期刊文献+
共找到528篇文章
< 1 2 27 >
每页显示 20 50 100
湖南大学化学化工实验教学中心的建设与实践
1
作者 赵艳 罗伟平 +5 位作者 刘浩然 匡永清 吴朝阳 阳卫军 李永军 郭栋才 《大学化学》 CAS 2024年第7期147-152,共6页
本文以国家级实验教学示范中心阶段性评估为契机,全面总结了2018–2022年间化学国家级实验教学示范中心(湖南大学)在管理制度和安全责任体系建设、教学条件改善、实验教学体系构建、实验课程与教材建设、人才培养成效、教学团队建设和... 本文以国家级实验教学示范中心阶段性评估为契机,全面总结了2018–2022年间化学国家级实验教学示范中心(湖南大学)在管理制度和安全责任体系建设、教学条件改善、实验教学体系构建、实验课程与教材建设、人才培养成效、教学团队建设和引领示范作用等方面的建设经验,并从示范中心承载能力、实验教学体系优化和实验项目开发、实验数字化建设、教学队伍建设、发挥示范辐射作用等方面制定了下一阶段建设规划,以期更好地支撑我校化学、化工、应化国家一流本科专业的建设,促进化学化工高质量人才培养。 展开更多
关键词 化学 实验教学 示范中心 建设经验
下载PDF
个人信息保护的行政规制:实践检视及完善路径 被引量:1
2
作者 叶战备 闫钊 《中共山西省委党校学报》 2024年第2期82-86,共5页
行政规制在个人信息保护方面发挥着重要作用,有利于弥补民法规制与刑法规制对个人信息保护的不足,较大程度地防止相关主体对个人信息权益的侵害。然而,实践中个人信息保护的行政规制存在立法内容的涵盖性有待加强、监督制度的有效性有... 行政规制在个人信息保护方面发挥着重要作用,有利于弥补民法规制与刑法规制对个人信息保护的不足,较大程度地防止相关主体对个人信息权益的侵害。然而,实践中个人信息保护的行政规制存在立法内容的涵盖性有待加强、监督制度的有效性有待提高、处罚制度的严谨性有待强化、救济程序的规范性有待提升等方面的不足,应通过完善现行立法内容、优化行政监督体制、调适行政处罚机制、改进行政救济程序等路径对个人信息保护的行政规制予以完善。 展开更多
关键词 个人信息 个人信息保护 行政规制 信息数据
下载PDF
Transfer of the zp3a gene results in changes in egg adhesiveness and buoyancy in transgenic zebrafish
3
作者 Yu-Qing Cao Yong-Xin Wang +5 位作者 yan zhao Jia Zhang Xian He Ping Xie Jun Chen Yu-Hua Sun 《Zoological Research》 SCIE CAS CSCD 2023年第2期259-268,共10页
Reproductive strategies and spawning habits play key roles in the evolution of endemic East Asian cyprinids.However,the molecular mechanisms underlying the regulation of spawning habits are not well understood.We rece... Reproductive strategies and spawning habits play key roles in the evolution of endemic East Asian cyprinids.However,the molecular mechanisms underlying the regulation of spawning habits are not well understood.We recently identified zona pellucida(Zp) as the top differentially expressed protein between East Asian cyprinids that produce adhesive and semi-buoyant eggs,suggesting that Zp protein may play important roles in the regulation of egg type.In this work,we generated transgenic zebrafish in which oocyte-specific expression of zp genes from rare minnow(Gobiocypris rarus),an East Asian cyprinid laying adhesive eggs,was driven by a zebrafish zp3.2 gene promoter.We found that the transgenic eggs obtained partial adhesiveness and exhibited alteration in hydration and buoyancy.Abnormal metabolism of vitellogenin(VTG) may contribute to enhanced hydration and/or buoyancy.Our work shows that expression of the exogenous zp3a gene from an adhesiveegg producing fish is sufficient to induce changes in both egg adhesiveness and buoyancy in zebrafish,emphasizing the important role of zp genes in the regulation of spawning habits.Our results thus provide new insights into how endemic East Asian cyprinids may have adapted to the Yangtze river-lake system via changes in spawning habits. 展开更多
关键词 Zona pellucida protein ADHESIVE BUOYANCY HYDRATION Egg envelope
下载PDF
反思与重构:行政自动化决策场域中的算法解释权——以《个人信息保护法》第24条第3款为旨
4
作者 叶战备 张芷维 闫钊 《南京航空航天大学学报(社会科学版)》 2024年第4期50-59,共10页
