Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline d...Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline development. In most existing studies, remote sensing images are used to quantify the morphological characteristics of lakes. However, the extraction accuracy of lake water is greatly affected by cloud cover and vegetation cover, and the inversion accuracy of lake elevation data is poor, which cannot accurately describe the response relationship of lake landscape morphology with water level change. Therefore, this paper takes Tonle Sap Lake as the research object, which is the largest natural freshwater lake in Southeast Asia. DEM is constructed based on high-resolution measured topographic data, and morphological indicators such as lake area, lake shoreline length, perimeter area ratio, longest axis length, maximum width, shoreline development index, lake shape complexity, compactness ratio and form ratio are adopted to researching the evolution law of high water overflows and low water outbursts quantitatively, and clarifying the variation characteristics of landscape morphology with water level gradient in Tonle Sap Lake. The research results have important theoretical significance for the scientific utilization of Tonle Sap Lake water resources and the protection of the lake ecosystem.展开更多
Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However...Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.展开更多
The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time perfor...The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time performance.However,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with time.This paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual feet.Aiming at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent noise.Aiming at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding windows.Aiming at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude error.We conduct extensive and well-designed experiments to evaluate the performance of the proposed method.The experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance.展开更多
Recent experimental findings have demonstrated the occurrence of superconductivity in Bernal bilayer graphene when induced by a magnetic field.In this study,we conduct a theoretical investigation of the potential pair...Recent experimental findings have demonstrated the occurrence of superconductivity in Bernal bilayer graphene when induced by a magnetic field.In this study,we conduct a theoretical investigation of the potential pairing symmetry within this superconducting system.By developing a theoretical model,we primarily calculate the free energy of the system with p+ip-wave parallel spin pairing,p+ip-wave anti-parallel spin pairing and d+i d-wave pairing symmetry.Our results confirm that the magnetic field is indeed essential for generating the superconductivity.We discover that the p+ip-wave parallel spin pairing leads to a lower free energy for the system.The numerical calculations of the energy band structure,zero-energy spectral function and density of states for each of the three pairing symmetries under consideration show a strong consistency with the free energy results.展开更多
Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge proce...Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.展开更多
BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accu...BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and mortality.Soluble triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory processes.AIM To explore the prognostic value of sTREM-1 in patients with AD of cirrhosis.METHODS A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at admission.All enrolled patients were followed-up for at least 1 year.RESULTS In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD scores.Additionally,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d follow-up.The ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF development.CONCLUSION Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.展开更多
With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(...With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(IDS).However,both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features,resulting in an analysis that is not an optimal set.Therefore,in order to extract more representative traffic features as well as to improve the accuracy of traffic identification,this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T^(2) and a multilayer convolutional bidirectional long short-term memory(MSC_BiLSTM)classifier model for network traffic intrusion detection.This method reduces the parameters and redundancy of the model by feature extraction and extracts the dependent features between the data by a bidirectional long short-term memory(BiLSTM)network,which fully considers the influence between the before and after features.The network traffic