High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(O...High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(Oryza sativa), wheat(Triticum aestivum), and maize(Zea mays). This study aimed to identify stable major-effect QTL associated with pod yield per plant, hundred-pod weight for double-seeded pods,hundred-seed weight, shelling percentage, and pod number per plant, allowing us to predict candidate genes by means of transcriptome and genome sequencing. To this end, we used a population of recombinant inbred lines comprising 192 F9:11families derived from a JH6 × KX01-6 cross to construct a highresolution genetic map(1705.7 c M) consisting of 2273 polymorphic SNPs, with 0.75 c M(on average)between adjacent SNPs. We identified two high-confidence, yield-related QTL, qHYF_A08 and qHYF_B06, explaining 5.78%–31.40% of phenotypic variation and with LOD values of 5.10–24.48, in six environments. qHYF_A08 mainly explained the variation in shelling percentage, whereas qHYF_B06explained variation in hundred-pod weight and hundred-seed weight and accounted for 8.77%–31.40%of the variation in effective pod number per plant, pod number per plant, and shelling percentage. We narrowed down qHYF_B06 to an 890-kb interval using an advanced mapping population.Transcriptome and genome analyses revealed that only Arahy.129FS0 and Arahy.3R9A5K in the candidate mapping interval were differentially expressed between JH6 and KX01-6, with substantial structural variations in their promoter and coding regions. Genotypes of 208 peanut accessions determined using a diagnostic CAPS marker suggested that the two haplotypes of Arahy.3R9A5K were highly associated with hundred-seed weight and hundred-pod weight;this diagnostic CAPs marker could therefore be useful for selecting high-yielding lines during peanut breeding. Overall, our results provide valuable information for cloning alleles with favorable effects on peanut yield.展开更多
Novel coronavirus is threatening the health of people all over the world and all possible treatment strategies are in urgent. The sensitive of virus to heat proposed temperature treatment as an effective method agains...Novel coronavirus is threatening the health of people all over the world and all possible treatment strategies are in urgent. The sensitive of virus to heat proposed temperature treatment as an effective method against coronavirus. Here, we proposed several non-drug therapies including far-infrared, thermal air, thermal oxygen, ozone, hydrogen therapy and plasma physical therapy for immediate clinical trial and implementation. Compared with the drug therapy, these methods are safe without side effects, the highest benefit-to-risk ratio, user-friendly, and low implementation costs. It is urgent and significant to start these non-drug therapeutic design and implementation as early as possible, to determine the safety and effectiveness of these therapeutic methods.展开更多
Previous theoretical studies have found that the concentration variations within a certain range have a prominent effect on inter-mineral equilibrium isotope fractionation(10^3 lna).Based on the density functional the...Previous theoretical studies have found that the concentration variations within a certain range have a prominent effect on inter-mineral equilibrium isotope fractionation(10^3 lna).Based on the density functional theory,we investigated how the average Ca–O bond length and the reduced partition function ratios(10^3 lnb)and103lna of 44 Ca/40 Ca in forsterite(Fo)are affected by its Ca concentration.Our results show that Ca–O bond length in forsterite ranges from 2.327 to 2.267 A with the Ca/(Ca+Mg)varying between a narrow range limited by an upper limit of 1/8 and a lower limit of 1/64.However,outside this narrow range,i.e.,Ca/(Ca+Mg)is lower than1/64 or higher than 1/8,Ca–O bond length becomes insensitive to Ca concentration and maintains to be a constant.Because the 10^3 lnb is negatively correlated with Ca–O bond length,the 10^3lnb significantly increases with decreasing Ca/(Ca+Mg)when 1/64<Ca/(Ca+Mg)<2/16.As a consequence,the 10^3lna between forsterite and other minerals also strongly depend on the Ca content in forsterite.Combining previous studies with our results,the heavier Ca isotopes enrichment sequence in minerals is:forsterite[orthopyroxene[clinopyroxene[calcite & diopside[dolomite[aragonite.Olivineand pyroxenes are enriched in heavier Ca isotope compared to carbonates.The 10^3lna between forsterite with a Ca/(Ca+Mg)of 1/64 and clinopyroxene(Ca/Mg=1/1,i.e.,diopside)is up to^0.64%at 1200 K.The large 103lnaFodiopsiderelative to the current analytical precision for Ca isotope measurements suggests that the dependence of10^3 lnaFo-diopsideon temperature can be used as a thermometer,similar to the one based on the 103lna of 44 Ca/40 Ca between orthopyroxene and diopside.These two Ca isotope thermometers both have a precision approximate to that of elemental thermometers and provide independent constraints on temperature.展开更多
