Background Coronary atherosclerosis and cognitive impairment are both age-related diseases,with similar risk factors.Coronary artery calcium(CAC),a marker of coronary atherosclerosis,may play a role in early detection...Background Coronary atherosclerosis and cognitive impairment are both age-related diseases,with similar risk factors.Coronary artery calcium(CAC),a marker of coronary atherosclerosis,may play a role in early detection of individuals prone to cognitive decline.This study aimed to investigate the relationship between CAC and cognitive function,and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based population.Methods A total of 1332 participants,aged 40-80 years and free of dementia from a community located in Beijing were included.All participants completed neurocognitive questionnaires and noncontrast CT examinations.Cognitive performance tests(including verbal memory,semantic fluency,executive function,and global cognitive function tests),the Cardiovascular Risk Factors,Aging,and Incidence of Dementia(CIDE)risk score,and the CAC score(CACS)were evaluated by questionnaires and CT.A CAIDE score≥10 was considered to indicate a high risk of dementia in late-life.Participants were divided into three groups according to CACS(0,1-399,≥400).Results After adjusting for risk factors,CACS was significantly associated with verbal memory(r=-0.083,P=0.003)and global cognitive function(r=-0.070,P=0.012).The prevalence of a high risk of dementia in the subgroups of CACS=0,1-399,and≥400 was 4.67%,13.66%,and 24.79%,respectively(P<0.001).Individuals with CACS≥400 had a higher risk of CAIDE score≥10[OR=2.30(1.56,4.56),P=0.014]than those with CACS=0.The receiver-operating characteristic curves showed that the capability of CACS to identify participants with a high risk of dementia was moderate(AUC=0.70,95%CI:0.67-0.72,P<0.001).Conclusions CAC,a marker of subclinical atherosclerosis,was significantly associated with cognitive performance in verbal memory and global cognitive function.CAC had a moderate capability to identify participants with a high risk of dementia,independent of age,education,and other risk factors.展开更多
We demonstrate a diode pumped Yb：LuVO4 laser that can be passively Q-switched by a Cr^（4＋）：YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generat...We demonstrate a diode pumped Yb：LuVO4 laser that can be passively Q-switched by a Cr^（4＋）：YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generated at a repetition rate of 285.7 kHz,approaching or very near the intrinsic upper limit imposed by the recovery time of the Cr^（4＋）：YAG saturable absorber,and the resulting pulse energy,duration and peak power are,respectively,8.2μJ,39.2ns and 0.209kW.展开更多
基金supported by the Ministry of Science and Technology of China(grant 2016YFC1300400)Chinese National Key Research and Development Project(grant 2016-I2M-1-011)。
文摘Background Coronary atherosclerosis and cognitive impairment are both age-related diseases,with similar risk factors.Coronary artery calcium(CAC),a marker of coronary atherosclerosis,may play a role in early detection of individuals prone to cognitive decline.This study aimed to investigate the relationship between CAC and cognitive function,and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based population.Methods A total of 1332 participants,aged 40-80 years and free of dementia from a community located in Beijing were included.All participants completed neurocognitive questionnaires and noncontrast CT examinations.Cognitive performance tests(including verbal memory,semantic fluency,executive function,and global cognitive function tests),the Cardiovascular Risk Factors,Aging,and Incidence of Dementia(CIDE)risk score,and the CAC score(CACS)were evaluated by questionnaires and CT.A CAIDE score≥10 was considered to indicate a high risk of dementia in late-life.Participants were divided into three groups according to CACS(0,1-399,≥400).Results After adjusting for risk factors,CACS was significantly associated with verbal memory(r=-0.083,P=0.003)and global cognitive function(r=-0.070,P=0.012).The prevalence of a high risk of dementia in the subgroups of CACS=0,1-399,and≥400 was 4.67%,13.66%,and 24.79%,respectively(P<0.001).Individuals with CACS≥400 had a higher risk of CAIDE score≥10[OR=2.30(1.56,4.56),P=0.014]than those with CACS=0.The receiver-operating characteristic curves showed that the capability of CACS to identify participants with a high risk of dementia was moderate(AUC=0.70,95%CI:0.67-0.72,P<0.001).Conclusions CAC,a marker of subclinical atherosclerosis,was significantly associated with cognitive performance in verbal memory and global cognitive function.CAC had a moderate capability to identify participants with a high risk of dementia,independent of age,education,and other risk factors.
基金Supported by the National Natural Science Foundation of China under Grant No 11574170
文摘We demonstrate a diode pumped Yb：LuVO4 laser that can be passively Q-switched by a Cr^（4＋）：YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generated at a repetition rate of 285.7 kHz,approaching or very near the intrinsic upper limit imposed by the recovery time of the Cr^（4＋）：YAG saturable absorber,and the resulting pulse energy,duration and peak power are,respectively,8.2μJ,39.2ns and 0.209kW.