is first characteristically downscaled by principal component analysis(PCA),and then the downscaled principal components are used as input to Hotelling’s T^(2) to compare the differences between groups.For datasets with outliers,Hotelling’s T^(2) can help identify the groups where the outliers are located and quantitatively measure the extent of the outliers.Finally,a multilayer convolutional neural network and a BiLSTM network are used to extract the spatial and temporal features of network traffic data.The empirical consequences exhibit that the suggested approach in this manuscript attains superior outcomes in precision,recall and F1-score juxtaposed with the prevailing techniques.The results show that the intrusion detection accuracy,precision,and F1-score of the proposed MSC_BiLSTM model for the CIC-IDS 2017 dataset are 98.71%,95.97%,and 90.22%.展开更多
Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluse...Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.展开更多
Herein,we designed and constructed a mesoporous LaAlOx via a solvent evaporation induced self-assembly protocol.The structure and physicochemical property of the corresponding NiMo supported catalyst was analyzed by a...Herein,we designed and constructed a mesoporous LaAlOx via a solvent evaporation induced self-assembly protocol.The structure and physicochemical property of the corresponding NiMo supported catalyst was analyzed by a set of characterizations,and its catalytic activity was investigated for hydrodesulfurization(HDS)of 4,6-dimethyldibenzothiophene.It has confirmed that the incorporation of La profoundly facilitate the generation of“Type II”NiMoS phase by weakening the interaction of Mo–O–Al leakage and promoting the sulfidation of both Ni and Mo oxides as well as changing the morphology of Ni promoted MoS2 slabs,thereafter boosting the HDS performance substantially.The finding here may contribute to the fundamental understanding of structure-activity in ultra-deep desulfurization and inspire the advancement of highly-efficient HDS catalyst in future.展开更多
Carrying out green energy transformation,implementing clean energy power replacement and supply,and developing a new power system are some primary driving forces needed to fulfill China’s carbon-peak and carbon-neutr...Carrying out green energy transformation,implementing clean energy power replacement and supply,and developing a new power system are some primary driving forces needed to fulfill China’s carbon-peak and carbon-neutral strategic goals.The construction of new power systems in China’s provinces and cities is developing rapidly,and the lack of a typical model promotes the application.The new power system path design should be based on the actual development of the power grid in different regions,energy use characteristics,and other actual needs to carry out the differentiated path design.In this context,this study analyzes the characteristics of the new domestic power system based on the policy background of the new domestic power system,constructs a new model for power system development stage identification,and proposes the overall design of the new power system development path from the power supply,transmission and distribution,and load sides.It also uses the Hebei South Network as an example to explore the development stage of the Hebei South Grid based on actual development needs.Finally,this study designs a novel power system development path for the entire supply and demand chain for the Hebei South Grid to propose ideas for constructing a new power system in China and to help green energy transformation.展开更多
As a general problem in the field of batteries,materials produced on a large industrial scale usually possess unsatisfactory electrochemical performances.Among them,manganese-based aqueous rechargeable zinc-ion batter...As a general problem in the field of batteries,materials produced on a large industrial scale usually possess unsatisfactory electrochemical performances.Among them,manganese-based aqueous rechargeable zinc-ion batteries(ARZBs)have been emerging as promising large-scale energy storage systems owing to their high energy densities,low manufacturing cost and intrinsic high safety.However,the direct application of industrial-scale Mn2O3(MO)cathode exhibits poor electrochemical performance especially at high current rates.Herein,a highly reversible Mn-based cathode is developed from the industrial-scale MO by nitridation and following electrochemical oxidation,which triples the ion diffusion rate and greatly promotes the charge transfer.Notably,the cathode delivers a capacity of 161 m Ah g^(-1) at a high current density of 10 A g^(-1),nearly-three times the capacity of pristine MO(60 m Ah g^(-1)).Impressive specific capacity(243.4 m Ah g^(-1))is obtained without Mn^(2+) additive added in the electrolyte,much superior to the pristine MO(124.5 m Ah g^(-1)),suggesting its enhanced reaction kinetics and structural stability.In addition,it possesses an outstanding energy output of 368.4 Wh kg^(-1) at 387.8 W kg^(-1),which exceeds many of reported cathodes in ARZBs,providing new opportunities for the large-scale application of highperformance and low-cost ARZBs.展开更多
