NiMo-based nanostructures are among the most active hydrogen evolution reaction(HER)catalysts under an alkaline environment due to their strong water dissociation ability.However,these nanostructures are vulnerable to...NiMo-based nanostructures are among the most active hydrogen evolution reaction(HER)catalysts under an alkaline environment due to their strong water dissociation ability.However,these nanostructures are vulnerable to the destructive effects of H_(2) production,especially at industry-standard current densities.Therefore,developing a strategy to improve their mechanical strength while maintaining or even further increasing the activity of these nanocatalysts is of great interest to both the research and industrial communities.Here,a hierarchical interconnected NiMoN(HW-NiMoN-2h)with a nanorod-nanowire morphology was synthesized based on a rational combination of hydrothermal and water bath processes.HW-NiMoN-2h is found to exhibit excellent HER activity due to the accomodation of abundant active sites on its hierarchical morphology,in which nanowires con-nect free-standing nanorods,concurrently strengthening its structural stability to withstand H_(2) production at 1 A cm^(−2).Seawater is an attractive feedstock for water electrolysis since H_(2) generation and water desalination can be addressed simultaneously in a single process.The HER performance of HW-NiMoN-2h in alkaline seawater suggests that the presence of Na+ions interferes with the reation kinetics,thus lowering its activity slightly.However,benefiting from its hierarchical and interconnected characteristics,HW-NiMoN-2h is found to deliver outstanding HER activity of 1 A cm^(−2) at 130 mV overpotential and to exhibit excellent stability at 1 A cm^(−2) over 70 h in 1 M KOH seawater.展开更多
BACKGROUND Renal denervation(RDN)is a promising treatment based on catheter intervention for patients with refractory hypertension.However,the effect in patients with isolated systolic hypertension(ISH)remains controv...BACKGROUND Renal denervation(RDN)is a promising treatment based on catheter intervention for patients with refractory hypertension.However,the effect in patients with isolated systolic hypertension(ISH)remains controversial.The aim of this meta-analysis was to determine the blood pressure lowing effect of RDN in patients with ISH compared with combined systolic/diastolic hypertension(CH)patients.METHODS PubMed,Embase,Cochrane and ClinicalTrials.gov were searched for prospective clinical studies that included RDN.The outcomes of interest were the change of 24-hour ambulatory systolic blood pressure(SBP)from baseline.We used the fixed effects model to calculate weighted mean difference(WMD)with 95%confidence interval(CI).RESULTS Six trials were included,with 1405 participants,including 597 patients with ISH and 808 patients with CH.Mean follow-up was five months.The reduction of 24-hour ambulatory SBP was significantly greater for the CH patients than the ISH patients(WMD=3.89,95%CI:2.32–5.45,P<0.0001).RDN also showed a greater reduction in office SBP in the CH patients compared to the ISH patients(WMD=10.24,95%CI:4.24–15.74,P=0.0003).And the effect was independent of age,length of follow-up,and ablation device.CONCLUSIONS RDN provides superior blood pressure control in the CH patients compared with the ISH patients,and the CH patients may be the best suitable population for which RDN is indicated.展开更多
Ventricular arrhythmia(VA)is a life-threatening cardiac emergency.When VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness a...Ventricular arrhythmia(VA)is a life-threatening cardiac emergency.When VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness and recurrence.[1]For patients with implantable cardioverter defibrillator(ICD),the notion is redefined as no fewer than three appropriate and separate(at least 5 min for each interval)ICD interventions given within 24 h.展开更多
目的使用2019版Beers标准对新疆医科大学第一附属医院老年住院患者潜在不适当用药(PIM)发生率进行评价,确定PIM发生相关危险因素,为促进老年患者的合理用药提供参考。方法采用回顾性研究方法,收集该院2019年9-12月老年病科、高血压科、...目的使用2019版Beers标准对新疆医科大学第一附属医院老年住院患者潜在不适当用药(PIM)发生率进行评价,确定PIM发生相关危险因素,为促进老年患者的合理用药提供参考。方法采用回顾性研究方法,收集该院2019年9-12月老年病科、高血压科、冠心病科年龄≥65岁出院患者病历资料,使用2019版Beers标准评价PIM发生情况,使用Logistic回归分析确定PIM发生相关危险因素。结果纳入病例344例,其中女178例(占51.74%),男166例(占48.26%),年龄65~92岁[平均(72.85±5.93)岁],住院时间3~23 d [平均(7.05±2.85) d],疾病诊断种类数1~26种[平均(8.52±4.36)种],住院期间用药种类数1~39种[平均(8.71±4.60)种]。其中124例(36.05%)发生最少1种PIM,发生PIM较多的是非甾体抗炎药、苯二氮类药物以及保钾利尿药联合肾素-血管紧张素系统抑制剂。Logistic回归分析结果显示,高血压科、疾病诊断种类6~10种、用药种类6~10种患者更易于发生PIM。结论老年住院患者PIM发生率较高,临床药师需更加关注患有6种以上疾病或使用6种以上药物的老年患者,优化患者用药,减少PIM发生,促进老年患者合理用药。展开更多