在Web2.0时代,因自动化决策嵌入公权力所引发的算法权力异化的风险指数级上升。为了规制人工智能时代的自动化决策,《个人信息保护法》第24条第3款构建了中国语境下的算法解释权。然而,作为新兴权利的算法解释权具有高度的抽象性和不确... 在Web2.0时代,因自动化决策嵌入公权力所引发的算法权力异化的风险指数级上升。为了规制人工智能时代的自动化决策,《个人信息保护法》第24条第3款构建了中国语境下的算法解释权。然而,作为新兴权利的算法解释权具有高度的抽象性和不确定性,存在行权时间(事前解释与事后解释)和解释程度(一般解释与具体解释)层面的解释分歧以及权力限度的适用困境。因此,有必要在对算法解释权进行公私场景类型化划分的基础上,以权力结构的对称性为标准,引入比例原则对算法解释权在行政自动化决策场域下的适用进行教义学阐释。同时,以比例原则为主、法益均衡原则为辅来构建算法解释的方式选择模型。在此基础上,《个人信息保护法》第24条第3款设定的算法解释权在公法领域应为一种事后的、具体的解释,与私法领域事前的、一般的解释相区别。 展开更多
关键词 行政自动化决策 算法解释权 公法领域 事后解释 具体解释
下载PDF
功能性乳制品功能特性及潜在机制研究进展 被引量:1
5
作者 王娜 谢强 +5 位作者 陈小红 宋涛 徐旨润 严钊 杨光 赵敏 《食品与发酵工业》 CAS CSCD 北大核心 2024年第3期345-356,共12页
近年来,消费者对食品健康益处的认识不断提高,这极大程度地推动了功能性食品的发展。功能性乳制品是一类新兴的乳制品,在全球功能性食品市场中占据着重要地位。该文主要综述了功能性乳制品的分类、功能特性(调节肠道健康、提高认知能力... 近年来,消费者对食品健康益处的认识不断提高,这极大程度地推动了功能性食品的发展。功能性乳制品是一类新兴的乳制品,在全球功能性食品市场中占据着重要地位。该文主要综述了功能性乳制品的分类、功能特性(调节肠道健康、提高认知能力、改善肥胖、降低糖尿病和心血管疾病的发生率、维持骨骼及口腔健康等)及其发挥重要功效的潜在机制,以期为功能性乳制品的开发和行业发展提供参考和借鉴。 展开更多
关键词 功能性乳制品 来源 分类 功能特性 机制
下载PDF
发酵乳制品风味形成机制及优化控制研究进展
6
作者 王娜 夏秀华 +4 位作者 李晶 徐旨润 严钊 杨光 赵敏 《中国乳品工业》 CAS 北大核心 2024年第3期43-50,共8页
发酵乳制品营养丰富,深受广大消费者喜爱。风味是发酵乳制品最重要的感官属性之一,但乳制品在发酵过程中极易产生不良风味,影响发酵乳制品的风味品质,因此充分了解发酵乳制品中风味物质的转化过程及形成机制对优化风味有重要意义。基于... 发酵乳制品营养丰富,深受广大消费者喜爱。风味是发酵乳制品最重要的感官属性之一,但乳制品在发酵过程中极易产生不良风味,影响发酵乳制品的风味品质,因此充分了解发酵乳制品中风味物质的转化过程及形成机制对优化风味有重要意义。基于相关研究,综合论述了发酵乳制品风味形成途径的重要研究进展,阐述了风味优化控制的重要技术措施。通过对相关文献的梳理,指出发酵乳制品风味形成过程中碳水化合物代谢、脂肪分解、蛋白质水解等关键生化转化途径,以及通过靶向筛选和鉴定产香乳酸菌、优化加工条件、应用基因工程等优化风味的方法。未来可就乳酸菌的开发及在调控风味生成的潜在代谢机制等方面展开深入研究。 展开更多
关键词 发酵乳制品 风味 机制 优化 控制
下载PDF
Metagenomic analysis revealing the metabolic role of microbial communities in the free amino acid biosynthesis of Monascus rice vinegar during fermentation 被引量:1
7
作者 Hang Gao Jian Zhang +4 位作者 Li Liu Lijun Fu yan zhao Germán Mazza Xin Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期2317-2326,共10页
Free amino acid(FAA)is the important component of vinegar that infl uences quality perception and consumer acceptance.FAA is one of the major metabolites produced by microorganisms;however,the microbial metabolic netw... Free amino acid(FAA)is the important component of vinegar that infl uences quality perception and consumer acceptance.FAA is one of the major metabolites produced by microorganisms;however,the microbial metabolic network on FAA biosynthesis remains unclear.Through metagenomic analysis,this work aimed to elucidate the roles of microbes in FAA biosynthesis during Monascus rice vinegar fermentation.Taxonomic profiles from functional analyses showed 14 dominant genera with high contributions to the metabolism pathways.The metabolic network for FAA biosynthesis was then constructed,and the microbial distribution in different metabolic pathways was illuminated.The results revealed that 5 functional genera were closely involved in FAA biosynthesis.This study illuminated the metabolic roles of microorganisms in FAA biosynthesis and provided crucial insights into the functional attributes of microbiota in vinegar fermentation. 展开更多
关键词 Monascus rice vinegar Metagenomic analysis Free amino acid synthesis Metabolic pathway Microbial distribution
下载PDF
内蒙古某矿床不同铁矿石类型中稀土矿化特征
8
作者 严钊 郭宾 +6 位作者 孟文祥 苑星宇 洪国敏 贾瑞敏 侯新宇 田畸 杨进军 《现代矿业》 CAS 2024年第4期41-45,50,共6页
