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针刺对脑梗死大鼠缺血脑组织血管新生相关因子表达的影响 被引量:2
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作者 孙雅洁 李晶 +2 位作者 Rainer Georgi Bernhard Kolberg 杨丽红 《Acupuncture and Herbal Medicine》 2023年第1期46-54,共9页
目的:动态研究脑梗死后血管新生相关因子的变化规律和针刺干预效应,从促进血管新生角度深入揭示针刺治疗脑梗死的分子机制。方法:以MCAO模型大鼠为研究对象,分为针刺组、模型组和空白组。观察脑梗死后神经功能缺损程度改变,同时采用免... 目的:动态研究脑梗死后血管新生相关因子的变化规律和针刺干预效应,从促进血管新生角度深入揭示针刺治疗脑梗死的分子机制。方法:以MCAO模型大鼠为研究对象,分为针刺组、模型组和空白组。观察脑梗死后神经功能缺损程度改变,同时采用免疫荧光双标记法观察缺血中心及边缘区的血管新生情况,应用RT-PCR和Western blot法检测脑梗死后缺穴区域血管新生相关因子Ang-1、Ang-2、PDGF-B和bFGF mRNA及蛋白变化规律和电针干预效应。结果:电针组各时相NSS评分均小于同时相模型组。MCAO后9h~7d时电针组血管内皮细胞增殖高于同时相模型组。电针组Ang-1、Ang-2 mRNA及蛋白表达水平明显高于模型组。电针组PDGF-B mRNA在3h~6h、3d~12d时明显高于模型组,蛋白水平在6h、3d~12d时明显高于模型组。针刺组bFGF mRNA在24h~12d、蛋白水平在3d~12d时明显高于模型组。结论:电针水沟穴能明显改善MCAO大鼠神经功能症状;能够促进MCAO模型大鼠梗死区周围血管内皮细胞增殖,并将血管内皮细胞增殖出现时间显著提前,其可能机制为电针水沟穴可上调血管新生相关因子的表达,并使表达时相前移,从而促进血管新生,对改善脑梗死的预后起到了明显的积极作用。 展开更多
关键词 人中穴 脑梗死 电针 血管新生
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Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy 被引量:9
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作者 yajie sun Xiangru Feng +3 位作者 Chao Wan Jonathan F.Lovell Honglin Jin Jianxun Ding 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第2期129-132,共4页
An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molec... An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molecular patterns(DAMPs),and pro-inflammatory cytokines,facilitates the presentation of TAAs and TSAs to adaptive immune cells,eliciting an emerging or reinstating a pre-existing anti-cancer immune response. 展开更多
关键词 IMMUNOTHERAPY CANCER DEATH
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Research on the Signal Reconstruction of the Phased Array Structural Health Monitoring Based Using the Basis Pursuit Algorithm 被引量:3
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作者 yajie sun Yanqing Yuan +3 位作者 Qi Wang Lihua Wang Enlu Li Li Qiao 《Computers, Materials & Continua》 SCIE EI 2019年第2期409-420,共12页
The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The metho... The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The method is derived from the compressive sensing theory and the signal is reconstructed by using the basis pursuit algorithm to process the ultrasonic phased array signals.According to the principles of the compressive sensing and signal processing method,non-sparse ultrasonic signals are converted to sparse signals by using sparse transform.The sparse coefficients are obtained by sparse decomposition of the original signal,and then the observation matrix is constructed according to the corresponding sparse coefficients.Finally,the original signal is reconstructed by using basis pursuit algorithm,and error analysis is carried on.Experimental research analysis shows that the signal reconstruction method can reduce the signal complexity and required the space efficiently. 展开更多
关键词 Basis pursuit algorithm compressive sensing phased array signal reconstruction
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Impact Force Magnitude and Location Recognition of Composite Materials 被引量:1
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作者 yajie sun Yanqing Yuan +3 位作者 Qi Wang Sai Ji Lihua Wang Shao’en Wu 《Computers, Materials & Continua》 SCIE EI 2020年第9期1647-1656,共10页
In order to identify the location and magnitude of the impact force accurately,determine the damage range of the structure and accelerate the health monitoring of key components of the composite,this paper studies the... In order to identify the location and magnitude of the impact force accurately,determine the damage range of the structure and accelerate the health monitoring of key components of the composite,this paper studies the location and magnitude of the impact force of composite plates by an inverse method.Firstly,a PZT sensor mounted on the material plate is used to collect the response signal generated by the impact force,which is from several impact locations,and establish transfer functions between the impact location and the PZT sensor.Secondly,this paper applies several forces to any location on the material plate,and collects the corresponding response signals,and reconstructs the impact force of several locations in turn.Finally,according to the reconstruction result of each location,the correct impact location is identified.Then,an improved regularization method is used to optimize the reconstructed impact force and accurate the magnitude of the impact force.The comparison experiments prove that the recognition error of this method is smaller. 展开更多
关键词 Impact force identification transfer function REGULARIZATION
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Impact Damage Identification for Composite Material Based on Transmissibility Function and OS-ELM Algorithm
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作者 yajie sun Yanqing Yuan +5 位作者 Qi Wang Sai Ji Lihua Wang Shaoen Wu Jie Chen Qin Zhang 《Journal of Quantum Computing》 2019年第1期1-8,共8页
A method is proposed based on the transmissibility function and the OnlineSequence Extreme Learning Machine (OS-ELM) algorithm, which is applied to theimpact damage of composite materials. First of all, the transmissi... A method is proposed based on the transmissibility function and the OnlineSequence Extreme Learning Machine (OS-ELM) algorithm, which is applied to theimpact damage of composite materials. First of all, the transmissibility functions of theundamaged signals and the damage signals at different points are calculated. Secondly,the difference between them is taken as the damage index. Finally, principal componentanalysis (PCA) is used to reduce the noise feature. And then, input to the online sequencelimit learning neural network classification to identify damage and confirm the damagelocation. Taking the amplitude of the transmissibility function instead of the accelerationresponse as the signal analysis for structural damage identification cannot be influencedby the excitation amplitude. The OS-ELM algorithm is based on the ELM (ExtremeLearning Machine) algorithm, in-creased training speed also increases the recognitionaccuracy. Experiment in the epoxy board shows that the method can effectively identifythe structural damage accurately. 展开更多
关键词 Impact damage transmissibility function OS-ELM
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Bifurcations,chaos analysis and control in a discrete predator-prey model with mixed functional responses
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作者 yajie sun Ming Zhao Yunfei Du 《International Journal of Biomathematics》 SCIE 2024年第3期185-210,共26页
Many discrete systems have more distinctive dynamical behaviors compared to continuous ones,which has led lots of researchers to investigate them.The discrete predatorprey model with two different functional responses... Many discrete systems have more distinctive dynamical behaviors compared to continuous ones,which has led lots of researchers to investigate them.The discrete predatorprey model with two different functional responses(Holling type I and II functional responses)is discussed in this paper,which depicts a complex population relationship.The local dynamical behaviors of the interior fixed point of this system are studied.The detailed analysis reveals this system undergoes flip bifurcation and Neimark-Sacker bifurcation.Especially,we prove the existence of Marotto's chaos by analytical method.In addition,the hybrid control method is applied to control the chaos of this system.Numerical simulations are presented to support our research and demonstrate new dynamical behaviors,such as period-10,19,29,39,48 orbits and chaos in the sense of Li-Yorke. 展开更多
关键词 Predator-prey model flip bifurcation Neimark-Sacker bifurcation Marotto's chaos chaos control
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