AIM:To determine whether the microRNA-27b-3p(miR-27b-3p)/NF-E2-related factor 2(Nrf2)pathway plays a role in human retinal pigment epithelial(hRPE)cell response to high glucose,how miR-27b-3p and Nrf2 expression are r...AIM:To determine whether the microRNA-27b-3p(miR-27b-3p)/NF-E2-related factor 2(Nrf2)pathway plays a role in human retinal pigment epithelial(hRPE)cell response to high glucose,how miR-27b-3p and Nrf2 expression are regulated,and whether this pathway could be specifically targeted.METHODS:hRPE cells were cultured in normal glucose or high glucose for 1,3,or 6d before measuring cellular proliferation rates using cell counting kit-8 and reactive oxygen species(ROS)levels using a dihydroethidium kit.miR-27b-3p,Nrf2,NAD(P)H quinone oxidoreductase 1(NQO1)and heme oxygenase-1(HO-1)mRNA and protein levels were analyzed using reverse transcription quantitative polymerase chain reaction(RT-qPCR)and immunocytofluorescence(ICF),respectively.Western blot analyses were performed to determine nuclear and total Nrf2 protein levels.Nrf2,NQO1,and HO-1 expression levels by RT-qPCR,ICF,or Western blot were further tested after miR-27b-3p overexpression or inhibitor lentiviral transfection.Finally,the expression level of those target genes was analyzed after treating hRPE cells with pyridoxamine.RESULTS:Persistent exposure to high glucose gradually suppressed hRPE Nrf2,NQO1,and HO-1 mRNA and protein levels and increased miR-27b-3p mRNA levels.High glucose also promoted ROS release and inhibited cellular proliferation.Nrf2,NQO1,and HO-1 mRNA levels decreased after miR-27b-3p overexpression and,conversely,both mRNA and protein levels increased after expressing a miR-27b-3p inhibitor.After treating hRPE cells exposed to high glucose with pyridoxamine,ROS levels tended to decreased,proliferation rate increased,Nrf2,NQO1,and HO-1 mRNA and protein levels were upregulated,and miR-27b-3p mRNA levels were suppressed.CONCLUSION:Nrf2 is a downstream target of miR-27b-3p.Furthermore,the miR-27b-3p inhibitor pyridoxamine can alleviate high glucose injury by regulating the miR-27b-3p/Nrf2 axis.展开更多
Magnesium alloys are the lightest structural alloys and have attracted substantial research attention in the past two decades. However, their mechanical properties, including ductility and strength, are limited after ...Magnesium alloys are the lightest structural alloys and have attracted substantial research attention in the past two decades. However, their mechanical properties, including ductility and strength, are limited after forming due to the formation of coarse grains and strong texture. This study proposes and proves a new cryogenic-hot forming process concept. Cryogenic deformation is imposed before the hot deformation. The effect of the cryogenic step has been compared with a conventional direct hot deformation process. The mechanical properties, microstructure,and texture of both the novel and conventional process routes have been compared. The cryogenic-hot deformed sample exhibits the highest ductility and fracture strength(ultimate tensile strength: 321 MPa, ductility: 21%) due to effective grain refinement and texture weakening by cryogenically formed twin-twin interaction induced recrystallisation. The proposed cryogenic-hot forming process can be a potential innovative manufacturing method for producing high-performance magnesium components.展开更多
Soil salinity greatly impairs plant growth and crop productivity.Rice(Oryza sativa L.)is a salt-sensitive crop.To better understand the molecular mechanisms of salt tolerance in roots,the BGISEQ-500 sequencing platfor...Soil salinity greatly impairs plant growth and crop productivity.Rice(Oryza sativa L.)is a salt-sensitive crop.To better understand the molecular mechanisms of salt tolerance in roots,the BGISEQ-500 sequencing platform was employed to elucidate transcriptome changes in rice roots after 0,3,24,and 72 h of salt stress.The results showed that root K+content decreased and Na+content increased rapidly after the initial stage of salt stress,but that fresh and dry weight in root did not significantly reduce.Compared to the control(no salt stress),1,292,453,and 486 differentially expressed genes(DEGs)were upregulated,respectively,and 939,894,and 646 DEGs were downregulated,respectively,after 3,24,and 72 h of salt treatment.The number of DEGs was higher during the early stage of salt stress(3 h)than in later stages(24 and 72 h).A number of DEGs involved in the response and adaptation to salt stress were related to protein kinase and calcium-binding,plant hormone signaling and metabolism,transcriptional regulation,metabolic pathways,antioxidant activity,and ion transport.Many of these DEGs were activated during the early stage of salt stress(3 h).The present study reports candidate salt-stressresponsive genes with the potential to genetically improve salt tolerance in rice elsewhere.展开更多