为明确内蒙古某矿床不同铁矿石类型与稀土矿化特征的关系,基于矿区内海量、系统的勘查工程所揭露的岩/矿石类型以及稀土、铁的基本分析数据,在已有的铁矿石分类基础上,进一步对铁和稀土资源进行分类。共划分出6种不同类型的铁-稀土矿石... 为明确内蒙古某矿床不同铁矿石类型与稀土矿化特征的关系,基于矿区内海量、系统的勘查工程所揭露的岩/矿石类型以及稀土、铁的基本分析数据,在已有的铁矿石分类基础上,进一步对铁和稀土资源进行分类。共划分出6种不同类型的铁-稀土矿石类型,并对各类型中稀土的成矿规模、强度及其在空间上的分布特征进行刻画。研究表明,不同类型的铁矿石中稀土成矿性和富集强度存在较大差异,稀土在浅部成矿富集规模大于深部;稀土与铁的矿化在空间产出上存在一定的相关性,但并非同体系流体成矿作用形成。 展开更多
关键词 矿石类型 铁-稀土矿石 矿化特征 成矿作用
下载PDF
Surface deterioration dependent on the crystal facets of spinel LiNi_(0.5)Mn_(1.5)O_(4) cathode active material
9
作者 Qian Li yan zhao +5 位作者 Jifu Zhu Wujiu Zhang Yi Liu Yaru Cui Chao Shen Keyu Xie 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第10期757-766,I0016,共11页
The spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode active materials(CAMs)are considered a promising alternative to commercially available cathodes such as layered and polyanion oxide cathodes,primarily due to their notab... The spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode active materials(CAMs)are considered a promising alternative to commercially available cathodes such as layered and polyanion oxide cathodes,primarily due to their notable safety and high energy density,particularly in their single-crystal type.Nevertheless,the industrial application of the LNMO CAMs is severely inhibited due to the interfacial deterioration and corrosion under proton-rich and high-voltage conditions.This study successfully designed and synthesized two typical types of crystal facets-exposed single-crystal LNMO CAMs.By tracking the electrochemical deterioration and chemical corrosion evolution,this study elucidates the surface degradation mechanisms and intrinsic instability of the LNMO,contingent upon their crystal facets.The(111)facet,due to its elevated surface energy,is found to be more susceptible to external attack compared to the(100)and(110)facets.Our study highlights the electrochemical corrosion stability of crystal plane engineering for spinel LNMO CAMs. 展开更多
关键词 LiNi_(0.5)Mn_(1.5)O_(4) Crystal facets Electrochemical degradation Chemical corrosion Surface energy
下载PDF
Genome-wide association study of grain micronutrient concentrations in bread wheat
10
作者 Yongchao Hao Fanmei Kong +8 位作者 Lili Wang Yu zhao Mengyao Li Naixiu Che Shuang Li Min Wang Ming Hao Xiaocun Zhang yan zhao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第5期1468-1480,共13页
Bread wheat(Triticum aestivum)is a staple food crop worldwide.The genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing... Bread wheat(Triticum aestivum)is a staple food crop worldwide.The genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing population.Here,45,298 single-nucleotide polymorphisms(SNPs)from 55K chip arrays were used to genotype a panel of 768 wheat cultivars,and a total of 154 quantitative trait loci(QTLs)were detected for eight traits under three environments by genome-wide association study(GWAS).Three QTLs(qMn-3B.1,qFe-3B.4,and qSe-3B.1/qFe-3B.6)detected repeatedly under different environments or traits were subjected to subsequent analyses based on linkage disequilibrium decay and the P-values of significant SNPs.Significant