Gold nanoparticles(Au NPs)have demonstrated great potential in chemical and biological sensing,catalysis,biomedicine,X-ray computed tomography,and other applications,owing to their unique properties.Au NPs with high-i...Gold nanoparticles(Au NPs)have demonstrated great potential in chemical and biological sensing,catalysis,biomedicine,X-ray computed tomography,and other applications,owing to their unique properties.Au NPs with high-index facets have attracted more attention in the past decade owing to their superior electrocatalytic activity in fuel cells and enhanced performance in surface-enhanced Raman spectroscopy(SERS)applications.This review presents an overview of our achievements in the direct synthesis of Au NPs with controlled shapes in water using cationic surfactants.By deliberately adjusting the nature of the surfactant stabilizers,preformed Au NPs with simple shapes can be readily transformed into Au NPs with complicated shapes with controlled high-index facets by simple seeded growth.The high-index facets of the as-prepared Au NPs can be consistently correlated with their superior performance in the electrooxidation of methanol and ethanol and their enhanced SERS activity.展开更多
Viral myocarditis(VMC)is a cardiac disease associated with myocardial inflammation and injury induced by virus infection.Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammati...Viral myocarditis(VMC)is a cardiac disease associated with myocardial inflammation and injury induced by virus infection.Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium.Kruppel-like factor 10(KLF10)is a crucial regulator of various pathological processes and plays different roles in a variety of diseases.However,its role in VMC induced by coxsackievirus B3(CVB3)infection remains unknown.In this study,we report that cardiac KLF10 confers enhanced protection against viral myocarditis.We found that KLF10 expression was downregulated upon CVB3 infection.KLF10 deficiency enhanced cardiac viral replication and aggravated VMC progress.Bone marrow chimera experiments indicated that KLF10 expression in nonhematopoietic cells was involved in the pathogenesis of VMC.We further identified MCP-1 as a novel target of KLF10 in cardiomyocytes,and KLF10 cooperated with histone deacetylase 1(HDAC1)to negatively regulate MCP-1 expression by binding its promoter,leading to activation of MCP-1 transcription and recruitment of Ly6C^(high) monocytes/macrophages into the myocardium.This novel mechanism of MCP-1 regulation by KLF10 might provide new insights into the pathogenesis of VMC and a potential therapeutic target for VMC.展开更多
To resimulate a customized fluid derived product by analyzing an existing fluid is significant and difficult.This paper proposes a driven model recovery method,which is challenging in fluid resimulation customization....To resimulate a customized fluid derived product by analyzing an existing fluid is significant and difficult.This paper proposes a driven model recovery method,which is challenging in fluid resimulation customization.First,fluid physical properties are calculated under the constraints of appearance and dynamic behavior of the example water.Second,a hybrid particle lattice Boltzmann method for shallow water(LBMSW)is recovered from the dynamic geometry on fluid surface.As it is found that the resimulation details fade gradually with LBMSW auto-advection,a physically-based enhancement scheme is presented.A nonlinear algorithm is introduced to stretch the faded density to retain resimulation details.Experiments show that the proposed approach can obtain more realistic resimulation products in several challenging scenarios.展开更多
基金jointly supported by the Earmarked Fund for CARS-13the Modern Agricultural Industrial Technology System of Hebei Province (HBCT2018090101 and HBCT2018090201)+3 种基金the Science and Technology Innovation Team of Modern Peanut Seed Industry (21326316D)the Technology Innovation Special Project(2022KJCXZX-LYS-11)the Basic Research Funds of Hebei Academy of Agriculture and Forestry Sciences (2021060201)the Talents Construction Project of Science and Technology Innovation,Hebei Academy of Agriculture and Forestry Sciences (C22R0311)。