BACKGROUND Polypoid endometriosis(PEM)is a rare and unique type of endometriosis.To date,no article has provided a systematic report of this disease.The current article provides a complete report on rare PEM based on ...BACKGROUND Polypoid endometriosis(PEM)is a rare and unique type of endometriosis.To date,no article has provided a systematic report of this disease.The current article provides a complete report on rare PEM based on ultrasound,magnetic resonance imaging,intraoperative findings and postoperative pathology data.CASE SUMMARY A 38-year-old female patient was admitted to our hospital after complaining of“vague pain in the right lower quadrant with an aggravated menstrual period for 8 mo”.The patient underwent laparoscopic exploratory surgery on January 7,2022.The postoperative pathology revealed extensive PEM.CONCLUSION PEM is a type of endometriosis that is a benign disease but has biological properties similar to malignant tumours.展开更多
Background:Elderly people with depression require special care and attention.However,nostalgia is a complex emotional situation for a person who recalls the missing past.To improve mental health,quality of life,and at...Background:Elderly people with depression require special care and attention.However,nostalgia is a complex emotional situation for a person who recalls the missing past.To improve mental health,quality of life,and attitudes toward aging in institutional care,group nostalgia therapy can be a nursing intermediary for the elderly.This study aimed to analyze the effect of group nostalgia therapy on quality of life cognitive function in elderly patients with depression.Methods:A total of 89 participants were enrolled in this study,which was further categorized into a control(n=40)and a nostalgia therapy group(n=49).A standard questionnaire was used to compare the QoL,MMSE and GDS scores between the control and the nostalgia therapy groups.Results:Neither the nostalgia group nor the control group showed any statistical difference based on the patient characteristics,and both groups had a homogeneous distribution with p<0.05.However,in the intervention with nostalgia therapy,the therapy group showed improvements in almost all four domains of quality of life:physical health,psychological,environmental and social well-being.Moreover,the standard regression residual plot observed that both the post-test scores of MMSE and GDS showed favorable scores with respect to WHO-QoL.Conclusion:The study observed that group nostalgia therapy helps improve the quality of life and cognitive function in elderly patients with depression.The study also concludes that reducing depressive symptoms through nostalgia therapy could improve all four domains of the WHOQoL BREF.展开更多
文摘Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline development. In most existing studies, remote sensing images are used to quantify the morphological characteristics of lakes. However, the extraction accuracy of lake water is greatly affected by cloud cover and vegetation cover, and the inversion accuracy of lake elevation data is poor, which cannot accurately describe the response relationship of lake landscape morphology with water level change. Therefore, this paper takes Tonle Sap Lake as the research object, which is the largest natural freshwater lake in Southeast Asia. DEM is constructed based on high-resolution measured topographic data, and morphological indicators such as lake area, lake shoreline length, perimeter area ratio, longest axis length, maximum width, shoreline development index, lake shape complexity, compactness ratio and form ratio are adopted to researching the evolution law of high water overflows and low water outbursts quantitatively, and clarifying the variation characteristics of landscape morphology with water level gradient in Tonle Sap Lake. The research results have important theoretical significance for the scientific utilization of Tonle Sap Lake water resources and the protection of the lake ecosystem.
基金financially supported by the National Natural Science Foundation of China,No.81303115,81774042 (both to XC)the Pearl River S&T Nova Program of Guangzhou,No.201806010025 (to XC)+3 种基金the Specialty Program of Guangdong Province Hospital of Chinese Medicine of China,No.YN2018ZD07 (to XC)the Natural Science Foundatior of Guangdong Province of China,No.2023A1515012174 (to JL)the Science and Technology Program of Guangzhou of China,No.20210201 0268 (to XC),20210201 0339 (to JS)Guangdong Provincial Key Laboratory of Research on Emergency in TCM,Nos.2018-75,2019-140 (to JS)
文摘Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.