SNPs in the three QTL regions formed six haplotypes for qMn-3B.1,three haplotypes for qFe-3B.4,and three haplotypes for qSe-3B.1/qFe-3B.6.Phenotypic analysis revealed significant differences among haplotypes.These results indicated that the concentrations of several nutrient elements have been modified during the domestication of landraces to modern wheat.Based on the QTL regions,we identified 15 high-confidence genes,eight of which were stably expressed in different tissues and/or developmental stages.TraesCS3B02G046100 in qMn-3B.1 and TraesCS3B02G199500 in qSe-3B.1/qFe-3B.6 were both inferred to interact with metal ions according to the Gene Ontology(GO)analysis.TraesCS3B02G199000,which belongs to qSe-3B.1/qFe-3B.6,was determined to be a member of the WRKY gene family.Overall,this study provides several reliable QTLs that may significantly affect the concentrations of nutrient elements in wheat grain,and this information will facilitate the breeding of wheat cultivars with improved grain properties. 展开更多
关键词 bread wheat nutritional element GWAS DOMESTICATION HAPLOTYPE
下载PDF
长期探寻的Au_(23)(S-Adm)_(16)结构及未曾预期的掺杂效应
11
作者 冯磊 朱泽敏 +5 位作者 杨颖 何宗兵 邹家丰 李漫波 赵燕 伍志鲲 《物理化学学报》 SCIE CAS CSCD 北大核心 2024年第5期1-2,共2页
一锅同时获得单个金属原子掺杂的纳米团簇与母体团簇富有挑战性。这样的合成可排除微量杂质的影响,使得掺杂和未掺杂纳米团簇的性质对比更加合理可靠。在此,我们首次实现了这种合成,得到了长期追寻的纳米团簇Au_(23)(SAdm)_(16)和其单... 一锅同时获得单个金属原子掺杂的纳米团簇与母体团簇富有挑战性。这样的合成可排除微量杂质的影响,使得掺杂和未掺杂纳米团簇的性质对比更加合理可靠。在此,我们首次实现了这种合成,得到了长期追寻的纳米团簇Au_(23)(SAdm)_(16)和其单镉掺杂的Au_(22)Cd_1(S-Adm)_(16)纳米团簇,并通过单晶X射线晶体学解析了其结构。令人惊讶的是,与以前的报道结果相反,Au_(23)(S-Adm)_(16)比Au_(22)Cd_1(S-Adm)_(16)更稳定。另一方面,由于掺入镉原子后,内核Au―Au键长度增加,光激发电子转移阻力增加,导致Au_(22)Cd_1(S-Adm)_(16)吸收和发射强度明显下降。因而,不仅团簇的稳定性,而且团簇的吸收和发射强度也与内核Au―Au键的长度关联。这项工作表明了两种团簇结构上的微小差异就可导致光学、热稳定性等方面的显著区别,也为研究金属纳米团簇的构效关系提供了良好的借鉴。 展开更多
关键词 金属纳米团簇 合成 Au―Au键长 性质 构效关系
下载PDF
官员生态问责对河长制政策成效的影响及作用机制
12
作者 张振波 闫钊 金太军 《中国人口·资源与环境》 CSSCI CSCD 北大核心 2024年第8期70-79,共10页
根据环保权责在纵向政府之间的配置趋向,可划分为环保监管集权和环境治理分权两种实践模式;其各自呈现鲜明治理优势,却又分别存在难以规避的内在体制困境。河长制政策统一了自上而下的压力型体制和官僚控制、自下而上的治理责任明确与... 根据环保权责在纵向政府之间的配置趋向,可划分为环保监管集权和环境治理分权两种实践模式;其各自呈现鲜明治理优势,却又分别存在难以规避的内在体制困境。河长制政策统一了自上而下的压力型体制和官僚控制、自下而上的治理责任明确与治理任务分工,一方面在权能下放、责任划分、社会公开等治理过程中呈现出典型的分权化治理逻辑,另一方面又以治理权责分级分域、党政领导直接定责以及地方官员显性责任即时惩戒等集权化环保监管为条件。正是因为河长制政策兼具监管集权与治理分权两种机制优势,因此成为该研究解析环保集权-分权悖论的可行政策工具。该研究以7大流域中由地级市主要官员担任河长的河流为样本,基于多期双重差分模型,实证检验了官员生态问责纠正、补充区域环保政策的效应机制。研究发现:①河长制政策施行显著降低了河流污染物浓度,实现了流域环境的整体改善;②晋升激励能够对河长制政策成效产生显著影响,即相较于以经济增长为目标的官员激励,强化官员考核中的生态问责更能提升河长制这一分权化环境治理模式的治理效能;③生态问责对河长制治理成效的促进作用,在政府环保注意力配置更低、环境治理财政投入与监管能力相对不足的区域中更为明显,表明环保集权能够在一定程度上修正和纠补治理分权下的区域间政策落差与偏差,进而能够克服地方环保治理中的政绩偏好替代、生态政策执行低效、环境治理碎片化与“搭便车”等问题。该研究发现调和了环保监管集权与环境治理分权之间的理论冲突,指出两者环境治理实践中可以呈现为互为条件、相互支撑的补充关系。 展开更多
关键词 环保监管集权 环境治理分权 官员生态问责 区域环境政策 河长制政策
下载PDF
Enhancing personalized exercise recommendation with student and exercise portraits
13
作者 Wei-Wei Gao Hui-Fang Ma +2 位作者 yan zhao Jing Wang Quan-Hong Tian 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第2期91-109,共19页
