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一种3D打印蛋白质模型的方法及其在教学中的应用
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作者 田恩麟 王宇翔 张文彬 《大学化学》 CAS 2023年第5期302-307,共6页
本文报道了一种3D打印蛋白质模型的方法,得到了一系列不同的蛋白质模型。这些模型可作为可视化教具,帮助学生理解蛋白质多级结构、蛋白质折叠、蛋白质-蛋白质相互作用等相关知识点,同时也可作为艺术展示教具应用于科学交流与科普宣传。
关键词 3D打印 蛋白质模型 蛋白质折叠 多级结构 蛋白质相互作用
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Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies 被引量:82
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作者 Qiang Guo yuxiang wang +3 位作者 Dan Xu Johannes Nossent Nathan J.Pavlos Jiake Xu 《Bone Research》 CAS CSCD 2018年第2期107-120,共14页
Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A... Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages:(i) triggering,(ii) maturation,(iii) targeting, and(iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies(including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. 展开更多
关键词 RA pathological mechanisms modern pharmacologic therapies
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Identification of novel Lynch syndrome mutations in Chinese patients with endometriod endometrial cancer 被引量:3
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作者 Caixia Ren Yan Liu +4 位作者 yuxiang wang Yan Tang Yawei Wei Congrong Liu Hongquan Zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第2期458-467,共10页
Objective:Lynch syndrome(LS)predisposes patients to early onset endometrioid endometrial cancer(EEC).However,little is known about LS-related EEC in the Chinese population.The aim of this study was to investigate the ... Objective:Lynch syndrome(LS)predisposes patients to early onset endometrioid endometrial cancer(EEC).However,little is known about LS-related EEC in the Chinese population.The aim of this study was to investigate the prevalence of LS and to identify the specific variants of LS in Chinese patients with EEC.Methods:We applied universal immunohistochemistry screening to detect the expression of mismatch repair(MMR)proteins,which was followed by MLH1 methylation analysis to identify suspected LS cases,next-generation sequencing(NGS)to confirm LS,and microsatellite instability(MSI)analysis to verify LS.Results:We collected 211 samples with EEC.Twenty-seven(27/211,12.8%)EEC cases had a loss of MMR protein expression.After MLH1 methylation analysis,16 EEC cases were suggested to be associated with LS.Finally,through NGS and MSI analysis,we determined that 10 EEC(10/209,4.78%)cases were associated with LS.Among those cases,3 unreported mutations(1 frameshift and 2 nonsense)were identified.M SH6 c.597_597delC,found in 4 patients,is likely to be a founder mutation in China.Conclusions:We demonstrated the feasibility of a process for LS screening in Chinese patients with EEC,by using universal immunohistochemistry screening followed by MLH1 methylation analysis and confirmation through NGS and MSI analysis.The novel mutations identified in this study expand knowledge of LS. 展开更多
关键词 DNA mismatch repair endometrial endometrioid cancer germline mutation Lynch syndrome next-generation sequencing
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SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction 被引量:2
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作者 HAN NIU XIN CHEN +9 位作者 XUEQI FU JINGTIAN ZHANG GUODONG LI yuxiang wang JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG 《BIOCELL》 SCIE 2021年第4期963-970,共8页
Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of ... Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. 展开更多
关键词 ALS BAX MITOCHONDRIA PSAP SOD1^(G93A)
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Lever Arm Compensation of Autonomous Underwater Vehicle for Fast Transfer Alignment 被引量:1
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作者 Qi wang Changsong Yang +1 位作者 Shaoen Wu yuxiang wang 《Computers, Materials & Continua》 SCIE EI 2019年第4期105-118,共14页