基金supported in part by National Key Research and Development Program under Grant No.2020YFB1708800China Postdoctoral Science Foundation under Grant No.2021M700385+5 种基金Guang Dong Basic and Applied Basic Research Foundation under Grant No.2021A1515110577Guangdong Key Research and Development Program under Grant No.2020B0101130007Central Guidance on Local Science and Technology Development Fund of Shanxi Province under Grant No.YDZJSX2022B019Fundamental Research Funds for Central Universities under Grant No.FRF-MP-20-37Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)under Grant No.FRF-IDRY-21-005National Natural Science Foundation of China under Grant No.62002026。
文摘The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time performance.However,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with time.This paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual feet.Aiming at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent noise.Aiming at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding windows.Aiming at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude error.We conduct extensive and well-designed experiments to evaluate the performance of the proposed method.The experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance.
基金Project supported by the National Natural Science Foundation of China (Grant No.12074130)the Natural Science Foundation of Guangdong Province (Grant No.2021A1515012340)。
文摘Recent experimental findings have demonstrated the occurrence of superconductivity in Bernal bilayer graphene when induced by a magnetic field.In this study,we conduct a theoretical investigation of the potential pairing symmetry within this superconducting system.By developing a theoretical model,we primarily calculate the free energy of the system with p+ip-wave parallel spin pairing,p+ip-wave anti-parallel spin pairing and d+i d-wave pairing symmetry.Our results confirm that the magnetic field is indeed essential for generating the superconductivity.We discover that the p+ip-wave parallel spin pairing leads to a lower free energy for the system.The numerical calculations of the energy band structure,zero-energy spectral function and density of states for each of the three pairing symmetries under consideration show a strong consistency with the free energy results.
基金supported by the National Natural Science Foundation of China(Nos.82170426 and 22078193)Double Thousand Plan of Jiangxi Province(Nos.461654,jxsq2019102052).
文摘Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.
基金National Natural Science Foundation of China,No.81970550,No.82070613 and No.82370638Natural Science Foundation of Hunan Province,China,No.2021JJ31067 and No.2021JJ41048+1 种基金Hunan innovative province construction project,No.2023JJ10095Innovative Talented Project of Hunan province,China,No.2022RC1212.
文摘BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and mortality.Soluble triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory processes.AIM To explore the prognostic value of sTREM-1 in patients with AD of cirrhosis.METHODS A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at admission.All enrolled patients were followed-up for at least 1 year.RESULTS In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD scores.Additionally,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d follow-up.The ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF development.CONCLUSION Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.
基金supported by Tianshan Talent Training Project-Xinjiang Science and Technology Innovation Team Program(2023TSYCTD).
文摘With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(IDS).However,both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features,resulting in an analysis that is not an optimal set.Therefore,in order to extract more representative traffic features as well as to improve the accuracy of traffic identification,this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T^(2) and a multilayer convolutional bidirectional long short-term memory(MSC_BiLSTM)classifier model for network traffic intrusion detection.This method reduces the parameters and redundancy of the model by feature extraction and extracts the dependent features between the data by a bidirectional long short-term memory(BiLSTM)network,which fully considers the influence between the before and after features.The network traffic is first characteristically downscaled by principal component analysis(PCA),and then the downscaled principal components are used as input to Hotelling’s T^(2) to compare the differences between groups.For datasets with outliers,Hotelling’s T^(2) can help identify the groups where the outliers are located and quantitatively measure the extent of the outliers.Finally,a multilayer convolutional neural network and a BiLSTM network are used to extract the spatial and temporal features of network traffic data.The empirical consequences exhibit that the suggested approach in this manuscript attains superior outcomes in precision,recall and F1-score juxtaposed with the prevailing techniques.The results show that the intrusion detection accuracy,precision,and F1-score of the proposed MSC_BiLSTM model for the CIC-IDS 2017 dataset are 98.71%,95.97%,and 90.22%.