The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions gen... The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely ignored.In this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list optimization.Technically,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)relationships.Then,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar portraits.Finally,we propose to optimize the recommendation list to obtain different exercise suggestions.After analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity. 展开更多
关键词 Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization Personalized learning
下载PDF
Tuning Structural and Electronic Configuration of FeN_(4) via External S for Enhanced Oxygen Reduction Reaction
14
作者 Shidong Li Lixue Xia +9 位作者 Jiantao Li Zhuo Chen Wei Zhang Jiexin Zhu Ruohan Yu Fang Liu Sungsik Lee yan zhao Liang Zhou Liqiang Mai 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期93-101,共9页
The Fe-N-C material represents an attractive oxygen reduction reaction electrocatalyst,and the FeN_(4)moiety has been identified as a very competitive catalytic active site.Fine tuning of the coordination structure of... The Fe-N-C material represents an attractive oxygen reduction reaction electrocatalyst,and the FeN_(4)moiety has been identified as a very competitive catalytic active site.Fine tuning of the coordination structure of FeN_(4)has an essential impact on the catalytic performance.Herein,we construct a sulfur-modified Fe-N-C catalyst with controllable local coordination environment,where the Fe is coordinated with four in-plane N and an axial external S.The external S atom affects not only the electron distribution but also the spin state of Fe in the FeN_(4)active site.The appearance of higher valence states and spin states for Fe demonstrates the increase in unpaired electrons.With the above characteristics,the adsorption and desorption of the reactants at FeN_(4)active sites are optimized,thus promoting the oxygen reduction reaction activity.This work explores the key point in electronic configuration and coordination environment tuning of FeN_(4)through S doping and provides new insight into the construction of M-N-C-based oxygen reduction reaction catalysts. 展开更多
关键词 coordination structure electronic configuration FeN_(4)moiety oxygen reduction reaction sulfur doping
下载PDF
ZmCER1,a putative ECERIFERUM 1 protein in maize,functions in cuticular wax biosynthesis and bulliform cell development
15
作者 yan zhao Qingzhi Liu +4 位作者 Xueran Wang Weixiao Zhang Wei Xu Yongzhong Zhang Baoshen Liu 《The Crop Journal》 SCIE CSCD 2024年第3期743-752,共10页
The cuticular wax,acting as the ultimate defense barrier,is essential for the normal morphogenesis of plant organs.Despite this importance,the connection between wax composition and leaf development has not been thoro... The cuticular wax,acting as the ultimate defense barrier,is essential for the normal morphogenesis of plant organs.Despite this importance,the connection between wax composition and leaf development has not been thoroughly explored.In this study,we characterized a new maize mutant,ragged leaf4(rgd4),which exhibits crinkled and ragged leaves starting from