Transfer alignment is used to initialize SINS(Strapdown Inertial Navigation System)in motion.Lever-arm effect compensation is studied existing in an AUV(Autonomous Underwater Vehicle)before launched from the mother sh... Transfer alignment is used to initialize SINS(Strapdown Inertial Navigation System)in motion.Lever-arm effect compensation is studied existing in an AUV(Autonomous Underwater Vehicle)before launched from the mother ship.The AUV is equipped with SINS,Doppler Velocity Log,depth sensor and other navigation sensors.The lever arm will cause large error on the transfer alignment between master inertial navigation system and slave inertial navigation system,especially in big ship situations.This paper presents a novel method that can effectively estimate and compensate the flexural lever arm between the main inertial navigation system mounted on the mother ship and the slave inertial navigation system equipped on the AUV.The nonlinear measurement equation of angular rate is derived based on three successive rotations of the body frame of the master inertial navigation system.Nonlinear filter is utilized as the nonlinear estimator for its capability of non-linear approximation.Observability analysis was conducted on the SINS state vector based on singular value decomposition method.State equation of SINS was adopted as the system state equation.Simulation experiments were conducted and results showed that the proposed method can estimate the flexural lever arm more accurately,the precision of transfer alignment was improved and alignment time was shortened accordingly. 展开更多
关键词 Transfer alignment SINS lever-arm effect AUV observability analysis
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Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer 被引量:1
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作者 yuxiang wang Xian Li +9 位作者 Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第4期836-836,共1页
In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The ... In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. 展开更多
关键词 FIGURE KRAS CDK4
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守信之心点亮信用建设之路—基于江苏个人信用度调查的实证分析
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作者 汪宇翔 曹文雯 吴继霞 《心理学进展》 2017年第11期1361-1370,共10页
民众的信用品质对个人信用建设而言意义非凡,了解社会个人信用度的整体状况,并推进个人信用品质培育,是信用建设的重点。本研究对2100名江苏省居民进行问卷调查并得出结论:1) 女性比男性更讲信用;2) 信用度随着年龄的增长而提高,年长者... 民众的信用品质对个人信用建设而言意义非凡,了解社会个人信用度的整体状况,并推进个人信用品质培育,是信用建设的重点。本研究对2100名江苏省居民进行问卷调查并得出结论:1) 女性比男性更讲信用;2) 信用度随着年龄的增长而提高,年长者更讲信用;3) 机关事业单位员工的信用较好,而个体工商户的信用相对落后;4) 无贷款或贷款经历的人比有贷款或贷款经历的人更讲信用;5) 不同受教育程度的民众的信用度之间没有差异。上述发现可以为信用教育提供方向,有的放矢,从而提高民众整体信用度,在全社会范围内形成求信之风。 展开更多
关键词 信用 信用品质 信用建设 信用教育
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Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
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作者 yuxiang wang Xian Li +9 位作者 Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第1期66-78,共13页
Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI... Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely unknown.Methods: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in vivo.Results: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb phosphorylation.Conclusions: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC. 展开更多
关键词 PI3Kα CDK4/6 KRAS NSCLC CYH33
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A Clustering Method Based on Brain Storm Optimization Algorithm
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作者 Tianyu wang Yu Xue +3 位作者 Yan Zhao yuxiang wang Yan Zhang yuxiang He 《Journal of Information Hiding and Privacy Protection》 2020年第3期135-142,共8页
In the field of data mining and machine learning,clustering is a typical issue which has been widely studied by many researchers,and lots of effective algorithms have been proposed,including K-means,fuzzy c-means(FCM)... In the field of data mining and machine learning,clustering is a typical issue which has been widely studied by many researchers,and lots of effective algorithms have been proposed,including K-means,fuzzy c-means(FCM)and DBSCAN.However,the traditional clustering methods are easily trapped into local optimum.Thus,many evolutionary-based clustering methods have been investigated.Considering the effectiveness of brain storm optimization(BSO)in increasing the diversity while the diversity optimization is performed,in this paper,we propose a new clustering model based on BSO to use the global ability of BSO.In our experiment,we apply the novel binary model to solve the problem.During the period of processing data,BSO was mainly utilized for iteration.Also,in the process of K-means,we set the more appropriate parameters selected to match it greatly.Four datasets were used in our experiment.In our model,BSO was first introduced in solving the clustering problem.With the algorithm running on each dataset repeatedly,our experimental results have obtained good convergence and diversity.In addition,by comparing the results with other clustering models,the BSO clustering model also guarantees high accuracy.Therefore,from many aspects,the simulation results show that the model of this paper has good performance. 展开更多
