类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中...类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中药复方及制剂、中药配伍,以及中医治疗通过调控骨保护蛋白(osteoprotegerin,OPG)/NF-κB受体激活因子(receptor activator of NF-κB,RANK)/NF-κB配体激活因子(receptor activator of NF-κB ligand,RANKL)信号通路干预RA的相关研究进行综述。结果表明,中药中的有效分子机制不同,但是可以起到调控信号通路的作用,刺激成骨细胞活性,抑制炎性细胞因子分泌,减少破骨细胞分化,从而防治RA,为中医药多靶点、多途径治疗RA提供理论依据。展开更多
骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间...骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间及股骨小转子下部近端,经病灶刮除+同种异体腓骨条支撑植骨+打压植骨+锁定接骨板内固定术治疗后,患者下肢生理长度及颈干角恢复,在25个月的随访中,下肢功能活动恢复情况良好,未见患肢疼痛或FD复发。展开更多
The relatedness between catalytic effect of activated carbon and passivation phenomenon during chalcopyrite bioleachingby mixed thermophilic Archaea culture(Acidianus brierleyi,Metallosphaera sedula,Acidianus manzaens...The relatedness between catalytic effect of activated carbon and passivation phenomenon during chalcopyrite bioleachingby mixed thermophilic Archaea culture(Acidianus brierleyi,Metallosphaera sedula,Acidianus manzaensis and Sulfolobusmetallicus)at65°C was studied.Leaching experiments showed that the addition of activated carbon could significantly promote thedissolution of chalcopyrite for both bioleaching and chemical leaching.The results of synchrotron-based X-ray diffraction,ironL-edge and sulfur K-edge X-ray absorption near edge structure spectroscopy indicated that activated carbon could change thetransition path of electrons through galvanic interactions to form more readily dissolved secondary mineral chalcocite at a low redoxpotential(?400mV)and then enhanced the copper dissolution.Jarosite accumulated immediately in the initial stage of bioleachingwith activated carbon but copper dissolution was not hindered.However,much jarosite precipitated on the surface of chalcopyrite inthe late stage of bioleaching,which might account for the decrease of copper dissolution rate.More elemental sulfur(S0)was alsodetected with additional activated carbon but the mixed thermophilic Archaea culture had a great sulfur oxidation activity,thus S0waseliminated and seemed to have no significant influence on the dissolution of chalcopyrite.展开更多
文摘类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中药复方及制剂、中药配伍,以及中医治疗通过调控骨保护蛋白(osteoprotegerin,OPG)/NF-κB受体激活因子(receptor activator of NF-κB,RANK)/NF-κB配体激活因子(receptor activator of NF-κB ligand,RANKL)信号通路干预RA的相关研究进行综述。结果表明,中药中的有效分子机制不同,但是可以起到调控信号通路的作用,刺激成骨细胞活性,抑制炎性细胞因子分泌,减少破骨细胞分化,从而防治RA,为中医药多靶点、多途径治疗RA提供理论依据。
文摘骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间及股骨小转子下部近端,经病灶刮除+同种异体腓骨条支撑植骨+打压植骨+锁定接骨板内固定术治疗后,患者下肢生理长度及颈干角恢复,在25个月的随访中,下肢功能活动恢复情况良好,未见患肢疼痛或FD复发。
基金Project(51274257) supported by the National Natural Science Foundation of ChinaProject(U1232103) supported by the Joint Funds of National Natural Science Foundation of China and Large Scientific Facility Foundation of Chinese Academy of Sciences+1 种基金Project(VR-12419) supported by the Beijing Synchrotron Radiation Facility Public User Program,ChinaProject(15ssrf00924) supported by the Shanghai Institute of Applied Physics Open Fund of Shanghai Synchrotron Radiation Facility,China
文摘The relatedness between catalytic effect of activated carbon and passivation phenomenon during chalcopyrite bioleachingby mixed thermophilic Archaea culture(Acidianus brierleyi,Metallosphaera sedula,Acidianus manzaensis and Sulfolobusmetallicus)at65°C was studied.Leaching experiments showed that the addition of activated carbon could significantly promote thedissolution of chalcopyrite for both bioleaching and chemical leaching.The results of synchrotron-based X-ray diffraction,ironL-edge and sulfur K-edge X-ray absorption near edge structure spectroscopy indicated that activated carbon could change thetransition path of electrons through galvanic interactions to form more readily dissolved secondary mineral chalcocite at a low redoxpotential(?400mV)and then enhanced the copper dissolution.Jarosite accumulated immediately in the initial stage of bioleachingwith activated carbon but copper dissolution was not hindered.However,much jarosite precipitated on the surface of chalcopyrite inthe late stage of bioleaching,which might account for the decrease of copper dissolution rate.More elemental sulfur(S0)was alsodetected with additional activated carbon but the mixed thermophilic Archaea culture had a great sulfur oxidation activity,thus S0waseliminated and seemed to have no significant influence on the dissolution of chalcopyrite.