the sixth leaf stage.The phenotype of rgd4 is conferred by ZmCER1,which encoding an aldehyde decarbonylase involved in wax biosynthesis.ZmCER1 function deficient mutant displayed reduced cuticular wax density and disordered bulliform cells(BCs),while ZmCER1 overexpressing plants exhibited the opposite effects,indicating that ZmCER1 regulates cuticular wax biosynthesis and BCs development.Additionally,as the density of cuticular wax increased,the water loss rate of detached leaf decreases,suggesting that ZmCER1 is positively correlated with plant drought tolerance. 展开更多
关键词 Ragged leaf ZmCER1 Cuticular wax Bulliform cells
下载PDF
伊马替尼治疗胃肠道间质瘤耐药的相关分子机制研究进展
16
作者 赵燕 王昱昊 +1 位作者 王娟 杨建军 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第4期197-202,共6页
研究胃肠道间质瘤(gastrointestinal stromal tumor,GIST)伊马替尼耐药的机制,开发新的治疗靶点和治疗方案,对改善GIST患者的长期预后具有重要意义。本文从GIST的分子特征、伊马替尼耐药机制、非编码RNA、溶酶体、关键蛋白和成纤维细胞... 研究胃肠道间质瘤(gastrointestinal stromal tumor,GIST)伊马替尼耐药的机制,开发新的治疗靶点和治疗方案,对改善GIST患者的长期预后具有重要意义。本文从GIST的分子特征、伊马替尼耐药机制、非编码RNA、溶酶体、关键蛋白和成纤维细胞生长因子2(fibroblast growth factor-2,FGF-2)等方面对GIST伊马替尼耐药机制的研究进行了综述。研究表明,不同的耐药机制网络之间是相互联系的。伊马替尼治疗和联合抑制多种耐药机制有望成为GIST治疗的新选择。此外,基于耐药机制的识别实施个体化治疗将为伊马替尼耐药的GIST患者提供新的辅助治疗选择,从而延缓GIST的进展。 展开更多
关键词 胃肠道间质瘤 伊马替尼 耐药 分子机制
下载PDF
Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway
17
作者 Da Zhang Xiaoqing Zhang +2 位作者 Li yang yan zhao Xingang Hu 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第1期101-110,共10页
Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participant... Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood cells.Methods:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific emotions.Relative expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also determined.Results:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative emotions.Relative gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia groups.Regarding the emotional score of disgust on video stage,the main effect was significant(F=335.58,P<.001),which showed that watching the three videos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency groups.The symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional status.Our findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological problems and negative emotions,particularly disgust.We also demonstrate that emotional regulation is related to mir191-Riok3-Mxi1 pathway activity,identifying these pathway components are potential targets for genetic therapies in combination with psychological therapy. 展开更多
关键词 ANEMIA Blood deficiency Emotional regulation miR191-Riok3-Mxi1 pathway Emotion-inducing experiments
下载PDF
Measurement of 2p-3d absorption in a hot molybdenum plasma
18
作者 Gang Xiong Bo Qing +17 位作者 Zhiyu Zhang Longfei Jing yang zhao Minxi Wei Yimeng yang Lifei Hou Chengwu Huang Tuo Zhu Tianming Song Min Lv yan zhao Yuxue Zhang Guohong yang Zeqing Wu Jun yan Yaming Zou Jiyan Zhang Jiamin yang 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第4期68-79,共12页