基金Element Resources,LLC,and Shell through UHETI,funded part of this work
文摘NiMo-based nanostructures are among the most active hydrogen evolution reaction(HER)catalysts under an alkaline environment due to their strong water dissociation ability.However,these nanostructures are vulnerable to the destructive effects of H_(2) production,especially at industry-standard current densities.Therefore,developing a strategy to improve their mechanical strength while maintaining or even further increasing the activity of these nanocatalysts is of great interest to both the research and industrial communities.Here,a hierarchical interconnected NiMoN(HW-NiMoN-2h)with a nanorod-nanowire morphology was synthesized based on a rational combination of hydrothermal and water bath processes.HW-NiMoN-2h is found to exhibit excellent HER activity due to the accomodation of abundant active sites on its hierarchical morphology,in which nanowires con-nect free-standing nanorods,concurrently strengthening its structural stability to withstand H_(2) production at 1 A cm^(−2).Seawater is an attractive feedstock for water electrolysis since H_(2) generation and water desalination can be addressed simultaneously in a single process.The HER performance of HW-NiMoN-2h in alkaline seawater suggests that the presence of Na+ions interferes with the reation kinetics,thus lowering its activity slightly.However,benefiting from its hierarchical and interconnected characteristics,HW-NiMoN-2h is found to deliver outstanding HER activity of 1 A cm^(−2) at 130 mV overpotential and to exhibit excellent stability at 1 A cm^(−2) over 70 h in 1 M KOH seawater.
基金the National Natural Science Foundation of China(No.81970285).
文摘BACKGROUND Renal denervation(RDN)is a promising treatment based on catheter intervention for patients with refractory hypertension.However,the effect in patients with isolated systolic hypertension(ISH)remains controversial.The aim of this meta-analysis was to determine the blood pressure lowing effect of RDN in patients with ISH compared with combined systolic/diastolic hypertension(CH)patients.METHODS PubMed,Embase,Cochrane and ClinicalTrials.gov were searched for prospective clinical studies that included RDN.The outcomes of interest were the change of 24-hour ambulatory systolic blood pressure(SBP)from baseline.We used the fixed effects model to calculate weighted mean difference(WMD)with 95%confidence interval(CI).RESULTS Six trials were included,with 1405 participants,including 597 patients with ISH and 808 patients with CH.Mean follow-up was five months.The reduction of 24-hour ambulatory SBP was significantly greater for the CH patients than the ISH patients(WMD=3.89,95%CI:2.32–5.45,P<0.0001).RDN also showed a greater reduction in office SBP in the CH patients compared to the ISH patients(WMD=10.24,95%CI:4.24–15.74,P=0.0003).And the effect was independent of age,length of follow-up,and ablation device.CONCLUSIONS RDN provides superior blood pressure control in the CH patients compared with the ISH patients,and the CH patients may be the best suitable population for which RDN is indicated.
基金supported by a grant (Z191100006619019) from the Capital Municipal Science and Technology Commissiona grant (2022-GSP-QZ-4) from the Chinese Academy of Medical Sciences Fuwai Hospital Top-level Hospital Clinical Scientific Research Funds
文摘Ventricular arrhythmia(VA)is a life-threatening cardiac emergency.When VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness and recurrence.[1]For patients with implantable cardioverter defibrillator(ICD),the notion is redefined as no fewer than three appropriate and separate(at least 5 min for each interval)ICD interventions given within 24 h.
文摘目的使用2019版Beers标准对新疆医科大学第一附属医院老年住院患者潜在不适当用药(PIM)发生率进行评价,确定PIM发生相关危险因素,为促进老年患者的合理用药提供参考。方法采用回顾性研究方法,收集该院2019年9-12月老年病科、高血压科、冠心病科年龄≥65岁出院患者病历资料,使用2019版Beers标准评价PIM发生情况,使用Logistic回归分析确定PIM发生相关危险因素。结果纳入病例344例,其中女178例(占51.74%),男166例(占48.26%),年龄65~92岁[平均(72.85±5.93)岁],住院时间3~23 d [平均(7.05±2.85) d],疾病诊断种类数1~26种[平均(8.52±4.36)种],住院期间用药种类数1~39种[平均(8.71±4.60)种]。其中124例(36.05%)发生最少1种PIM,发生PIM较多的是非甾体抗炎药、苯二氮类药物以及保钾利尿药联合肾素-血管紧张素系统抑制剂。Logistic回归分析结果显示,高血压科、疾病诊断种类6~10种、用药种类6~10种患者更易于发生PIM。结论老年住院患者PIM发生率较高,临床药师需更加关注患有6种以上疾病或使用6种以上药物的老年患者,优化患者用药,减少PIM发生,促进老年患者合理用药。
