学生老年医学教学中取得了良好的教学效果。