关键词 Clustering method brain storm optimization algorithm(BSO) evolutionary clustering algorithm data mining
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Performance and mechanism of La-Fe metal-organic framework as a highly efficient adsorbent for fluoride removal from mine water 被引量:1
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作者 Chaomin Jia Jianbing wang +3 位作者 Huijiao wang Sichao Zhu Xiaohui Zhang yuxiang wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第5期245-257,共13页
Water fluoride pollution has caused non-negligible harm to the environment and humans,and thus it is crucial to find a suitable treatment technology.In this study,La-Fe@PTA adsorbent was synthesized for the defluorida... Water fluoride pollution has caused non-negligible harm to the environment and humans,and thus it is crucial to find a suitable treatment technology.In this study,La-Fe@PTA adsorbent was synthesized for the defluoridation of mine water.The results showed that the optimum conditions for defluoridation by La-Fe@PTA were p H close to 7.0,the initial F-concentration of 10 mg/L,the dosage of 0.5 g/L and the adsorption time of 240 min.Compared with SO_4^(2-),Cl^(-),NO_(3)^(-),Ca^(2+)and Mg^(2+),CO_(3)^(2-)and HCO_(3)^(-)presented severer inhibition on fluoride uptake by La-Fe@PTA.The adsorption process fits well with the pseudo-second-order kinetic model and Freundlich model,and the maximum adsorption capacity of Langmuir model was 95 mg/g.Fixed-bed adsorption results indicated that fluoride in practical fluorinated mine water could be effectively removed from 3.6 mg/L to less than 1.5 mg/L within130 bed volume(BV)by using 1.5 g La-Fe@PTA.Furthermore,the adsorbent still had good adsorption capacity after regeneration,which confirms the great application potential of La-Fe@PTA as a fluoride ion adsorbent.The mechanism analysis showed that La-Fe@PTA adsorption of fluorine ions is a physicochemical reaction driven by electrostatic attraction and ion exchange. 展开更多
关键词 ADSORPTION La-Fe@PTA Fluoride ion Mine water MECHANISM
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Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier 被引量:1
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作者 Dongsheng Bai Jiawei Zhao +7 位作者 Runde wang Jiaying Du Chen Zhou Chunyang Gu yuxiang wang Lulu Zhang Yue Zhao Na Lu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第4期1677-1692,共16页
Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal conse-quences.Despite identifying i... Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal conse-quences.Despite identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is evident.In our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus barrier.This enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory response.Importantly,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy drugs.Mechanistically,E.copr up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRNA and an increase in mucin synthesis in goblet cells.An espe-cially significant finding is that E.copr activates the AhR pathway,thereby promoting the expression of AUF1.In summary,our results strongly indicate that E.copr enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRNA stability. 展开更多
关键词 CHEMOTHERAPY MUCOSITIS Eubacterium coprostanoligenes MUC2 AUF1
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AI for organic and polymer synthesis
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作者 Xin Hong Qi Yang +18 位作者 Kuangbiao Liao Jianfeng Pei Mao Chen Fanyang Mo Hua Lu Wen-Bin Zhang Haisen Zhou Jiaxiao Chen Lebin Su Shuo-Qing Zhang Siyuan Liu Xu Huang Yi-Zhou Sun yuxiang wang Zexi Zhang Zhunzhun Yu Sanzhong Luo Xue-Feng Fu Shu-Li You 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第8期2461-2496,共36页
Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This synergy offers innovative and intelligent solutions to a range of classic ... Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This synergy offers innovative and intelligent solutions to a range of classic problems in synthetic chemistry. These exciting advancements include the prediction of molecular property, multi-step retrosynthetic pathway planning, elucidation of the structure-performance relationship of single-step transformation, establishment of the quantitative linkage between polymer structures and their functions, design and optimization of polymerization process, prediction of the structure and sequence of biological macromolecules, as well as automated and intelligent synthesis platforms. Chemists can now explore synthetic chemistry with unprecedented precision and efficiency, creating novel reactions, catalysts, and polymer materials under the datadriven paradigm. Despite these thrilling developments, the field of artificial intelligence(AI) synthetic chemistry is still in its infancy, facing challenges and limitations in terms of data openness, model interpretability, as well as software and hardware support. This review aims to provide an overview of the current progress, key challenges, and future development suggestions in the interdisciplinary field between AI and synthetic chemistry. It is hoped that this overview will offer readers a comprehensive understanding of this emerging field, inspiring and promoting further scientific research and development. 展开更多
关键词 organic synthesis polymer synthesis machine learning prediction chemical database automated synthesis
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Effect of Y and Ce Micro-alloying on Microstructure and Hot Tearing of As-Cast Al-Cu-Mg Alloy
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作者 Chunyu Yue Bowen Zheng +4 位作者 Ming Su yuxiang wang Xiaojiao Zuo Yinxiao wang Xiaoguang Yuan 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2024年第6期939-952,共14页
In this work,the Al-Cu-Mg alloy with different Y(0-0.2 wt%)and Ce(0.5-1.5 wt%)are designed.The effect of mixed addition of Y and Ce on the grain structure and hot tearing for Al-4.4Cu-1.5Mg-0.15Zr alloy was investigat... In this work,the Al-Cu-Mg alloy with different Y(0-0.2 wt%)and Ce(0.5-1.5 wt%)are designed.The effect of mixed addition of Y and Ce on the grain structure and hot tearing for Al-4.4Cu-1.5Mg-0.15Zr alloy was investigated using"cross"hot tearing mould.The results indicate that as rare earth Y and Ce increases,the grain size becomes finer,the grain morphology changes from dendrite to equiaxed grain,and effectively reduce the hot tearing sensitivity coefficient(HTS1)and crack susceptibility coefficient(CSC)of the alloy.With the increase of Ce element(0.5-1.5 wt%),the hot tearing susceptibility of the alloy decreases first and then increases.With the increase of Y element(0-0.2 wt%),the hot tearing sensitivity of the alloy decreases.When the content of rare earth is 0.2 wt%Y+1.0 wt%Ce,the minimum HTS1 value and CSC value of the alloy are 68 and 0.53,respectively.Rare earth Ce refines the alloy microstructure,shortens the feeding channel,and reduces the hot tearing initiation.Meanwhile,the rare earth Y can form Al6Cu6Y phase at the grain boundary,improve the feeding capacity of the alloy.Therefore,appropriate addition of rare earth Y and Ce can effectively reduce the hot tearing tendency of the alloy. 展开更多
关键词 Al-Cu-Mg alloy Y and Ce MICROSTRUCTURE Thermal analysis Hot tearing sensitivity
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Memristive switching in the surface of a charge-density-wave topological semimetal
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作者 Jianwen Ma Xianghao Meng +20 位作者 Binhua Zhang yuxiang wang Yicheng Mou Wenting Lin Yannan Dai Luqiu Chen Haonan wang Haoqi Wu Jiaming Gu Jiayu wang Yuhan Du Chunsen Liu Wu Shi Zhenzhong Yang Bobo Tian Lin Miao Peng Zhou Chun-Gang Duan Changsong Xu Xiang Yuan Cheng Zhang 《Science Bulletin》 SCIE EI CAS CSCD 2024年第13期2042-2049,共8页
Owing to the outstanding properties provided by nontrivial band topology,topological phases of matter are considered as a promising platform towards low-dissipation electronics,efficient spin-charge conversion,and top... Owing to the outstanding properties provided by nontrivial band topology,topological phases of matter are considered as a promising platform towards low-dissipation electronics,efficient spin-charge conversion,and topological quantum computation.Achieving ferroelectricity in topological materials enables the non-volatile control of the quantum states,which could greatly facilitate topological electronic research.However,ferroelectricity is generally incompatible with systems featuring metallicity due to the screening effect of free carriers.In this study,we report the observation of memristive switching based on the ferroelectric surface state of a topological