基金This work was supported by the National Key R&D Program of China(Project No.2019YFA0111900 to C.J.L.and Y.J.,2022YFC3601900 to G.H.L.,2022YFC3601903 to X.H.L.,and 2022YFC3601905)the National Natural Science Foundation of China(Grant Nos.82261160397,82272560,81922017 to C.J.L.and 81930022,91749105 to X.H.L.)+3 种基金the NSFC/RGC Joint Research Scheme,the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(NSFC/RGC Project No.N_CUHK483/22 to Y.J.)the Hunan Provincial Science and Technology Department(2023JJ30896 to C.J.L.)the Key Research and Development Program of Hunan Province(2022SK2023 to C.J.L.)the Science and Technology Innovation Program of Hunan Province(2023RC1027 to C.J.L.,2022RC1009 to J.W,and 2022RC3075 to C.Z.).
文摘Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.
基金financial support of the National Natural Science Foundation of China(22002050,22178154)the Project of Jiangsu University Senior Talents Foundation(20JDG35)+1 种基金Postdoctoral Science Foundation of China(2022T150765,2020M683154)National Engineering Laboratory for Mobile Source Emission Control Technology(NELMS2020B01).
文摘Herein,we designed and constructed a mesoporous LaAlOx via a solvent evaporation induced self-assembly protocol.The structure and physicochemical property of the corresponding NiMo supported catalyst was analyzed by a set of characterizations,and its catalytic activity was investigated for hydrodesulfurization(HDS)of 4,6-dimethyldibenzothiophene.It has confirmed that the incorporation of La profoundly facilitate the generation of“Type II”NiMoS phase by weakening the interaction of Mo–O–Al leakage and promoting the sulfidation of both Ni and Mo oxides as well as changing the morphology of Ni promoted MoS2 slabs,thereafter boosting the HDS performance substantially.The finding here may contribute to the fundamental understanding of structure-activity in ultra-deep desulfurization and inspire the advancement of highly-efficient HDS catalyst in future.
基金funded by the State Grid Hebei Electric Power Co.,Ltd projectthe National Natural Science Foundation of China’s major project,“Research on the Construction of China’s Economic Transformation Mode for Carbon Neutrality(72140001)This study is titled“Research on Novel Power System Development Path”。
文摘Carrying out green energy transformation,implementing clean energy power replacement and supply,and developing a new power system are some primary driving forces needed to fulfill China’s carbon-peak and carbon-neutral strategic goals.The construction of new power systems in China’s provinces and cities is developing rapidly,and the lack of a typical model promotes the application.The new power system path design should be based on the actual development of the power grid in different regions,energy use characteristics,and other actual needs to carry out the differentiated path design.In this context,this study analyzes the characteristics of the new domestic power system based on the policy background of the new domestic power system,constructs a new model for power system development stage identification,and proposes the overall design of the new power system development path from the power supply,transmission and distribution,and load sides.It also uses the Hebei South Network as an example to explore the development stage of the Hebei South Grid based on actual development needs.Finally,this study designs a novel power system development path for the entire supply and demand chain for the Hebei South Grid to propose ideas for constructing a new power system in China and to help green energy transformation.