文摘High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(Oryza sativa), wheat(Triticum aestivum), and maize(Zea mays). This study aimed to identify stable major-effect QTL associated with pod yield per plant, hundred-pod weight for double-seeded pods,hundred-seed weight, shelling percentage, and pod number per plant, allowing us to predict candidate genes by means of transcriptome and genome sequencing. To this end, we used a population of recombinant inbred lines comprising 192 F9:11families derived from a JH6 × KX01-6 cross to construct a highresolution genetic map(1705.7 c M) consisting of 2273 polymorphic SNPs, with 0.75 c M(on average)between adjacent SNPs. We identified two high-confidence, yield-related QTL, qHYF_A08 and qHYF_B06, explaining 5.78%–31.40% of phenotypic variation and with LOD values of 5.10–24.48, in six environments. qHYF_A08 mainly explained the variation in shelling percentage, whereas qHYF_B06explained variation in hundred-pod weight and hundred-seed weight and accounted for 8.77%–31.40%of the variation in effective pod number per plant, pod number per plant, and shelling percentage. We narrowed down qHYF_B06 to an 890-kb interval using an advanced mapping population.Transcriptome and genome analyses revealed that only Arahy.129FS0 and Arahy.3R9A5K in the candidate mapping interval were differentially expressed between JH6 and KX01-6, with substantial structural variations in their promoter and coding regions. Genotypes of 208 peanut accessions determined using a diagnostic CAPS marker suggested that the two haplotypes of Arahy.3R9A5K were highly associated with hundred-seed weight and hundred-pod weight;this diagnostic CAPs marker could therefore be useful for selecting high-yielding lines during peanut breeding. Overall, our results provide valuable information for cloning alleles with favorable effects on peanut yield.
文摘Novel coronavirus is threatening the health of people all over the world and all possible treatment strategies are in urgent. The sensitive of virus to heat proposed temperature treatment as an effective method against coronavirus. Here, we proposed several non-drug therapies including far-infrared, thermal air, thermal oxygen, ozone, hydrogen therapy and plasma physical therapy for immediate clinical trial and implementation. Compared with the drug therapy, these methods are safe without side effects, the highest benefit-to-risk ratio, user-friendly, and low implementation costs. It is urgent and significant to start these non-drug therapeutic design and implementation as early as possible, to determine the safety and effectiveness of these therapeutic methods.
基金financially supported by the Natural Science Foundation of China (Nos. 41721002, 41473011)Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund
文摘Previous theoretical studies have found that the concentration variations within a certain range have a prominent effect on inter-mineral equilibrium isotope fractionation(10^3 lna).Based on the density functional theory,we investigated how the average Ca–O bond length and the reduced partition function ratios(10^3 lnb)and103lna of 44 Ca/40 Ca in forsterite(Fo)are affected by its Ca concentration.Our results show that Ca–O bond length in forsterite ranges from 2.327 to 2.267 A with the Ca/(Ca+Mg)varying between a narrow range limited by an upper limit of 1/8 and a lower limit of 1/64.However,outside this narrow range,i.e.,Ca/(Ca+Mg)is lower than1/64 or higher than 1/8,Ca–O bond length becomes insensitive to Ca concentration and maintains to be a constant.Because the 10^3 lnb is negatively correlated with Ca–O bond length,the 10^3lnb significantly increases with decreasing Ca/(Ca+Mg)when 1/64<Ca/(Ca+Mg)<2/16.As a consequence,the 10^3lna between forsterite and other minerals also strongly depend on the Ca content in forsterite.Combining previous studies with our results,the heavier Ca isotopes enrichment sequence in minerals is:forsterite[orthopyroxene[clinopyroxene[calcite & diopside[dolomite[aragonite.Olivineand pyroxenes are enriched in heavier Ca isotope compared to carbonates.The 10^3lna between forsterite with a Ca/(Ca+Mg)of 1/64 and clinopyroxene(Ca/Mg=1/1,i.e.,diopside)is up to^0.64%at 1200 K.The large 103lnaFodiopsiderelative to the current analytical precision for Ca isotope measurements suggests that the dependence of10^3 lnaFo-diopsideon temperature can be used as a thermometer,similar to the one based on the 103lna of 44 Ca/40 Ca between orthopyroxene and diopside.These two Ca isotope thermometers both have a precision approximate to that of elemental thermometers and provide independent constraints on temperature.