semimetal(TaSe_(4))2I.We find that the surface state of(TaSe_(4))2I presents out-of-plane ferroelectric polarization due to surface reconstruction.With the combination of ferroelectric surface and charge-density-wave-gapped bulk states,an electric-switchable barrier height can be achieved in(TaSe_(4))2I-metal contact.By employing a multi-terminal-grounding design,we manage to construct a prototype ferroelectric memristor based on(TaSe_(4))2I with on/off ratio up to 103,endurance over 103 cycles,and good retention characteristics.The origin of the ferroelectric surface state is further investigated by first-principles calculations,which reveal an interplay between ferroelectricity and band topology.The emergence of ferroelectricity in(TaSe_(4))2I not only demonstrates it as a rare but essential case of ferroelectric topological materials,but also opens new routes towards the implementation of topological materials in functional electronic devices. 展开更多
关键词 Topological semimetal Schottky barrier Surface ferroelectricity Memristor
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Universal materials model of deep-learning density functional theory Hamiltonian
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作者 yuxiang wang Yang Li +14 位作者 Zechen Tang He Li Zilong Yuan Honggeng Tao Nianlong Zou Ting Bao Xinghao Liang Zezhou Chen Shanghua Xu Ce Bian Zhiming Xu Chong wang Chen Si Wenhui Duan Yong Xu 《Science Bulletin》 SCIE EI CAS CSCD 2024年第16期2514-2521,共8页
Realizing large materials models has emerged as a critical endeavor for materials research in the new era of artificial intelligence,but how to achieve this fantastic and challenging objective remains elusive.Here,we ... Realizing large materials models has emerged as a critical endeavor for materials research in the new era of artificial intelligence,but how to achieve this fantastic and challenging objective remains elusive.Here,we propose a feasible pathway to address this paramount pursuit by developing universal materials models of deep-learning density functional theory Hamiltonian(Deep H),enabling computational modeling of the complicated structure-property relationship of materials in general.By constructing a large materials database and substantially improving the Deep H method,we obtain a universal materials model of Deep H capable of handling diverse elemental compositions and material structures,achieving remarkable accuracy in predicting material properties.We further showcase a promising application of fine-tuning universal materials models for enhancing specific materials models.This work not only demonstrates the concept of Deep H's universal materials model but also lays the groundwork for developing large materials models,opening up significant opportunities for advancing artificial intelligencedriven materials discovery. 展开更多
关键词 Large materials model Universal materials model Deep-learning density functional theory Artificial intelligence-driven materials discovery
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Absence of metallicity and bias-dependent resistivity in low-carrier-density EuCd_(2)As_(2)
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作者 yuxiang wang Jianwen Ma +10 位作者 Jian Yuan Wenbin Wu Yong Zhang Yicheng Mou Jiaming Gu Peihong Cheng Wu Shi Xiang Yuan Jinglei Zhang Yanfeng Guo Cheng Zhang 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2024年第4期119-125,共7页
EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments... EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet state.However,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal hypothesis.Here,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band bending.Moreover,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric resonance.Such nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band edge.Our results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system. 展开更多
关键词 magnetic Weyl semimetal quantum transport Hall effect nonlinear resistivity
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Injectable immunoregulatory hydrogels sequentially drive phenotypic polarization of macrophages for infected wound healing
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作者 yuxiang wang Chen Zhou +11 位作者 Zhulian Li Gong Li Yaping Zou Xing Li Peiyang Gu Jingyi Liu Lang Bai Hong Yan Jie Liang Xingdong Zhang Yujiang Fan Yong Sun 《Bioactive Materials》 SCIE CSCD 2024年第11期193-206,共14页