基金supports from the National Natural Science Foundation of China(No.21805063)the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars(No.2018B030306022)+2 种基金the Project of International Science and Technology Cooperation in Guangdong Province(No.2020A0505100016)the Shenzhen Sauvage Nobel Laureate Laboratory for Smart Materialsthe Shenzhen Science and Technology Program(Nos.KQTD20200820113045083,ZDSYS20190902093220279)。
文摘As a general problem in the field of batteries,materials produced on a large industrial scale usually possess unsatisfactory electrochemical performances.Among them,manganese-based aqueous rechargeable zinc-ion batteries(ARZBs)have been emerging as promising large-scale energy storage systems owing to their high energy densities,low manufacturing cost and intrinsic high safety.However,the direct application of industrial-scale Mn2O3(MO)cathode exhibits poor electrochemical performance especially at high current rates.Herein,a highly reversible Mn-based cathode is developed from the industrial-scale MO by nitridation and following electrochemical oxidation,which triples the ion diffusion rate and greatly promotes the charge transfer.Notably,the cathode delivers a capacity of 161 m Ah g^(-1) at a high current density of 10 A g^(-1),nearly-three times the capacity of pristine MO(60 m Ah g^(-1)).Impressive specific capacity(243.4 m Ah g^(-1))is obtained without Mn^(2+) additive added in the electrolyte,much superior to the pristine MO(124.5 m Ah g^(-1)),suggesting its enhanced reaction kinetics and structural stability.In addition,it possesses an outstanding energy output of 368.4 Wh kg^(-1) at 387.8 W kg^(-1),which exceeds many of reported cathodes in ARZBs,providing new opportunities for the large-scale application of highperformance and low-cost ARZBs.
基金Supported by National Natural Science Foundation of China(No.2020J01652)the Training Project for Young and Middleaged Core Talents in Health System of Fujian Province(No.2016-ZQN-62).
文摘AIM:To determine whether the microRNA-27b-3p(miR-27b-3p)/NF-E2-related factor 2(Nrf2)pathway plays a role in human retinal pigment epithelial(hRPE)cell response to high glucose,how miR-27b-3p and Nrf2 expression are regulated,and whether this pathway could be specifically targeted.METHODS:hRPE cells were cultured in normal glucose or high glucose for 1,3,or 6d before measuring cellular proliferation rates using cell counting kit-8 and reactive oxygen species(ROS)levels using a dihydroethidium kit.miR-27b-3p,Nrf2,NAD(P)H quinone oxidoreductase 1(NQO1)and heme oxygenase-1(HO-1)mRNA and protein levels were analyzed using reverse transcription quantitative polymerase chain reaction(RT-qPCR)and immunocytofluorescence(ICF),respectively.Western blot analyses were performed to determine nuclear and total Nrf2 protein levels.Nrf2,NQO1,and HO-1 expression levels by RT-qPCR,ICF,or Western blot were further tested after miR-27b-3p overexpression or inhibitor lentiviral transfection.Finally,the expression level of those target genes was analyzed after treating hRPE cells with pyridoxamine.RESULTS:Persistent exposure to high glucose gradually suppressed hRPE Nrf2,NQO1,and HO-1 mRNA and protein levels and increased miR-27b-3p mRNA levels.High glucose also promoted ROS release and inhibited cellular proliferation.Nrf2,NQO1,and HO-1 mRNA levels decreased after miR-27b-3p overexpression and,conversely,both mRNA and protein levels increased after expressing a miR-27b-3p inhibitor.After treating hRPE cells exposed to high glucose with pyridoxamine,ROS levels tended to decreased,proliferation rate increased,Nrf2,NQO1,and HO-1 mRNA and protein levels were upregulated,and miR-27b-3p mRNA levels were suppressed.CONCLUSION:Nrf2 is a downstream target of miR-27b-3p.Furthermore,the miR-27b-3p inhibitor pyridoxamine can alleviate high glucose injury by regulating the miR-27b-3p/Nrf2 axis.
基金the financial support from the President’s PhD Scholarship of Imperial College Londonthe funding support by EPSRC under the Grant Agreement EP/R001715/1 on “Light Form: Embedding Materials Engineering in Manufacturing with Light Alloys”。
文摘Magnesium alloys are the lightest structural alloys and have attracted substantial research attention in the past two decades. However, their mechanical properties, including ductility and strength, are limited after forming due to the formation of coarse grains and strong texture. This study proposes and proves a new cryogenic-hot forming process concept. Cryogenic deformation is imposed before the hot deformation. The effect of the cryogenic step has been compared with a conventional direct hot deformation process. The mechanical properties, microstructure,and texture of both the novel and conventional process routes have been compared. The cryogenic-hot deformed sample exhibits the highest ductility and fracture strength(ultimate tensile strength: 321 MPa, ductility: 21%) due to effective grain refinement and texture weakening by cryogenically formed twin-twin interaction induced recrystallisation. The proposed cryogenic-hot forming process can be a potential innovative manufacturing method for producing high-performance magnesium components.