基金supported by the National Natural Sci-ence Foundation of China(22072076 and 21773142)Taishan Schol-arship in Shandong Province(No.tsqn20161001)+1 种基金Fundamental Re-search Funds of Shandong University,Shandong Provincial Natural Sci-ence Foundation(ZR2020QE005)Young Doctor Cooperation Fund Project of Qilu University of Technology(Shandong Academy of Sci-ences)(2019BSHZ0018).
文摘Gold nanoparticles(Au NPs)have demonstrated great potential in chemical and biological sensing,catalysis,biomedicine,X-ray computed tomography,and other applications,owing to their unique properties.Au NPs with high-index facets have attracted more attention in the past decade owing to their superior electrocatalytic activity in fuel cells and enhanced performance in surface-enhanced Raman spectroscopy(SERS)applications.This review presents an overview of our achievements in the direct synthesis of Au NPs with controlled shapes in water using cationic surfactants.By deliberately adjusting the nature of the surfactant stabilizers,preformed Au NPs with simple shapes can be readily transformed into Au NPs with complicated shapes with controlled high-index facets by simple seeded growth.The high-index facets of the as-prepared Au NPs can be consistently correlated with their superior performance in the electrooxidation of methanol and ethanol and their enhanced SERS activity.
基金This work was supported by the Chinese National Natural Science Foundation(31400769,31870903,31870868,and 31670930)Jiangsu Province Natural Science Foundation(BK20140371)+1 种基金Jiangsu Postdoctoral Science Foundation(1402176C)Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Viral myocarditis(VMC)is a cardiac disease associated with myocardial inflammation and injury induced by virus infection.Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium.Kruppel-like factor 10(KLF10)is a crucial regulator of various pathological processes and plays different roles in a variety of diseases.However,its role in VMC induced by coxsackievirus B3(CVB3)infection remains unknown.In this study,we report that cardiac KLF10 confers enhanced protection against viral myocarditis.We found that KLF10 expression was downregulated upon CVB3 infection.KLF10 deficiency enhanced cardiac viral replication and aggravated VMC progress.Bone marrow chimera experiments indicated that KLF10 expression in nonhematopoietic cells was involved in the pathogenesis of VMC.We further identified MCP-1 as a novel target of KLF10 in cardiomyocytes,and KLF10 cooperated with histone deacetylase 1(HDAC1)to negatively regulate MCP-1 expression by binding its promoter,leading to activation of MCP-1 transcription and recruitment of Ly6C^(high) monocytes/macrophages into the myocardium.This novel mechanism of MCP-1 regulation by KLF10 might provide new insights into the pathogenesis of VMC and a potential therapeutic target for VMC.
基金supported and funded by NSFC Grant Nos.61532002,61272199,61070128 and 61473013National High-tech R&D Program of China(863 Program)under Grant No.2015AA016404+1 种基金Specialized Research Fund for Doctoral Program of Higher Education under Grant No.20130076110008Open Funding Project of State Key Laboratory of Virtual Reality Technology and Systems of Beihang University under Grant no.BUAA-VR-15KF-14。
文摘To resimulate a customized fluid derived product by analyzing an existing fluid is significant and difficult.This paper proposes a driven model recovery method,which is challenging in fluid resimulation customization.First,fluid physical properties are calculated under the constraints of appearance and dynamic behavior of the example water.Second,a hybrid particle lattice Boltzmann method for shallow water(LBMSW)is recovered from the dynamic geometry on fluid surface.As it is found that the resimulation details fade gradually with LBMSW auto-advection,a physically-based enhancement scheme is presented.A nonlinear algorithm is introduced to stretch the faded density to retain resimulation details.Experiments show that the proposed approach can obtain more realistic resimulation products in several challenging scenarios.
