BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we ai...BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we aimed to determine a new method for long-term retention of the ventilation tube.AIM To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.METHODS A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube placement.The patients were randomly divided into two groups:Control group and treatment group.Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm removed.Only conventional ventilation tubes were placed in this study.Outcome measures were tube position and patency.Tube retention time and any complications were documented.RESULTS Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study.The tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.展开更多
Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural ...Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural stability of NaMN was investigated.The physicochemical characterizations suggest that the introduction of Sc and Zn broaden Na^(+) diffusion channels and weaken the Na—O bonds,thereby facilitating the diffusion of sodium ions.Simulations indicate that the Sc and Zn dual-substitution decreases the diffusion barrier of Na-ions and improves the conductivity of the material.The dual-substituted NaMn_(0.5)Ni_(0.4)Sc_(0.04)Zn_(0.04)O_(2)(Na MNSZ44)cathode delivers impressive cycle stability with capacity retention of 71.2%after 200 cycles at 1C and 54.8%after 400 cycles at 5C.Additionally,the full cell paired with hard carbon anode exhibits a remarkable long-term cycling stability,showing capacity retention of 64.1%after 250 cycles at 1C.These results demonstrate that Sc and Zn dual-substitution is an effective strategy to improve the Na^(+) diffusion dynamics and structural stability of NaMN.展开更多
To the Editor: POU domain class 3 transcription factor 4 or BRN-4 (POU3F4) is a causative gene of non-syndromic X-linked hearing loss (HL), which is characterized by inner ear anomalies. To date, six X-linked non-synd...To the Editor: POU domain class 3 transcription factor 4 or BRN-4 (POU3F4) is a causative gene of non-syndromic X-linked hearing loss (HL), which is characterized by inner ear anomalies. To date, six X-linked non-syndromic HL loci (DFNX1-6) have been mapped to chromosome X and five of these genes have been identified: phosphoribosyl pyrophosphate synthetase 1 (PRPS1)(DFNX1, OMIM: 304500), POU3F4 (DFNX2, OMIM: 304400),[1] small muscle protein, X-linked (SMPX)(DFNX4, OMIM: 300066), apoptosis-inducing factor, mitochondria-associated, 1 (AIFM1)(DFNX5, OMIM: 300614), and collagen, type IV alpha-6 (COL4A6)(DFNX6, OMIM;300914). POU3F4 mutation accounts for nearly 50% of all cases of DFNX.展开更多
基金Supported by Shanghai Leadership Talent Training Plan,No. 2017062the Key Project of Shanghai Jiao Tong University Medicine Science and Engineering Interdisciplinary Foundation,No. YG2016ZD02+3 种基金Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support,No.20152233Multi-Center Clinical Research Plan of Medical College of Shanghai Jiao Tong University,No. DLY201823the Clinical Research Plan of Shanghai Shen Kang Hospital Development Center,No. 16CR4022A and No.16CR3041ANational Natural Science Foundation of China,No.81974142.
文摘BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we aimed to determine a new method for long-term retention of the ventilation tube.AIM To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.METHODS A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube placement.The patients were randomly divided into two groups:Control group and treatment group.Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm removed.Only conventional ventilation tubes were placed in this study.Outcome measures were tube position and patency.Tube retention time and any complications were documented.RESULTS Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study.The tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.
基金financial support from the National Natural Science Foundation of China(No.52377220)the Natural Science Foundation of Hunan Province,China(No.kq2208265)。
文摘Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural stability of NaMN was investigated.The physicochemical characterizations suggest that the introduction of Sc and Zn broaden Na^(+) diffusion channels and weaken the Na—O bonds,thereby facilitating the diffusion of sodium ions.Simulations indicate that the Sc and Zn dual-substitution decreases the diffusion barrier of Na-ions and improves the conductivity of the material.The dual-substituted NaMn_(0.5)Ni_(0.4)Sc_(0.04)Zn_(0.04)O_(2)(Na MNSZ44)cathode delivers impressive cycle stability with capacity retention of 71.2%after 200 cycles at 1C and 54.8%after 400 cycles at 5C.Additionally,the full cell paired with hard carbon anode exhibits a remarkable long-term cycling stability,showing capacity retention of 64.1%after 250 cycles at 1C.These results demonstrate that Sc and Zn dual-substitution is an effective strategy to improve the Na^(+) diffusion dynamics and structural stability of NaMN.
基金This work was supported by the grants &om the State Key Program of National Natural Science Foundation of China (No.81530029)the International Cooperation and Exchange of the National Natural Science Foundation of China (No.8171001156)+1 种基金the National Natural Science Foundation of China (No.81771007)the National Natural Science Foundation of the State Youth Fund (No.81800919).
文摘To the Editor: POU domain class 3 transcription factor 4 or BRN-4 (POU3F4) is a causative gene of non-syndromic X-linked hearing loss (HL), which is characterized by inner ear anomalies. To date, six X-linked non-syndromic HL loci (DFNX1-6) have been mapped to chromosome X and five of these genes have been identified: phosphoribosyl pyrophosphate synthetase 1 (PRPS1)(DFNX1, OMIM: 304500), POU3F4 (DFNX2, OMIM: 304400),[1] small muscle protein, X-linked (SMPX)(DFNX4, OMIM: 300066), apoptosis-inducing factor, mitochondria-associated, 1 (AIFM1)(DFNX5, OMIM: 300614), and collagen, type IV alpha-6 (COL4A6)(DFNX6, OMIM;300914). POU3F4 mutation accounts for nearly 50% of all cases of DFNX.