We present measurements of the 2p-3d transition opacity of a hot molybdenum-scandium sample with nearly half-vacant molybdenum M-shell configurations.A plastic-tamped molybdenum-scandium foil sample is radiatively hea... We present measurements of the 2p-3d transition opacity of a hot molybdenum-scandium sample with nearly half-vacant molybdenum M-shell configurations.A plastic-tamped molybdenum-scandium foil sample is radiatively heated to high temperature in a compact D-shaped gold Hohlraum driven by∼30 kJ laser energy at the SG-100 kJ laser facility.X rays transmitted through the molybdenum and scandium plasmas are diffracted by crystals and finally recorded by image plates.The electron temperatures in the sample in particular spatial and temporal zones are determined by the K-shell absorption of the scandium plasma.A combination of the IRAD3D view factor code and the MULTI hydrodynamic code is used to simulate the spatial distribution and temporal behavior of the sample temperature and density.The inferred temperature in the molybdenum plasma reaches a average of 138±11 eV.A detailed configuration-accounting calculation of the n=2–3 transition absorption of the molybdenum plasma is compared with experimental measurements and quite good agreement is found.The present measurements provide an opportunity to test opacity models for complicated M-shell configurations. 展开更多
关键词 MOLYBDENUM ABSORPTION CONFIGURATION
下载PDF
Self-consistent and precise measurement of time-dependent radiative albedo of gold based on specially symmetrical triple-cavity Hohlraum
19
作者 Zhiyu Zhang yang zhao +19 位作者 Xiaoying Han Liling Li Bo Qing Lifei Hou Yulong Li YuXue Zhang Huan Zhang Xiangming Liu Bo Deng Gang Xiong Min Lv Tuo Zhu Chengwu Huang Tianming Song yan zhao Yingjie Li Lu Zhang Xufei Xie Jiyan Zhang Jiamin yang 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第3期57-64,共8页
A self-consistent and precise method to determine the time-dependent radiative albedo,i.e.,the ratio of the reemission flux to the incident flux,for an indirect-drive inertial confinement fusion Hohlraum wall material... A self-consistent and precise method to determine the time-dependent radiative albedo,i.e.,the ratio of the reemission flux to the incident flux,for an indirect-drive inertial confinement fusion Hohlraum wall material is proposed.A specially designed symmetrical triple-cavity gold Hohlraum is used to create approximately constant and near-equilibrium uniform radiation with a peak temperature of 160 eV.The incident flux at the secondary cavity waist is obtained from flux balance analysis and from the shock velocity of a standard sample.The results agree well owing to the symmetrical radiation in the secondary cavity.A self-consistent and precise time-dependent radiative albedo is deduced from the reliable reemission flux and the incident flux,and the result from the shock velocity is found to have a smaller uncertainty than that from the multi-angle flux balance analysis,and also to agree well with the result of a simulation using the HYADES opacity. 展开更多
关键词 PRECISE cavity RADIATIVE
下载PDF
上一页 1 2 27 下一页 到第
使用帮助 返回顶部