基金funded by the National Natural Science Foundation of China(Grant No.32101678)Henan Key Scientific Research Project(Grant Nos.22A210009,22B210010)+1 种基金Xinyang Agriculture and Forestry University Youth Fund Project(Grant No.QN2021021)Xinyang Agriculture and Forestry University High-Level Research Incubator Construction Project(Grant No.FCL202011).
文摘Soil salinity greatly impairs plant growth and crop productivity.Rice(Oryza sativa L.)is a salt-sensitive crop.To better understand the molecular mechanisms of salt tolerance in roots,the BGISEQ-500 sequencing platform was employed to elucidate transcriptome changes in rice roots after 0,3,24,and 72 h of salt stress.The results showed that root K+content decreased and Na+content increased rapidly after the initial stage of salt stress,but that fresh and dry weight in root did not significantly reduce.Compared to the control(no salt stress),1,292,453,and 486 differentially expressed genes(DEGs)were upregulated,respectively,and 939,894,and 646 DEGs were downregulated,respectively,after 3,24,and 72 h of salt treatment.The number of DEGs was higher during the early stage of salt stress(3 h)than in later stages(24 and 72 h).A number of DEGs involved in the response and adaptation to salt stress were related to protein kinase and calcium-binding,plant hormone signaling and metabolism,transcriptional regulation,metabolic pathways,antioxidant activity,and ion transport.Many of these DEGs were activated during the early stage of salt stress(3 h).The present study reports candidate salt-stressresponsive genes with the potential to genetically improve salt tolerance in rice elsewhere.
文摘BACKGROUND Polypoid endometriosis(PEM)is a rare and unique type of endometriosis.To date,no article has provided a systematic report of this disease.The current article provides a complete report on rare PEM based on ultrasound,magnetic resonance imaging,intraoperative findings and postoperative pathology data.CASE SUMMARY A 38-year-old female patient was admitted to our hospital after complaining of“vague pain in the right lower quadrant with an aggravated menstrual period for 8 mo”.The patient underwent laparoscopic exploratory surgery on January 7,2022.The postoperative pathology revealed extensive PEM.CONCLUSION PEM is a type of endometriosis that is a benign disease but has biological properties similar to malignant tumours.
基金funded by Longyan Science and Technology Innovation Joint Fund Health Project(2021LYF17053).
文摘Background:Elderly people with depression require special care and attention.However,nostalgia is a complex emotional situation for a person who recalls the missing past.To improve mental health,quality of life,and attitudes toward aging in institutional care,group nostalgia therapy can be a nursing intermediary for the elderly.This study aimed to analyze the effect of group nostalgia therapy on quality of life cognitive function in elderly patients with depression.Methods:A total of 89 participants were enrolled in this study,which was further categorized into a control(n=40)and a nostalgia therapy group(n=49).A standard questionnaire was used to compare the QoL,MMSE and GDS scores between the control and the nostalgia therapy groups.Results:Neither the nostalgia group nor the control group showed any statistical difference based on the patient characteristics,and both groups had a homogeneous distribution with p<0.05.However,in the intervention with nostalgia therapy,the therapy group showed improvements in almost all four domains of quality of life:physical health,psychological,environmental and social well-being.Moreover,the standard regression residual plot observed that both the post-test scores of MMSE and GDS showed favorable scores with respect to WHO-QoL.Conclusion:The study observed that group nostalgia therapy helps improve the quality of life and cognitive function in elderly patients with depression.The study also concludes that reducing depressive symptoms through nostalgia therapy could improve all four domains of the WHOQoL BREF.