Regulating macrophage phenotypes to reconcile the conflict between bacterial suppression and tissue regeneration is ideal for treating infectious skin wounds. Here, an injectable immunoregulatory hydrogel (SrmE20) tha... Regulating macrophage phenotypes to reconcile the conflict between bacterial suppression and tissue regeneration is ideal for treating infectious skin wounds. Here, an injectable immunoregulatory hydrogel (SrmE20) that sequentially drives macrophage phenotypic polarization (M0 to M1, then to M2) was constructed by integrating anti-inflammatory components and proinflammatory solvents. In vitro experiments demonstrated that the proinflammatory solvent ethanol stabilized the hydrogel structure, maintained the phenolic hydroxyl group activity, and achieved macrophages' proinflammatory transition (M0 to M1) to enhance antibacterial effects. With ethanol depletion, the hydrogel's cations and phenolic hydroxyl groups synergistically regulated macrophages' anti-inflammatory transition (M1 to M2) to initiate regeneration. In the anti-contraction full-thickness wound model with infection, this hydrogel effectively eliminated bacteria and even achieved anti-inflammatory M2 macrophage accumulation at three days post-surgery, accelerated angiogenesis and collagen deposition. By sequentially driving macrophage phenotypic polarization, this injectable immunoregulatory hydrogel will bring new guidance for the care and treatment of infected wounds. 展开更多
关键词 Sequential immunoregulation Macrophage phenotypic polarization Injectable hydrogel Infected wounds
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Impaired autophagy activity-induced abnormal differentiation of bone marrow stem cells is related to adolescent idiopathic scoliosis osteopenia 被引量:2
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作者 Hongqi Zhang Guanteng Yang +3 位作者 Jiong Li Lige Xiao Chaofeng Guo yuxiang wang 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第17期2077-2085,共9页
Background:Osteopenia has been well documented in adolescent idiopathic scoliosis(AIS).Bone marrow stem cells(BMSCs)are a crucial regulator of bone homeostasis.Our previous study revealed a decreased osteogenic abilit... Background:Osteopenia has been well documented in adolescent idiopathic scoliosis(AIS).Bone marrow stem cells(BMSCs)are a crucial regulator of bone homeostasis.Our previous study revealed a decreased osteogenic ability of BMSCs in AIS-related osteopenia,but the underlying mechanism of this phenomenon remains unclear.Methods:A total of 22 AIS patients and 18 age-matched controls were recruited for this study.Anthropometry and bone mass were measured in all participants.Bone marrow blood was collected for BMSC isolation and culture.Osteogenic and adipogenic induction were performed to observe the differences in the differentiation of BMSCs between the AIS-related osteopenia group and the control group.Furthermore,a total RNA was extracted from isolated BMSCs to perform RNA sequencing and subsequent analysis.Results:A lower osteogenic capacity and increased adipogenic capacity of BMSCs in AIS-related osteopenia were revealed.Differences in mRNA expression levels between the AIS-related osteopenia group and the control group were identified,including differences in the expression of LRRC17,DCLK1,PCDH7,TSPAN5,NHSL2,and CPT1B.Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed several biological processes involved in the regulation of autophagy and mitophagy.The Western blotting results of autophagy markers in BMSCs suggested impaired autophagic activity in BMSCs in the AIS-related osteopenia group.Conclusion:Our study revealed that BMSCs from AIS-related osteopenia patients have lower autophagic activity,which may be related to the lower osteogenic capacity and higher adipogenic capacity of BMSCs and consequently lead to the lower bone mass in AIS patients. 展开更多
关键词 Adolescent idiopathic scoliosis Bone marrow stem cell AUTOPHAGY OSTEOPENIA
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Infuence of Liquid Film Characteristics on Hot Cracking Initiation in Al–Cu Alloys at the End of Solidifcation
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作者 Ming Su Xiaoguang Yuan +3 位作者 Chunyu Yue Wentao Zheng yuxiang wang Jian Kang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2023年第1期103-117,共15页
In this study,Al–4Cu alloy specimens with spherical grains and liquid flms were obtained by isothermal reheating treatment.The hot cracking of the solidifcation process was determined using a modifed constrained rod ... In this study,Al–4Cu alloy specimens with spherical grains and liquid flms were obtained by isothermal reheating treatment.The hot cracking of the solidifcation process was determined using a modifed constrained rod casting experimental apparatus,and the efect of liquid flm characteristics at the end of solidifcation on hot cracking initiation of Al–4Cu alloys was systematically investigated by combining molecular dynamics simulations and other methods.With the extension of soaking time,the liquid fraction(liquid flm fraction at the end of solidifcation)and grain shape factor increased with higher isothermal reheating temperatures.Additionally,the widened flling channel decreased the hot cracking initiation temperature and the critical hot cracking shrinkage stress was found to increase,thus reducing the hot cracking severity in Al–4Cu alloys.Molecular dynamics simulations revealed that with the extension of soaking time,the composition of the liquid flm changed at diferent isothermal reheating temperatures,but the short-range structure and atomic ordering of the liquid flm remained the same.The activity of the liquid flm increased in equilibrium,leading to a decrease in viscosity and an increase in fuidity,which contributed to the flling behaviour.After isothermal reheating at 640℃for 60 min,the liquid fraction reached the maximum,and the viscosity of the liquid flm was the minimum.In addition,almost no hot cracks were found. 展开更多
关键词 Al-4Cu alloy Liquid flm characteristics Isothermal reheating Molecular dynamics simulation Hot cracking initiation mechanism
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Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway
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作者 Hongqi Zhang Gang Xiang +5 位作者 Jiong Li Sihan He Yunjia wang Ang Deng yuxiang wang Chaofeng Guo 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第12期1468-1477,共10页
Background:Congenital scoliosis(CS)is a complex spinal malformation of unknown etiology with abnormal bone metabolism.Fibroblast growth factor 23(FGF23),secreted by osteoblasts and osteocytes,can inhibit bone formatio... Background:Congenital scoliosis(CS)is a complex spinal malformation of unknown etiology with abnormal bone metabolism.Fibroblast growth factor 23(FGF23),secreted by osteoblasts and osteocytes,can inhibit bone formation and mineralization.This research aims to investigate the relationship between CS and FGF23.Methods:We collected peripheral blood from two pairs of identical twins for methylation sequencing of the target region.FGF23 mRNA levels in the peripheral blood of CS patients and age-matched controls were measured.Receiver operator characteristic(ROC)curve analyses were conducted to evaluate the specificity and sensitivity of FGF23.The expression levels of FGF23 and its downstream factors fibroblast growth factor receptor 3(FGFr3)/tissue non-specific alkaline phosphatase(TNAP)/osteopontin(OPN)in primary osteoblasts from CS patients(CS-Ob)and controls(CT-Ob)were detected.In addition,the osteogenic abilities of FGF23-knockdown or FGF23-overexpressing Ob were examined.Results:DNA methylation of the FGF23 gene in CS patients was decreased compared to that of their identical twins,accompanied by increased mRNA levels.CS patients had increased peripheral blood FGF23 mRNA levels and decreased computed tomography(CT)values compared with controls.The FGF23 mRNA levels were negatively correlated with the CT value of the spine,and ROCs of FGF23 mRNA levels showed high sensitivity and specificity for CS.Additionally,significantly increased levels of FGF23,FGFr3,OPN,impaired osteogenic mineralization and lower TNAP levels were observed in CS-Ob.Moreover,FGF23 overexpression in CT-Ob increased FGFr3 and OPN levels and decreased TNAP levels,while FGF23 knockdown induced downregulation of FGFr3 and OPN but upregulation of TNAP in CS-Ob.Mineralization of CS-Ob was rescued after FGF23 knockdown.Conclusions:Our results suggested increased peripheral blood FGF23 levels,decreased bone mineral density in CS patients,and a good predictive ability of CS by peripheral blood FGF23 levels.FGF23 may contribute to osteopenia in CS patients through FGFr3/TNAP/OPN pathway. 展开更多
关键词 SCOLIOSIS Fibroblast growth factor 23 Fibroblast growth factor receptor 3 OSTEOPENIA
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